{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:55Z","timestamp":1791928915874,"version":"4.3.4"},"reference-count":94,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,5,28]]},"DOI":"10.1167\/iovs.66.5.41","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T10:30:45Z","timestamp":1748428245000},"page":"41","source":"Crossref","is-referenced-by-count":3,"title":["Tear Proteomic Analysis From Offspring of Keratoconus Patients: New Insights Into Corneal Biomechanical Weakness and Disease Risk Stages"],"prefix":"10.1167","volume":"66","author":[{"given":"Maite","family":"L\u00f3pez-L\u00f3pez","sequence":"first","affiliation":[{"name":"Corneal Neurodegeneration Group (RENOIR), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain"},{"name":"Departamento de Cirux\u00eda e Especialidades M\u00e9dico-Cir\u00farxicas, Facultade de \u00d3ptica e Optometr\u00eda, Universidade de Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ux\u00eda","family":"Regueiro","sequence":"additional","affiliation":[{"name":"Corneal Neurodegeneration Group (RENOIR), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain"},{"name":"Departamento de Cirux\u00eda e Especialidades M\u00e9dico-Cir\u00farxicas, Facultade de \u00d3ptica e Optometr\u00eda, Universidade de Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Bravo","sequence":"additional","affiliation":[{"name":"Proteomic Unit, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Pena","sequence":"additional","affiliation":[{"name":"Proteomic Unit, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaiza","family":"Pastoriza","sequence":"additional","affiliation":[{"name":"Corneal Neurodegeneration Group (RENOIR), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain"},{"name":"Departamento de Cirux\u00eda e Especialidades M\u00e9dico-Cir\u00farxicas, Facultade de \u00d3ptica e Optometr\u00eda, Universidade de Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Conde-Amboage","sequence":"additional","affiliation":[{"name":"Department of Statistics, Mathematical Analysis and Optimization, Universidade de Santiago de Compostela (USC), Spain"},{"name":"CITMAga, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Hervella","sequence":"additional","affiliation":[{"name":"Neuroimaging and Biotechnology Group (NOBEL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Lema","sequence":"additional","affiliation":[{"name":"Corneal Neurodegeneration Group (RENOIR), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain"},{"name":"Departamento de Cirux\u00eda e Especialidades M\u00e9dico-Cir\u00farxicas, Facultade de \u00d3ptica e Optometr\u00eda, Universidade de Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Instituto Galego de Oftalmolox\u00eda (INGO), Complexo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ajo.2011.03.028","article-title":"What's in a name: keratoconus, pellucid marginal degeneration, and related thinning disorders","volume":"152","author":"Belin","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.clae.2007.03.001","article-title":"Collaborative Longitudinal Evaluation of Keratoconus (CLEK) study: methods and findings to date","volume":"30","author":"Wagner","year":"2007","journal-title":"Cont Lens Anterior Eye"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1097\/ICO.0b013e31817f815a","article-title":"Keratoconus clinical findings according to different age and gender groups","volume":"27","author":"Ertan","year":"2008","journal-title":"Cornea"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.exer.2007.06.016","article-title":"Longitudinal study of keratoconus progression","volume":"85","author":"Li","year":"2007","journal-title":"Exp Eye Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ajo.2012.01.025","article-title":"Scalability and severity of keratoconus in children","volume":"154","author":"L\u00e9oni-Mespli\u00e9","year":"2012","journal-title":"Am J Ophthalmol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1111\/opo.12237","article-title":"Risk factors for keratoconus in Israel: a case-control study","volume":"35","author":"Gordon-Shaag","year":"2015","journal-title":"Ophthalmic Physiol Opt"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1001\/jamaophthalmol.2022.4716","article-title":"Toward universal eye health coverage\u2014key outcomes of the World Health Organization Package of Eye Care Interventions: a systematic review","volume":"140","author":"Keel","year":"2022","journal-title":"JAMA Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3928\/1081597X-20160629-01","article-title":"Detection of keratoconus with a new biomechanical index","volume":"32","author":"Vinciguerra","year":"2016","journal-title":"J Refract Surg"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"4490","DOI":"10.1167\/iovs.14-14450","article-title":"Biomechanical characterization of keratoconus corneas ex vivo with Brillouin microscopy","volume":"55","author":"Scarcelli","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"108398","DOI":"10.1016\/j.exer.2020.108398","article-title":"Update on the genetics of keratoconus","volume":"202","author":"Bykhovskaya","year":"2021","journal-title":"Exp Eye Res"},{"key":"bib11","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1755-3768.2012.02448.x","article-title":"Keratoconus in 18 pairs of twins","volume":"90","author":"Tuft","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.clae.2006.03.003","article-title":"The variable expression of keratoconus within monozygotic twins: Dundee University Scottish Keratoconus Study (DUSKS)","volume":"29","author":"Weed","year":"2006","journal-title":"Contact Lens Anterior Eye"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1111\/ceo.13852","article-title":"Topographic screening reveals keratoconus to be extremely common in Down