{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:53Z","timestamp":1791928853374,"version":"4.3.4"},"reference-count":45,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,2,6]]},"DOI":"10.1167\/iovs.66.2.15","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T11:31:14Z","timestamp":1738841474000},"page":"15","source":"Crossref","is-referenced-by-count":4,"title":["Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)"],"prefix":"10.1167","volume":"66","author":[{"given":"Hao","family":"Chi","sequence":"first","affiliation":[{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Qingdao, China"},{"name":"Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanxing","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Jinan, China"},{"name":"Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Eye Institute of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Bai","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Jinan, China"},{"name":"Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Eye Institute of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyao","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Jinan, China"},{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjun","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Jinan, China"},{"name":"https:\/\/orcid.org\/0000-0003-1581-8377"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyun","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Jinan, China"},{"name":"Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Eye Institute of Shandong First Medical University, Jinan, China"},{"name":"https:\/\/orcid.org\/0000-0003-4106-373X"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"100758","DOI":"10.1016\/j.preteyeres.2019.04.002","article-title":"Immune privilege in corneal transplantation","volume":"72","author":"Hori","year":"2019","journal-title":"Prog Retin Eye Res"},{"issue":"11","key":"bib2","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/nri1224","article-title":"Ocular immune privilege: therapeutic opportunities from an experiment of nature","volume":"3","author":"Streilein","year":"2003","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"bib3","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1097\/TP.0000000000002938","article-title":"High-risk corneal transplantation: recent developments and future possibilities","volume":"103","author":"Armitage","year":"2019","journal-title":"Transplantation"},{"issue":"11","key":"bib4","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1136\/bjophthalmol-2021-319745","article-title":"Preincubation of donor tissue with a VEGF cytokine trap promotes subsequent high-risk corneal transplant survival","volume":"106","author":"Zhang","year":"2022","journal-title":"Br J Ophthalmol"},{"issue":"10","key":"bib5","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/nrd.2017.116","article-title":"Senescent cells: an emerging target for diseases of ageing","volume":"16","author":"Childs","year":"2017","journal-title":"Nat Rev Drug Discov"},{"issue":"15","key":"bib6","doi-asserted-by":"publisher","first-page":"e158450","DOI":"10.1172\/JCI158450","article-title":"Cellular senescence: a key therapeutic target in aging and diseases","volume":"132","author":"Zhang","year":"2022","journal-title":"J Clin Invest"},{"issue":"8","key":"bib7","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41583-020-0325-z","article-title":"Cellular senescence and Alzheimer disease: the egg and the chicken scenario","volume":"21","author":"Saez-Atienzar","year":"2020","journal-title":"Nat Rev Neurosci"},{"issue":"7884","key":"bib8","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/s41586-021-03995-1","article-title":"Virus-induced senescence is a driver and therapeutic target in COVID-19","volume":"599","author":"Lee","year":"2021","journal-title":"Nature"},{"issue":"362","key":"bib9","doi-asserted-by":"publisher","first-page":"362ra144","DOI":"10.1126\/scitranslmed.aaf9440","article-title":"Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy","volume":"8","author":"Oubaha","year":"2016","journal-title":"Sci Transl Med"},{"issue":"6326","key":"bib10","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1126\/science.aal0092","article-title":"Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice","volume":"355","author":"Williams","year":"2017","journal-title":"Science"},{"issue":"2","key":"bib11","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"bib12","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/s41593-019-0372-9","article-title":"Senolytic therapy alleviates A\u00df-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease mode","volume":"22","author":"Zhang","year":"2019","journal-title":"Nat