{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:26Z","timestamp":1791928886557,"version":"4.3.4"},"reference-count":67,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"14","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,11,21]]},"DOI":"10.1167\/iovs.66.14.57","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T13:30:44Z","timestamp":1763731844000},"page":"57","source":"Crossref","is-referenced-by-count":2,"title":["Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outflow and Intraocular Pressure"],"prefix":"10.1167","volume":"66","author":[{"given":"Sarah N.","family":"Redmon","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Yarishkin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher N.","family":"Rudzitis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, Utah, United States"},{"name":"Department of Medical Engineering, University of South Florida, Tampa, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Lakk","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"van Batenburg-Sherwood","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Nicou","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering, University of South Florida, Tampa, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Passaglia","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering, University of South Florida, Tampa, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl R.","family":"Overby","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Imperial College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kri\u017eaj","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, Utah, United States"},{"name":"Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States"},{"name":"Department of Neurobiology, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1152\/physrev.00021.2023","article-title":"Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries","volume":"104","author":"Martinez","year":"2024","journal-title":"Physiol Rev"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1001\/archopht.1963.00960050494011","article-title":"Effect of corticosteroids on intraocular pressure and fluid dynamics. II. The effect of dexamethasone in the glaucomatous eye","volume":"70","author":"Armaly","year":"1963","journal-title":"Arch Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.survophthal.2020.01.002","article-title":"Steroid-induced glaucoma: epidemiology, pathophysiology, and clinical management","volume":"65","author":"Roberti","year":"2020","journal-title":"Surv Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"481","DOI":"10.2147\/OPTH.S442749","article-title":"Glucocorticoid-induced ocular hypertension and glaucoma","volume":"18","author":"Harvey","year":"2024","journal-title":"Clin Ophthalmol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1073\/pnas.1814889116","article-title":"In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model","volume":"116","author":"Li","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1080\/19336950.2019.1618149","article-title":"Mechano-electrical transduction in trabecular meshwork involves parallel activation of TRPV4 and TREK-1 channels","volume":"13","author":"Yarishkin","year":"2019","journal-title":"Channels (Austin)"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1113\/JP281011","article-title":"Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow","volume":"599","author":"Yarishkin","year":"2021","journal-title":"J Physiol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S1350-9462(99)00015-4","article-title":"The regulation of trabecular meshwork and ciliary muscle contractility","volume":"19","author":"Wiederholt","year":"2000","journal-title":"Prog Retin Eye Res"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"RP104894","DOI":"10.7554\/eLife.104894","article-title":"TRPV4 activation by TGF\u00df2 enhances cellular contractility and drives ocular hypertension","volume":"14","author":"Rudzitis","year":"2025","journal-title":"eLife"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"100917","DOI":"10.1016\/j.preteyeres.2020.100917","article-title":"Aqueous outflow regulation - 21st century concepts","volume":"83","author":"Johnstone","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1089\/jop.1998.14.57","article-title":"The ocular hypertensive effects of topical 0.1% dexamethasone in beagles with inherited glaucoma","volume":"14","author":"Gelatt","year":"1998","journal-title":"J Ocul Pharmacol Ther"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/cm.20049","article-title":"Dexamethasone alters F-actin architecture and promotes cross-linked actin network formation in human trabecular meshwork tissue","volume":"60","author":"Clark","year":"2005","journal-title":"Cell Motil Cytoskeleton"},{"key":"bib15","first-page":"2001","article-title":"Proteomic similarities in steroid responsiveness in normal and glaucomatous trabecular meshwork cells","volume":"18","author":"Bollinger","year":"2012","journal-title":"Mol Vis"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"4922","DOI":"10.1167\/iovs.14-14429","article-title":"Ultrastructural changes associated with dexamethasone-induced ocular hypertension in mice","volume":"55","author":"Overby","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"4447","DOI":"10.1167\/iovs.15-16739","article-title":"Dexamethasone stiffens trabecular meshwork, trabecular meshwork cells, and matrix","volume":"56","author":"Raghunathan","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"9854","DOI":"10.1074\/jbc.RA118.002540","article-title":"Transforming growth factor \u00df2 (TGF\u00df2) signaling plays a key role in glucocorticoid-induced ocular hypertension","volume":"293","author":"Kasetti","year":"2018","journal-title":"J Biol Chem"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"8636","DOI":"10.1167\/iovs.11-7563","article-title":"Gene expression changes in steroid-induced IOP elevation in bovine trabecular meshwork","volume":"52","author":"Danias","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1167\/iovs.61.4.24","article-title":"The molecular processes in the trabecular meshwork after exposure to corticosteroids and in corticosteroid-induced ocular