{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:35Z","timestamp":1791928895364,"version":"4.3.4"},"reference-count":37,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,3,6]]},"DOI":"10.1167\/iovs.66.3.13","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T11:32:38Z","timestamp":1741260758000},"page":"13","source":"Crossref","is-referenced-by-count":9,"title":["Factors Associated With Retinal Vessel Traits in the Canadian Longitudinal Study on Aging"],"prefix":"10.1167","volume":"66","author":[{"given":"Alexis","family":"O'Neil","sequence":"first","affiliation":[{"name":"School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan A.","family":"Welikala","sequence":"additional","affiliation":[{"name":"School of Computer Science and Mathematics, Kingston University London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Barman","sequence":"additional","affiliation":[{"name":"School of Computer Science and Mathematics, Kingston University London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Owen","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, St. George's School of Health and Medical Sciences, City St. George's, University of London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja R.","family":"Rudnicka","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, St. George's School of Health and Medical Sciences, City St. George's, University of London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Rakesh","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Roy-Gagnon","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Maberley","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen E.","family":"Freeman","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Department of Ophthalmology, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib2","first-page":"3391","article-title":"VAMPIRE: vessel assessment and measurement platform for images of the retina","volume":"2011","author":"Perez-Rovira","year":"2011","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"issue":"8","key":"bib3","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1007\/s00417-023-06002-7","article-title":"Review and comparison of retinal vessel calibre and geometry software and their application to diabetes, cardiovascular disease, and dementia","volume":"261","author":"Brazionis","year":"2023","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"5","key":"bib4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/ceo.13119","article-title":"Review of the association between retinal microvascular characteristics and eye disease","volume":"46","author":"Newman","year":"2018","journal-title":"Clin Exp Ophthalmol"},{"issue":"21","key":"bib5","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1001\/archinte.166.21.2388","article-title":"Quantitative retinal venular caliber and risk of cardiovascular disease in older persons: the cardiovascular health study","volume":"166","author":"Wong","year":"2006","journal-title":"Arch Intern Med"},{"issue":"1","key":"bib6","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.survophthal.2008.10.003","article-title":"Retinal vascular caliber: systemic, environmental, and genetic associations","volume":"54","author":"Sun","year":"2009","journal-title":"Surv Ophthalmol"},{"issue":"6","key":"bib7","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1167\/iovs.05-1539","article-title":"Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA)","volume":"47","author":"Wong","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib8","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1167\/iovs.06-0893","article-title":"Age, blood pressure, and retinal vessel diameter: separate effects and interaction of blood pressure and age","volume":"48","author":"Kaushik","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib9","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1161\/HYPERTENSIONAHA.119.13752","article-title":"Associations of retinal microvascular diameters and tortuosity with blood pressure and arterial stiffness: United Kingdom Biobank","volume":"74","author":"Tapp","year":"2019","journal-title":"Hypertension"},{"issue":"9","key":"bib10","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1002\/oby.22885","article-title":"Retinal vascular tortuosity and diameter associations with adiposity and components of body composition","volume":"28","author":"Tapp","year":"2020","journal-title":"Obesity (Silver Spring)"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"104090","DOI":"10.1016\/j.ijmedinf.2020.104090","article-title":"Automatic image analyser to assess retinal vessel calibre (ALTAIR). A new tool to evaluate the thickness, area and length of the vessels of the retina","volume":"136","author":"Maderuelo-Fernandez","year":"2020","journal-title":"Int J Med Inform"},{"issue":"6","key":"bib12","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1093\/ije\/dyz173","article-title":"Cohort profile: the Canadian Longitudinal Study on Aging (CLSA)","volume":"48","author":"Raina","year":"2019","journal-title":"Int J Epidemiol"},{"issue":"1","key":"bib14","doi-asserted-by":"publisher","first-page":"100004","DOI":"10.1016\/j.xops.2021.100004","article-title":"A deep learning architecture for vascular area measurement in fundus images","volume":"1","author":"Fukutsu","year":"2021","journal-title":"Ophthalmol Sci"},{"issue":"1","key":"bib15","doi-asserted-by":"publisher","first-page":"3695","DOI":"10.1038\/s41598-022-07439-2","article-title":"Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography","volume":"12","author":"Maloca","year":"2022","journal-title":"Sci Rep"},{"issue":"5","key":"bib16","doi-asserted-by":"publisher","first-page":"3650","DOI":"10.1167\/iovs.12-11126","article-title":"Racial differences in retinal vessel geometric characteristics: a multiethnic study in healthy Asians","volume":"54","author":"Li","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib17","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1167\/iovs.07-0150","article-title":"Ethnic variability in retinal vessel caliber: a potential source of measurement error from ocular pigmentation?