{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:57Z","timestamp":1791928857346,"version":"4.3.4"},"reference-count":49,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"DOI":"10.1167\/iovs.66.3.2","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T10:31:29Z","timestamp":1740997889000},"page":"2","source":"Crossref","is-referenced-by-count":3,"title":["Ocular Surface Involvements in the Development of Sj\u00f6gren's Syndrome\u2013Associated Dry Eye in the IL14\u03b1 Transgenic Mouse"],"prefix":"10.1167","volume":"66","author":[{"given":"Minjie","family":"Zhang","sequence":"first","affiliation":[{"name":"Xiamen University affiliated Xiamen Eye Center; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Eye Institute of Xiamen University; School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Ophthalmology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Liang","sequence":"additional","affiliation":[{"name":"Oncology Department, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China"},{"name":"Cancer Institute affiliated to Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China"},{"name":"Medical College, Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[{"name":"Xiamen University affiliated Xiamen Eye Center; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Eye Institute of Xiamen University; School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Zong","sequence":"additional","affiliation":[{"name":"Xiamen University affiliated Xiamen Eye Center; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Eye Institute of Xiamen University; School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Zhang","sequence":"additional","affiliation":[{"name":"C-MER (Shenzhen) Dennis Lam Eye Hospital, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"He","sequence":"additional","affiliation":[{"name":"Xiamen University affiliated Xiamen Eye Center; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Eye Institute of Xiamen University; School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Sol","family":"Reinach","sequence":"additional","affiliation":[{"name":"School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Xiamen University affiliated Xiamen Eye Center; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Eye Institute of Xiamen University; School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Shen","sequence":"additional","affiliation":[{"name":"Oncology Department, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China"},{"name":"Cancer Institute affiliated to Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China"},{"name":"Medical College, Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Xiamen University affiliated Xiamen Eye Center; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science; Eye Institute of Xiamen University; School of Medicine, Xiamen University, Xiamen, Fujian, China"},{"name":"Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","article-title":"Sjogren's syndrome","volume":"366","author":"Fox","year":"2005","journal-title":"Lancet"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"673658","DOI":"10.3389\/fimmu.2021.673658","article-title":"IL-14alpha as a putative biomarker for stratification of dry eye in primary Sjogren's syndrome","volume":"12","author":"Liang","year":"2021","journal-title":"Front Immunol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"R172","DOI":"10.1186\/ar4359","article-title":"Efficacy and safety of rituximab treatment in early primary Sjogren's syndrome: a prospective, multi-center, follow-up study","volume":"15","author":"Carubbi","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1136\/bjophthalmol-2012-301767","article-title":"Prevalence and predictors of Sjogren's syndrome in a prospective cohort of patients with aqueous-deficient dry eye","volume":"96","author":"Liew","year":"2012","journal-title":"Br J Ophthalmol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ophtha.2014.07.026","article-title":"Ocular and systemic morbidity in a longitudinal cohort of Sjogren's syndrome","volume":"122","author":"Akpek","year":"2015","journal-title":"Ophthalmology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.3390\/ijms18071398","article-title":"Dry eye management: targeting the ocular surface microenvironment","volume":"18","author":"Zhang","year":"2017","journal-title":"Int J Mol Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.3109\/02713688709025234","article-title":"Lacrimal gland, cornea, and tear film in the NZB\/NZW F1 hybrid mouse","volume":"6","author":"Gilbard","year":"1987","journal-title":"Curr Eye Res"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"744","DOI":"10.2353\/ajpath.2010.091116","article-title":"Spontaneous autoimmune dacryoadenitis in aged CD25KO mice","volume":"177","author":"Rahimy","year":"2010","journal-title":"Am J Pathol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/icb.2017.38","article-title":"CD8 T cells contribute to lacrimal gland pathology in the nonobese diabetic mouse model of Sjogren syndrome","volume":"95","author":"Barr","year":"2017","journal-title":"Immunol Cell Biol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.exer.2018.09.002","article-title":"NOD