{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:57Z","timestamp":1791928917913,"version":"4.3.4"},"reference-count":35,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,3,18]]},"DOI":"10.1167\/iovs.66.3.33","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T11:31:14Z","timestamp":1742297474000},"page":"33","source":"Crossref","is-referenced-by-count":5,"title":["Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation"],"prefix":"10.1167","volume":"66","author":[{"given":"Yue","family":"Li","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China"},{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China"},{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaojing","family":"Jing","sequence":"additional","affiliation":[{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"},{"name":"Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Li","sequence":"additional","affiliation":[{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ma","sequence":"additional","affiliation":[{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Kang","sequence":"additional","affiliation":[{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Rong","sequence":"additional","affiliation":[{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"},{"name":"Stem Cell and Regenerative Medicine Lab, Beijing Institute of Radiation Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlu","family":"Liu","sequence":"additional","affiliation":[{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Yao","sequence":"additional","affiliation":[{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinji","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China"},{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"615993","DOI":"10.3389\/fendo.2020.615993","article-title":"Epidemiology, natural history, risk factors, and prevention of graves' orbitopathy","volume":"11","author":"Bartalena","year":"2020","journal-title":"Front Endocrinol"},{"issue":"4","key":"bib2","doi-asserted-by":"publisher","first-page":"G43","DOI":"10.1530\/EJE-21-0479","article-title":"The 2021 european group on graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of graves' orbitopathy","volume":"185","author":"Bartalena","year":"2021","journal-title":"Eur J Endocrinol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"619989","DOI":"10.3389\/fendo.2020.619989","article-title":"Integrative analysis of proteomics and DNA methylation in orbital fibroblasts from graves' ophthalmopathy","volume":"11","author":"Virakul","year":"2020","journal-title":"Front Endocrinol"},{"issue":"6","key":"bib4","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1111\/j.1365-2265.2004.02044.x","article-title":"Comparison of practical methods for urinary glycosaminoglycans and serum hyaluronan with clinical activity scores in patients with graves' ophthalmopathy","volume":"60","author":"Martins","year":"2004","journal-title":"Clin Endocrinol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"412158","DOI":"10.1155\/2014\/412158","article-title":"Markers of inflammation and fibrosis in the orbital fat\/connective tissue of patients with graves' orbitopathy: clinical implications","volume":"2014","author":"Pawlowski","year":"2014","journal-title":"Mediators Inflamm"},{"key":"bib6","doi-asserted-by":"crossref","first-page":"2528046","DOI":"10.1155\/2022\/2528046","article-title":"Cytokines in thyroid-associated ophthalmopathy","volume":"2022","author":"Zhang","year":"2022","journal-title":"J Immunol Res"},{"issue":"4","key":"bib7","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1136\/bjo.2006.094607","article-title":"Clinical features of dysthyroid optic neuropathy: a european group on graves\u2019 orbitopathy (EUGOGO) survey","volume":"91","author":"McKeag","year":"2007","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"bib8","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1001\/jamaophthalmol.2018.0806","article-title":"Association of T and B cells infiltrating orbital tissues with clinical features of graves orbitopathy","volume":"136","author":"Rotondo Dottore","year":"2018","journal-title":"JAMA Ophthalmol"},{"issue":"9","key":"bib9","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1016\/j.ophtha.2016.05.052","article-title":"Orbital angiogenesis and lymphangiogenesis in thyroid eye disease: an analysis of vascular growth factors with clinical correlation","volume":"123","author":"Wong","year":"2016","journal-title":"Ophthalmology"},{"issue":"2","key":"bib10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s40618-019-01116-4","article-title":"Immunohistochemical analysis of human orbital tissue in graves\u2019 orbitopathy","volume":"43","author":"Hai","year":"2020","journal-title":"J Endocrinol Invest"},{"issue":"6","key":"bib11","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/S0002-9394(14)72787-4","article-title":"Diagnostic criteria for graves' ophthalmopathy","volume":"119","author":"Bartley","year":"1995","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"bib12","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S0002-9394(02)01429-0","article-title":"Comparability of proptosis measurements by different techniques","volume":"133","author":"Segni","year":"2002","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"bib13","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1097\/01.IOP.0000143712.42344.8C","article-title":"Comparison of unilateral and simultaneous bilateral measurement of the globe position, using the Hertel exophthalmometer","volume":"20","author":"Ameri","year":"2004","journal-title":"Ophthal Plast Reconstr Surg"},{"issue":"2","key":"bib14","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0889-8529(18)30485-7","article-title":"Choice of therapy and criteria for assessing treatment outcome in thyroid-associated ophthalmopathy","volume":"16","author":"Bahn","year":"1987","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"20","key":"bib15","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1093\/eurheartj\/ehaa033","article-title":"Impact of myocardial fibrosis on left ventricular remodelling, recovery, and outcome after transcatheter aortic valve implantation