\u2014The Sydney Childhood Eye Study","volume":"49","author":"Rochtchina","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib18","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1161\/01.HYP.0000208330.68355.72","article-title":"Genome-wide linkage study of retinal vessel diameters in the Beaver Dam Eye Study","volume":"47","author":"Xing","year":"2006","journal-title":"Hypertension"},{"issue":"3","key":"bib19","doi-asserted-by":"publisher","first-page":"100288","DOI":"10.1016\/j.xops.2023.100288","article-title":"Genome-wide association studies of retinal vessel tortuosity identify numerous novel loci revealing genes and pathways associated with ocular and cardiometabolic diseases","volume":"3","author":"Tomasoni","year":"2023","journal-title":"Ophthalmol Sci"},{"issue":"1","key":"bib20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1161\/CIRCGENETICS.115.001142","article-title":"Novel genetic loci associated with retinal microvascular diameter","volume":"9","author":"Jensen","year":"2016","journal-title":"Circ Cardiovasc Genet"},{"issue":"5","key":"bib21","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1007\/s00417-023-06223-w","article-title":"Effects of firsthand tobacco smoking on retinal vessel caliber: a systematic review and meta-analysis","volume":"262","author":"Yuen","year":"2024","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"11","key":"bib22","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1093\/aje\/kwm255","article-title":"Long-term effects of smoking on retinal microvascular caliber","volume":"166","author":"Kifley","year":"2007","journal-title":"Am J Epidemiol"},{"issue":"1","key":"bib23","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1159\/000526753","article-title":"Retinal vascular caliber in coronary heart disease and its risk factors","volume":"66","author":"Liang","year":"2023","journal-title":"Ophthalmic Res"},{"issue":"7","key":"bib24","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1007\/s00417-004-1083-8","article-title":"Response of retinal blood flow to systemic hyperoxia in smokers and nonsmokers","volume":"243","author":"Wimpissinger","year":"2005","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1026987","DOI":"10.3389\/fphys.2023.1026987","article-title":"Retinal blood vessel diameters in children and adults exposed to a simulated altitude of 3,000 m","volume":"14","author":"Mlinar","year":"2023","journal-title":"Front Physiol"},{"issue":"1","key":"bib26","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1001\/archopht.124.1.87","article-title":"Are inflammatory factors related to retinal vessel caliber? The Beaver Dam Eye Study","volume":"124","author":"Klein","year":"2006","journal-title":"Arch Ophthalmol"},{"issue":"10","key":"bib27","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1016\/j.jacc.2003.12.047","article-title":"The pathophysiology of cigarette smoking and cardiovascular disease: an update","volume":"43","author":"Ambrose","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"bib28","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1007\/s00109-021-02108-9","article-title":"Retinal tissue develops an inflammatory reaction to tobacco smoke and electronic cigarette vapor in mice","volume":"99","author":"Wang","year":"2021","journal-title":"J Mol Med (Berl)"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.atherosclerosis.2021.09.025","article-title":"The association between markers of inflammation and retinal microvascular parameters: a systematic review and meta-analysis","volume":"336","author":"Liu","year":"2021","journal-title":"Atherosclerosis"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"104629","DOI":"10.1016\/j.mvr.2023.104629","article-title":"Quantitative evaluation of choroidal and retinal microvasculature post-alcohol consumption: a pilot study","volume":"152","author":"Zhuang","year":"2024","journal-title":"Microvasc Res"},{"issue":"2","key":"bib31","doi-asserted-by":"publisher","first-page":"H605","DOI":"10.1152\/ajpheart.01162.2007","article-title":"Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter","volume":"294","author":"Spaak","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"6","key":"bib32","doi-asserted-by":"publisher","first-page":"e20174090","DOI":"10.1542\/peds.2017-4090","article-title":"Obesity, blood pressure, and retinal vessels: a meta-analysis","volume":"141","author":"Kochli","year":"2018","journal-title":"Pediatrics"},{"issue":"2","key":"bib33","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.survophthal.2006.12.003","article-title":"Obesity and eye diseases","volume":"52","author":"Cheung","year":"2007","journal-title":"Surv Ophthalmol"},{"issue":"9559","key":"bib34","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S0140-6736(07)60198-6","article-title":"The eye in hypertension","volume":"369","author":"Wong","year":"2007","journal-title":"Lancet"},{"issue":"12","key":"bib35","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1038\/ajh.2011.166","article-title":"Remodeling of retinal small arteries in hypertension","volume":"24","author":"Lehmann","year":"2011","journal-title":"Am J Hypertens"},{"issue":"10","key":"bib36","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s11892-017-0909-9","article-title":"Diameter changes of retinal vessels in diabetic retinopathy","volume":"17","author":"Bek","year":"2017","journal-title":"Curr Diab Rep"},{"issue":"7","key":"bib37","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.tem.2006.07.006","article-title":"Retinal vascular manifestations of metabolic disorders","volume":"17","author":"Nguyen","year":"2006","journal-title":"Trends Endocrinol Metab"},{"key":"bib1","article-title":"Artificial intelligence-enabled retinal vasculometry at scale utilizing the UK Biobank, CLSA, and NEL DESP datasets","volume-title":"Paper presented at IEEE\u2013EMBS International Conference on Biomedical and Health Informatics (BHI\u201924), November 10\u201313, 2024","author":"Welikala"},{"key":"bib13","first-page":"1","article-title":"Automated quantification of retinal vessel morphometry in the UK Biobank cohort","volume-title":"Proceedings of the 2017 Seventh International Conference on Image Processing Theory, Tools and Applications (IPTA)","author":"Welikala","year":"2017"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:58Z","timestamp":1791927118000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.3.13","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,6]]}}}