{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:31Z","timestamp":1791928891018,"version":"4.3.4"},"reference-count":81,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,4,24]]},"DOI":"10.1167\/iovs.66.4.73","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T10:30:35Z","timestamp":1745490635000},"page":"73","source":"Crossref","is-referenced-by-count":1,"title":["Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study"],"prefix":"10.1167","volume":"66","author":[{"given":"Yan-Jie","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, First Hospital of Shanxi Medical University, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng-Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, First Hospital of Shanxi Medical University, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, First Hospital of Shanxi Medical University, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, China"},{"name":"Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Lu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Xia","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, First Hospital of Shanxi Medical University, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Ran","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, First Hospital of Shanxi Medical University, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng-Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Educational Science and Technology, Jinzhong University, Jinzhong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"25538","DOI":"10.1038\/s41598-024-77663-5","article-title":"Temporal trends of thyroid cancer in China and globally from 1990 to 2021: an analysis of the Global Burden of Disease Study 2021","volume":"14","author":"Huang","year":"2024","journal-title":"Sci Rep"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/nrendo.2016.110","article-title":"The changing incidence of thyroid cancer","volume":"12","author":"Kitahara","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S2213-8587(21)00027-9","article-title":"Thyroid cancer incidence trends by histology in 25 countries: a population-based study","volume":"9","author":"Miranda-Filho","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1007\/s10552-021-01458-6","article-title":"Changing incidence and projections of thyroid cancer in mainland China, 1983-2032: evidence from Cancer Incidence in Five Continents","volume":"32","author":"Li","year":"2021","journal-title":"Cancer Causes Control"},{"key":"bib5","first-page":"640","article-title":"Genetic pathological features of papillary thyroid carcinoma with distant metastasis","volume":"44","author":"Liu","year":"2024","journal-title":"Chinese Journal of Practical Surgery"},{"key":"bib6","first-page":"277","article-title":"Retina and nerve fiber layer thickness in eyes with thyroid-associated ophthalmopathy","volume":"19","author":"Blum","year":"2017","journal-title":"Isr Med Assoc J"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1080\/02713683.2019.1675177","article-title":"Reduced retinal microvascular density related to activity status and serum antibodies in patients with Graves' ophthalmopathy","volume":"45","author":"Wu","year":"2020","journal-title":"Curr Eye Res"},{"key":"bib8","first-page":"1764","article-title":"Advances in the study of age-related macular degeneration and tumor correlation","volume":"43","author":"Li","year":"2023","journal-title":"Chinese Journal of Gerontology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1167\/iovs.63.2.19","article-title":"OCTA derived vessel skeleton density versus flux and their associations with systemic determinants of health","volume":"63","author":"Kushner-Lenhoff","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1056\/NEJMra0801537","article-title":"Age-related macular degeneration","volume":"358","author":"Jager","year":"2008","journal-title":"N Engl J Med"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1007\/s00125-024-06093-9","article-title":"Glucose tolerance and insulin resistance\/sensitivity associate with retinal layer characteristics: the LIFE-Adult-Study","volume":"67","author":"Rauscher","year":"2024","journal-title":"Diabetologia"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1093\/annonc\/mdx402","article-title":"Risk of age-related macular degeneration in patients with prostate cancer: a nationwide, population-based cohort study","volume":"28","author":"Lin","year":"2017","journal-title":"Ann Oncol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1158\/1055-9965.EPI-16-0759","article-title":"The Association between age-related macular degeneration and renal cell carcinoma: a nested case-control study","volume":"26","author":"Keizman","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5","key":"bib14","doi-asserted-by":"publisher","first-page":"902","DOI":"10.3390\/ijerph15050902","article-title":"Evidence for an association between macular degeneration and thyroid cancer in the aged population","volume":"15","author":"Lin","year":"2018","journal-title":"Int J Environ Res Public Health"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1097\/IAE.0000000000002940","article-title":"Optical coherence tomography angiography findings of microvascular and neural changes in primary pulmonary hypertension","volume":"41","author":"Gu","year":"2021","journal-title":"Retina"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1194320","DOI":"10.3389\/fpubh.2023.1194320","article-title":"Central and peripheral changes in the retina and choroid in patients with diabetes mellitus without clinical diabetic retinopathy assessed by ultra-wide-field optical coherence tomography angiography","volume":"11","author":"Zhao","year":"2023","journal-title":"Front Public Health"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1167\/iovs.04-1340","article-title":"The Ins2Akita mouse as a model of early retinal complications in