{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:27Z","timestamp":1791928887488,"version":"4.3.4"},"reference-count":54,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,4,22]]},"DOI":"10.1167\/iovs.66.4.65","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T11:30:31Z","timestamp":1745321431000},"page":"65","source":"Crossref","is-referenced-by-count":4,"title":["Quantifications of Outer Retinal Bands in Geographic Atrophy by Comparing Superior Axial Resolution and Conventional OCT"],"prefix":"10.1167","volume":"66","author":[{"given":"Sophie","family":"Frank-Publig","sequence":"first","affiliation":[{"name":"Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrvoje","family":"Bogunovic","sequence":"additional","affiliation":[{"name":"Christian Doppler Laboratory for Artificial Intelligence in Retina, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria"},{"name":"Institute of Artificial Intelligence, Center for Medical Data Science, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaudia","family":"Birner","sequence":"additional","affiliation":[{"name":"Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Gumpinger","sequence":"additional","affiliation":[{"name":"Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard M.","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Mares","sequence":"additional","affiliation":[{"name":"Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Michel","sequence":"additional","affiliation":[{"name":"Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona Sophia","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Schmidt-Erfurth","sequence":"additional","affiliation":[{"name":"Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor S.","family":"Reiter","sequence":"additional","affiliation":[{"name":"Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"2","key":"bib1","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob Health"},{"issue":"11","key":"bib2","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.oret.2022.05.030","article-title":"The effect of pegcetacoplan treatment on photoreceptor maintenance in geographic atrophy monitored by artificial intelligence-based OCT analysis","volume":"6","author":"Riedl","year":"2022","journal-title":"Ophthalmol Retina"},{"issue":"5035","key":"bib3","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1126\/science.1957169","article-title":"Optical coherence tomography","volume":"254","author":"Huang","year":"1991","journal-title":"Science"},{"issue":"3","key":"bib4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1097\/IAE.0000000000001946","article-title":"Optical coherence tomography and histology of age-related macular degeneration support mitochondria as reflectivity sources","volume":"38","author":"Litts","year":"2018","journal-title":"Retina"},{"issue":"8","key":"bib5","doi-asserted-by":"publisher","first-page":"4166","DOI":"10.1167\/iovs.14-15256","article-title":"RefMoB, a reflectivity feature model-based automated method for measuring four outer retinal hyperreflective bands in optical coherence tomography","volume":"56","author":"Ross","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib6","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1016\/j.ophtha.2014.02.023","article-title":"Proposed lexicon for anatomic landmarks in normal posterior segment spectral-domain optical coherence tomography: the IN\u2022OCT consensus","volume":"121","author":"Staurenghi","year":"2014","journal-title":"Ophthalmology"},{"issue":"4","key":"bib7","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1167\/iovs.07-0838","article-title":"Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography","volume":"49","author":"Srinivasan","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"24","key":"bib8","doi-asserted-by":"publisher","first-page":"36723","DOI":"10.1364\/OE.409076","article-title":"Three-dimensional assessment of para- and perifoveal photoreceptor densities and the impact of meridians and age in healthy eyes with adaptive-optics optical coherence tomography (AO-OCT)","volume":"28","author":"Reumueller","year":"2020","journal-title":"Opt Express"},{"issue":"4","key":"bib9","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1167\/iovs.18-25702","article-title":"Three-dimensional adaptive optics-assisted visualization of photoreceptors in healthy and pathologically aged eyes","volume":"60","author":"Reumueller","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib10","doi-asserted-by":"publisher","first-page":"5287","DOI":"10.1167\/iovs.12-9767","article-title":"Effect of angle of incidence on macular thickness and volume measurements obtained by spectral-domain optical coherence tomography","volume":"53","author":"Hariri","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib11","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.1167\/iovs.10-6377","article-title":"Human chorioretinal layer thicknesses measured in macula-wide, high-resolution histologic sections","volume":"52","author":"Curcio","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib12","doi-asserted-by":"publisher","first-page":"4137","DOI":"10.1167\/iovs.08-1967","article-title":"High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration","volume":"49","author":"Fleckenstein","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib13","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.survophthal.2012.01.006","article-title":"Evaluation of age-related macular degeneration with optical coherence tomography","volume":"57","author":"Keane","year":"2012","journal-title":"Surv Ophthalmol"},{"issue":"1","key":"bib14","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ajo.2009.08.037","article-title":"Spectral-domain optical coherence tomography: a comparison of modern high-resolution retinal imaging systems","volume":"149","author":"Kiernan","year":"2010","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"bib15","doi-asserted-by":"publisher","first-page":"438","DOI":"10.3390\/bioengineering10040438","article-title":"Reliability of retinal layer annotation with a novel, high-resolution optical