{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:01Z","timestamp":1791928861822,"version":"4.3.4"},"reference-count":70,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,3,12]]},"DOI":"10.1167\/iovs.66.3.28","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T11:31:07Z","timestamp":1741779067000},"page":"28","source":"Crossref","is-referenced-by-count":11,"title":["Corneal Keratocytes, Fibroblasts, and Myofibroblasts Exhibit Distinct Transcriptional Profiles In Vitro"],"prefix":"10.1167","volume":"66","author":[{"given":"Kara","family":"Poole","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, UT Southwestern Medical Center, Dallas, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krithika S.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Texas at Dallas, Richardson, Texas, United States"},{"name":"Department of Biomedical Engineering, UT Southwestern Medical Center, Dallas, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Schmidtke","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Texas at Dallas, Richardson, Texas, United States"},{"name":"Department of Biomedical Engineering, UT Southwestern Medical Center, Dallas, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Matthew","family":"Petroll","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, UT Southwestern Medical Center, Dallas, Texas, United States"},{"name":"Department of Biomedical Engineering, UT Southwestern Medical Center, Dallas, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor D.","family":"Varner","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Texas at Dallas, Richardson, Texas, United States"},{"name":"Department of Biomedical Engineering, UT Southwestern Medical Center, Dallas, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"4","key":"bib1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S1350-9462(98)00033-0","article-title":"Keratocyte and fibroblast phenotypes in the repairing cornea","volume":"18","author":"Fini","year":"1999","journal-title":"Prog Retin Eye Res"},{"issue":"2","key":"bib2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s12551-009-0011-x","article-title":"Corneal collagen-its role in maintaining corneal shape and transparency","volume":"1","author":"Meek","year":"2009","journal-title":"Biophys Rev"},{"issue":"1","key":"bib3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S1350-9462(99)00007-5","article-title":"Growth factors: importance in wound healing and maintenance of transparency of the cornea","volume":"19","author":"Imanishi","year":"2000","journal-title":"Prog Retin Eye Res"},{"issue":"5","key":"bib4","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S1350-9462(01)00008-8","article-title":"The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells","volume":"20","author":"Wilson","year":"2001","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1006\/exer.2000.0926","article-title":"Kinetics of keratocyte proliferation in response to epithelial debridement","volume":"72","author":"Zieske","year":"2001","journal-title":"Exp Eye Res"},{"issue":"12","key":"bib6","doi-asserted-by":"publisher","first-page":"7352","DOI":"10.1167\/iovs.15-17978","article-title":"Corneal fibroblast migration patterns during intrastromal wound healing correlate with ECM structure and alignment","volume":"56","author":"Petroll","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"Suppl 1","key":"bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1463-5224.2009.00742.x","article-title":"Meet the corneal myofibroblast: the role of myofibroblast transformation in corneal wound healing and pathology","volume":"12","author":"Myrna","year":"2009","journal-title":"Vet Ophthalmol"},{"issue":"5","key":"bib8","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1097\/00003226-199609000-00011","article-title":"Induction of a-smooth muscle actin expression and myofibroblast transformation in cultured corneal keratocytes","volume":"15","author":"Jester","year":"1996","journal-title":"Cornea"},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"11350","DOI":"10.1038\/s41598-023-37776-9","article-title":"Growth factors and mechano-regulated reciprocal crosstalk with extracellular matrix tune the keratocyte\u2013fibroblast\/myofibroblast transition","volume":"13","author":"Pot","year":"2023","journal-title":"Sci Rep"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.exer.2012.03.018","article-title":"Corneal myofibroblast biology and pathobiology: generation, persistence, and transparency","volume":"99","author":"Wilson","year":"2012","journal-title":"Exp Eye Res"},{"issue":"3","key":"bib11","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S1350-9462(98)00021-4","article-title":"Corneal stromal wound healing in refractive surgery: the role of myofibroblasts","volume":"18","author":"Jester","year":"1999","journal-title":"Prog Retin Eye Res"},{"issue":"2","key":"bib12","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.exer.2009.11.016","article-title":"Characterization of corneal keratocyte morphology and mechanical activity within 3-D collagen matrices","volume":"90","author":"Lakshman","year":"2010","journal-title":"Exp Eye