diabetes","volume":"46","author":"Barber","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"6488","DOI":"10.1167\/iovs.12-9758","article-title":"Reduced ocular blood flow as an early indicator of diabetic retinopathy in a mouse model of diabetes","volume":"53","author":"Muir","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1167\/iovs.63.2.18","article-title":"In vivo capillary structure and blood cell flux in the normal and diabetic mouse eye","volume":"63","author":"Dholakia","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s00592-024-02273-6","article-title":"Comparison of the optical coherence tomography-angiography (OCT-A) vascular measurements between molecularly confirmed MODY and age-matched healthy controls","volume":"61","author":"\u00c7avdarli","year":"2024","journal-title":"Acta Diabetol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41572-022-00342-0","article-title":"Hypertensive eye disease","volume":"8","author":"Cheung","year":"2022","journal-title":"Nat Rev Dis Primers"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/s41598-020-79594-3","article-title":"Retinal capillary rarefaction is associated with arterial and kidney damage in hypertension","volume":"11","author":"Frost","year":"2021","journal-title":"Sci Rep"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"18902","DOI":"10.1038\/s41598-022-23756-y","article-title":"Different characteristics of retinal damage between chronic hypertension and hypertensive retinopathy","volume":"12","author":"Nam","year":"2022","journal-title":"Sci Rep"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00125-017-4435-8","article-title":"Diabetic retinopathy: hyperglycaemia, oxidative stress and beyond","volume":"61","author":"Hammes","year":"2018","journal-title":"Diabetologia"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1167\/iovs.14-16221","article-title":"In vivo quantification of retinal changes associated with drusen in age-related macular degeneration","volume":"56","author":"Rogala","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1159\/000503295","article-title":"Characteristics of the foveal microvasculature in Asian patients with dry age-related macular degeneration: an optical coherence tomography angiography study","volume":"243","author":"Shin","year":"2020","journal-title":"Ophthalmologica"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1167\/iovs.13-12172","article-title":"Differential vulnerability of retinal layers to early age-related macular degeneration: evidence by SD-OCT segmentation analysis","volume":"55","author":"Savastano","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"102030","DOI":"10.1016\/j.pdpdt.2020.102030","article-title":"Quantitative analysis of inner retinal structural and microvascular alterations in intermediate age-related macular degeneration: a swept-source OCT angiography study","volume":"32","author":"Ozcaliskan","year":"2020","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1097\/IAE.0000000000000962","article-title":"Retinal vascular plexuses' changes in dry age-related macular degeneration, evaluated by means of optical coherence tomography angiography [j]","volume":"36","author":"Toto","year":"2016","journal-title":"Retina"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1136\/bjophthalmol-2016-309160","article-title":"Association between outer retinal alterations and microvascular changes in intermediate stage age-related macular degeneration: an optical coherence tomography angiography study","volume":"101","author":"Toto","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1167\/tvst.8.4.20","article-title":"Vascular changes in intermediate age-related macular degeneration quantified using optical coherence tomography angiography","volume":"8","author":"Trinh","year":"2019","journal-title":"Transl Vis Sci Technol"},{"issue":"7203","key":"bib32","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.survophthal.2016.02.005","article-title":"Perspectives on reticular pseudodrusen in age-related macular degeneration","volume":"61","author":"Sivaprasad","year":"2016","journal-title":"Surv Ophthalmol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ajo.2014.03.014","article-title":"Immune responses in age-related macular degeneration and a possible long-term therapeutic strategy for prevention","volume":"158","author":"Nussenblatt","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1080\/09273948.2018.1485960","article-title":"Complete blood cell count-derived inflammation biomarkers in men with age-related macular degeneration","volume":"27","author":"Pinna","year":"2019","journal-title":"Ocul Immunol Inflamm"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3109\/09273948.2014.921715","article-title":"Assessment of neutrophil\/lymphocyte ratio in patients with age-related macular degeneration","volume":"23","author":"Ilhan","year":"2015","journal-title":"Ocul Immunol Inflamm"},{"key":"bib37","first-page":"754","article-title":"Correlation of neutrophil\/lymphocyte and platelet\/lymphocyte ratio with visual acuity and macular thickness in age-related macular degeneration","volume":"10","author":"Sengul","year":"2017","journal-title":"Int J Ophthalmol"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/aos.13330","article-title":"New neovascular age-related macular degeneration is associated with systemic leucocyte activity","volume":"95","author":"Subhi","year":"2017","journal-title":"Acta Ophthalmol"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3341\/kjo.2016.30.5.377","article-title":"The relationship between neutrophil-to-lymphocyte ratio and age-related macular degeneration","volume":"30","author":"Kurtul","year":"2016","journal-title":"Korean J Ophthalmol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1143045","DOI":"10.3389\/fmed.2023.1143045","article-title":"Assessment of aggregate index of systemic inflammation