{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:39Z","timestamp":1791928899378,"version":"4.3.4"},"reference-count":45,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,8,29]]},"DOI":"10.1167\/iovs.66.12.2","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T12:30:47Z","timestamp":1756816247000},"page":"2","source":"Crossref","is-referenced-by-count":0,"title":["Nkx3.2 Inhibits Retinal Degeneration by Modulating Inflammation and Cell Death in RPE"],"prefix":"10.1167","volume":"66","author":[{"given":"Minsun","family":"Park","sequence":"first","affiliation":[{"name":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea"},{"name":"ICM Company Limited, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea"},{"name":"ICM Company Limited, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Un","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Sol","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea"},{"name":"Korea Mouse Sensory Phenotyping Center, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeon","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Life Science, College of Science, Ewha Womans University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Kyoung","family":"Oh","sequence":"additional","affiliation":[{"name":"ICM Company Limited, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ho","family":"Jang","sequence":"additional","affiliation":[{"name":"ICM Company Limited, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nari","family":"Ryu","sequence":"additional","affiliation":[{"name":"ICM Company Limited, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjin","family":"Jeong","sequence":"additional","affiliation":[{"name":"ICM Company Limited, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Do","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea"},{"name":"ICM Company Limited, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Yul","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea"},{"name":"Korea Mouse Sensory Phenotyping Center, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghyuk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Life Science, College of Science, Ewha Womans University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea"},{"name":"ICM Company Limited, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ceb.2019.08.001","article-title":"Retinal pigment epithelium polarity in health and blinding diseases","volume":"62","author":"Caceres","year":"2020","journal-title":"Curr Opin Cell Biol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"727870","DOI":"10.3389\/fphar.2021.727870","article-title":"Functions and diseases of the retinal pigment epithelium","volume":"12","author":"Yang","year":"2021","journal-title":"Front Pharmacol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.preteyeres.2017.03.002","article-title":"The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD","volume":"60","author":"Datta","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41572-021-00265-2","article-title":"Age-related macular degeneration","volume":"7","author":"Fleckenstein","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3390\/ijms23010386","article-title":"The role of inflammation in retinal neurodegeneration and degenerative diseases","volume":"23","author":"Kaur","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.3390\/antiox11061086","article-title":"Inherited retinal dystrophies: role of oxidative stress and inflammation in their physiopathology and therapeutic implications","volume":"11","author":"Pinilla","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"e965","DOI":"10.1038\/cddis.2013.478","article-title":"Induction of necrotic cell death by oxidative stress in retinal pigment epithelial cells","volume":"4","author":"Hanus","year":"2013","journal-title":"Cell Death Dis"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"16054","DOI":"10.1038\/cddiscovery.2016.54","article-title":"Retinal pigment epithelial cell necroptosis in response to sodium iodate","volume":"2","author":"Hanus","year":"2016","journal-title":"Cell Death Discov"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"831463","DOI":"10.3389\/fmed.2022.831463","article-title":"Blue light induces RPE cell necroptosis, which can be inhibited by minocycline","volume":"9","author":"Song","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"e128834","DOI":"10.1172\/jci.insight.128834","article-title":"Necroptosis: a crucial pathogenic mediator of human disease","volume":"4","author":"Choi","year":"2019","journal-title":"JCI Insight"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.molcel.2014.03.003","article-title":"Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3","volume":"54","author":"Wang","year":"2014","journal-title":"Mol Cell"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"16072","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","article-title":"The role of synovitis in osteoarthritis pathogenesis","volume":"51","author":"Scanzello","year":"2012","journal-title":"Bone"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","article-title":"Synovial inflammation in osteoarthritis progression","volume":"18","author":"Sanchez-Lopez","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1042\/BJ20112062","article-title":"Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation","volume":"443","author":"Choi","year":"2012","journal-title":"Biochem J"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.cellsig.2017.05.001","article-title":"Nkx3.2 induces oxygen concentration-independent and lysosome-dependent degradation of HIF-1a to modulate hypoxic responses in chondrocytes","volume":"36","author":"Im","year":"2017","journal-title":"Cell Signal"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/jcp.25446","article-title":"Cartilage-specific and cre-dependent Nkx3.2 overexpression in vivo causes skeletal dwarfism by delaying cartilage hypertrophy","volume":"232","author":"Jeong","year":"2017","journal-title":"J Cell Physiol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"e34703","DOI":"10.1371\/journal.pone.0034703","article-title":"Nkx3.2 promotes primary chondrogenic differentiation by