{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:42:58Z","timestamp":1792183378781,"version":"4.4.0"},"reference-count":61,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,8,14]]},"DOI":"10.1167\/iovs.66.11.37","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T13:00:37Z","timestamp":1755176437000},"page":"37","source":"Crossref","is-referenced-by-count":1,"title":["Dual VEGF-Targeting Strategy Via AAV2-Delivered sFLT-1 and shVEGF for Retinal Neovascularization Therapy"],"prefix":"10.1167","volume":"66","author":[{"given":"Cuiting","family":"Chen","sequence":"first","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Disease, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"},{"name":"Huaxia Eye Hospital of Quanzhou, Quanzhou, Fujian, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqin","family":"Yang","sequence":"additional","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Disease, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyue","family":"Jiang","sequence":"additional","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Disease, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"},{"name":"Huaxia Eye Hospital of Quanzhou, Quanzhou, Fujian, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Disease, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"},{"name":"Huaxia Eye Hospital of Quanzhou, Quanzhou, Fujian, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Huang","sequence":"additional","affiliation":[{"name":"Slovemed Xiamen limited, Xiamen, Fujian, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdie","family":"Li","sequence":"additional","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Disease, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Disease, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Disease, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabin","family":"Deng","sequence":"additional","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zu","sequence":"additional","affiliation":[{"name":"Slovemed Xiamen limited, Xiamen, Fujian, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuo","family":"Dong","sequence":"additional","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Disease, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"},{"name":"Huaxia Eye Hospital of Quanzhou, Quanzhou, Fujian, People's Republic of China"},{"name":"Xiamen Key Laboratory of Ophthalmology Corneal and Ocular Surface Diseases, Xiamen, Fujian, People's Republic of China"},{"name":"Translational Medicine Institute of Xiamen Eye Center of Xiamen University, Xiamen, Fujian, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center, State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science and Ocular Surface and Corneal Disease, School of Medicine, Xiamen University, Xiamen, Fujian, People's Republic of China"},{"name":"Huaxia Eye Hospital of Quanzhou, Quanzhou, Fujian, People's Republic of China"},{"name":"Shen Zhen Research Institute of Xiamen University, Shenzhen, Guangdong, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"6","key":"bib1","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nm0603-653","article-title":"Angiogenesis in health and disease","volume":"9","author":"Carmeliet","year":"2003","journal-title":"Nat Med"},{"issue":"9070","key":"bib2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/S0140-6736(97)01107-0","article-title":"Retinopathy of prematurity in middle-income countries","volume":"350","author":"Gilbert","year":"1997","journal-title":"Lancet"},{"issue":"3","key":"bib3","doi-asserted-by":"publisher","first-page":"e2021053924","DOI":"10.1542\/peds.2021-053924","article-title":"Retinopathy of prematurity: a global perspective and recent developments","volume":"150","author":"Sabri","year":"2022","journal-title":"Pediatrics"},{"issue":"10153","key":"bib4","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/S0140-6736(18)31550-2","article-title":"Age-related macular degeneration","volume":"392","author":"Mitchell","year":"2018","journal-title":"Lancet"},{"issue":"6398","key":"bib5","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/359843a0","article-title":"Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis","volume":"359","author":"Shweiki","year":"1992","journal-title":"Nature"},{"issue":"21","key":"bib6","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.3390\/cells11213453","article-title":"A linkage between angiogenesis and inflammation in neovascular age-related macular degeneration","volume":"11","author":"Heloter\u00e4","year":"2022","journal-title":"Cells"},{"issue":"3","key":"bib7","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/jcp.21698","article-title":"Oxidative stress promotes ocular neovascularization","volume":"219","author":"Dong","year":"2009","journal-title":"J Cell