Res"},{"issue":"5","key":"bib13","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S0014-4835(03)00188-X","article-title":"Modulation of cultured corneal keratocyte phenotype by growth factors\/cytokines control in vitro contractility and extracellular matrix contraction","volume":"77","author":"Jester","year":"2003","journal-title":"Exp Eye Res"},{"issue":"2","key":"bib14","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1167\/iovs.09-4200","article-title":"Growth factor regulation of corneal keratocyte differentiation and migration in compressed collagen matrices","volume":"51","author":"Kim","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.exer.2014.09.003","article-title":"Mechanical interactions and crosstalk between corneal keratocytes and the extracellular matrix","volume":"133","author":"Petroll","year":"2015","journal-title":"Exp Eye Res"},{"issue":"3","key":"bib16","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1167\/iovs.15-16388","article-title":"The role of thrombin and cell contractility in regulating clustering and collective migration of corneal fibroblasts in different ECM environments","volume":"56","author":"Miron-Mendoza","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib17","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1167\/iovs.11-8609","article-title":"Growth factor regulation of corneal keratocyte mechanical phenotypes in 3-D collagen matrices","volume":"53","author":"Lakshman","year":"2012","journal-title":"Invest Opthalmol Vis Sci"},{"issue":"9","key":"bib18","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/j.bpj.2020.08.040","article-title":"ECM stiffness controls the activation and contractility of corneal keratocytes in response to TGF-\u00df1","volume":"119","author":"Maruri","year":"2020","journal-title":"Biophys J"},{"issue":"3","key":"bib19","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/nbt0308-303","article-title":"What is principal component analysis?","volume":"26","author":"Ringn\u00e9r","year":"2008","journal-title":"Nat Biotechnol"},{"issue":"2","key":"bib20","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.semcdb.2007.09.015","article-title":"Corneal crystallins and the development of cellular transparency","volume":"19","author":"Jester","year":"2008","journal-title":"Semin Cell Dev Biol"},{"issue":"3","key":"bib21","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3&lt;311::AID-JCP1&gt;3.0.CO;2-9","article-title":"The Ki-67 protein: from the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"J Cell Physiol"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3390\/cells11010178","article-title":"Isolation and propagation of human corneal stromal keratocytes for tissue engineering and cell therapy","volume":"11","author":"Binte","year":"2022","journal-title":"Cells"},{"issue":"3","key":"bib23","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1034\/j.1600-0420.1998.760311.x","article-title":"Expression of proliferating cell nuclear antigen in corneas kept in long term culture","volume":"76","author":"Gan","year":"1998","journal-title":"Acta Ophthalmol Scand"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3390\/biom13010087","article-title":"The yin and yang of mesenchymal cells in the corneal stromal fibrosis response to injury: the cornea as a model of fibrosis in other organs","volume":"13","author":"Wilson","year":"2022","journal-title":"Biomolecules"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jtos.2023.05.005","article-title":"Tenascins and osteopontin in biological response in cornea","volume":"29","author":"Sumioka","year":"2023","journal-title":"Ocul Surf"},{"issue":"5","key":"bib26","first-page":"809","article-title":"Expression of a-smooth muscle (a-SM) actin during corneal stromal wound healing","volume":"36","author":"Jester","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"47","key":"bib27","doi-asserted-by":"publisher","first-page":"44173","DOI":"10.1074\/jbc.M107596200","article-title":"Proteoglycan expression during transforming growth factor beta -induced keratocyte-myofibroblast transdifferentiation","volume":"276","author":"Funderburgh","year":"2001","journal-title":"J Biol Chem"},{"issue":"2","key":"bib28","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00441-015-2233-5","article-title":"Collagens and proteoglycans of the cornea: importance in transparency and visual disorders","volume":"363","author":"Massoudi","year":"2016","journal-title":"Cell and Tissue Research"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1146\/annurev.biochem.67.1.721","article-title":"The DNA replication fork in eukaryotic cells","volume":"67","author":"Waga","year":"1998","journal-title":"Annu Rev Biochem"},{"issue":"1 Suppl","key":"bib30","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1177\/1758834011422556","article-title":"An overview of the c-MET signaling pathway","volume":"3","author":"Organ","year":"2011","journal-title":"Ther Adv Med Oncol"},{"issue":"6","key":"bib31","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.3390\/ijms22062935","article-title":"Cyclin-dependent kinases (CDK) and their role in diseases development-review","volume":"22","author":"Lukasik","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"bib32","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ceb.2005.02.009","article-title":"Linking