hypertension","volume":"61","author":"Liesenborghs","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1002\/bit.25899","article-title":"Bioengineered glaucomatous 3D human trabecular meshwork as an in vitro disease model","volume":"113","author":"Torrejon","year":"2016","journal-title":"Biotechnol Bioeng"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"3614","DOI":"10.1073\/pnas.1320768111","article-title":"Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels","volume":"111","author":"Brohawn","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1085\/jgp.201812179","article-title":"TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells","volume":"150","author":"Yarishkin","year":"2018","journal-title":"J Gen Physiol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"15244","DOI":"10.1038\/s41598-024-66192-w","article-title":"Activation of hTREK-1 by polyunsaturated fatty acids involves direct interaction","volume":"14","author":"Bechard","year":"2024","journal-title":"Sci Rep"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1167\/iovs.19-26851","article-title":"Trabecular meshwork TREK-1 channels function as polymodal integrators of pressure and pH","volume":"60","author":"Yarishkin","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1152\/physrev.00029.2009","article-title":"Molecular background of leak K+ currents: two-pore domain potassium channels","volume":"90","author":"Enyedi","year":"2010","journal-title":"Physiol Rev"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1113\/jphysiol.2014.287268","article-title":"The family of K2P channels: salient structural and functional properties","volume":"593","author":"Feliciangeli","year":"2015","journal-title":"J Physiol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"9062","DOI":"10.3390\/ijms22169062","article-title":"Negative influence by the force: mechanically induced hyperpolarization via K2P background potassium channels","volume":"22","author":"Lengyel","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/nature22988","article-title":"K2P2.1 (TREK-1)\u2013activator complexes reveal a cryptic selectivity filter binding site","volume":"547","author":"Lolicato","year":"2017","journal-title":"Nature"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"100145","DOI":"10.1016\/j.jlr.2021.100145","article-title":"Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension","volume":"62","author":"Lakk","year":"2021","journal-title":"J Lipid Res"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"805076","DOI":"10.3389\/fimmu.2022.805076","article-title":"Emergent temporal signaling in human trabecular meshwork cells: role of TRPV4-TRPM4 interactions","volume":"13","author":"Yarishkin","year":"2022","journal-title":"Front Immunol"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.exer.2018.03.001","article-title":"Consensus recommendations for trabecular meshwork cell isolation, characterization and culture","volume":"171","author":"Keller","year":"2018","journal-title":"Exp Eye Res"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1002\/glia.23979","article-title":"TRPV4 channels mediate the mechanoresponse in retinal microglia","volume":"69","author":"Redmon","year":"2021","journal-title":"Glia"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"4091","DOI":"10.1113\/JP288706","article-title":"TRPV4 controls circadian and pathological ocular hypertension","volume":"603","author":"Redmon","year":"2025","journal-title":"J Physiol"},{"key":"bib35","article-title":"Corticosteroids elevate intraocular pressure through suppression of TREK-1 signaling","author":"Redmon","year":"2025","journal-title":"bioRxiv"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"30583","DOI":"10.1038\/srep30583","article-title":"TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye","volume":"6","author":"Ryskamp","year":"2016","journal-title":"Sci Rep"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/cne.25228","article-title":"The RNA-binding protein and stress granule component ATAXIN-2 is expressed in mouse and human tissues associated with glaucoma pathogenesis","volume":"530","author":"Sundberg","year":"2022","journal-title":"J Comp Neurol"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"108487","DOI":"10.1016\/j.visres.2024.108487","article-title":"Resting trabecular meshwork cells experience constitutive cation influx","volume":"224","author":"Yarishkin","year":"2024","journal-title":"Vision Res"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"e0150694","DOI":"10.1371\/journal.pone.0150694","article-title":"Measurement of outflow facility using iPerfusion","volume":"11","author":"Sherwood","year":"2016","journal-title":"PLoS One"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1167\/iovs.61.10.45","article-title":"Aqueous humor outflow requires active cellular metabolism in mice","volume":"61","author":"Reina-Torres","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1007\/s10439-017-1896-3","article-title":"A wireless pressure sensor for continuous monitoring of intraocular pressure in conscious animals","volume":"45","author":"Bello","year":"2017","journal-title":"Ann Biomed Eng"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"108727","DOI":"10.1016\/j.exer.2021.108727","article-title":"Effects of acute stress, general anesthetics, tonometry, and temperature on intraocular pressure in rats","volume":"210","author":"Nicou","year":"2021","journal-title":"Exp Eye Res"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41598-017-00430-2","article-title":"Interaction of cochlin and mechanosensitive channel TREK-1 in trabecular meshwork cells influences the regulation of intraocular pressure","volume":"7","author":"Carreon","year":"2017","journal-title":"Sci Rep"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/jcp.24524","article-title":"Regulation of plasticity and fibrogenic activity of trabecular meshwork cells by Rho GTPase signaling","volume":"229","author":"Pattabiraman","year":"2014","journal-title":"J Cell Physiol"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ejphar.2016.06.018","article-title":"Glucocorticoid therapy and ocular hypertension","volume":"787","author":"Dibas","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1167\/iovs.65.14.32","article-title":"Consensus recommendations for studies of