Physiol"},{"issue":"1","key":"bib8","first-page":"182","article-title":"Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression","volume":"40","author":"Ozaki","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.cell.2005.10.036","article-title":"VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells","volume":"124","author":"Grunewald","year":"2006","journal-title":"Cell"},{"issue":"8","key":"bib10","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1136\/bjo.2008.148841","article-title":"Differences in retinal neovascular tissue and vitreous humour in patients with type 1 and type 2 diabetes","volume":"93","author":"Kinnunen","year":"2009","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1001\/jamaophthalmol.2015.4110","article-title":"Comparison of aflibercept, bevacizumab, and ranibizumab for treatment of diabetic macular edema: extrapolation of data to clinical practice","volume":"134","author":"Heier","year":"2016","journal-title":"JAMA Ophthalmol"},{"issue":"2-a Suppl","key":"bib12","first-page":"S3","article-title":"Optimizing anti-VEGF treatment outcomes for patients with neovascular age-related macular degeneration","volume":"24","author":"Wykoff","year":"2018","journal-title":"J Manag Care Spec Pharm"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ophtha.2019.04.017","article-title":"HAWK and HARRIER: phase 3, multicenter, randomized, double-masked trials of brolucizumab for neovascular age-related macular degeneration","volume":"127","author":"Dugel","year":"2020","journal-title":"Ophthalmology"},{"issue":"10","key":"bib14","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.3390\/medicina59101856","article-title":"Intraocular inflammation secondary to intravitreal brolucizumab injection for neovascular age-related macular degeneration in a patient with cognitive impairment","volume":"59","author":"Ueji","year":"2023","journal-title":"Medicina (Kaunas)"},{"issue":"3","key":"bib15","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/1469-0691.12118","article-title":"Endophthalmitis","volume":"19","author":"Durand","year":"2013","journal-title":"Clin Microbiol Infect"},{"issue":"51","key":"bib16","doi-asserted-by":"publisher","first-page":"e36589","DOI":"10.1097\/MD.0000000000036589","article-title":"Application of intravitreal aflibercept to treat bilateral exudative retinal detachment secondary to retinitis pigmentosa: case report and review of literature","volume":"102","author":"Kao","year":"2023","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"bib17","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.ophtha.2011.12.039","article-title":"Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE","volume":"119","author":"Nguyen","year":"2012","journal-title":"Ophthalmology"},{"issue":"9","key":"bib18","doi-asserted-by":"publisher","first-page":"e2335148","DOI":"10.1001\/jamanetworkopen.2023.35148","article-title":"Intravitreal vascular endothelial growth factor inhibitor therapy in Denmark and 5-year projections","volume":"6","author":"Thinggaard","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.joco.2018.01.006","article-title":"Prospect of retinal gene therapy following commercialization of voretigene neparvovec-rzyl for retinal dystrophy mediated by RPE65 mutation","volume":"30","author":"Ameri","year":"2018","journal-title":"J Curr Ophthalmol"},{"issue":"2","key":"bib20","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3390\/diseases6020042","article-title":"Viral vectors in gene therapy","volume":"6","author":"Lundstrom","year":"2018","journal-title":"Diseases"},{"issue":"3","key":"bib21","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1007\/s00253-017-8670-1","article-title":"Molecular design for recombinant adeno-associated virus (rAAV) vector production","volume":"102","author":"Aponte-Ubillus","year":"2018","journal-title":"Appl Microbiol Biotechnol"},{"issue":"11","key":"bib22","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/gt.2008.55","article-title":"Adeno-associated virus integration: virus versus vector","volume":"15","author":"Smith","year":"2008","journal-title":"Gene Ther"},{"issue":"4","key":"bib23","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s40259-017-0234-5","article-title":"Adeno-associated virus (AAV) as a vector for gene therapy","volume":"31","author":"Naso","year":"2017","journal-title":"BioDrugs"},{"issue":"22","key":"bib24","doi-asserted-by":"publisher","first-page":"10705","DOI":"10.1073\/pnas.90.22.10705","article-title":"Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor","volume":"90","author":"Kendall","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"issue":"15","key":"bib25","doi-asserted-by":"publisher","first-page":"8795","DOI":"10.1073\/pnas.95.15.8795","article-title":"Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate","volume":"95","author":"Goldman","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib26","first-page":"141","article-title":"Short hairpin RNA (shRNA): design, delivery, and assessment of gene knockdown","volume":"629","author":"Moore","year":"2010","journal-title":"Methods Mol