{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:19Z","timestamp":1791928939975,"version":"4.3.4"},"reference-count":53,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"14","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"DOI":"10.1167\/iovs.66.14.61","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T13:30:37Z","timestamp":1764077437000},"page":"61","source":"Crossref","is-referenced-by-count":2,"title":["<i>\n                      RPGR\n                      <sup>ORF15<\/sup>\n                    <\/i>\n                    Mutations Disrupt Lysosomal Lipid Metabolism in Retinal Pigment Epithelium Cells and Cause Retinitis Pigmentosa"],"prefix":"10.1167","volume":"66","author":[{"given":"Mengmeng","family":"Ren","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Visual Neuroscience and Stem Cell Engineering, College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Reilly","sequence":"additional","affiliation":[{"name":"Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqiao","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualei","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Dai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunwei","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Department of Ophthalmology, Tulane Personalized Health Institute, Tulane University, New Orleans, Louisiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mugen","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"issue":"9","key":"bib1","doi-asserted-by":"publisher","first-page":"4883","DOI":"10.3390\/ijms23094883","article-title":"Retinitis pigmentosa: progress in molecular pathology and biotherapeutical strategies","volume":"23","author":"Liu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.exer.2015.06.007","article-title":"RPGR: its role in photoreceptor physiology, human disease, and future therapies","volume":"138","author":"Megaw","year":"2015","journal-title":"Exp Eye Res"},{"issue":"11","key":"bib3","doi-asserted-by":"publisher","first-page":"a041280","DOI":"10.1101\/cshperspect.a041280","article-title":"RPGR-related retinopathy: clinical features, molecular genetics, and gene replacement therapy","volume":"13","author":"Awadh Hashem","year":"2023","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"4","key":"bib4","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/78182","article-title":"Mutational hot spot within a new RPGR exon in X-linked retinitis pigmentosa","volume":"25","author":"Vervoort","year":"2000","journal-title":"Nat Genet"},{"issue":"4","key":"bib5","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1073\/pnas.1817639116","article-title":"Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP","volume":"116","author":"Zhang","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"bib6","doi-asserted-by":"publisher","first-page":"6255","DOI":"10.1167\/iovs.15-17726","article-title":"Evolutionary characterization of the retinitis pigmentosa GTPase regulator gene","volume":"56","author":"Raghupathy","year":"2015","journal-title":"Invest Ophth Vis Sci"},{"key":"bib7","doi-asserted-by":"crossref","first-page":"E2925","DOI":"10.1073\/pnas.1523201113","article-title":"Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused by TTLL5 mutations","volume":"113","author":"Sun","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"bib8","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1093\/hmg\/11.9.993","article-title":"Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degeneration","volume":"11","author":"Zhang","year":"2002","journal-title":"Hum Mol Genet"},{"issue":"8","key":"bib9","doi-asserted-by":"publisher","first-page":"e23021","DOI":"10.1371\/journal.pone.0023021","article-title":"Allelic heterogeneity and genetic modifier loci contribute to clinical variation in males with X-linked retinitis pigmentosa due to RPGR mutations","volume":"6","author":"Fahim","year":"2011","journal-title":"PLoS One"},{"issue":"1-2","key":"bib10","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41434-021-00258-6","article-title":"Restoration of RPGR expression in vivo using CRISPR\/Cas9 gene editing","volume":"29","author":"Gumerson","year":"2022","journal-title":"Gene Ther"},{"issue":"4","key":"bib11","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1093\/hmg\/ddp533","article-title":"Zebrafish Rpgr is required for normal retinal development and plays a role in dynein-based retrograde transport processes","volume":"19","author":"Shu","year":"2010","journal-title":"Hum Mol Genet"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1169941","DOI":"10.3389\/fcell.2023.1169941","article-title":"Retinal degeneration in rpgra mutant zebrafish","volume":"11","author":"Liu","year":"2023","journal-title":"Front Cell Dev Biol"},{"issue":"6","key":"bib13","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1167\/iovs.02-1206","article-title":"RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia","volume":"44","author":"Hong","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"18","key":"bib14","doi-asserted-by":"publisher","first-page":"3591","DOI":"10.1093\/hmg\/ddq275","article-title":"Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration","volume":"19","author":"Murga-Zamalloa","year":"2010","journal-title":"Hum Mol Genet"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"999695","DOI":"10.3389\/fgene.2022.999695","article-title":"Analysis