{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:36Z","timestamp":1791928896924,"version":"4.3.4"},"reference-count":52,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,2,3]]},"DOI":"10.1167\/iovs.66.2.2","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T10:31:16Z","timestamp":1738578676000},"page":"2","source":"Crossref","is-referenced-by-count":4,"title":["Lamp2 Deficiency Enhances Susceptibility to Oxidative Stress\u2013Induced RPE Degeneration"],"prefix":"10.1167","volume":"66","author":[{"given":"Guannan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Notomi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Maehara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keijiro","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Hisatomi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Fukuoka University Chikushi Hospital, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh-Hei","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","article-title":"Biological functions of autophagy genes: a disease perspective","volume":"176","author":"Levine","year":"2019","journal-title":"Cell"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.cell.2013.06.012","article-title":"Noncanonical autophagy promotes the visual cycle","volume":"154","author":"Kim","year":"2013","journal-title":"Cell"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.tins.2023.09.006","article-title":"Lysosomes in retinal health and disease","volume":"46","author":"Boya","year":"2023","journal-title":"Trends Neurosci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"e2100122118","DOI":"10.1073\/pnas.2100122118","article-title":"Lipofuscin causes atypical necroptosis through lysosomal membrane permeabilization","volume":"118","author":"Pan","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1038\/35022595","article-title":"Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice","volume":"406","author":"Tanaka","year":"2000","journal-title":"Nature"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.ophtha.2006.02.030","article-title":"Ophthalmic manifestations of Danon disease","volume":"113","author":"Prall","year":"2006","journal-title":"Ophthalmology"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S1471-4914(00)01868-2","article-title":"Disease model: LAMP-2 enlightens Danon disease","volume":"7","author":"Saftig","year":"2001","journal-title":"Trends Mol Med"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1016\/j.jacc.2023.08.014","article-title":"International consensus on differential diagnosis and management of patients with Danon disease: JACC state-of-the-art review","volume":"82","author":"Hong","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1038\/35022595","article-title":"Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice","volume":"406","author":"Tanaka","year":"2000","journal-title":"Nature"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"3132","DOI":"10.1091\/mbc.e04-02-0103","article-title":"Disturbed cholesterol traffic but normal proteolytic function in LAMP-1\/LAMP-2 double-deficient fibroblasts","volume":"15","author":"Eskelinen","year":"2004","journal-title":"Mol Biol Cell"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"23724","DOI":"10.1073\/pnas.1906643116","article-title":"Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina","volume":"116","author":"Notomi","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1001\/jama.2023.26074","article-title":"Age-related macular degeneration: a review","volume":"331","author":"Fleckenstein","year":"2024","journal-title":"JAMA"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Global Health"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s10384-023-00985-w","article-title":"Efficacy, durability, and safety of faricimab up to every 16 weeks in patients with neovascular age-related macular degeneration: 1-year results from the Japan subgroup of the phase 3 TENAYA trial","volume":"67","author":"Mori","year":"2023","journal-title":"Jpn J Ophthalmol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s10384-023-01040-4","article-title":"One-year results of treat-and-extend regimen with intravitreal faricimab for treatment-na\u00efve neovascular age-related macular degeneration","volume":"68","author":"Matsumoto","year":"2024","journal-title":"Jpn J Ophthalmol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.mam.2012.03.009","article-title":"Consequences of oxidative stress in age-related macular degeneration","volume":"33","author":"Jarrett","year":"2012","journal-title":"Mol Aspects Med"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/cdd.2014.150","article-title":"Oxidative stress and autophagy: the clash between damage and metabolic needs","volume":"22","author":"Filomeni","year":"2015","journal-title":"Cell Death Differ"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.freeradbiomed.2014.03.025","article-title":"Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics","volume":"71","author":"Levonen","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1042\/BJ20111451","article-title":"Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling","volume":"441","author":"Lee","year":"2012","journal-title":"Biochem J"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.4161\/auto.36184","article-title":"Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD","volume":"10","author":"Mitter","year":"2014","journal-title":"Autophagy"},{"key":"bib22","first-page":"2896036","article-title":"Autophagy in age-related macular degeneration: a regulatory mechanism of oxidative stress","volume":"2020","author":"Zhang","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"9218","DOI":"10.3390\/ijms22179218","article-title":"Sodium iodate-induced degeneration results in local complement changes and inflammatory processes in murine retina","volume":"22","author":"Enzbrenner","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12929-019-0531-z","article-title":"Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death","volume":"26","author":"Chan","year":"2019","journal-title":"J Biomed Sci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"101971","DOI":"10.1016\/j.redox.2021.101971","article-title":"HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration","volume":"43","author":"Tang","year":"2021","journal-title":"Redox Biol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.exer.2013.04.004","article-title":"Endogenous regeneration of damaged retinal pigment epithelium