Neurosci"},{"issue":"6552","key":"bib13","doi-asserted-by":"publisher","first-page":"eabe4832","DOI":"10.1126\/science.abe4832","article-title":"Senolytics reduce coronavirus-related mortality in old mice","volume":"373","author":"Camell","year":"2021","journal-title":"Science"},{"issue":"4","key":"bib14","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.cmet.2021.01.011","article-title":"Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition","volume":"33","author":"Crespo-Garcia","year":"2021","journal-title":"Cell Metab"},{"issue":"11","key":"bib15","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1111\/ajt.17154","article-title":"Renal inflamm-aging provokes intra-graft inflammation following experimental kidney transplantation","volume":"22","author":"He","year":"2022","journal-title":"Am J Transplant"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"4289","DOI":"10.1038\/s41467-020-18039-x","article-title":"Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation","volume":"11","author":"Iske","year":"2020","journal-title":"Nat Commun"},{"issue":"2","key":"bib17","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1161\/CIRCULATIONAHA.114.014917","article-title":"CD11c+ dendritic cells accelerate the rejection of older cardiac transplants via interleukin-17A","volume":"132","author":"Oberhuber","year":"2015","journal-title":"Circulation"},{"issue":"674","key":"bib18","doi-asserted-by":"publisher","first-page":"eabj4375","DOI":"10.1126\/scitranslmed.abj4375","article-title":"Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage","volume":"14","author":"Ferreira-Gonzalez","year":"2022","journal-title":"Sci Transl Med"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"109971","DOI":"10.1016\/j.exer.2024.109971","article-title":"The ocular immunological alterations in the process of high-risk corneal transplantation rejection","volume":"245","author":"Chi","year":"2024","journal-title":"Exp Eye Res"},{"issue":"7","key":"bib20","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1111\/ajt.12271","article-title":"Biliary epithelial senescence and plasticity in acute cellular rejection","volume":"13","author":"Brain","year":"2013","journal-title":"Am J Transplant"},{"issue":"2","key":"bib21","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1111\/ajt.16350","article-title":"DelCFHR3-1 influences graft survival in transplant patients with IgA nephropathy via complement-mediated cellular senescence","volume":"21","author":"Pesce","year":"2021","journal-title":"Am J Transplant"},{"issue":"12","key":"bib22","doi-asserted-by":"publisher","first-page":"3354","DOI":"10.1111\/ajt.16071","article-title":"The NLRP3 inflammasome regulates corneal allograft rejection through enhanced phosphorylation of STAT3","volume":"20","author":"Wei","year":"2020","journal-title":"Am J Transplant"},{"issue":"5","key":"bib23","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1111\/ajt.16968","article-title":"Enhanced autophagy alleviated corneal allograft rejection via inhibiting NLRP3 inflammasome activity","volume":"22","author":"Wei","year":"2022","journal-title":"Am J Transplant"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/nm.4010","article-title":"Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice","volume":"22","author":"Chang","year":"2016","journal-title":"Nat Med"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"108061","DOI":"10.1016\/j.abb.2019.07.026","article-title":"Angiotensin-converting enzyme 2 regulates autophagy in acute lung injury through AMPK\/mTOR signaling","volume":"672","author":"Zhang","year":"2019","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"bib26","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/s41590-020-00859-0","article-title":"IRGM1 links mitochondrial quality control to autoimmunity","volume":"22","author":"Rai","year":"2021","journal-title":"Nat Immunol"},{"issue":"3","key":"bib27","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.molcel.2018.11.018","article-title":"The Crohn's disease risk factor IRGM limits NLRP3 inflammasome activation by impeding its assembly and by mediating its selective autophagy","volume":"73","author":"Mehto","year":"2019","journal-title":"Mol Cell"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"111254","DOI":"10.1016\/j.mce.2021.111254","article-title":"Renin-angiotensin system and inflammation update","volume":"529","author":"Cantero-Navarro","year":"2021","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"bib29","doi-asserted-by":"publisher","first-page":"e13299","DOI":"10.1111\/acel.13299","article-title":"Targeting age-specific changes in CD4+ T cell metabolism ameliorates alloimmune responses and prolongs graft survival","volume":"20","author":"Nian","year":"2021","journal-title":"Aging Cell"},{"issue":"8","key":"bib30","first-page":"4182","article-title":"Lymph