{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:16Z","timestamp":1791928876554,"version":"4.3.4"},"reference-count":60,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,4,17]]},"DOI":"10.1167\/iovs.66.4.48","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T11:31:17Z","timestamp":1744889477000},"page":"48","source":"Crossref","is-referenced-by-count":8,"title":["Targeted Neuroprotection of Retinal Ganglion Cells Via AAV2-hSyn-NGF Gene Therapy in Glaucoma Models"],"prefix":"10.1167","volume":"66","author":[{"given":"Xinlei","family":"Zhu","sequence":"first","affiliation":[{"name":"Qingdao Medical College, Qingdao University, Qingdao, China"},{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benxiang","family":"Qi","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmei","family":"Ren","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cong","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Pan","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Xie","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, China"},{"name":"State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"7","key":"bib1","doi-asserted-by":"publisher","first-page":"3161","DOI":"10.1007\/s10571-023-01373-1","article-title":"Regulated cell death of retinal ganglion cells in glaucoma: molecular insights and therapeutic potentials","volume":"43","author":"Zhao","year":"2023","journal-title":"Cell Mol Neurobiol"},{"issue":"10108","key":"bib2","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1016\/S0140-6736(17)31469-1","article-title":"Glaucoma","volume":"390","author":"Jonas","year":"2017","journal-title":"Lancet"},{"issue":"3","key":"bib3","doi-asserted-by":"publisher","first-page":"506","DOI":"10.4103\/1673-5374.293145","article-title":"Dysfunction of axonal transport in normal-tension glaucoma: a biomarker of disease progression and a potential therapeutic target","volume":"16","author":"Hirooka","year":"2021","journal-title":"Neural Regen Res"},{"issue":"13","key":"bib4","first-page":"225","article-title":"The diagnosis and treatment of glaucoma","volume":"117","author":"Schuster","year":"2020","journal-title":"Dtsch Arztebl Int"},{"issue":"2","key":"bib5","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1001\/jama.2020.21899","article-title":"Glaucoma in adults-screening, diagnosis, and management: a review","volume":"325","author":"Stein","year":"2021","journal-title":"JAMA"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"117303","DOI":"10.1016\/j.lfs.2020.117303","article-title":"Bio-tactics for neuroprotection of retinal ganglion cells in the treatment of glaucoma","volume":"243","author":"Yadav","year":"2020","journal-title":"Life Sci"},{"issue":"2","key":"bib7","doi-asserted-by":"publisher","first-page":"380","DOI":"10.4103\/ijo.IJO_1158_21","article-title":"Neuroprotection in glaucoma","volume":"70","author":"Vishwaraj","year":"2022","journal-title":"Indian J Ophthalmol"},{"issue":"2","key":"bib8","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog Retin Eye Res"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"9329310","DOI":"10.1155\/2020\/9329310","article-title":"Innovative IOP-independent neuroprotection and neuroregeneration strategies in the pipeline for glaucoma","volume":"2020","author":"Tsai","year":"2020","journal-title":"J Ophthalmol"},{"issue":"5","key":"bib10","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.ophtha.2011.11.003","article-title":"Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement","volume":"119","author":"Chang","year":"2012","journal-title":"Ophthalmology"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"102687","DOI":"10.1016\/j.redox.2023.102687","article-title":"Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma","volume":"62","author":"Zeng","year":"2023","journal-title":"Redox Biol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"101988","DOI":"10.1016\/j.redox.2021.101988","article-title":"Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction","volume":"43","author":"Tribble","year":"2021","journal-title":"Redox Biol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"101136","DOI":"10.1016\/j.preteyeres.2022.101136","article-title":"Glaucomatous optic neuropathy: mitochondrial dynamics, dysfunction and protection in retinal ganglion cells","volume":"95","author":"Ju","year":"2023","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"bib14","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3390\/biom11040581","article-title":"Use of gene therapy in retinal ganglion cell neuroprotection: current concepts and future