following low dose sodium iodate administration: an insight into the role of glial cells in retinal repair","volume":"112","author":"Machalinska","year":"2013","journal-title":"Exp Eye Res"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"3476","DOI":"10.1167\/iovs.17-23532","article-title":"Irreversible photoreceptors and RPE cells damage by intravenous sodium iodate in mice is related to macrophage accumulation","volume":"59","author":"Moriguchi","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.exer.2005.08.002","article-title":"Behavioral and anatomical abnormalities in a sodium iodate-induced model of retinal pigment epithelium degeneration","volume":"82","author":"Enzmann","year":"2006","journal-title":"Exp Eye Res"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1007\/s11064-010-0248-6","article-title":"Sodium iodate selectively injuries the posterior pole of the retina in a dose-dependent manner: morphological and electrophysiological study","volume":"35","author":"Machalinska","year":"2010","journal-title":"Neurochem Res"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3390\/antiox11010103","article-title":"Fine tuning of an oxidative stress model with sodium iodate revealed protective effect of NF-?B inhibition and sex-specific difference in susceptibility of the retinal pigment epithelium","volume":"11","author":"Yang","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.1167\/iovs.15-16432","article-title":"Subducted and melanotic cells in advanced age-related macular degeneration are derived from retinal pigment epithelium","volume":"56","author":"Zanzottera","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.preteyeres.2017.03.002","article-title":"The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD","volume":"60","author":"Datta","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J Clin Invest"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"101623","DOI":"10.1016\/j.redox.2020.101623","article-title":"Oxidative stress in the retina and retinal pigment epithelium (RPE): role of aging, and DJ-1","volume":"37","author":"Upadhyay","year":"2020","journal-title":"Redox Biology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: a generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nature Methods"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1016\/j.ophtha.2013.07.047","article-title":"Circularity index as a risk factor for progression of geographic atrophy","volume":"120","author":"Domalpally","year":"2013","journal-title":"Ophthalmology"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/jfb4010038","article-title":"Cultivation of human microvascular endothelial cells on topographical substrates to mimic the human corneal endothelium","volume":"4","author":"Chua","year":"2013","journal-title":"J Funct Biomater"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"20636","DOI":"10.1038\/srep20636","article-title":"Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina","volume":"6","author":"O'Koren","year":"2016","journal-title":"Sci Rep"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/0022-1759(96)00056-7","article-title":"Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine","volume":"193","author":"van Rooijen","year":"1996","journal-title":"J Immunol Methods"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12974-016-0504-z","article-title":"Macrophage depletion reduced brain injury following middle cerebral artery occlusion in mice","volume":"13","author":"Ma","year":"2016","journal-title":"J Neuroinflamm"},{"key":"bib41","first-page":"101822","article-title":"Altered fatty acid distribution in lysosome-associated membrane protein-2 deficient mice","volume":"40","author":"Xu","year":"2024","journal-title":"Biochem Biophys Rep"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.redox.2018.09.011","article-title":"Loss of NRF-2 and PGC-1a genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration","volume":"20","author":"Felszeghy","year":"2019","journal-title":"Redox Biol"},{"key":"bib43","doi-asserted-by":"crossref","first-page":"484613","DOI":"10.1155\/2013\/484613","article-title":"Role of redox signaling in neuroinflammation and neurodegenerative diseases","volume":"2013","author":"Hsieh","year":"2013","journal-title":"Biomed Res Int"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/s41590-020-0699-0","article-title":"Redox homeostasis maintained by GPX4 facilitates STING activation","volume":"21","author":"Jia","year":"2020","journal-title":"Nat Immunol"},{"key":"bib45","doi-asserted-by":"crossref","first-page":"2524174","DOI":"10.1155\/2020\/2524174","article-title":"Protective effect of metformin against hydrogen peroxide-induced oxidative damage in human retinal pigment epithelial (RPE) cells by enhancing autophagy through activation of AMPK pathway","volume":"2020","author":"Zhao","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.3390\/antiox12071368","article-title":"Antioxidative role of heterophagy, autophagy, and mitophagy in the retina and their association with the age-related macular degeneration (AMD) etiopathogenesis","volume":"12","author":"Nita","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.bbrc.2019.10.138","article-title":"Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells","volume":"521","author":"Lee","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"8433","DOI":"10.1038\/s41598-017-08702-7","article-title":"Monocyte infiltration and proliferation reestablish myeloid cell homeostasis in the mouse retina following retinal pigment epithelial cell injury","volume":"7","author":"Ma","year":"2017","journal-title":"Sci Rep"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.preteyeres.2017.06.002","article-title":"On phagocytes and macular degeneration","volume":"61","author":"Guillonneau","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"901672","DOI":"10.3389\/fimmu.2022.901672","article-title":"Occurrences and functions of Ly6C(hi) and Ly6C(lo) macrophages in health and disease","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.immuni.2018.11.004","article-title":"Single-Cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes","volume":"50","author":"Hammond","year":"2019","journal-title":"Immunity"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:59Z","timestamp":1791927119000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,3]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.2.2","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,3]]}}}