{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:27Z","timestamp":1791928887510,"version":"4.3.4"},"reference-count":69,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"15","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,12,30]]},"DOI":"10.1167\/iovs.66.15.73","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T15:30:34Z","timestamp":1767108634000},"page":"73","source":"Crossref","is-referenced-by-count":1,"title":["Altered High-Density Lipoprotein Expression Pattern in the Aqueous Humor From Eyes With Age-Related Macular Degeneration"],"prefix":"10.1167","volume":"66","author":[{"given":"Adi","family":"Kramer","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batya","family":"Rinsky","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Elbaz-Hayoun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Khateb","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareq","family":"Jaouni","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Jaskoll","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liran","family":"Tiosano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Durst","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itay","family":"Chowers","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"104088","DOI":"10.1016\/j.jprot.2020.104088","article-title":"Proteomic analysis of aqueous humor in patients with pathologic myopia","volume":"234","author":"Xue","year":"2021","journal-title":"J Proteomics"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s12944-021-01555-0","article-title":"Intra-population differences of apolipoproteins in the aqueous humor","volume":"20","author":"Patel","year":"2021","journal-title":"Lipids Health Dis"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"4755","DOI":"10.3390\/ijms20194755","article-title":"Proteomic biomarkers of retinal inflammation in diabetic retinopathy","volume":"20","author":"Youngblood","year":"2019","journal-title":"Int J Mol Sci"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/s43856-025-00862-2","article-title":"Proteomics approach identifies aqueous humor biomarkers in retinal diseases","volume":"5","author":"Huang","year":"2025","journal-title":"Commun Med (Lond)."},{"key":"bib5","doi-asserted-by":"publisher","first-page":"4868","DOI":"10.1016\/j.cell.2023.09.012","article-title":"Liquid-biopsy proteomics combined with AI identifies cellular drivers of eye aging and disease in vivo","volume":"186","author":"Wolf","year":"2023","journal-title":"Cell"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1167\/iovs.65.3.4","article-title":"Age-related macular degeneration, a mathematically tractable disease","volume":"65","author":"Curcio","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12886-018-0941-9","article-title":"Quantitative proteomic analysis of aqueous humor from patients with drusen and reticular pseudodrusen in age-related macular degeneration","volume":"18","author":"Baek","year":"2018","journal-title":"BMC Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1186\/s12886-021-02152-6","article-title":"Aqueous humor cytokine levels through microarray analysis and a sub-analysis based on optical coherence tomography in wet age-related macular degeneration patients","volume":"21","author":"Joo","year":"2021","journal-title":"BMC Ophthalmol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1002\/prca.201200012","article-title":"Proteomic analysis of the aqueous humor in patients with wet age-related macular degeneration","volume":"7","author":"Yao","year":"2013","journal-title":"Proteomics Clin Appl"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.1021\/pr300080s","article-title":"Proteomic analysis of the aqueous humor in age-related macular degeneration (AMD) patients","volume":"11","author":"Kim","year":"2012","journal-title":"J Proteome Res"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"893","DOI":"10.7150\/ijms.73489","article-title":"Proteomic profiling of aqueous humor exosomes from age-related macular degeneration patients","volume":"19","author":"Tsai","year":"2022","journal-title":"Int J Med Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1167\/iovs.62.10.18","article-title":"Analysis of the aqueous humor proteome in patients with age-related macular degeneration","volume":"62","author":"Rinsky","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"692272","DOI":"10.3389\/fmed.2021.692272","article-title":"Novel possible protein targets in neovascular age-related macular degeneration: a pilot study experiment","volume":"8","author":"Coronado","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"e144469","DOI":"10.1172\/JCI144469","article-title":"Aqueous proteins help predict the response of patients with neovascular age-related macular degeneration to anti-VEGF therapy","volume":"132","author":"Cao","year":"2022","journal-title":"J Clin Invest"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1167\/tvst.8.1.14","article-title":"Proteomic profiles in advanced age-related macular degeneration using an aptamer-based proteomic technology","volume":"8","author":"Lynch","year":"2019","journal-title":"Transl Vis Sci Technol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"7166","DOI":"10.1167\/iovs.14-15168","article-title":"Identification of vinculin as a potential plasma marker for age-related macular degeneration","volume":"55","author":"Kim","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"32548","DOI":"10.1038\/srep32548","article-title":"Proteomics-based identification and validation of novel plasma biomarkers phospholipid transfer protein and mannan-binding lectin serine protease-1 in age-related macular degeneration","volume":"6","author":"Kim","year":"2016","journal-title":"Sci Rep"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S0197-2456(99)00031-8","article-title":"The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no. 1","volume":"20","author":"Age-Related Eye Disease Study Research Group","year":"1999","journal-title":"Control Clin Trials"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat Methods"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"850","DOI":"10.3390\/cells10040850","article-title":"High density lipoproteins and diabetes","volume":"10","author":"Cochran","year":"2021","journal-title":"Cells"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"e021731","DOI":"10.1161\/JAHA.120.021731","article-title":"Inflammation alters relationship between high-density lipoprotein cholesterol and cardiovascular