of RPGR gene mutations in 41 Chinese families affected by X-linked inherited retinal dystrophy","volume":"13","author":"Liu","year":"2022","journal-title":"Front Genet"},{"issue":"3","key":"bib16","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol Rev"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ceb.2019.08.001","article-title":"Retinal pigment epithelium polarity in health and blinding diseases","volume":"62","author":"Caceres","year":"2020","journal-title":"Curr Opin Cell Biol"},{"issue":"2","key":"bib18","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s42255-022-00728-0","article-title":"Phagocytosis in the retina promotes local insulin production in the eye","volume":"5","author":"Etchegaray","year":"2023","journal-title":"Nat Metab"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"604205","DOI":"10.3389\/fimmu.2020.604205","article-title":"Phagocytosis by the retinal pigment epithelium: recognition, resolution, recycling","volume":"11","author":"Kwon","year":"2020","journal-title":"Front Immunol"},{"issue":"6","key":"bib20","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/s41419-021-03865-8","article-title":"RIP3 impedes transcription factor EB to suppress autophagic degradation in septic acute kidney injury","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis"},{"issue":"9","key":"bib21","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1083\/jcb.201711083","article-title":"Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons","volume":"217","author":"Cheng","year":"2018","journal-title":"J Cell Biol"},{"issue":"47","key":"bib22","doi-asserted-by":"publisher","first-page":"23724","DOI":"10.1073\/pnas.1906643116","article-title":"Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina","volume":"116","author":"Notomi","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"issue":"21","key":"bib23","doi-asserted-by":"publisher","first-page":"5468","DOI":"10.1073\/pnas.1709211115","article-title":"Defective phagosome motility and degradation in cell nonautonomous RPE pathogenesis of a dominant macular degeneration","volume":"115","author":"Esteve-Rudd","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.preteyeres.2015.09.002","article-title":"Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration","volume":"51","author":"Ferrington","year":"2016","journal-title":"Prog Retin Eye Res"},{"issue":"5","key":"bib25","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1167\/iovs.63.5.32","article-title":"Accumulation of lipid droplets in a novel Bietti crystalline dystrophy zebrafish model with impaired PPARa pathway","volume":"63","author":"Gao","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"bib26","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1080\/15548627.2023.2220540","article-title":"Clearance of lipid droplets by chimeric autophagy-tethering compound ameliorates the age-related macular degeneration phenotype in mice lacking APOE","volume":"19","author":"Zhang","year":"2023","journal-title":"Autophagy"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"108482","DOI":"10.1016\/j.pharmthera.2023.108482","article-title":"Retina and RPE lipid profile changes linked with ABCA4 associated Stargardt's maculopathy","volume":"249","author":"Farnoodian","year":"2023","journal-title":"Pharmacol Ther"},{"issue":"1","key":"bib28","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/hmg\/ddp469","article-title":"Human retinopathy-associated ciliary protein retinitis pigmentosa GTPase regulator mediates cilia-dependent vertebrate development","volume":"19","author":"Ghosh","year":"2010","journal-title":"Hum Mol Genet"},{"issue":"4","key":"bib29","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1167\/iovs.61.4.31","article-title":"In vivo CRISPR\/Cas9-mediated genome editing mitigates photoreceptor degeneration in a mouse model of X-linked retinitis pigmentosa","volume":"61","author":"Hu","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib30","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.1073\/pnas.97.7.3649","article-title":"A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3)","volume":"97","author":"Hong","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"bib31","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1093\/nar\/gkab003","article-title":"Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing","volume":"49","author":"Li","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"bib32","doi-asserted-by":"publisher","first-page":"e1009841","DOI":"10.1371\/journal.pgen.1009841","article-title":"Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration","volume":"18","author":"Liu","year":"2022","journal-title":"PLoS Genet"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"e45100","DOI":"10.7554\/eLife.45100","article-title":"Impaired ABCA1\/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration","volume":"8","author":"Storti","year":"2019","journal-title":"Elife"},{"issue":"11","key":"bib34","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/s41419-022-05372-w","article-title":"Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish","volume":"13","author":"Jia","year":"2022","journal-title":"Cell Death Dis"},{"issue":"12","key":"bib35","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1093\/hmg\/ddx137","article-title":"CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish","volume":"26","author":"Yu","year":"2017","journal-title":"Hum Mol Genet"},{"issue":"5","key":"bib36","doi-asserted-by":"publisher","first-page":"L873","DOI":"10.1152\/ajplung.00238.2017","article-title":"Use of proper statistical techniques for research studies with small samples","volume":"313","author":"Morgan","year":"2017","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"18","key":"bib37","first-page":"1","article-title":"Using the Student's t-test with extremely small sample sizes.","author":"de Winter","year":"2013","journal-title":"Pract Assess Res Eval."