and NOR mice exhibit comparable development of lacrimal gland secretory dysfunction but NOD mice have more severe autoimmune dacryoadenitis","volume":"176","author":"Ju","year":"2018","journal-title":"Exp Eye Res"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1182\/blood.V86.1.283.bloodjournal861283","article-title":"Identification of B-cell growth factors (interleukin-14; high molecular weight-B-cell growth factors) in effusion fluids from patients with aggressive B-cell lymphomas","volume":"86","author":"Ford","year":"1995","journal-title":"Blood"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.clim.2008.10.006","article-title":"IL-14 alpha, the nexus for primary Sjogren's disease in mice and humans","volume":"130","author":"Shen","year":"2009","journal-title":"Clin Immunol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1097\/00007890-201407151-03066","article-title":"The B cell growth factor interleukin 14 (IL14): a potential biomarker for immune activation and mediator of de novo DSA after renal transplantation.  Abstract# B791","volume":"98","author":"Xuan","year":"2014","journal-title":"Transplantation"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.clim.2016.04.008","article-title":"Central role for marginal zone B cells in an animal model of Sjogren's syndrome","volume":"168","author":"Shen","year":"2016","journal-title":"Clin Immunol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1016\/j.jaci.2004.12.252","article-title":"Constitutive expression of interleukin 14 (IL-14) in transgenic mice leads to enhanced responses to vaccinations and autoimmunity","volume":"115","author":"Xu","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"608","DOI":"10.4049\/jimmunol.1203440","article-title":"Different stages of primary Sjogren's syndrome involving lymphotoxin and type 1 IFN","volume":"191","author":"Shen","year":"2013","journal-title":"J Immunol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"6056","DOI":"10.1167\/iovs.17-22852","article-title":"Topical application of mizoribine suppresses CD4+ T-cell-mediated pathogenesis in murine dry eye","volume":"58","author":"Zhang","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1472-6831-13-51","article-title":"Temporal histological changes in lacrimal and major salivary glands in mouse models of Sjogren's syndrome","volume":"13","author":"Xuan","year":"2013","journal-title":"BMC Oral Health"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1167\/iovs.07-0685","article-title":"Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease","volume":"49","author":"Li","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","first-page":"549","article-title":"Elevated expression of transglutaminase 1 and keratinization-related proteins in conjunctiva in severe ocular surface disease","volume":"42","author":"Nakamura","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1167\/iovs.07-0069","article-title":"Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma","volume":"48","author":"De Paiva","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/mi.2009.5","article-title":"IL-17 disrupts corneal barrier following desiccating stress","volume":"2","author":"De Paiva","year":"2009","journal-title":"Mucosal immunol"},{"key":"bib23","first-page":"240","article-title":"Dry eye: an inflammatory ocular disease","volume":"9","author":"Hessen","year":"2014","journal-title":"J Ophthalmic Vis Res"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.preteyeres.2009.04.003","article-title":"Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases","volume":"28","author":"Dartt","year":"2009","journal-title":"Prog Retin Eye Res"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"12034","DOI":"10.1038\/ncomms12034","article-title":"PACAP suppresses dry eye signs by stimulating tear secretion","volume":"7","author":"Nakamachi","year":"2016","journal-title":"Nat Commun"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1038\/s41433-018-0149-5","article-title":"Meibomian gland dropout in Sjogren's syndrome and non-Sjogren's dry eye patients","volume":"32","author":"Zang","year":"2018","journal-title":"Eye (Lond)"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.3389\/fimmu.2020.01158","article-title":"Recent advances in mouse models of Sjogren's syndrome","volume":"11","author":"Gao","year":"2020","journal-title":"Front Immunol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"8409","DOI":"10.4049\/jimmunol.175.12.8409","article-title":"Immunization with short peptides from the 60-kDa Ro antigen recapitulates the serological and pathological findings as well as the salivary gland dysfunction of Sjogren's syndrome","volume":"175","author":"Scofield","year":"2005","journal-title":"J Immunol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1006\/exer.2000.0855","article-title":"Autologous lacrimal-lymphoid mixed-cell reactions induce dacryoadenitis in rabbits","volume":"71","author":"Guo","year":"2000","journal-title":"Exp Eye Res"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.2353\/ajpath.2009.081058","article-title":"Sjogren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice","volume":"175","author":"Turpie","year":"2009","journal-title":"Am