directions","volume":"11","author":"Rhee","year":"2021","journal-title":"Biomolecules"},{"issue":"6","key":"bib15","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1080\/13816810.2018.1533027","article-title":"Gene therapy for RPE65-related retinal disease","volume":"39","author":"Miraldi Utz","year":"2018","journal-title":"Ophthalmic Genet"},{"issue":"17","key":"bib16","doi-asserted-by":"publisher","first-page":"6262","DOI":"10.3390\/ijms21176262","article-title":"Neuroprotection of retinal ganglion cells with AAV2-BDNF pretreatment restoring normal TrkB receptor protein levels in glaucoma","volume":"21","author":"W\u00f3jcik-Gryciuk","year":"2020","journal-title":"Int J Mol Sci"},{"key":"bib17","first-page":"409","article-title":"Tyrosine triple mutated AAV2-BDNF gene therapy in an inner retinal injury model induced by intravitreal injection of N-methyl-D-aspartate (NMDA)","volume":"26","author":"Shiozawa","year":"2020","journal-title":"Mol Vis"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"113167","DOI":"10.1016\/j.expneurol.2019.113167","article-title":"Intravitreal application of AAV-BDNF or mutant AAV-CRMP2 protects retinal ganglion cells and stabilizes axons and myelin after partial optic nerve injury","volume":"326","author":"Chiha","year":"2020","journal-title":"Exp Neurol"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/fcp.12494","article-title":"Adeno-associated virus (AAV)-mediated neuroprotective effects on the degenerative retina: the therapeutic potential of erythropoietin","volume":"34","author":"Tao","year":"2020","journal-title":"Fundam Clin Pharmacol"},{"issue":"3","key":"bib20","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1167\/iovs.17-22972","article-title":"SIRT1 and NRF2 gene transfer mediate distinct neuroprotective effects upon retinal ganglion cell survival and function in experimental optic neuritis","volume":"59","author":"McDougald","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10414","key":"bib21","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1016\/S0140-6736(23)01289-8","article-title":"Glaucoma: now and beyond","volume":"402","author":"Jayaram","year":"2023","journal-title":"Lancet"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/ceo.13336","article-title":"Neuroprotection in glaucoma: recent advances and clinical translation","volume":"47","author":"Guymer","year":"2019","journal-title":"Clin Exp Ophthalmol"},{"issue":"1","key":"bib23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ophtha.2019.08.020","article-title":"Topical recombinant human nerve growth factor (Cenegermin) for neurotrophic keratopathy: a multicenter randomized vehicle-controlled pivotal trial","volume":"127","author":"Pflugfelder","year":"2020","journal-title":"Ophthalmology"},{"issue":"Pt 2","key":"bib24","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/brain\/awv366","article-title":"Nerve growth factor improves visual loss in childhood optic gliomas: a randomized, double-blind, phase II clinical trial","volume":"139","author":"Falsini","year":"2016","journal-title":"Brain"},{"issue":"1","key":"bib25","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/cells12010047","article-title":"Neurotrophic factors in health and disease","volume":"12","author":"Severini","year":"2022","journal-title":"Cells"},{"issue":"4","key":"bib26","doi-asserted-by":"publisher","first-page":"3866","DOI":"10.3390\/ijms24043866","article-title":"Neurotrophic factors as regenerative therapy for neurodegenerative diseases: current status, challenges and future perspectives","volume":"24","author":"El Ouaamari","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"bib27","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/s12974-021-02366-x","article-title":"Interplay between M\u00fcller cells and microglia aggravates retinal inflammatory response in experimental glaucoma","volume":"18","author":"Hu","year":"2021","journal-title":"J Neuroinflammation"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"101169","DOI":"10.1016\/j.preteyeres.2023.101169","article-title":"Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma","volume":"93","author":"Miao","year":"2023","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib29","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3390\/ijms18010098","article-title":"Time-dependent nerve growth factor signaling changes in the rat retina during optic nerve crush-induced degeneration of retinal ganglion cells","volume":"18","author":"Mesentier-Louro","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"6","key":"bib30","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41434-022-00380-z","article-title":"Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters","volume":"30","author":"Nieuwenhuis","year":"2023","journal-title":"Gene