},{"issue":"15","key":"bib38","doi-asserted-by":"publisher","first-page":"3936","DOI":"10.1073\/pnas.1717338115","article-title":"Reduction of lipid accumulation rescues Bietti's crystalline dystrophy phenotypes","volume":"115","author":"Hata","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"bib39","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nrm3565","article-title":"Signals from the lysosome: a control centre for cellular clearance and energy metabolism","volume":"14","author":"Settembre","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"39","key":"bib40","doi-asserted-by":"publisher","first-page":"33580","DOI":"10.1074\/jbc.M505827200","article-title":"RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins","volume":"280","author":"Khanna","year":"2005","journal-title":"J Biol Chem"},{"issue":"4","key":"bib41","doi-asserted-by":"publisher","first-page":"114010","DOI":"10.1016\/j.celrep.2024.114010","article-title":"RPGR is a guanine nucleotide exchange factor for the small GTPase RAB37 required for retinal function via autophagy regulation","volume":"43","author":"Ying","year":"2024","journal-title":"Cell Rep"},{"issue":"12","key":"bib42","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1080\/15548627.2020.1717128","article-title":"Donor MSCs release apoptotic bodies to improve myocardial infarction via autophagy regulation in recipient cells","volume":"16","author":"Liu","year":"2020","journal-title":"Autophagy"},{"issue":"9","key":"bib43","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1080\/15548627.2018.1463120","article-title":"TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis","volume":"14","author":"Wang","year":"2018","journal-title":"Autophagy"},{"issue":"1","key":"bib44","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.molcel.2013.01.024","article-title":"ZKSCAN3 is a master transcriptional repressor of autophagy","volume":"50","author":"Chauhan","year":"2013","journal-title":"Mol Cell"},{"issue":"5","key":"bib45","doi-asserted-by":"publisher","first-page":"E420","DOI":"10.1073\/pnas.1424576112","article-title":"MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells","volume":"112","author":"Ploper","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"bib46","doi-asserted-by":"publisher","first-page":"835","DOI":"10.3390\/ijms21030835","article-title":"RPGR-associated dystrophies: clinical, genetic, and histopathological features","volume":"21","author":"Nguyen","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"bib47","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/s41467-017-00111-8","article-title":"Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models","volume":"8","author":"Megaw","year":"2017","journal-title":"Nat Commun"},{"issue":"24","key":"bib48","doi-asserted-by":"publisher","first-page":"4840","DOI":"10.1093\/hmg\/ddr423","article-title":"The role of RPGR in cilia formation and actin stability","volume":"20","author":"Gakovic","year":"2011","journal-title":"Hum Mol Genet"},{"issue":"3","key":"bib49","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1080\/15548627.2022.2103307","article-title":"Ambra1 haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration","volume":"19","author":"Ram\u00edrez-Pardo","year":"2023","journal-title":"Autophagy"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"991","DOI":"10.3389\/fnins.2019.00991","article-title":"Retinal phenotype in the rd9 mutant mouse, a model of X-linked RP","volume":"13","author":"Falasconi","year":"2019","journal-title":"Front Neurosci"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1080\/15548627.2024.2413305","article-title":"AKT2-mediated lysosomal dysfunction promotes secretory autophagy in retinal pigment epithelium (RPE) cells","volume":"20","author":"Ghosh","year":"2024","journal-title":"Autophagy"},{"issue":"5","key":"bib52","doi-asserted-by":"publisher","first-page":"596","DOI":"10.3390\/antiox14050596","article-title":"Targeting lysosomal dysfunction and oxidative stress in age-related macular degeneration","volume":"14","author":"Falcao","year":"2025","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"bib53","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.3390\/ijms23031790","article-title":"Lipid droplet accumulation promotes RPE dysfunction","volume":"23","author":"Yako","year":"2022","journal-title":"Int J Mol Sci"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.66.14.61","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:09Z","timestamp":1791927129000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.66.14.61"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":53,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,11,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.14.61","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,25]]}}}