{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:27Z","timestamp":1791928887571,"version":"4.3.4"},"reference-count":35,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,4,23]]},"DOI":"10.1167\/iovs.66.4.67","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:30:35Z","timestamp":1745407835000},"page":"67","source":"Crossref","is-referenced-by-count":12,"title":["Microglia-Derived IL-6 Promotes M\u00fcller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration"],"prefix":"10.1167","volume":"66","author":[{"given":"Jie","family":"Xu","sequence":"first","affiliation":[{"name":"Key Lab of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Key Lab of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Li","sequence":"additional","affiliation":[{"name":"Key Lab of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Tan","sequence":"additional","affiliation":[{"name":"Key Lab of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lining","family":"Cao","sequence":"additional","affiliation":[{"name":"Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Lab of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"7","key":"bib1","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nrn3723","article-title":"Muller glial cell reprogramming and retina regeneration","volume":"15","author":"Goldman","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.exer.2013.06.019","article-title":"A comparative analysis of Muller glia-mediated regeneration in the vertebrate retina","volume":"123","author":"Gallina","year":"2014","journal-title":"Exp Eye Res"},{"issue":"6519","key":"bib3","doi-asserted-by":"publisher","first-page":"eabb8598","DOI":"10.1126\/science.abb8598","article-title":"Gene regulatory networks controlling vertebrate retinal regeneration","volume":"370","author":"Hoang","year":"2020","journal-title":"Science"},{"issue":"12","key":"bib4","doi-asserted-by":"publisher","first-page":"3635","DOI":"10.4103\/NRR.NRR-D-23-02083","article-title":"Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and M\u00fcller glia during zebrafish retina regeneration","volume":"20","author":"Xu","year":"2024","journal-title":"Neural Regen Res"},{"issue":"22","key":"bib5","doi-asserted-by":"publisher","first-page":"4510","DOI":"10.1242\/dev.090738","article-title":"A self-renewing division of zebrafish Muller glial cells generates neuronal progenitors that require N-cadherin to regenerate retinal neurons","volume":"140","author":"Nagashima","year":"2013","journal-title":"Development"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"RP86507","DOI":"10.7554\/eLife.86507","article-title":"Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration","volume":"12","author":"Celotto","year":"2023","journal-title":"Elife"},{"issue":"2","key":"bib7","first-page":"445","article-title":"Sox11b regulates the migration and fate determination of Muller glia-derived progenitors during retina regeneration in zebrafish","volume":"18","author":"Song","year":"2023","journal-title":"Neural Regen Res"},{"issue":"5","key":"bib8","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1007\/s12035-020-02274-w","article-title":"Muller glia-mediated retinal regeneration","volume":"58","author":"Gao","year":"2021","journal-title":"Mol Neurobiol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1146\/annurev-vision-121219-081808","article-title":"Reprogramming Muller glia to regenerate retinal neurons","volume":"6","author":"Lahne","year":"2020","journal-title":"Annu Rev Vis Sci"},{"issue":"4","key":"bib10","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3390\/cells10040783","article-title":"Inflammation regulates the multi-step process of retinal regeneration in zebrafish","volume":"10","author":"Nagashima","year":"2021","journal-title":"Cells"},{"issue":"7","key":"bib11","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.1007\/s12035-022-02857-9","article-title":"Context-dependent effects of inflammation on retina regeneration","volume":"59","author":"Zhou","year":"2022","journal-title":"Mol Neurobiol"},{"issue":"9","key":"bib12","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.4103\/1673-5374.306059","article-title":"Inflammation induces zebrafish regeneration","volume":"16","author":"Iribarne","year":"2021","journal-title":"Neural Regen Res"},{"issue":"6","key":"bib13","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.devcel.2017.11.010","article-title":"Zebrafish regulatory T cells mediate organ-specific regenerative programs","volume":"43","author":"Hui","year":"2017","journal-title":"Dev Cell"},{"issue":"1","key":"bib14","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/glia.23707","article-title":"Inflammation-induced mammalian target of rapamycin signaling is essential for retina regeneration","volume":"68","author":"Zhang","year":"2020","journal-title":"Glia"},{"issue":"18","key":"bib15","doi-asserted-by":"publisher","first-page":"E3719","DOI":"10.1073\/pnas.1617721114","article-title":"Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina","volume":"114","author":"White","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"bib16","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1002\/glia.22703","article-title":"Reactive microglia and macrophage facilitate the formation of Muller glia-derived retinal