{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:58Z","timestamp":1791928858426,"version":"4.3.4"},"reference-count":33,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,9,8]]},"DOI":"10.1167\/iovs.66.12.18","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T12:31:00Z","timestamp":1757334660000},"page":"18","source":"Crossref","is-referenced-by-count":2,"title":["Tropism and Retinal Transduction Efficiency of Adeno-Associated Virus Serotypes in Mice"],"prefix":"10.1167","volume":"66","author":[{"given":"Wenjing","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States"},{"name":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"McRae","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asa","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin-Paul","family":"Agbaga","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States"},{"name":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"645600","DOI":"10.3389\/fcell.2021.645600","article-title":"Updating the genetic landscape of inherited retinal dystrophies","volume":"9","author":"Garc\u00eda Boh\u00f3rquez","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1167\/iovs.65.13.38","article-title":"Optimization of HITI-mediated gene insertion for rhodopsin and peripherin-2 in mouse rod photoreceptors: targeting dominant retinitis pigmentosa","volume":"65","author":"Onishi","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1310050","DOI":"10.3389\/fmed.2023.1310050","article-title":"Adeno-associated virus vectors for retinal gene therapy in basic research and clinical studies","volume":"10","author":"Xia","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S0140-6736(17)31868-8","article-title":"Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial","volume":"390","author":"Russell","year":"2017","journal-title":"Lancet"},{"key":"bib7","first-page":"0291","article-title":"AAV for gene therapy in ocular diseases: progress and prospects","volume":"6","author":"He","year":"2023","journal-title":"Research (Wash D C)"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/978-3-031-27681-1","article-title":"AAV serotypes and their suitability for retinal gene therapy","volume":"1415","author":"Ebner","year":"2023","journal-title":"Adv Exp Med Biol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1086\/595830","article-title":"Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses","volume":"199","author":"Calcedo","year":"2009","journal-title":"J Infect Dis"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1167\/tvst.13.12.28","article-title":"Inherited retinal degenerations and non-neovascular age-related macular degeneration: progress and unmet needs","volume":"13","author":"Duncan","year":"2024","journal-title":"Transl Vis Sci Technol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1089\/jop.2017.0121","article-title":"Intravitreal, subretinal, and suprachoroidal injections: evolution of microneedles for drug delivery","volume":"34","author":"Hartman","year":"2018","journal-title":"J Ocul Pharmacol Ther"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"4717","DOI":"10.3390\/jcm11164717","article-title":"Subretinal injection techniques for retinal disease: a review","volume":"11","author":"Irigoyen","year":"2022","journal-title":"J Clin Med"},{"key":"bib13","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.4103\/1673-5374.306063","article-title":"The future of retinal gene therapy: evolving from subretinal to intravitreal vector delivery","volume":"16","author":"Ross","year":"2021","journal-title":"Neural Regeneration Res"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"189ra176","DOI":"10.1126\/scitranslmed.3005708","article-title":"In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous","volume":"5","author":"Dalkara","year":"2013","journal-title":"Sci Transl Med"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"e135112","DOI":"10.1172\/jci.insight.135112","article-title":"In vivo-directed evolution of adeno-associated virus in the primate retina","volume":"5","author":"Byrne","year":"2020","journal-title":"JCI insight"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1002\/bit.26031","article-title":"Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8","volume":"113","author":"Khabou","year":"2016","journal-title":"Biotechnol Bioeng"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1089\/hum.2016.111","article-title":"Evaluation of Dose and Safety of AAV7m8 and AAV8BP2 in the Non-Huma Primate Retina","volume":"28","author":"Ramachandran","year":"2017","journal-title":"Hum Gene Ther"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"e6317","DOI":"10.7717\/peerj.6317","article-title":"Evaluation of AAV-DJ vector for retinal gene therapy","volume":"7","author":"Katada","year":"2019","journal-title":"PeerJ"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/mt.2010.234","article-title":"Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina","volume":"19","author":"Petrs-Silva","year":"2011","journal-title":"Mol Ther"},{"key":"bib20","first-page":"101646","article-title":"Intravitreal injection of new adeno-associated viral vector: enhancing retinoschisin 1 gene transduction in a mouse model of X-linked retinoschisis","volume":"37","author":"Sun","year":"2024","journal-title":"Biochey Biophys Rep"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.omtn.2023.05.001","article-title":"Improved gene therapy for MFRP deficiency-mediated retinal degeneration by knocking down endogenous bicistronic Mfrp and Ctrp5 transcript","volume":"32","author":"Tian","year":"2023","journal-title":"Mole Ther Nucleic Acids"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"4215","DOI":"10.1128\/JVI.00200-16","article-title":"Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors","volume":"90","author":"Boye","year":"2016","journal-title":"J Virol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/s41434-024-00477-7","article-title":"The AAV2.7m8 capsid packages a higher degree of heterogeneous vector genomes than AAV2","volume":"31","author":"Cui","year":"2024","journal-title":"Gene Ther"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"102394","DOI":"10.1016\/j.eclinm.2023.102394","article-title":"Safety and efficacy of ixoberogene soroparvovec in neovascular age-related macular degeneration in the United States (OPTIC): a prospective, two-year, multicentre phase 1 study","volume":"67","author":"Khanani","year":"2024","journal-title":"EClinicalMedicine"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/S0140-6736(17)30979-0","article-title":"Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial","volume":"390","author":"Heier","year":"2017","journal-title":"Lancet"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"5887","DOI":"10.1128\/JVI.00254-08","article-title":"In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses","volume":"82","author":"Grimm","year":"2008","journal-title":"J Virol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"e2115202119","DOI":"10.1073\/pnas.2115202119","article-title":"The interplay of environmental luminance and genetics in the retinal dystrophy induced by the dominant RPE65 mutation","volume":"119","author":"Wu","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1167\/iovs.65.3.34","article-title":"NLRP3 inflammasome priming in the retina of diabetic mice requires REDD1-dependent activation of GSK3\u00df","volume":"65","author":"McCurry","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.bbr.2017.07.040","article-title":"Vision in laboratory rodents\u2014tools to measure it and implications for behavioral research","volume":"352","author":"Leinonen","year":"2018","journal-title":"Behav Brain Res"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1007\/s00417-015-3127-7","article-title":"Elevated vitreous body glial fibrillary acidic protein in retinal diseases","volume":"253","author":"J\u00fcnemann","year":"2015","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"31104","DOI":"10.1038\/srep31104","article-title":"Electroretinographic evaluations of retinal function before, just after and after intravitreal injections","volume":"6","author":"Yagura","year":"2016","journal-title":"Sci Rep"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.4103\/ijo.IJO_3117_20","article-title":"Gene therapy in retinal diseases: a review","volume":"69","author":"Dhurandhar","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1167\/iovs.64.7.39","article-title":"Gene therapy for retinal degenerative diseases: progress, challenges, and future directions","volume":"64","author":"Drag","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib2","article-title":"RetNet, the Retinal Information Network. Summaries of genes and loci causing retinal diseases"},{"key":"bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-981-16-7337-5_1","article-title":"Molecular genetics of inherited retinal diseases","volume-title":"Inherited Retinal Disease","author":"Ma","year":"2022"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:59Z","timestamp":1791927119000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,9,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.12.18","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,8]]}}}