Ther"},{"issue":"4","key":"bib31","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1002\/sctm.16-0428","article-title":"Bone marrow-derived mesenchymal stem cells-derived exosomes promote survival of retinal ganglion cells through miRNA-dependent mechanisms","volume":"6","author":"Mead","year":"2017","journal-title":"Stem Cells Transl Med"},{"issue":"2","key":"bib32","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.exer.2006.01.025","article-title":"Three experimental glaucoma models in rats: comparison of the effects of intraocular pressure elevation on retinal ganglion cell size and death","volume":"83","author":"Urcola","year":"2006","journal-title":"Exp Eye Res"},{"issue":"17","key":"bib33","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.3390\/cells11172689","article-title":"Retinal ganglion cells: global number, density and vulnerability to glaucomatous injury in common laboratory mice","volume":"11","author":"Claes","year":"2022","journal-title":"Cells"},{"issue":"1","key":"bib34","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12974-022-02418-w","article-title":"Evaluation of neuroprotective and immunomodulatory properties of mesenchymal stem cells in an ex vivo retinal explant model","volume":"19","author":"Reboussin","year":"2022","journal-title":"J Neuroinflammation"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"100799","DOI":"10.1016\/j.preteyeres.2019.100799","article-title":"Inducible rodent models of glaucoma","volume":"75","author":"Pang","year":"2020","journal-title":"Prog Retin Eye Res"},{"issue":"127","key":"bib36","first-page":"55865","article-title":"Optical coherence tomography: imaging mouse retinal ganglion cells in vivo","author":"Jagodzinska","year":"2017","journal-title":"J Vis Exp"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"108728","DOI":"10.1016\/j.exer.2021.108728","article-title":"Overexpression of BMP4 protects retinal ganglion cells in a mouse model of experimental glaucoma","volume":"210","author":"Liu","year":"2021","journal-title":"Exp Eye Res"},{"issue":"13","key":"bib38","doi-asserted-by":"publisher","first-page":"5473","DOI":"10.1167\/iovs.18-25310","article-title":"Mesenchymal stem cell-derived small extracellular vesicles promote neuroprotection in a genetic DBA\/2J mouse model of glaucoma","volume":"59","author":"Mead","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib39","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1167\/iovs.61.12.19","article-title":"Neuroretinal-derived caveolin-1 promotes endotoxin-induced inflammation in the murine retina","volume":"61","author":"Gurley","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"20","key":"bib40","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.3390\/cells11203246","article-title":"NGF prevents loss of TrkA\/VEGFR2 cells, and VEGF isoform dysregulation in the retina of adult diabetic rats","volume":"11","author":"Fico","year":"2022","journal-title":"Cells"},{"issue":"3","key":"bib41","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/S0306-4522(96)00616-1","article-title":"Ligand-induced down-regulation of Trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons","volume":"78","author":"Knusel","year":"1997","journal-title":"Neuroscience"},{"issue":"10","key":"bib42","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/s41419-018-1041-8","article-title":"Neuroprotection of retinal ganglion cells by a novel gene therapy construct that achieves sustained enhancement of brain-derived neurotrophic factor\/tropomyosin-related kinase receptor-B signaling","volume":"9","author":"Osborne","year":"2018","journal-title":"Cell Death Dis"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"659783","DOI":"10.3389\/fcell.2021.659783","article-title":"Exosome-mediated delivery of the neuroprotective peptide PACAP38 promotes retinal ganglion cell survival and axon regeneration in rats with traumatic optic neuropathy","volume":"9","author":"Wang","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"12","key":"bib44","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1001\/jamaophthalmol.2022.4462","article-title":"Association of intraocular pressure with retinal nerve fiber layer thinning in patients with glaucoma","volume":"140","author":"Nishida","year":"2022","journal-title":"JAMA Ophthalmol"},{"issue":"9","key":"bib45","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.immuni.2022.07.014","article-title":"Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma","volume":"55","author":"Margeta","year":"2022","journal-title":"Immunity"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"102541","DOI":"10.1016\/j.redox.2022.102541","article-title":"Inhibition