upregulating Col2a1 transcription","volume":"7","author":"Kawato","year":"2012","journal-title":"PLoS One"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/ncb1538","article-title":"Constitutive RelA activation mediated by Nkx3.2 controls chondrocyte viability","volume":"9","author":"Park","year":"2007","journal-title":"Nat Cell Biol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"2802","DOI":"10.1128\/MCB.00253-10","article-title":"Exogenous signal-independent nuclear I?B kinase activation triggered by Nkx3.2 enables constitutive nuclear degradation of I?B-a in chondrocytes","volume":"31","author":"Yong","year":"2011","journal-title":"Mol Cell Biol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.bbrc.2021.07.074","article-title":"Suppression of osteoarthritis progression by post-natal induction of Nkx3.2","volume":"571","author":"Oh","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"11582","DOI":"10.1038\/s41598-020-68565-3","article-title":"Comparison of ophthalmic toxicity of light-emitting diode and organic light-emitting diode light sources","volume":"10","author":"Jun","year":"2020","journal-title":"Sci Rep"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"e0132643","DOI":"10.1371\/journal.pone.0132643","article-title":"Optimization of an image-guided laser-induced choroidal neovascularization model in mice","volume":"10","author":"Gong","year":"2015","journal-title":"PLoS One"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"7836828","DOI":"10.1155\/2022\/7836828","article-title":"Role of oxidative stress in retinal disease and the early intervention strategies: a review","volume":"2022","author":"Wang","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/iovs.62.7.9","article-title":"Age-related retinal changes in wild-type C57BL\/6J mice between 2 and 32 months","volume":"62","author":"Ferdous","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.3390\/ijms22042096","article-title":"Retinal inflammation, cell death and inherited retinal dystrophies","volume":"22","author":"Olivares-Gonzalez","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/ncb2883","article-title":"Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis","volume":"16","author":"Cai","year":"2014","journal-title":"Nat Cell Biol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.molcel.2018.05.016","article-title":"PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation","volume":"70","author":"Choi","year":"2018","journal-title":"Mol Cell"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ncb3314","article-title":"CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3","volume":"18","author":"Seo","year":"2016","journal-title":"Nat Cell Biol"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.preteyeres.2017.03.003","article-title":"Unravelling the genetics of inherited retinal dystrophies: past, present and future","volume":"59","author":"Broadgate","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.1007\/s00018-016-2318-7","article-title":"Metabolic and redox signaling in the retina","volume":"74","author":"Leveillard","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.3390\/genes11101120","article-title":"Mechanisms of Photoreceptor Death in Retinitis Pigmentosa","volume":"11","author":"Newton","year":"2020","journal-title":"Genes (Basel)"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"5381","DOI":"10.3390\/ijms22105381","article-title":"Retinal pigment epithelium remodeling in mouse models of retinitis pigmentosa","volume":"22","author":"Napoli","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/jcp.20346","article-title":"Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa","volume":"203","author":"Shen","year":"2005","journal-title":"J Cell Physiol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"101201","DOI":"10.1016\/j.redox.2019.101201","article-title":"Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors","volume":"24","author":"Brown","year":"2019","journal-title":"Redox Biol"},{"key":"bib38","article-title":"Rescuing photoreceptors in RPE dysfunction-driven retinal degeneration: the role of small extracellular vesicles secreted from retinal pigment epithelium","author":"Pollalis","year":"2024","journal-title":"bioRxiv"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"e145029","DOI":"10.1172\/jci.insight.145029","article-title":"Nrf2 overexpression rescues the RPE in mouse models of retinitis pigmentosa","volume":"6","author":"Wu","year":"2021","journal-title":"JCI Insight"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.arr.2015.09.002","article-title":"RPE necroptosis in response to oxidative stress and in AMD","volume":"24","author":"Hanus","year":"2015","journal-title":"Ageing Res Rev"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12974-018-1106-8","article-title":"Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation","volume":"15","author":"Touhami","year":"2018","journal-title":"J Neuroinflammation"},{"key":"bib42","first-page":"724648","article-title":"Inflammation in retinal disease","volume":"2013","author":"Whitcup","year":"2013","journal-title":"Int J Inflam"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.3389\/fimmu.2019.01618","article-title":"IL-1 family members mediate cell death, inflammation and angiogenesis in retinal degenerative diseases","volume":"10","author":"Wooff","year":"2019","journal-title":"Front Immunol"},{"key":"bib44","doi-asserted-by":"crossref","first-page":"9945725","DOI":"10.1155\/2021\/9945725","article-title":"Complement inhibitors in age-related macular degeneration: a potential therapeutic option","volume":"2021","author":"Qin","year":"2021","journal-title":"J Immunol Res"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.3390\/cells10051049","article-title":"Anti-VEGF-resistant retinal diseases: a review of the latest treatment options","volume":"10","author":"Wallsh","year":"2021","journal-title":"Cells"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:59Z","timestamp":1791927119000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,9,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.12.2","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8,29]]}}}