Rap to cell adhesion","volume":"17","author":"Bos","year":"2005","journal-title":"Curr Opin Cell Biol"},{"issue":"24 Pt B","key":"bib33","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1016\/j.jmb.2016.10.016","article-title":"Differences in the phosphorylation-dependent regulation of prenylation of Rap1A and Rap1B","volume":"428","author":"Wilson","year":"2016","journal-title":"J Mol Biol"},{"issue":"3","key":"bib34","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1186\/bcr3433","article-title":"Profilin-1 versus profilin-2: two faces of the same coin?","volume":"15","author":"Ding","year":"2013","journal-title":"Breast Cancer Res"},{"issue":"1-2","key":"bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.124.1.1","article-title":"Bcl-2 and the regulation of programmed cell death","volume":"124","author":"Reed","year":"1994","journal-title":"J Cell Biol"},{"issue":"4","key":"bib36","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/sj.leu.2402090","article-title":"Phosphorylation of Bcl2 and regulation of apoptosis","volume":"15","author":"Ruvolo","year":"2001","journal-title":"Leukemia"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"108272","DOI":"10.1016\/j.exer.2020.108272","article-title":"Corneal myofibroblasts and fibrosis","volume":"201","author":"Wilson","year":"2020","journal-title":"Exp Eye Res"},{"issue":"3","key":"bib38","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s002239900103","article-title":"Bone chondroadherin promotes attachment of osteoblastic cells to solid-state substrates and shows affinity to collagen","volume":"59","author":"Mizuno","year":"1996","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"bib39","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1083\/jcb.138.5.1159","article-title":"Integrin alpha2beta1 is a receptor for the cartilage matrix protein chondroadherin","volume":"138","author":"Camper","year":"1997","journal-title":"J Cell Biol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"103923","DOI":"10.1155\/2014\/103923","article-title":"Hyaluronan and RHAMM in wound repair and the \u201ccancerization\u201d of stromal tissues","volume":"2014","author":"Tolg","year":"2014","journal-title":"Biomed Res Int"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"108229","DOI":"10.1016\/j.exer.2020.108229","article-title":"Corneal fibroblasts: function and markers","volume":"200","author":"Fukuda","year":"2020","journal-title":"Exp Eye Res"},{"issue":"2","key":"bib42","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S0002-9440(10)64555-5","article-title":"Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair","volume":"157","author":"Soo","year":"2000","journal-title":"Am J Pathol"},{"issue":"14","key":"bib43","doi-asserted-by":"publisher","first-page":"4059","DOI":"10.1158\/0008-5472.CAN-18-0327","article-title":"LRRC15 is a novel mesenchymal protein and stromal target for antibody-drug conjugates","volume":"78","author":"Purcell","year":"2018","journal-title":"Cancer Res"},{"issue":"7934","key":"bib44","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41586-022-05272-1","article-title":"LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity","volume":"611","author":"Krishnamurty","year":"2022","journal-title":"Nature"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"17","DOI":"10.12703\/P5-17","article-title":"Signal integration in TGF-\u00df, WNT, and Hippo pathways","volume":"5","author":"Attisano","year":"2013","journal-title":"F1000Prime Rep"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3389\/fmolb.2019.00157","article-title":"Hippo signaling-mediated mechanotransduction in cell movement and cancer metastasis","volume":"6","author":"Chang","year":"2019","journal-title":"Front Mol Biosci"},{"issue":"1","key":"bib47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0925-4439(93)90146-R","article-title":"The functions of thrombospondin and its involvement in physiology and pathophysiology","volume":"1182","author":"Lahav","year":"1993","journal-title":"Biochim Biophys Acta"},{"issue":"10","key":"bib49","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.1167\/iovs.04-0343","article-title":"Microarray studies reveal macrophage-like function of stromal keratocytes in the cornea","volume":"45","author":"Chakravarti","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.jtos.2020.10.006","article-title":"Corneal stromal wound healing: major regulators and therapeutic targets","volume":"19","author":"Kamil","year":"2021","journal-title":"Ocul Surf"},{"issue":"3","key":"bib51","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1080\/02713683.2019.1663874","article-title":"Corneal stromal regeneration: current status and future therapeutic potential","volume":"45","author":"Lagali","year":"2020","journal-title":"Curr Eye Res"},{"issue":"1","key":"bib52","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41584-019-0324-5","article-title":"Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases","volume":"16","author":"Hinz","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"985363","DOI":"10.3389\/fonc.2022.985363","article-title":"The role of BCL-2 