and systemic inflammatory response index in dry age-related macular degeneration: a retrospective study","volume":"10","author":"Sannan","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"bib41","doi-asserted-by":"crossref","first-page":"m4979","DOI":"10.1136\/bmj.m4979","article-title":"Uveitis for the non-ophthalmologist","volume":"372","author":"Burkholder","year":"2021","journal-title":"BMJ"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/ceo.13470","article-title":"Optical coherence tomography and optical coherence tomography angiography in uveitis: a review","volume":"47","author":"Invernizzi","year":"2019","journal-title":"Clin Exp Ophthalmol"},{"issue":"7-8","key":"bib43","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1080\/09273948.2021.1954200","article-title":"Retinal microvascular alterations in patients with quiescent posterior and panuveitis using optical coherence tomography angiography","volume":"30","author":"Agarwal","year":"2022","journal-title":"Ocul Immunol Inflamm"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ajo.2016.01.004","article-title":"Enhanced depth imaging optical coherence tomography in uveitis: an intravisit and interobserver reproducibility study","volume":"164","author":"Kim","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"344","DOI":"10.4103\/sjopt.sjopt_69_22","article-title":"Interpreting posterior uveitis by integrating indocyanine green angiography, optical coherence tomography, and optical coherence tomography angiography data: a narrative review","volume":"36","author":"Chandrasekaran","year":"2022","journal-title":"Saudi J Ophthalmol"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1080\/09273948.2020.1803923","article-title":"Anterior segment inflammation in pediatric uveitis is associated with reduced retinal vascular density as quantified by optical coherence tomography angiography","volume":"30","author":"Qu","year":"2022","journal-title":"Ocul Immunol Inflamm"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12348-014-0014-z","article-title":"Variation of choroidal thickness and vessel diameter in patients with posterior non-infectious uveitis","volume":"4","author":"Bittencourt","year":"2014","journal-title":"J Ophthalmic Inflamm Infect"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"e0297201","DOI":"10.1371\/journal.pone.0297201","article-title":"Relationship between vitreous interleukin-6 levels and vitreous particles findings on widefield optical coherence tomography in posterior uveitis","volume":"19","author":"Tomita","year":"2024","journal-title":"PLoS One"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"901263","DOI":"10.3389\/fimmu.2022.901263","article-title":"Dynamic immune function changes before and after the first radioactive iodine therapy after total resection of differentiated thyroid carcinoma","volume":"13","author":"Shi","year":"2022","journal-title":"Front Immunol"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1111\/aos.14851","article-title":"Optical coherence tomography angiography changes in cardiovascular systemic diseases and risk factors: a review","volume":"100","author":"Monteiro-Henriques","year":"2022","journal-title":"Acta Ophthalmol"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"101292","DOI":"10.1016\/j.preteyeres.2024.101292","article-title":"Optical coherence tomography angiography of the retina and choroid in systemic diseases","volume":"103","author":"Chua","year":"2024","journal-title":"Prog Retin Eye Res"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1038\/s41433-023-02438-7","article-title":"Optical coherence tomography angiography in Parkinson's disease: a systematic review and meta-analysis","volume":"37","author":"Katsimpris","year":"2023","journal-title":"Eye (Lond)"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s13195-024-01551-3","article-title":"Association of outer retinal and choroidal alterations with neuroimaging and clinical features in posterior cortical atrophy","volume":"16","author":"Gao","year":"2024","journal-title":"Alzheimers Res Ther"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.oret.2019.02.002","article-title":"Retinal microvascular and neurodegenerative changes in Alzheimer's disease and mild cognitive impairment compared with control participants","volume":"3","author":"Yoon","year":"2019","journal-title":"Ophthalmol Retina"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"3506","DOI":"10.1167\/iovs.17-21414","article-title":"Reduced retinal vessel density in obstructive sleep apnea syndrome patients: an optical coherence tomography angiography study","volume":"58","author":"Yu","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s00406-022-01455-z","article-title":"Optical coherence tomography reveals retinal thinning in schizophrenia spectrum disorders","volume":"273","author":"Boudriot","year":"2023","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1136\/annrheumdis-2018-214235","article-title":"Evaluation of retinal microvascular density in patients affected by systemic lupus erythematosus: an optical coherence tomography angiography study","volume":"78","author":"Conigliaro","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"bib58","first-page":"276","article-title":"Obstructive sleep apnea syndrome (OSAS) and cardiovascular system","volume":"108","author":"Lombardi","year":"2017","journal-title":"Med Lav"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"17184","DOI":"10.1038\/s41598-018-35562-6","article-title":"Optical coherence tomography angiography analysis of changes in the retina and the choroid after haemodialysis","volume":"8","author":"Shin","year":"2018","journal-title":"Sci Rep"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1007\/s00417-019-04358-3","article-title":"Retinal and choroidal vasculature changes associated with chronic kidney