coherence tomography device: a comparative study","volume":"10","author":"von der Emde","year":"2023","journal-title":"Bioengineering (Basel)"},{"issue":"4","key":"bib16","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.oret.2023.10.011","article-title":"Atrophic lesions associated with age-related macular degeneration: high-resolution versus standard OCT","volume":"8","author":"Mahmoudi","year":"2024","journal-title":"Ophthalmol Retina"},{"issue":"4","key":"bib17","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.ophtha.2017.09.028","article-title":"Consensus definition for atrophy associated with age-related macular degeneration on OCT: Classification of Atrophy Report 3","volume":"125","author":"Sadda","year":"2018","journal-title":"Ophthalmology"},{"issue":"1","key":"bib18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/eye.2016.260","article-title":"Impact of optical coherence tomography scanning density on quantitative analyses in neovascular age-related macular degeneration","volume":"31","author":"Velaga","year":"2017","journal-title":"Eye (Lond)."},{"issue":"10","key":"bib19","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1109\/TMI.2008.923966","article-title":"Intraretinal layer segmentation of macular optical coherence tomography images using optimal 3-D graph search","volume":"27","author":"Garvin","year":"2008","journal-title":"IEEE Trans Med Imaging"},{"issue":"8","key":"bib20","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1097\/IAE.0b013e3182247535","article-title":"Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model","volume":"31","author":"Spaide","year":"2011","journal-title":"Retina"},{"issue":"5","key":"bib21","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1167\/iovs.15-16431","article-title":"The Project MACULA retinal pigment epithelium grading system for histology and optical coherence tomography in age-related macular degeneration","volume":"56","author":"Zanzottera","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib22","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.ophtha.2009.07.014","article-title":"Reticular pseudodrusen are subretinal drusenoid deposits","volume":"117","author":"Zweifel","year":"2010","journal-title":"Ophthalmology"},{"issue":"6","key":"bib23","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.survophthal.2018.05.005","article-title":"Subretinal drusenoid deposits AKA pseudodrusen","volume":"63","author":"Spaide","year":"2018","journal-title":"Surv Ophthalmol"},{"issue":"4","key":"bib24","doi-asserted-by":"publisher","first-page":"100325","DOI":"10.1016\/j.xops.2023.100325","article-title":"Reticular pseudodrusen: interreader agreement of evaluation on OCT imaging in age-related macular degeneration","volume":"3","author":"Wu","year":"2023","journal-title":"Ophthalmol Sci"},{"issue":"1","key":"bib25","doi-asserted-by":"publisher","first-page":"5619","DOI":"10.1038\/s41598-020-62329-9","article-title":"Automated quantification of photoreceptor alteration in macular disease using optical coherence tomography and deep learning","volume":"10","author":"Orlando","year":"2020","journal-title":"Sci Rep"},{"issue":"9","key":"bib26","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1007\/s00417-020-04774-w","article-title":"Subtype-differentiated impacts of subretinal drusenoid deposits on photoreceptors revealed by adaptive optics scanning laser ophthalmoscopy","volume":"258","author":"Xu","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"10","key":"bib27","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1097\/IAE.0000000000002182","article-title":"Histology of geographic atrophy secondary to age-related macular degeneration: a multilayer approach","volume":"38","author":"Li","year":"2018","journal-title":"Retina"},{"issue":"suppl 1","key":"bib28","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/IAE.0000000000001276","article-title":"Visualizing retinal pigment epithelium phenotypes in the transition to geographic atrophy in age-related macular degeneration","volume":"36","author":"Zanzottera","year":"2016","journal-title":"Retina"},{"issue":"3","key":"bib29","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1097\/ICU.0b013e3283524162","article-title":"The inner segment\/outer segment junction: what have we learnt so far?","volume":"23","author":"Wong","year":"2012","journal-title":"Curr Opin Ophthalmol"},{"issue":"11","key":"bib30","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1364\/OPEX.12.002435","article-title":"Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography","volume":"12","author":"Cense","year":"2004","journal-title":"Opt Express"},{"issue":"15","key":"bib31","doi-asserted-by":"publisher","first-page":"11083","DOI":"10.1364\/OE.16.011083","article-title":"Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina","volume":"16","author":"Fern\u00e1ndez","year":"2008","journal-title":"Opt Express"},{"issue":"12","key":"bib32","doi-asserted-by":"publisher","first-page":"7904","DOI":"10.1167\/iovs.14-14907","article-title":"The cellular origins of the outer retinal bands in optical coherence tomography images","volume":"55","author":"Jonnal","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"24","key":"bib33","doi-asserted-by":"publisher","first-page":"29792","DOI":"10.1364\/OE.21.029792","article-title":"A dual-modal retinal imaging system with adaptive optics","volume":"21","author":"Meadway","year":"2013","journal-title":"Opt Express"},{"issue":"4","key":"bib34","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1167\/iovs.14-15838","article-title":"Inner segment remodeling and mitochondrial translocation in cone photoreceptors in age-related macular degeneration with outer retinal tubulation","volume":"56","author":"Litts","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib35","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.jcjo.2013.03.022","article-title":"Microperimetry, fundus autofluorescence, and retinal layer changes in progressing geographic atrophy","volume":"48","author":"Pilotto","year":"2013","journal-title":"Can J