risk in patients with chronic kidney disease: results from KNOW-CKD","volume":"10","author":"Kim","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/tvst.12.11.9","article-title":"Correlation of aqueous, vitreous, and serum protein levels in patients with retinal diseases","volume":"12","author":"Wilson","year":"2023","journal-title":"Transl Vis Sci Technol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"4902","DOI":"10.1038\/s41467-019-12780-8","article-title":"Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration","volume":"10","author":"Menon","year":"2019","journal-title":"Nat Commun"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"24100","DOI":"10.1073\/pnas.1914143116","article-title":"Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration","volume":"116","author":"Voigt","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1167\/iovs.65.2.16","article-title":"Role of Serine Protease Inhibitors A1 and A3 in Ocular Pathologies","volume":"65","author":"Kontoh-Twumasi","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1107295","DOI":"10.3389\/fimmu.2023.1107295","article-title":"Proteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory biomarkers of vitreoretinal eye diseases","volume":"14","author":"Santos","year":"2023","journal-title":"Front Immunol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1161\/ATVBAHA.112.300135","article-title":"High density lipoprotein biogenesis, cholesterol efflux, and immune cell function","volume":"32","author":"Sorci-Thomas","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"33","DOI":"10.18240\/ijo.2023.01.05","article-title":"Apolipoprotein A1 suppresses the hypoxia-induced angiogenesis of human retinal endothelial cells by targeting PlGF","volume":"16","author":"Hu","year":"2023","journal-title":"Int J Ophthalmol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1161\/CIRCULATIONAHA.110.961193","article-title":"High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide","volume":"122","author":"Suzuki","year":"2010","journal-title":"Circulation"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1016\/S0022-2275(20)31499-1","article-title":"Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein","volume":"42","author":"Blanco-Vaca","year":"2001","journal-title":"J Lipid Res"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1172\/JCI119554","article-title":"Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles","volume":"100","author":"Castellani","year":"1997","journal-title":"J Clin Invest"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"31333","DOI":"10.1074\/jbc.272.50.31333","article-title":"The effect of apolipoprotein A-II on the structure and function of apolipoprotein A-I in a homogeneous reconstituted high density lipoprotein particle","volume":"272","author":"Durbin","year":"1997","journal-title":"J Biol Chem"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"7615","DOI":"10.1074\/jbc.M111.291070","article-title":"Apolipoprotein A-II-mediated conformational changes of apolipoprotein A-I in discoidal high density lipoproteins","volume":"287","author":"Gauthamadasa","year":"2012","journal-title":"J Biol Chem"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1006\/bbrc.2001.6295","article-title":"Paraoxonase 1 overexpression in mice and its effect on high-density lipoproteins","volume":"290","author":"Oda","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1161\/01.CIR.0000023623.87083.4F","article-title":"Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice","volume":"106","author":"Tward","year":"2002","journal-title":"Circulation"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/28406","article-title":"Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis","volume":"394","author":"Shih","year":"1998","journal-title":"Nature"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1097\/IAE.0b013e31822529b1","article-title":"Serum paraoxonase phenotype distribution in exudative age-related macular degeneration and its relationship to homocysteine and oxidized low-density lipoprotein","volume":"32","author":"Javadzadeh","year":"2012","journal-title":"Retina"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"249","DOI":"10.5935\/0004-2749.20210033","article-title":"Association between the L55M and Q192R polymorphisms of the paraoxonase-1 gene and age-related macular degeneration: a meta-analysis","volume":"84","author":"Elguezabal-Rodelo","year":"2021","journal-title":"Arq Bras Oftalmol"},{"key":"bib39","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2217\/clp.10.37","article-title":"Apolipoproteins in the brain: implications for neurological and psychiatric disorders","volume":"51","author":"Elliott","year":"2010","journal-title":"Clin Lipidol"},{"issue":"Suppl 269","key":"bib40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/aos.15226","article-title":"Lipid metabolism and retinal diseases","volume":"100","author":"Gabrielle","year":"2022","journal-title":"Acta Ophthalmol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nm.4059","article-title":"Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1","volume":"22","author":"Joyal","year":"2016","journal-title":"Nat Med"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1001\/jamaophthalmol.2013.7376","article-title":"Secondary analyses of the effects of lutein\/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3","volume":"132","author":"Age-Related Eye Disease Study 2 Research, G","year":"2014","journal-title":"JAMA Ophthalmol"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1001\/jamaophthalmol.2022.1640","article-title":"Long-term outcomes of adding lutein\/zeaxanthin and ?