Biol"},{"issue":"11","key":"bib27","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1038\/nprot.2009.187","article-title":"Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis","volume":"4","author":"Connor","year":"2009","journal-title":"Nat Protoc"},{"issue":"10","key":"bib28","doi-asserted-by":"publisher","first-page":"4564","DOI":"10.1172\/JCI74527","article-title":"Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature","volume":"124","author":"Shen","year":"2014","journal-title":"J Clin Invest"},{"issue":"3","key":"bib29","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00441-019-03166-9","article-title":"M2 macrophages promote vasculogenesis during retinal neovascularization by regulating bone marrow-derived cells via SDF-1\/VEGF","volume":"380","author":"Wang","year":"2020","journal-title":"Cell Tissue Res"},{"issue":"12","key":"bib30","doi-asserted-by":"publisher","first-page":"e139202","DOI":"10.1172\/JCI139202","article-title":"HIF-1a and HIF-2a redundantly promote retinal neovascularization in patients with ischemic retinal disease","volume":"131","author":"Zhang","journal-title":"J Clin Invest"},{"issue":"4","key":"bib31","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1111\/febs.16330","article-title":"The blood-retina barrier in health and disease","volume":"290","author":"O'Leary","year":"2023","journal-title":"FEBS J"},{"issue":"4","key":"bib32","doi-asserted-by":"publisher","first-page":"e21437","DOI":"10.1096\/fj.202002755R","article-title":"CaMKIId is upregulated by pro-inflammatory cytokine IL-6 in a JAK\/STAT3-dependent manner to promote angiogenesis","volume":"35","author":"O'Brien","year":"2021","journal-title":"FASEB J"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/B978-0-444-64032-1.00032-1","article-title":"Electroretinograms","volume":"160","author":"Creel","year":"2019","journal-title":"Handb Clin Neurol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/978-3-319-58290-0","article-title":"Anti-angiogenic therapy for retinal disease","volume":"242","author":"Paulus","year":"2017","journal-title":"Handb Exp Pharmacol"},{"key":"bib35","first-page":"0291","article-title":"AAV for gene therapy in ocular diseases: progress and prospects","volume":"6","author":"He","year":"2023","journal-title":"Research (Wash D C)"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1038\/ncomms1977","article-title":"The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis","volume":"3","author":"Cudmore","year":"2012","journal-title":"Nat Commun"},{"issue":"1","key":"bib37","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/gt.2008.115","article-title":"Novel anti-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization","volume":"16","author":"Pechan","year":"2009","journal-title":"Gene Ther"},{"issue":"12","key":"bib38","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/sj.gt.3301695","article-title":"Potential long-term inhibition of ocular neovascularisation by recombinant adeno-associated virus-mediated secretion gene therapy","volume":"9","author":"Lai","year":"2002","journal-title":"Gene Ther"},{"issue":"10089","key":"bib39","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/S0140-6736(17)30979-0","article-title":"Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial","volume":"390","author":"Heier","year":"2017","journal-title":"Lancet"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ajo.2017.02.018","article-title":"Gene therapy in neovascular age-related macular degeneration: three-year follow-up of a phase 1 randomized dose escalation trial","volume":"177","author":"Constable","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.ebiom.2016.11.016","article-title":"Phase 2a randomized clinical trial: safety and post hoc analysis of subretinal rAAV.sFLT-1 for wet age-related macular degeneration","volume":"14","author":"Constable","year":"2016","journal-title":"EBioMedicine"},{"issue":"9","key":"bib42","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.addr.2009.04.004","article-title":"siRNA vs. shRNA: similarities and differences","volume":"61","author":"Rao","year":"2009","journal-title":"Adv Drug Deliv Rev"},{"issue":"9","key":"bib43","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/nmeth927","article-title":"Expressing short hairpin RNAs in vivo","volume":"3","author":"Sn\u00f8ve","year":"2006","journal-title":"Nat Methods"},{"issue":"3","key":"bib44","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1159\/000331428","article-title":"Suppression of retinal neovascularization by lentivirus-mediated netrin-1 small hairpin RNA","volume":"47","author":"Xu","year":"2012","journal-title":"Ophthalmic Res"},{"issue":"11","key":"bib45","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1007\/s00417-020-04797-3","article-title":"Inhibition of retinal neovascularization by VEGF siRNA delivered via bioreducible lipid-like nanoparticles","volume":"258","author":"Wang","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"1","key":"bib46","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/2211-5463.13281","article-title":"AAV expressing an mTOR-inhibiting