of ferroptosis promotes retina ganglion cell survival in experimental optic neuropathies","volume":"58","author":"Guo","year":"2022","journal-title":"Redox Biol"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.exer.2015.06.019","article-title":"Using genetic mouse models to gain insight into glaucoma: past results and future possibilities","volume":"141","author":"Fernandes","year":"2015","journal-title":"Exp Eye Res"},{"issue":"6326","key":"bib48","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1126\/science.aal0092","article-title":"Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice","volume":"355","author":"Williams","year":"2017","journal-title":"Science"},{"issue":"1","key":"bib49","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13024-022-00524-0","article-title":"Solving neurodegeneration: common mechanisms and strategies for new treatments","volume":"17","author":"Wareham","year":"2022","journal-title":"Mol Neurodegener"},{"issue":"6","key":"bib50","doi-asserted-by":"publisher","first-page":"102535","DOI":"10.1016\/j.autrev.2020.102535","article-title":"Glaucoma is an autoimmune disease","volume":"19","author":"Geyer","year":"2020","journal-title":"Autoimmun Rev"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"108196","DOI":"10.1016\/j.visres.2023.108196","article-title":"Adeno-associated virus mediated gene therapy for neuroprotection of retinal ganglion cells in glaucoma","volume":"206","author":"Starr","year":"2023","journal-title":"Vision Res"},{"issue":"15","key":"bib52","doi-asserted-by":"publisher","first-page":"7994","DOI":"10.3390\/ijms22157994","article-title":"Risk factors for retinal ganglion cell distress in glaucoma and neuroprotective potential intervention","volume":"22","author":"Vernazza","year":"2021","journal-title":"Int J Mol Sci"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"108506","DOI":"10.1016\/j.exer.2021.108506","article-title":"Protection of retinal ganglion cells in glaucoma: current status and future","volume":"205","author":"Shen","year":"2021","journal-title":"Exp Eye Res"},{"issue":"3","key":"bib54","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1159\/000514441","article-title":"Neuroprotective factors of the retina and their role in promoting survival of retinal ganglion cells: a review","volume":"64","author":"Fudalej","year":"2021","journal-title":"Ophthalmic Res"},{"issue":"2","key":"bib55","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1097\/IJG.0b013e3181d787e5","article-title":"Ocular application of nerve growth factor protects degenerating retinal ganglion cells in a rat model of glaucoma","volume":"20","author":"Colafrancesco","year":"2011","journal-title":"J Glaucoma"},{"issue":"32","key":"bib56","doi-asserted-by":"publisher","first-page":"13469","DOI":"10.1073\/pnas.0906678106","article-title":"Experimental and clinical evidence of neuroprotection by nerve growth factor eye drops: implications for glaucoma","volume":"106","author":"Lambiase","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"issue":"1","key":"bib57","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1038\/s41598-020-60427-2","article-title":"Topical recombinant human nerve growth factor (rh-NGF) is neuroprotective to retinal ganglion cells by targeting secondary degeneration","volume":"10","author":"Guo","year":"2020","journal-title":"Sci Rep"},{"issue":"2","key":"bib58","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1007\/s12035-018-1154-1","article-title":"Nerve growth factor role on retinal ganglion cell survival and axon regrowth: effects of ocular administration in experimental model of optic nerve injury","volume":"56","author":"Mesentier-Louro","year":"2019","journal-title":"Mol Neurobiol"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ajo.2021.11.002","article-title":"Phase 1b randomized controlled study of short course topical recombinant human nerve growth factor (rhNGF) for neuroenhancement in glaucoma: safety, tolerability, and efficacy measure outcomes","volume":"234","author":"Beykin","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"22","DOI":"10.2337\/db24-0393","article-title":"Long-term nerve regeneration in diabetic keratopathy mediated by a novel NGF delivery system","volume":"74","author":"Cong","year":"2025","journal-title":"Diabetes"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:06Z","timestamp":1791927126000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.4.48","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,17]]}}}