node fibroblastic reticular cells deposit fibrosis-associated collagen following organ transplantation","volume":"130","author":"Li","year":"2020","journal-title":"J Clin Invest"},{"issue":"22","key":"bib31","doi-asserted-by":"publisher","first-page":"4868","DOI":"10.1016\/j.cell.2023.09.012","article-title":"Liquid-biopsy proteomics combined with AI identifies cellular drivers of eye aging and disease in vivo","volume":"186","author":"Wolf","year":"2023","journal-title":"Cell"},{"issue":"1","key":"bib32","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/s41392-023-01377-9","article-title":"Activation of immune signals during organ transplantation","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"bib33","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/imr.12153","article-title":"Innate allorecognition","volume":"258","author":"Oberbarnscheidt","year":"2014","journal-title":"Immunol Rev"},{"issue":"9","key":"bib34","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1016\/j.ajt.2024.04.010","article-title":"Cyclic guanosine monophosphate-adenosine monophosphate synthetase\/stimulator of interferon genes signaling aggravated corneal allograft rejection through neutrophil extracellular traps","volume":"24","author":"Wei","year":"2024","journal-title":"Am J Transplant"},{"issue":"5","key":"bib35","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.immuni.2018.09.008","article-title":"Inhibiting inflammation with myeloid cell-specific nanobiologics promotes organ transplant acceptance","volume":"49","author":"Braza","year":"2018","journal-title":"Immunity"},{"issue":"8","key":"bib36","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1172\/JCI74370","article-title":"Non-self recognition by monocytes initiates allograft rejection","volume":"124","author":"Oberbarnscheidt","year":"2014","journal-title":"J Clin Invest"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"104419","DOI":"10.1016\/j.ebiom.2022.104419","article-title":"Danger signals released during cold ischemia storage activate NLRP3 inflammasome in myeloid cells and influence early allograft function in liver transplantation","volume":"87","author":"Lucas-Ruiz","year":"2023","journal-title":"EBioMedicine"},{"issue":"4","key":"bib38","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1002\/lt.25429","article-title":"Damage-associated molecular patterns induce inflammatory injury during machine preservation of the liver: potential targets to enhance a promising technology","volume":"25","author":"Scheuermann","year":"2019","journal-title":"Liver Transpl"},{"issue":"3","key":"bib39","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol Rev"},{"issue":"7408","key":"bib40","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/nature11228","article-title":"ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation","volume":"487","author":"Hashimoto","year":"2012","journal-title":"Nature"},{"issue":"1","key":"bib41","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1053\/j.gastro.2020.07.067","article-title":"The role of angiotensin converting enzyme 2 in modulating gut microbiota, intestinal inflammation, and coronavirus infection","volume":"160","author":"Penninger","year":"2021","journal-title":"Gastroenterology"},{"issue":"8","key":"bib42","doi-asserted-by":"publisher","first-page":"10505","DOI":"10.1096\/fj.202001020R","article-title":"The ACE2-deficient mouse: a model for a cytokine storm-driven inflammation","volume":"34","author":"Wang","year":"2020","journal-title":"FASEB J"},{"issue":"5","key":"bib43","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1038\/s41440-023-01189-y","article-title":"Is the anti-aging effect of ACE2 due to its role in the renin-angiotensin system?\u2014Findings from a comparison of the aging phenotypes of ACE2-deficient, Tsukuba hypertensive, and Mas-deficient mice","volume":"46","author":"Takeshita","year":"2023","journal-title":"Hypertens Res"},{"issue":"10","key":"bib44","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1111\/ajt.15878","article-title":"Donor apoptotic cell-based therapy for effective inhibition of donor-specific memory T and B cells to promote long-term allograft survival in allosensitized recipients","volume":"20","author":"Dangi","year":"2020","journal-title":"Am J Transplant"},{"issue":"1","key":"bib45","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.1038\/s41467-019-11338-y","article-title":"Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes","volume":"10","author":"Singh","year":"2019","journal-title":"Nat Commun"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:58Z","timestamp":1791927118000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.2.15","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,6]]}}}