{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:22Z","timestamp":1791928942605,"version":"4.3.4"},"reference-count":32,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,8,29]]},"DOI":"10.1167\/iovs.66.11.75","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:00:43Z","timestamp":1756468843000},"page":"75","source":"Crossref","is-referenced-by-count":3,"title":["Predicting the Structure\u2013Function Relationship in Glaucoma Using a Physiological Model"],"prefix":"10.1167","volume":"66","author":[{"given":"Chris","family":"Bradley","sequence":"first","affiliation":[{"name":"Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jithin","family":"Yohannan","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States"},{"name":"Malone Center of Engineering in Healthcare, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"4","key":"bib1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/j.1442-9071.2012.02770.x","article-title":"'Structure-function relationship' in glaucoma: past thinking and current concepts","volume":"40","author":"Malik","year":"2012","journal-title":"Clin Exp Ophthalmol"},{"issue":"2","key":"bib2","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.preteyeres.2007.08.001","article-title":"A framework for comparing structural and functional measures of glaucomatous damage","volume":"26","author":"Hood","year":"2007","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"bib3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.preteyeres.2010.02.001","article-title":"Linking structure and function in glaucoma","volume":"29","author":"Harwerth","year":"2010","journal-title":"Prog Retin Eye Res"},{"issue":"7","key":"bib4","first-page":"1774","article-title":"Scaling the hill of vision: the physiological relationship between light sensitivity and ganglion cell numbers","volume":"41","author":"Garway-Heath","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib5","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1167\/iovs.03-0374","article-title":"Perimetric defects and ganglion cell damage: interpreting linear relations using a two-stage neural model","volume":"45","author":"Swanson","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib6","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1097\/OPX.0b013e31818b94af","article-title":"Ganglion cell loss and dysfunction: relationship to perimetric sensitivity","volume":"85","author":"Drasdo","year":"2008","journal-title":"Optom Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.1016\/j.visres.2007.01.007","article-title":"The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual field","volume":"47","author":"Drasdo","year":"2007","journal-title":"Vis Res"},{"issue":"7","key":"bib8","first-page":"2213","article-title":"Relationship between electrophysiological, psychophysical, and anatomical measurements in glaucoma","volume":"43","author":"Garway-Heath","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7\u20138","key":"bib9","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/0042-6989(91)90058-D","article-title":"The relative contributions of pre-neural and neural factors to areal summation in the fovea","volume":"31","author":"Davila","year":"1991","journal-title":"Vis Res"},{"issue":"11","key":"bib10","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1167\/6.11.2","article-title":"A cortical pooling model of spatial summation for perimetric stimuli","volume":"6","author":"Pan","year":"2006","journal-title":"J Vis"},{"issue":"12","key":"bib12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1167\/14.12.22","article-title":"Retina-V1 model of detectability across the visual field","volume":"14","author":"Bradley","year":"2014","journal-title":"J Vis"},{"issue":"2","key":"bib14","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1364\/JOSAA.10.000201","article-title":"Modulation transfer function of the human eye as a function of retinal eccentricity","volume":"10","author":"Navarro","year":"1993","journal-title":"J Opt Soc Am A"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/0042-6989(65)90033-7","article-title":"Quantitative analysis of cat retinal ganglion cell response to visual stimuli","volume":"5","author":"Rodieck","year":"1965","journal-title":"Vis Res"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.preteyeres.2018.06.003","article-title":"The dynamic receptive fields of retinal ganglion cells","volume":"67","author":"Wienbar","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"bib17","first-page":"441061","article-title":"The mosaic of nerve cells in the mammalian retina","volume":"200","author":"W\u00e4ssle","year":"1978","journal-title":"Proc R Soc London Ser B, Biol Sci."},{"issue":"12","key":"bib18","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1038\/eye.2012.216","article-title":"Retinal nerve fiber layer and optic disc measurements by spectral domain OCT: normative values and association in young adults","volume":"26","author":"Tariq","year":"2012","journal-title":"Eye (Lond)"},{"issue":"6","key":"bib19","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.ajo.2010.06.024","article-title":"Comparison of retinal nerve fiber layer thickness in normal eyes using time-domain and spectral-domain optical coherence tomography","volume":"150","author":"Seibold","year":"2010","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"bib20","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.ophtha.2008.12.032","article-title":"Comparison of retinal nerve fiber layer measurements using time domain and spectral domain optical coherent tomography","volume":"116","author":"Knight","year":"2009","journal-title":"Ophthalmology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"6344","DOI":"10.1167\/iovs.15-17248","article-title":"Residual and dynamic range of retinal nerve fiber layer thickness in glaucoma: comparison of three OCT platforms","volume":"56","author":"Mwanza","year":"2015","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1097\/IJG.0000000000001374","article-title":"Structure-function relationship in advanced glaucoma after reaching the RNFL floor","volume":"28","author":"Sung","year":"2019","journal-title":"J Glaucoma"},{"issue":"1","key":"bib23","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0042-6989(94)E0066-T","article-title":"Receptive fields of P and M ganglion cells across the primate retina","volume":"35","author":"Croner","year":"1995","journal-title":"Vis Res"},{"issue":"7","key":"bib24","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1016\/j.ophtha.2014.01.020","article-title":"Assessment of the reliability of standard automated perimetry in regions of glaucomatous damage","volume":"121","author":"Gardiner","year":"2014","journal-title":"Ophthalmology"},{"issue":"10","key":"bib25","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0161-6420(00)00284-0","article-title":"Mapping the visual field to the optic disc in normal tension glaucoma eyes","volume":"100","author":"Garway-Heath","year":"2000","journal-title":"Ophthalmology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1523\/JNEUROSCI.11-04-00994.1991","article-title":"The effects of parvocellular lateral geniculate lesions on the acuity and contrast sensitivity of macaque monkeys","volume":"11","author":"Merigan","year":"1991","journal-title":"J Neurosci"},{"issue":"8","key":"bib27","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1073\/pnas.83.8.2755","article-title":"The primate retina contains two types of ganglion cells, with high and low contrast sensitivity","volume":"83","author":"Kaplan","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12\u201328","key":"bib28","first-page":"63","article-title":"Physiology, morphology and spatial densities of identified ganglion cell types primate retina","volume":"184","author":"Dacey","year":"1994","journal-title":"Ciba Found Symp"},{"issue":"7","key":"bib29","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1167\/14.7.15","article-title":"A formula for human retinal ganglion cell receptive field density as a function of visual field location","volume":"14","author":"Watson","year":"2014","journal-title":"J Vis."},{"issue":"4","key":"bib30","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1167\/jov.23.4.2","article-title":"Spatiotemporal summation of perimetric stimuli in healthy observers","volume":"23","author":"Montesano","year":"2023","journal-title":"J Vis."},{"issue":"10","key":"bib31","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1167\/tvst.9.10.15","article-title":"Revisiting the Drasdo model: implications for structure-function analysis of the macular region","volume":"9","author":"Montesano","year":"2020","journal-title":"Tranl Vis Sci Technol"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.exer.2012.10.008","article-title":"A mathematical model for describing the retinal nerve fiber bundle trajectories in the human eye: average course, variability, and influence of refraction, optic disc size and optic disc position","volume":"105","author":"Jansonius","year":"2012","journal-title":"Exp Eye Res"},{"key":"bib11","author":"Our World in Data"},{"key":"bib13","first-page":"542","article-title":"Development of an image\/threshold database for designing and testing human vision models","volume-title":"Proceedings Volume 3644, Human Vision and Electronic Imaging IV","author":"Carney","year":"1999"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:12Z","timestamp":1791927132000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.11.75","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,29]]}}}