{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:40:50Z","timestamp":1793108450862,"version":"4.5.0"},"reference-count":40,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,9,24]]},"DOI":"10.1167\/iovs.66.12.55","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:30:46Z","timestamp":1758724246000},"page":"55","source":"Crossref","is-referenced-by-count":3,"title":["Topical Application of Everolimus Attenuates Lens-Induced Myopia Through mTORC1 Suppression"],"prefix":"10.1167","volume":"66","author":[{"given":"Ruiheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyao","family":"Yu","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoyue","family":"Dong","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhan","family":"Shi","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenda","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China"},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Dong","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shao","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China"},{"name":"Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"},{"name":"Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jost B.","family":"Jonas","sequence":"additional","affiliation":[{"name":"Rothschild Foundation Hospital, Paris, France"},{"name":"Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore"},{"name":"Privatpraxis Prof Jonas und Dr. Panda-Jonas, Heidelberg, Germany"},{"name":"Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China"},{"name":"L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41572-020-00231-4","article-title":"Myopia","volume":"6","author":"Baird","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1136\/bjophthalmol-2017-311266","article-title":"Global prevalence of visual impairment associated with myopic macular degeneration and temporal trends from 2000 through 2050: systematic review, meta-analysis and modelling","volume":"102","author":"Fricke","year":"2018","journal-title":"Br J Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.ophtha.2017.12.005","article-title":"Progression of myopic maculopathy during 18-year follow-up","volume":"125","author":"Fang","year":"2018","journal-title":"Ophthalmology"},{"issue":"1","key":"bib4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ajo.2013.08.010","article-title":"Epidemiology and disease burden of pathologic myopia and myopic choroidal neovascularization: an evidence-based systematic review","volume":"157","author":"Wong","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.preteyeres.2017.09.004","article-title":"The epidemics of myopia: aetiology and prevention","volume":"62","author":"Morgan","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1136\/bjo-2023-323887","article-title":"Advances in myopia control strategies for children","volume":"109","author":"Zhang","year":"2025","journal-title":"Br J Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/iovs.66.7.6","article-title":"Childhood myopia part I: contemporary treatment options","volume":"66","author":"Khanal","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/iovs.66.7.7","article-title":"Childhood myopia part II: treatment mechanisms, emerging options, and considerations","volume":"66","author":"Khanal","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.ophtha.2024.03.013","article-title":"Five-year clinical trial of the Low-Concentration Atropine for Myopia Progression (LAMP) study: phase 4 report","volume":"131","author":"Zhang","year":"2024","journal-title":"Ophthalmology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1167\/iovs.65.10.21","article-title":"Choroidal changes during and after discontinuing long-term 0.01% atropine treatment for myopia control","volume":"65","author":"Lee","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1001\/jama.2022.24162","article-title":"Effect of low-concentration atropine eyedrops vs placebo on myopia incidence in children: the LAMP2 randomized clinical trial","volume":"329","author":"Yam","year":"2023","journal-title":"JAMA"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1167\/iovs.64.10.24","article-title":"mTORC1 signaling and negative lens-induced axial elongation","volume":"64","author":"Zhang","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1167\/iovs.64.4.11","article-title":"Intravitreal short-hairpin RNA attenuated adeno-associated virus-induced knockdown of amphiregulin and axial elongation in experimental myopia","volume":"64","author":"Dong","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12886-025-03936-w","article-title":"In-vivo sclera thickness measurements in experimental myopia of guinea pigs","volume":"25","author":"Zhang","year":"2025","journal-title":"BMC Ophthalmol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1016\/j.ophtha.2018.06.015","article-title":"Intravitreal sirolimus for the treatment of noninfectious uveitis: evolution through preclinical and clinical studies","volume":"125","author":"Nguyen","year":"2018","journal-title":"Ophthalmology"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1208\/s12249-014-0244-2","article-title":"Nanomicellar topical aqueous drop formulation of rapamycin for back-of-the-eye delivery","volume":"16","author":"Cholkar","year":"2015","journal-title":"AAPS PharmSciTech"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"121755","DOI":"10.1016\/j.ijpharm.2022.121755","article-title":"The topical ocular delivery of rapamycin to posterior eye tissues and the suppression of retinal inflammatory disease","volume":"621","author":"Badr","year":"2022","journal-title":"Int J Pharm"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1016\/j.visres.2006.01.027","article-title":"Normal development of refractive state and ocular dimensions in guinea pigs","volume":"46","author":"Zhou","year":"2006","journal-title":"Vis Res"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/0042-6989(92)90026-F","article-title":"Normal