family proteins in regulating apoptosis and cancer therapy","volume":"12","author":"Qian","year":"2022","journal-title":"Front Oncol"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3389\/fcell.2020.00773","article-title":"Senescence in wound repair: emerging strategies to target chronic healing wounds","volume":"8","author":"Wilkinson","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"714320","DOI":"10.3389\/fcell.2021.714320","article-title":"Cell cycle dysregulation and renal fibrosis","volume":"9","author":"Wu","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"46","key":"bib56","doi-asserted-by":"publisher","first-page":"45629","DOI":"10.1074\/jbc.M303292200","article-title":"Keratocyte phenotype mediates proteoglycan structure: a role for fibroblasts in corneal fibrosis","volume":"278","author":"Funderburgh","year":"2003","journal-title":"J Biol Chem"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.clinbiochem.2018.07.003","article-title":"The multiple functions and mechanisms of osteopontin","volume":"59","author":"Icer","year":"2018","journal-title":"Clin Biochem"},{"issue":"11","key":"bib58","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.3390\/cancers12113379","article-title":"Osteopontin: a key regulator of tumor progression and immunomodulation","volume":"12","author":"Moorman","year":"2020","journal-title":"Cancers"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.exer.2014.12.015","article-title":"Modulation of Smad signaling by non-TGF\u00df components in myofibroblast generation during wound healing in corneal stroma","volume":"142","author":"Saika","year":"2016","journal-title":"Exp Eye Res"},{"issue":"3","key":"bib60","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1161\/CIRCRESAHA.107.160408","article-title":"Osteopontin expression is required for myofibroblast differentiation","volume":"102","author":"Lenga","year":"2008","journal-title":"Circ Res"},{"issue":"12","key":"bib61","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.3390\/cells8121558","article-title":"Osteopontin: a promising therapeutic target in cardiac fibrosis","volume":"8","author":"Abdelaziz Mohamed","year":"2019","journal-title":"Cells"},{"issue":"4","key":"bib62","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1167\/iovs.07-1007","article-title":"Corneal wound healing in an osteopontin-deficient mouse","volume":"49","author":"Miyazaki","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"886759","DOI":"10.3389\/fcell.2022.886759","article-title":"Signaling downstream of focal adhesions regulates stiffness-dependent differences in the TGF-\u00df1-mediated myofibroblast differentiation of corneal keratocytes","volume":"10","author":"Maruri","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"108228","DOI":"10.1016\/j.exer.2020.108228","article-title":"Keratocyte mechanobiology","volume":"200","author":"Petroll","year":"2020","journal-title":"Exp Eye Res"},{"issue":"11","key":"bib65","doi-asserted-by":"publisher","first-page":"5030","DOI":"10.1167\/iovs.07-0443","article-title":"Regulation of corneal fibroblast morphology and collagen reorganization by extracellular matrix mechanical properties","volume":"48","author":"Karamichos","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib66","doi-asserted-by":"publisher","first-page":"5901","DOI":"10.1167\/iovs.12-11575","article-title":"Substratum compliance modulates corneal fibroblast to myofibroblast transformation","volume":"54","author":"Dreier","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib67","doi-asserted-by":"publisher","first-page":"7018","DOI":"10.1074\/jbc.C110.212621","article-title":"Hippo pathway-independent restriction of TAZ and YAP by angiomotin","volume":"286","author":"Chan","year":"2011","journal-title":"J Biol Chem"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.exer.2018.12.009","article-title":"YAP and TAZ are distinct effectors of corneal myofibroblast transformation","volume":"180","author":"Muppala","year":"2019","journal-title":"Exp Eye Res"},{"issue":"10","key":"bib69","doi-asserted-by":"publisher","first-page":"e109811","DOI":"10.1371\/journal.pone.0109811","article-title":"Involvement of YAP, TAZ and HSP90 in contact guidance and intercellular junction formation in corneal epithelial cells","volume":"9","author":"Raghunathan","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"bib70","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1006\/exer.2002.2066","article-title":"TGF\u00df induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGF\u00df, PDGF and integrin signaling","volume":"75","author":"Jester","year":"2002","journal-title":"Exp Eye Res"},{"key":"bib48","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/B978-0-12-398358-9.00015-X","article-title":"Chapter 15 - Regulation of cell behavior by extracellular proteins","volume-title":"Principles of Tissue Engineering","author":"Bradshaw","year":"2014","edition":"Fourth Edition"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:01Z","timestamp":1791927121000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,12]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.3.28","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,12]]}}}