progenitors","volume":"62","author":"Fischer","year":"2014","journal-title":"Glia"},{"issue":"7","key":"bib17","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1002\/glia.23792","article-title":"Inflammation and matrix metalloproteinase 9 (Mmp-9) regulate photoreceptor regeneration in adult zebrafish","volume":"68","author":"Silva","year":"2020","journal-title":"Glia"},{"issue":"10","key":"bib18","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/s41577-023-00856-y","article-title":"Targeting IL-6 trans-signalling: past, present and future prospects","volume":"23","author":"Rose-John","year":"2023","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"bib19","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.7150\/ijbs.4989","article-title":"IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6","volume":"8","author":"Rose-John","year":"2012","journal-title":"Int J Biol Sci"},{"issue":"8","key":"bib20","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.modgep.2006.04.006","article-title":"GFAP transgenic zebrafish","volume":"6","author":"Bernardos","year":"2006","journal-title":"Gene Expr Patterns"},{"issue":"10","key":"bib21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0320-5","article-title":"Interleukin-6 signaling regulates hematopoietic stem cell emergence","volume":"51","author":"Tie","year":"2019","journal-title":"Exp Mol Med"},{"issue":"3","key":"bib22","first-page":"71","article-title":"An improvement of the 2^(-delta delta CT) method for quantitative real-time polymerase chain reaction data analysis","volume":"3","author":"Rao","year":"2013","journal-title":"Biostat Bioinforma Biomath"},{"issue":"5","key":"bib23","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"bib24","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.jds.2012.09.023","article-title":"Inhibitory effects of di-O-demethylcurcumin on interleukin-1\u00df-induced interleukin-6 production from human gingival fibroblasts","volume":"7","author":"Aroonrerk","year":"2012","journal-title":"J Dent Sci"},{"issue":"5","key":"bib25","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1523\/JNEUROSCI.4853-07.2008","article-title":"The proneural basic helix-loop-helix gene ascl1a is required for retina regeneration","volume":"28","author":"Fausett","year":"2008","journal-title":"J Neurosci"},{"issue":"23","key":"bib26","doi-asserted-by":"publisher","first-page":"6303","DOI":"10.1523\/JNEUROSCI.0332-06.2006","article-title":"A role for alpha1 tubulin-expressing Muller glia in regeneration of the injured zebrafish retina","volume":"26","author":"Fausett","year":"2006","journal-title":"J Neurosci"},{"issue":"1","key":"bib27","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.celrep.2014.08.047","article-title":"Leptin and IL-6 family cytokines synergize to stimulate Muller glia reprogramming and retina regeneration","volume":"9","author":"Zhao","year":"2014","journal-title":"Cell Rep"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"35703","DOI":"10.1038\/srep35703","article-title":"Jak\/Stat signaling regulates the proliferation and neurogenic potential of Muller glia-derived progenitor cells in the avian retina","volume":"6","author":"Todd","year":"2016","journal-title":"Sci Rep"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"155577","DOI":"10.1016\/j.cyto.2021.155577","article-title":"Therapeutic targeting of IL-6 trans-signaling","volume":"144","author":"Rose-John","year":"2021","journal-title":"Cytokine"},{"issue":"5","key":"bib30","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.cell.2020.02.013","article-title":"Repopulating microglia promote brain repair in an IL-6-dependent manner","volume":"180","author":"Willis","year":"2020","journal-title":"Cell"},{"issue":"6","key":"bib31","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1002\/hep.30774","article-title":"IL-6 trans-signaling controls liver regeneration after partial hepatectomy","volume":"70","author":"Fazel Modares","year":"2019","journal-title":"Hepatology"},{"issue":"15","key":"bib32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/iovs.64.15.1","article-title":"Diabetic Muller-glial-cell-specific Il6ra knockout mice exhibit accelerated retinal functional decline and thinning of the inner nuclear layer","volume":"64","author":"Glass","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib33","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.bbrc.2019.07.044","article-title":"Interleukin-6 (IL-6) mediates protection against glucose toxicity in human Muller cells via activation of VEGF-A signaling","volume":"517","author":"Coughlin","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"bib34","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/glia.22942","article-title":"Muller glia as an important source of cytokines and inflammatory factors present in the gliotic retina during proliferative vitreoretinopathy","volume":"64","author":"Eastlake","year":"2016","journal-title":"Glia"},{"issue":"2","key":"bib35","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1530\/JME-21-0123","article-title":"Synoviolin inhibits the inflammatory cytokine secretion of Muller cells by reducing NLRP3","volume":"68","author":"Zhang","year":"2022","journal-title":"J Mol Endocrinol"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:10Z","timestamp":1791927130000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.4.67","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,23]]}}}