development of refractive state and ocular component dimensions in the tree shrew (Tupaia belangeri)","volume":"32","author":"Norton","year":"1992","journal-title":"Vis Res"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1080\/08164622.2021.1878827","article-title":"Visual function in guinea pigs: behavior and electrophysiology","volume":"104","author":"Jnawali","year":"2021","journal-title":"Clin Exp Optom"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1016\/j.ophtha.2015.05.031","article-title":"Fundus tessellation: prevalence and associated factors: the Beijing Eye Study 2011","volume":"122","author":"Yan","year":"2015","journal-title":"Ophthalmology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"105649","DOI":"10.1016\/j.yrtph.2024.105649","article-title":"Comparison of permitted daily exposure (PDE) values for active pharmaceutical ingredients (APIs)\u2014evidence of a robust approach","volume":"150","author":"Sehner","year":"2024","journal-title":"Regul Toxicol Pharmacol"},{"key":"bib24","first-page":"251","article-title":"A quantitative study on the relationship between transcorneal permeability of drugs and their hydrophobicity","volume":"24","author":"Kishida","year":"1980","journal-title":"Jpn J Ophthalmol"},{"issue":"6","key":"bib25","doi-asserted-by":"publisher","first-page":"2820","DOI":"10.3390\/molecules28062820","article-title":"Assessment of lipophilicity parameters of antimicrobial and immunosuppressive compounds","volume":"28","author":"Wardecki","year":"2023","journal-title":"Molecules (Basel, Switzerland)"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.ijpharm.2017.04.010","article-title":"Cyclodextrins and topical drug delivery to the anterior and posterior segments of the eye","volume":"531","author":"Loftsson","year":"2017","journal-title":"Int J Pharm"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.ijpharm.2018.08.001","article-title":"Optimization of \u00df-cyclodextrin consolidated micellar dispersion for promoting the transcorneal permeation of a practically insoluble drug","volume":"549","author":"Sayed","year":"2018","journal-title":"Int J Pharm"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"119880","DOI":"10.1016\/j.carbpol.2022.119880","article-title":"Integration of cyclodextrins and associated toxicities: a roadmap for high quality biomedical applications","volume":"295","author":"Trotta","year":"2022","journal-title":"Carbohydrate Polymers"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"121012","DOI":"10.1016\/j.ijpharm.2021.121012","article-title":"Progress in drug formulation design and delivery of medicinal substances used in ophthalmology","volume":"607","author":"Wr\u00f3blewska","year":"2021","journal-title":"Int J Pharm"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.7150\/thno.26281","article-title":"Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration","volume":"9","author":"Huang","year":"2019","journal-title":"Theranostics"},{"key":"bib31","first-page":"3024","article-title":"Roles of RPE mTOR signaling in choroid homeostasis","volume":"62","author":"Chen","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"108962","DOI":"10.1016\/j.exer.2022.108962","article-title":"Association of MTOR and PDGFRA gene polymorphisms with different degrees of myopia severity","volume":"217","author":"Li","year":"2022","journal-title":"Exp Eye Res"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1080\/13816810.2021.1923035","article-title":"Corneal curvature-associated MTOR variant differentiates mild myopia from high myopia in Han Chinese population","volume":"42","author":"Yuan","year":"2021","journal-title":"Ophthalmic Genet"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"11008","DOI":"10.1038\/ncomms11008","article-title":"Meta-analysis of gene\u2013environment-wide association scans accounting for education level identifies additional loci for refractive error","volume":"7","author":"Fan","year":"2016","journal-title":"Nat Commun"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.ebiom.2017.02.021","article-title":"Amphiregulin antibody and reduction of axial elongation in experimental myopia","volume":"17","author":"Jiang","year":"2017","journal-title":"EBioMedicine"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"e460","DOI":"10.1111\/aos.14080","article-title":"Amphiregulin and ocular axial length","volume":"97","author":"Dong","year":"2019","journal-title":"Acta Ophthalmol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/j.ophtha.2020.03.033","article-title":"Efficacy and safety of intravitreal sirolimus for noninfectious uveitis of the posterior segment: results from the Sirolimus Study Assessing Double-Masked Uveitis Treatment (SAKURA) Program","volume":"127","author":"Merrill","year":"2020","journal-title":"Ophthalmology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12964-019-0380-0","article-title":"mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV","volume":"17","author":"Yang","year":"2019","journal-title":"Cell Commun Signal"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1016\/j.apsb.2021.10.022","article-title":"Intravenous route to choroidal neovascularization by macrophage-disguised nanocarriers for mTOR modulation","volume":"12","author":"Xia","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"3138","DOI":"10.1167\/iovs.15-18795","article-title":"Blockage of PI3K\/mTOR pathways inhibits laser-induced choroidal neovascularization and improves outcomes relative to VEGF-A suppression alone","volume":"57","author":"Ma","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:08Z","timestamp":1791927128000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,24]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,9,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.12.55","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,24]]}}}