disease","volume":"257","author":"Vadal\u00e0","year":"2019","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1167\/iovs.19-26956","article-title":"Retinal vascular changes during pregnancy detected with optical coherence tomography angiography","volume":"60","author":"Chanwimol","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"4299","DOI":"10.1167\/iovs.18-24090","article-title":"The EYE-MI pilot study: a prospective acute coronary syndrome cohort evaluated with retinal optical coherence tomography angiography","volume":"59","author":"Arnould","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.jfo.2019.07.026","article-title":"Influence of cardiac hemodynamic variables on retinal vessel density measurement on optical coherence tomography angiography in patients with myocardial infarction","volume":"43","author":"Arnould","year":"2020","journal-title":"J Fr Ophtalmol"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"e29107","DOI":"10.1016\/j.heliyon.2024.e29107","article-title":"Associations between the retinal\/choroidal microvasculature and carotid plaque in patients with CAD: an OCTA study","volume":"10","author":"Jiang","year":"2024","journal-title":"Heliyon"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"103556","DOI":"10.1016\/j.pdpdt.2023.103556","article-title":"Retinal microvascular changes in patients recovered from COVID-19 compared to healthy controls: a meta-analysis","volume":"42","author":"Kazantzis","year":"2023","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.survophthal.2024.04.007","article-title":"Optical coherence tomography angiography measurements in systemic lupus erythematosus: a systematic review and meta-analysis","volume":"69","author":"Fekrazad","year":"2024","journal-title":"Surv Ophthalmol"},{"issue":"24","key":"bib67","doi-asserted-by":"publisher","first-page":"7417","DOI":"10.3390\/jcm11247417","article-title":"Evaluation of subclinical retinal disease in patients affected by systemic lupus erythematosus with no evidence of ocular involvement-an optical coherence tomography angiography original study","volume":"11","author":"Mimier-Janczak","year":"2022","journal-title":"J Clin Med"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"6580","DOI":"10.1167\/iovs.14-15166","article-title":"?d T cells as a major source of IL-17 production during age-dependent RPE degeneration","volume":"55","author":"Zhao","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.preteyeres.2018.10.003","article-title":"Immune regulation in the aging retina","volume":"69","author":"Chen","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1002\/emmm.201302692","article-title":"CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice","volume":"5","author":"Sennlaub","year":"2013","journal-title":"EMBO Mol Med"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1167\/iovs.11-8601","article-title":"Changes in murine hyalocytes are valuable early indicators of ocular disease","volume":"53","author":"Vagaja","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1016\/j.neurobiolaging.2011.03.010","article-title":"Accumulation of murine subretinal macrophages: effects of age, pigmentation and CX3CR1","volume":"33","author":"Chinnery","year":"2012","journal-title":"Neurobiol Aging"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"7377","DOI":"10.1167\/iovs.15-17587","article-title":"Retinal microglial activation following topical application of intracellular Toll-like receptor ligands","volume":"56","author":"Chinnery","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/BF00920033","article-title":"Autoantibodies to retinal astrocytes associated with age-related macular degeneration","volume":"228","author":"Penfold","year":"1990","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"11830","DOI":"10.1073\/pnas.192203399","article-title":"The Alzheimer's A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration","volume":"99","author":"Johnson","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"bib77","doi-asserted-by":"publisher","first-page":"810","DOI":"10.3390\/medicina60050810","article-title":"Circulating anti-endothelial cell antibodies in patients with geographic atrophy related to dry age-related macular degeneration","volume":"60","author":"Zuber-Laskawiec","year":"2024","journal-title":"Medicina (Kaunas)"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1167\/iovs.13-11821","article-title":"Fc? receptor upregulation is associated with immune complex inflammation in the mouse retina and early age-related macular degeneration","volume":"55","author":"Murinello","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"5528","DOI":"10.3390\/curroncol31090409","article-title":"Long-term outcome of patients with low-risk differentiated thyroid cancer treated with total thyroidectomy alone","volume":"31","author":"Matrone","year":"2024","journal-title":"Curr Oncol"},{"key":"bib80","doi-asserted-by":"publisher","first-page":"5273","DOI":"10.1167\/iovs.16-19735","article-title":"Thyroid dysfunction and ten-year incidence of age-related macular degeneration","volume":"57","author":"Gopinath","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12916-015-0329-0","article-title":"Thyroid function and age-related macular degeneration: a prospective population-based cohort study\u2013the Rotterdam Study","volume":"13","author":"Chaker","year":"2015","journal-title":"BMC Med"},{"key":"bib70","first-page":"e16490","article-title":"Subretinal mononuclear phagocytes induce cone segment loss via IL-1\u00df","volume-title":"Elife","author":"Eandi","year":"2016"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:11Z","timestamp":1791927131000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2802918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,24]]},"references-count":81,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.4.73","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,24]]}}}