siRNA exhibits therapeutic potential in retinal vascular disorders by preserving endothelial integrity","volume":"12","author":"Cha","year":"2022","journal-title":"FEBS Open Bio"},{"issue":"9","key":"bib47","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1016\/j.ophtha.2012.03.043","article-title":"Evaluation of the siRNA PF-04523655 versus ranibizumab for the treatment of neovascular age-related macular degeneration (MONET Study)","volume":"119","author":"Nguyen","year":"2012","journal-title":"Ophthalmology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/978-1-4939-7522-8","article-title":"Development of multigenic lentiviral vectors for cell-specific expression of antiangiogenic miRNAs and protein factors","volume":"1715","author":"Askou","year":"2018","journal-title":"Methods Mol Biol"},{"issue":"10","key":"bib49","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s00109-018-1683-0","article-title":"Cell-specific gene therapy driven by an optimized hypoxia-regulated vector reduces choroidal neovascularization","volume":"96","author":"Biswal","year":"2018","journal-title":"J Mol Med"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.omtn.2019.01.012","article-title":"Suppression of choroidal neovascularization by AAV-based dual-acting antiangiogenic gene therapy","volume":"16","author":"Askou","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"issue":"14","key":"bib51","doi-asserted-by":"publisher","first-page":"11767","DOI":"10.3390\/ijms241411767","article-title":"MicroRNA-124-3p attenuated retinal neovascularization in oxygen-induced retinopathy mice by inhibiting the dysfunction of retinal neuroglial cells through STAT3 pathway","volume":"24","author":"Hong","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"11","key":"bib52","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1167\/iovs.64.11.8","article-title":"SYVN1 promotes STAT3 protein ubiquitination and exerts antiangiogenesis effects in retinopathy of prematurity development","volume":"64","author":"Chen","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib53","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1001\/archophthalmol.2011.298","article-title":"Gene therapy for Leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years","volume":"130","author":"Jacobson","year":"2012","journal-title":"Arch Ophthalmol"},{"issue":"189","key":"bib54","doi-asserted-by":"publisher","first-page":"189ra76","DOI":"10.1126\/scitranslmed.3005708","article-title":"In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous","volume":"5","author":"Dalkara","year":"2013","journal-title":"Sci Transl Med"},{"issue":"4","key":"bib55","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/j.1748-1716.2011.02355.x","article-title":"Structure and function of a complex sensory synapse","volume":"204","author":"Regus-Leidig","year":"2012","journal-title":"Acta Physiol (Oxf)"},{"issue":"5","key":"bib56","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1096\/fj.13-248021","article-title":"Progressive dysfunction of the retinal pigment epithelium and retina due to increased VEGF-A levels","volume":"28","author":"Ablonczy","year":"2014","journal-title":"FASEB J"},{"issue":"13","key":"bib57","doi-asserted-by":"publisher","first-page":"8125","DOI":"10.1167\/iovs.13-12496","article-title":"Systemic inflammation perturbs developmental retinal angiogenesis and neuroretinal function","volume":"54","author":"Tremblay","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib58","doi-asserted-by":"crossref","first-page":"e154","DOI":"10.1111\/j.1755-3768.2012.02546.x","article-title":"Effects of repeated intravitreal bevacizumab injections on the inner retinal function in neovascular age-related macular degeneration","volume":"91","author":"Kim","year":"2013","journal-title":"Acta Ophthalmol"},{"issue":"7","key":"bib59","doi-asserted-by":"publisher","first-page":"3138","DOI":"10.1167\/iovs.17-21593","article-title":"The urokinase receptor-derived peptide UPARANT recovers dysfunctional electroretinogram and blood-retinal barrier leakage in a rat model of diabetes","volume":"58","author":"Cammalleri","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"bib60","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/j.ophtha.2020.04.017","article-title":"Retinal vasculitis and intraocular inflammation after intravitreal injection of brolucizumab","volume":"127","author":"Baumal","year":"2020","journal-title":"Ophthalmology"},{"issue":"9","key":"bib61","doi-asserted-by":"publisher","first-page":"e231067","DOI":"10.1001\/jamaophthalmol.2023.1067","article-title":"Choroidal detachment after intravitreal injection of faricimab","volume":"141","author":"Sch\u00f6nbach","year":"2023","journal-title":"JAMA Ophthalmol"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:04Z","timestamp":1791927124000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":61,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.11.37","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,14]]}}}