in different haemodynamic subtypes of severe aortic stenosis","volume":"41","author":"Puls","year":"2020","journal-title":"Eur Heart J"},{"issue":"2","key":"bib16","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jri.2005.03.005","article-title":"Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: determinations of a panel of nine cytokines in clinical sample culture supernatants","volume":"66","author":"dupont","year":"2005","journal-title":"J Reprod Immunol"},{"issue":"10","key":"bib17","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1177\/2472555220954389","article-title":"Comparative analysis of multiple immunoassays for cytokine profiling in drug discovery","volume":"25","author":"Platchek","year":"2020","journal-title":"SLAS Discov"},{"issue":"12","key":"bib18","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1089\/thy.2022.0173","article-title":"A Multicenter, Single-Blind, Case-Control, Immunohistochemical Study of Orbital Tissue in Thyroid Eye Disease","volume":"32","author":"Hai","year":"2022","journal-title":"Thyroid"},{"issue":"6","key":"bib19","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1136\/bjo.2003.035915","article-title":"Thyroid associated ophthalmopathy: evidence for CD4(+) gammadelta T cells; de novo differentiation of RFD7(+) macrophages, but not of RFD1(+) dendritic cells; and loss of gammadelta and alphabeta T cell receptor expression","volume":"88","author":"Eckstein","year":"2004","journal-title":"Br J Ophthalmol"},{"issue":"23","key":"bib20","doi-asserted-by":"publisher","first-page":"9145","DOI":"10.3390\/ijms21239145","article-title":"Distinctive features of orbital adipose tissue (OAT) in graves\u2019 orbitopathy","volume":"21","author":"Zhang","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"4","key":"bib21","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1097\/IOP.0b013e31820365d5","article-title":"Densities of orbital fat and extraocular muscles in graves orbitopathy patients and controls","volume":"27","author":"Regensburg","year":"2011","journal-title":"Ophthalmic Plast Reconstr Surg"},{"issue":"2","key":"bib22","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/j.1365-2265.2008.03219.x","article-title":"Role of macrophage infiltration in the orbital fat of patients with graves\u2019 ophthalmopathy","volume":"69","author":"Chen","year":"2008","journal-title":"Clin Endocrinol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1089\/thy.2007.0407","article-title":"Immune mechanisms in thyroid eye disease","volume":"18","author":"Lehmann","year":"2008","journal-title":"Thyroid"},{"key":"bib24","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1055\/s-0035-1555762","article-title":"Current insights into the pathogenesis of Graves'ophthalmopathy","volume":"47","author":"Bahn","year":"2015","journal-title":"Horm Metab Res"},{"issue":"2","key":"bib25","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1530\/eje.0.1500225","article-title":"The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases","volume":"150","author":"Aust","year":"2004","journal-title":"Eur J Endocrinol"},{"issue":"7","key":"bib26","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/nm.3895","article-title":"IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases","volume":"21","author":"Teng","year":"2015","journal-title":"Nat Med"},{"issue":"9","key":"bib27","doi-asserted-by":"publisher","first-page":"e19250","DOI":"10.1016\/j.heliyon.2023.e19250","article-title":"Roles of four targets in the pathogenesis of graves' orbitopathy","volume":"9","author":"Ren","year":"2023","journal-title":"Heliyon"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"107300","DOI":"10.1016\/j.intimp.2020.107300","article-title":"Elevated IL-38 inhibits IL-23R expression and IL-17A production in thyroid-associated ophthalmopathy","volume":"91","author":"Pan","year":"2021","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"bib29","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1046\/j.1365-2265.2003.01708.x","article-title":"TSH-R expression and cytokine profile in orbital tissue of active vs. inactive graves' ophthalmopathy patients","volume":"58","author":"Wakelkamp","year":"2003","journal-title":"Clin Endocrinol"},{"issue":"10","key":"bib30","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1089\/105072501753210984","article-title":"Interleukin-6 stimulates thyrotropin receptor expression in human orbital preadipocyte fibroblasts from patients with graves' ophthalmopathy","volume":"11","author":"Jyonouchi","year":"2001","journal-title":"Thyroid"},{"issue":"8","key":"bib31","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1056\/NEJMra0905750","article-title":"Graves\u2019 ophthalmopathy.","volume":"362","author":"Bahn","year":"2010","journal-title":"N Engl J Med"},{"issue":"3","key":"bib32","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1089\/thy.2022.0254","article-title":"M1-like macrophages modulate fibrosis and inflammation of orbital fibroblasts in graves\u2019 orbitopathy: potential relevance to soluble interleukin-6 receptor","volume":"33","author":"Lu","year":"2023","journal-title":"Thyroid"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.ajo.2018.07.038","article-title":"Efficacy of tocilizumab in patients with moderate-to-severe corticosteroid-resistant graves orbitopathy: a randomized clinical trial","volume":"195","author":"Perez-Moreiras","year":"2018","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"bib34","first-page":"1802","article-title":"Inducible Fgf13 ablation alleviates cardiac fibrosis via regulation of microtubule stability","volume":"56","author":"Wang","year":"2024","journal-title":"Acta Biochim Biophys Sin"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.exer.2015.02.007","article-title":"Current perspectives on the role of orbital fibroblasts in the pathogenesis of graves\u2019 ophthalmopathy","volume":"142","author":"Dik","year":"2016","journal-title":"Exp Eye Res"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:03Z","timestamp":1791927123000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.3.33","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,18]]}}}