Ophthalmol"},{"issue":"3","key":"bib36","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1167\/iovs.17-22712","article-title":"Structure-function analysis in patients with intermediate age-related macular degeneration","volume":"59","author":"Sa\u00dfmannshausen","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib37","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/IAE.0b013e3181e91132","article-title":"Inner segment-outer segment junctional layer integrity and corresponding retinal sensitivity in dry and wet forms of age-related macular degeneration","volume":"31","author":"Landa","year":"2011","journal-title":"Retina"},{"issue":"1","key":"bib38","doi-asserted-by":"publisher","first-page":"14933","DOI":"10.1038\/s41598-022-18875-5","article-title":"Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report","volume":"12","author":"Sa\u00dfmannshausen","year":"2022","journal-title":"Sci Rep"},{"issue":"6","key":"bib39","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1136\/bjo-2023-324246","article-title":"Imaging geographic atrophy: integrating structure and function to better understand the effects of new treatments","volume":"108","author":"Vujosevic","year":"2024","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"bib40","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.1167\/iovs.15-16432","article-title":"Subducted and melanotic cells in advanced age-related macular degeneration are derived from retinal pigment epithelium","volume":"56","author":"Zanzottera","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib41","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.ophtha.2012.10.007","article-title":"Histologic basis of variations in retinal pigment epithelium autofluorescence in eyes with geographic atrophy","volume":"120","author":"Rudolf","year":"2013","journal-title":"Ophthalmology"},{"issue":"7","key":"bib42","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1001\/jamaophthalmol.2020.1376","article-title":"Characterization of drusen and hyperreflective foci as biomarkers for disease progression in age-related macular degeneration using artificial intelligence in optical coherence tomography","volume":"138","author":"Waldstein","year":"2020","journal-title":"JAMA Ophthalmol"},{"issue":"11","key":"bib43","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.oret.2020.05.001","article-title":"Hyperreflective foci and specks are associated with delayed rod-mediated dark adaptation in nonneovascular age-related macular degeneration","volume":"4","author":"Echols","year":"2020","journal-title":"Ophthalmol Retina"},{"issue":"1","key":"bib44","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.oret.2022.08.003","article-title":"Predicting topographic disease progression and treatment response of pegcetacoplan in geographic atrophy quantified by deep learning","volume":"7","author":"Vogl","year":"2023","journal-title":"Ophthalmol Retina"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.ajo.2020.03.042","article-title":"Role of deep learning\u2013quantified hyperreflective foci for the prediction of geographic atrophy progression","volume":"216","author":"Schmidt-Erfurth","year":"2020","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"bib46","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1001\/jamaophthalmol.2013.5799","article-title":"Geographic atrophy: a histopathological assessment","volume":"132","author":"Bird","year":"2014","journal-title":"JAMA Ophthalmol"},{"issue":"13","key":"bib47","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1167\/iovs.61.13.19","article-title":"Measuring the contributions of basal laminar deposit and Bruch's membrane in age-related macular degeneration","volume":"61","author":"Sura","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib48","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.oret.2022.09.007","article-title":"OCT risk factors for development of atrophy in eyes with intermediate age-related macular degeneration","volume":"7","author":"Hirabayashi","year":"2023","journal-title":"Ophthalmol Retina"},{"issue":"2","key":"bib49","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1097\/IAE.0b013e31827e25e0","article-title":"Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model","volume":"33","author":"Curcio","year":"2013","journal-title":"Retina"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ajo.2023.12.013","article-title":"En face optical coherence tomography illustrates the trizonal distribution of drusen and subretinal drusenoid deposits in the macula","volume":"261","author":"Voichanski","year":"2024","journal-title":"Am J Ophthalmol"},{"issue":"14","key":"bib51","doi-asserted-by":"publisher","first-page":"4131","DOI":"10.3390\/jcm13144131","article-title":"Retro mode imaging for detection and quantification of sub-RPE drusen and subretinal drusenoid deposits in age-related macular degeneration","volume":"13","author":"Sa\u00dfmannshausen","year":"2024","journal-title":"J Clin Med"},{"issue":"10","key":"bib52","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1167\/iovs.65.10.25","article-title":"Extent and topography of subretinal drusenoid deposits associate with rod-mediated vision in aging and AMD: ALSTAR2 baseline","volume":"65","author":"Goerdt","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib53","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1167\/iovs.65.3.4","article-title":"Age-related macular degeneration, a mathematically tractable disease","volume":"65","author":"Curcio","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib54","doi-asserted-by":"publisher","first-page":"3761","DOI":"10.1167\/iovs.10-7021","article-title":"Fundus autofluorescence and spectral-domain optical coherence tomography characteristics in a rapidly progressing form of geographic atrophy","volume":"52","author":"Fleckenstein","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:10Z","timestamp":1791927130000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,22]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.4.65","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,22]]}}}