-3 fatty acids to the AREDS supplements on age-related macular degeneration progression: AREDS2 Report 28","volume":"140","author":"Chew","year":"2022","journal-title":"JAMA Ophthalmol"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"109429","DOI":"10.1016\/j.exer.2023.109429","article-title":"Mechanism for the selective uptake of macular carotenoids mediated by the HDL cholesterol receptor SR-BI","volume":"229","author":"Li","year":"2023","journal-title":"Exp Eye Res"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1194\/jlr.M700580-JLR200","article-title":"Xanthophylls are preferentially taken up compared with beta-carotene by retinal cells via a SRBI-dependent mechanism","volume":"49","author":"During","year":"2008","journal-title":"J Lipid Res"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1167\/iovs.12-10867","article-title":"Genetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study","volume":"54","author":"Meyers","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1167\/iovs.13-13216","article-title":"Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS)","volume":"55","author":"Meyers","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"AMD182","DOI":"10.1167\/iovs.18-24883","article-title":"Antecedents of soft drusen, the specific deposits of age-related macular degeneration, in the biology of human macula","volume":"59","author":"Curcio","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"100263","DOI":"10.1016\/j.xops.2022.100263","article-title":"Macular and plasma xanthophylls are higher in age-related macular degeneration than in normal aging: Alabama Study on Early Age-related Macular Degeneration 2 Baseline","volume":"3","author":"McGwin","year":"2023","journal-title":"Ophthalmol Sci"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/ng.3448","article-title":"A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants","volume":"48","author":"Fritsche","year":"2016","journal-title":"Nat Genet"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ophtha.2023.08.023","article-title":"Genome-wide meta-analysis identifies risk loci and improves disease prediction of age-related macular degeneration","volume":"131","author":"He","year":"2024","journal-title":"Ophthalmology"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"e10329","DOI":"10.1371\/journal.pone.0010329","article-title":"Abundant lipid and protein components of drusen","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3945\/ajcn.117.153825","article-title":"?-3 and ?-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases","volume":"106","author":"Gong","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1167\/iovs.14-15838","article-title":"Inner segment remodeling and mitochondrial translocation in cone photoreceptors in age-related macular degeneration with outer retinal tubulation","volume":"56","author":"Litts","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib55","first-page":"3016","article-title":"Mitochondrial abnormalities in ageing macular photoreceptors","volume":"42","author":"Barron","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1161\/CIRCRESAHA.119.312617","article-title":"HDL and reverse cholesterol transport","volume":"124","author":"Ouimet","year":"2019","journal-title":"Circ Res"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1093\/eurheartj\/ehac605","article-title":"High-density lipoprotein revisited: biological functions and clinical relevance","volume":"44","author":"von Eckardstein","year":"2023","journal-title":"Eur Heart J"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"7472","DOI":"10.3390\/ijms21207472","article-title":"Early pro-inflammatory remodeling of HDL proteome in a model of diet-induced obesity: 2H2O-metabolic labeling-based kinetic approach","volume":"21","author":"Sadana","year":"2020","journal-title":"Int J Mol Sci"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1194\/jlr.M059089","article-title":"Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity","volume":"56","author":"Vaisar","year":"2015","journal-title":"J Lipid Res"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.ophtha.2018.09.045","article-title":"Increased high-density lipoprotein levels associated with age-related macular degeneration: evidence from the EYE-RISK and European Eye Epidemiology Consortia","volume":"126","author":"Colijn","year":"2019","journal-title":"Ophthalmology"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"100341","DOI":"10.1016\/j.xops.2023.100341","article-title":"Systemic dyslipidemia in age-related macular degeneration: an updated systematic review and meta-analysis","volume":"4","author":"Li","year":"2024","journal-title":"Ophthalmol Sci"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.ophtha.2020.06.020","article-title":"Integrating metabolomics, genomics, and disease pathways in age-related macular degeneration: the EYE-RISK Consortium","volume":"127","author":"Acar","year":"2020","journal-title":"Ophthalmology"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1093\/cvr\/cvv104","article-title":"The role of high-density lipoproteins in the regulation of angiogenesis","volume":"106","author":"Tan","year":"2015","journal-title":"Cardiovasc Res"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1161\/01.ATV.0000066134.79956.58","article-title":"High density lipoprotein-induced angiogenesis requires the activation of Ras\/MAP kinase in human coronary artery endothelial cells","volume":"23","author":"Miura","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1080\/15384101.2023.2296184","article-title":"High-density lipoprotein protects vascular endothelial cells from indoxyl sulfate insults through its antioxidant ability","volume":"22","author":"Chen","year":"2023","journal-title":"Cell Cycle"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"13601","DOI":"10.1074\/jbc.RA119.012305","article-title":"High-density lipoproteins are a potential therapeutic target for age-related macular degeneration","volume":"295","author":"Kelly","year":"2020","journal-title":"J Biol Chem"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1167\/iovs.18-25786","article-title":"Apolipoprotein A-I mimetic peptide L-4F removes Bruch's membrane lipids in aged nonhuman primates","volume":"60","author":"Rudolf","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1161\/CIRCULATIONAHA.107.704031","article-title":"Apolipoprotein A-II is inversely associated with risk of future coronary artery disease","volume":"116","author":"Birjmohun","year":"2007","journal-title":"Circulation"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.diabres.2018.03.055","article-title":"Abnormalities in the relationship of paraoxonase 1 with HDL and apolipoprotein A1 and their possible connection to HDL dysfunctionality in type 2 diabetes","volume":"140","author":"Viktorinova","year":"2018","journal-title":"Diabetes Res Clin Pract"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2811294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:11Z","timestamp":1791927131000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2811294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":69,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2025,12,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.15.73","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,30]]}}}