outflow facility and intraocular pressure regulation using ex vivo perfusion approaches","volume":"65","author":"Acott","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"10339","DOI":"10.1073\/pnas.2001250117","article-title":"Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis","volume":"117","author":"van Zyl","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"5848","DOI":"10.1038\/s41598-018-24165-w","article-title":"The relationship between outflow resistance and trabecular meshwork stiffness in mice","volume":"8","author":"Wang","year":"2018","journal-title":"Sci Rep"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/iovs.64.2.7","article-title":"Rho kinase inhibitor AR-12286 reverses steroid-induced changes in intraocular pressure, effective filtration areas, and morphology in mouse eyes","volume":"64","author":"Ren","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1007\/s00424-013-1404-z","article-title":"Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2","volume":"466","author":"Renigunta","year":"2014","journal-title":"Pfl\u00fcgers Arch"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"5984","DOI":"10.1167\/iovs.16-19734","article-title":"Aberrant collagen composition of the trabecular meshwork results in reduced aqueous humor drainage and elevated IOP in MMP-9 null mice","volume":"57","author":"De Groef","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib52","first-page":"281","article-title":"Glucocorticoid-induced formation of cross-linked actin networks in cultured human trabecular meshwork cells","volume":"35","author":"Clark","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.exer.2008.10.004","article-title":"The role of steroids in outflow resistance","volume":"88","author":"Clark","year":"2009","journal-title":"Exp Eye Res"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"728932","DOI":"10.3389\/fmolb.2021.728932","article-title":"RhoA\/ROCK-YAP\/TAZ axis regulates the fibrotic activity in dexametha-sone-treated human trabecular meshwork cells","volume":"8","author":"Liu","year":"2021","journal-title":"Front Mol Biosci"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"26555","DOI":"10.1073\/pnas.1911837116","article-title":"Increased stiffness and flow resistance of the inner wall of Schlemm's canal in glaucomatous human eyes","volume":"116","author":"Vahabikashi","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1113\/jphysiol.1996.sp021354","article-title":"Water compartmentalization and extracellular tortuosity after osmotic changes in cerebellum of Trachemys scripta","volume":"492","author":"Krizaj","year":"1996","journal-title":"J Physiol"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"13525","DOI":"10.1523\/JNEUROSCI.1987-15.2015","article-title":"TRPV4 and AQP4 channels synergistically regulate cell volume and calcium homeostasis in retinal M\u00fcller glia","volume":"35","author":"Jo","year":"2015","journal-title":"J Neurosci"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1001\/archopht.1997.01100150377011","article-title":"Ultrastructural changes in the trabecular meshwork of human eyes treated with corticosteroids","volume":"115","author":"Johnson","year":"1997","journal-title":"Arch Ophthalmol"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"e34309","DOI":"10.1371\/journal.pone.0034309","article-title":"Cochlin, intraocular pressure regulation and mechanosensing","volume":"7","author":"Goel","year":"2012","journal-title":"PLoS One"},{"key":"bib60","first-page":"35","article-title":"No cell is an island: trabecular meshwork ion channels as sensors of the ambient milieu","volume":"3","author":"Krizaj","year":"2020","journal-title":"Glaucoma Res Clin Adv"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"C1013","DOI":"10.1152\/ajpcell.00599.2020","article-title":"TRPV4-Rho signaling drives cytoskeletal and focal adhesion remodeling in trabecular meshwork cells","volume":"320","author":"Lakk","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"1352259","DOI":"10.3389\/fcell.2024.1352259","article-title":"Cholesterol regulation of mechanosensitive ion channels","volume":"12","author":"Beverley","year":"2024","journal-title":"Front Cell Dev Biol"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"207","DOI":"10.4103\/1673-5374.226383","article-title":"Dyslipidemia modulates M\u00fcller glial sensing and transduction of ambient information","volume":"13","author":"Lakk","year":"2018","journal-title":"Neural Regen Res"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1038\/sj.emboj.7601116","article-title":"TREK-1, a K+ channel involved in polymodal pain perception","volume":"25","author":"Alloui","year":"2006","journal-title":"EMBO J"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1038\/emboj.2009.57","article-title":"The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception","volume":"28","author":"Noel","year":"2009","journal-title":"EMBO J"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1523\/JNEUROSCI.4497-07.2008","article-title":"Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia","volume":"28","author":"Alessandri-Haber","year":"2008","journal-title":"J Neurosci"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"e60831","DOI":"10.7554\/eLife.60831","article-title":"Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis","volume":"10","author":"Li","year":"2021","journal-title":"eLife"},{"key":"bib7","article-title":"What is glaucoma","volume-title":"Webvision: The Organization of the Retina and Visual System","author":"Krizaj","year":"1995"},{"key":"bib12","first-page":"15","article-title":"Intraocular pressure control through linked trabecular meshwork and collector channel motion","volume-title":"Glaucoma Research and Clinical Advances: Regulation of Intraocular Pressure","author":"Johnstone","year":"2025"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2811136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:08Z","timestamp":1791927128000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2811136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":67,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,11,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.14.57","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,21]]}}}