J Pathol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"3628","DOI":"10.3390\/ijms19113628","article-title":"Deciphering molecular and phenotypic changes associated with early autoimmune disease in the aire-deficient mouse model of Sjogren's syndrome","volume":"19","author":"Chen","year":"2018","journal-title":"Int J Mol Sci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1167\/iovs.14-15668","article-title":"Age-related conjunctival disease in the C57BL\/6.NOD-Aec1Aec2 mouse model of Sjogren syndrome develops independent of lacrimal dysfunction","volume":"56","author":"You","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/S0161-6420(85)33967-2","article-title":"Staging of conjunctival squamous metaplasia by impression cytology","volume":"92","author":"Tseng","year":"1985","journal-title":"Ophthalmology"},{"key":"bib34","first-page":"2185","article-title":"Lacrimal gland HGF, KGF, and EGF mRNA levels increase after corneal epithelial wounding","volume":"40","author":"Wilson","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.3390\/ijms18061209","article-title":"Pathological analysis of ocular lesions in a murine model of Sjogren's syndrome","volume":"18","author":"Ushio","year":"2017","journal-title":"Int J Mol Sci"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"916089","DOI":"10.3389\/fmicb.2022.916089","article-title":"High-fat diet-induced intestinal dysbiosis is associated with the exacerbation of Sjogren's syndrome","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Microbiol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1586\/1744666X.2014.891440","article-title":"What causes dryness in Sjogren's syndrome patients and how can it be targeted?","volume":"10","author":"Pflugfelder","year":"2014","journal-title":"Expert Rev Clin Immunol"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1016\/j.ajpath.2011.06.030","article-title":"Desiccating stress induces CD4+ T-cell-mediated Sjogren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-gamma","volume":"179","author":"Zhang","year":"2011","journal-title":"Am J Pathol"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1167\/iovs.07-0419","article-title":"Delayed disruption of barrier function in cultured human corneal epithelial cells induced by tumor necrosis factor-alpha in a manner dependent on NF-kappaB","volume":"49","author":"Kimura","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1167\/iovs.08-2606","article-title":"Interleukin-1beta-induced disruption of barrier function in cultured human corneal epithelial cells","volume":"50","author":"Kimura","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"DES151","DOI":"10.1167\/iovs.17-23623","article-title":"Secreted Mucins on the Ocular Surface","volume":"59","author":"Hori","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.exer.2006.10.021","article-title":"Lymphocytic infiltration and goblet cell marker alteration in the conjunctiva of the MRL\/MpJ-Faslprmouse model of Sj\u00f6gren's syndrome","volume":"84","author":"Diebold","year":"2007","journal-title":"Exp Eye Res"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.3390\/ijms19092760","article-title":"Severity of Sj\u00f6gren's syndrome keratoconjunctivitis sicca increases with increased percentage of conjunctival antigen-presenting cells","volume":"19","author":"Pflugfelder","year":"2018","journal-title":"Int J Mol Sci"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1167\/iovs.03-0812","article-title":"Chemokines in autoimmune lacrimal gland disease in MRL\/MpJ mice","volume":"45","author":"Akpek","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39859","article-title":"2016 American College of Rheumatology\/European League Against Rheumatism Classification Criteria for Primary Sjogren's Syndrome: a consensus and data-driven methodology involving three international patient cohorts","volume":"69","author":"Shiboski","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1002\/art.23214","article-title":"Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjogren's syndrome: findings in humans and mice","volume":"58","author":"Nguyen","year":"2008","journal-title":"Arthritis Rheum"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/eye.2014.38","article-title":"Analysis of Th17-associated cytokines in tears of patients with dry eye syndrome","volume":"28","author":"Tan","year":"2014","journal-title":"Eye (Lond)"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1080\/09273948.2023.2182327","article-title":"Mapping resident immune cells in the murine ocular surface and lacrimal gland by flow cytometry","volume":"31","author":"Ma","year":"2023","journal-title":"Ocul Immunol Inflamm"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1167\/iovs.63.12.13","article-title":"Conjunctiva resident gammadelta T cells expressed high level of IL-17A and promoted the severity of dry eye","volume":"63","author":"Li","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:59Z","timestamp":1791927119000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.3.2","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,3]]}}}