syndrome","volume":"48","author":"Mathan","year":"2020","journal-title":"Clin Exp Ophthalmol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1442-9071.2005.00941.x","article-title":"Computerized corneal topography in a paediatric population with Down syndrome","volume":"33","author":"Vincent","year":"2005","journal-title":"Clin Exp Ophthalmol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"571","DOI":"10.5694\/j.1326-5377.1975.tb111590.x","article-title":"Keratoconus and the Ehlers-Danlos syndrome: a new aspect of keratoconus","volume":"1","author":"Robertson","year":"1975","journal-title":"Med J Aust"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3928\/0191-3913-19940101-08","article-title":"Leber congenital amaurosis and its association with keratoconus and keratoglobus","volume":"31","author":"Elder","year":"1994","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"bib17","first-page":"629","article-title":"A novel locus for Leber congenital amaurosis (LCA4) with anterior keratoconus mapping to chromosome 17p13","volume":"41","author":"Hameed","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.2147\/OPTH.S183347","article-title":"Optimal management of pediatric keratoconus: challenges and solutions","volume":"13","author":"Olivo-Payne","year":"2019","journal-title":"Clin Ophthalmol"},{"issue":"3","key":"bib19","doi-asserted-by":"publisher","first-page":"101559","DOI":"10.1016\/j.clae.2021.101559","article-title":"Keratoconus: an updated review","volume":"45","author":"Santodomingo-Rubido","year":"2022","journal-title":"Cont Lens Anterior Eye"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ajo.2019.05.032","article-title":"Tomographic and refractive characteristics of pediatric first-degree relatives of keratoconus patients","volume":"207","author":"Awwad","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.3109\/02713683.2015.1128553","article-title":"Association between family history and keratoconus severity","volume":"41","author":"Naderan","year":"2016","journal-title":"Curr Eye Res"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.ophtha.2004.11.050","article-title":"Inflammatory molecules in the tears of patients with keratoconus","volume":"112","author":"Lema","year":"2005","journal-title":"Ophthalmology"},{"key":"bib23","first-page":"2055","article-title":"Proteomic analysis of the tear film in patients with keratoconus","volume":"16","author":"Lema","year":"2010","journal-title":"Mol Vis"},{"key":"bib24","first-page":"2124","article-title":"Preliminary identification of differentially expressed tear proteins in keratoconus","volume":"19","author":"Balasubramanian","year":"2013","journal-title":"Mol Vis"},{"issue":"10","key":"bib25","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1167\/iovs.62.10.30","article-title":"Tear proteomics in keratoconus: a quantitative SWATH-MS analysis","volume":"62","author":"L\u00f3pez-L\u00f3pez","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib26","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1167\/iovs.63.5.12","article-title":"Shotgun proteomics for the identification and profiling of the tear proteome of keratoconus patients","volume":"63","author":"L\u00f3pez-L\u00f3pez","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1046\/j.1475-1313.2001.00575.x","article-title":"Grading scales for contact lens complications","volume":"18","author":"Efron","year":"1998","journal-title":"Ophthalmic Physiol Opt"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/978-1-0716-1178-4","article-title":"SWATH-MS protocols in human diseases","volume":"2259","author":"Chantada-V\u00e1zquez","year":"2021","journal-title":"Methods Mol Biol"},{"issue":"1","key":"bib29","doi-asserted-by":"publisher","first-page":"M110.003335","DOI":"10.1074\/mcp.M110.003335","article-title":"A robust method for quantitative high-throughput analysis of proteomes by 18O labeling","volume":"10","author":"Bonzon-Kulichenko","year":"2011","journal-title":"Mol Cell Proteomics"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"11649","DOI":"10.1074\/jbc.M112.445304","article-title":"The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machinery toward exosomes","volume":"288","author":"Perez-Hernandez","year":"2013","journal-title":"J Biol Chem"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1097\/ICO.0000000000002546","article-title":"Keratoconus prevalence in families: a French study","volume":"39","author":"Lapeyre","year":"2020","journal-title":"Cornea"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1097\/ICO.0b013e31816f5edc","article-title":"Topographic evaluation of relatives of patients with keratoconus","volume":"27","author":"Karimian","year":"2008","journal-title":"Cornea"},{"issue":"5","key":"bib33","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/ICO.0b013e318165d110","article-title":"Evaluation of corneal topography with Orbscan II in first-degree relatives of patients with keratoconus","volume":"27","author":"Kaya","year":"2008","journal-title":"Cornea"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/opo.12706","article-title":"The prevalence of corneal abnormalities in first-degree relatives of patients with keratoconus: a prospective case-control study","volume":"40","author":"Shneor","year":"2020","journal-title":"Ophthalmic Physiol Opt"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1097\/ICO.0b013e3182490924","article-title":"Biomechanical evaluation of cornea in topographically normal relatives of patients with keratoconus","volume":"32","author":"Kara","year":"2013","journal-title":"Cornea"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"4285268","DOI":"10.1155\/2018\/4285268","article-title":"Overexpression of tear inflammatory cytokines as additional findings in keratoconus patients and their first degree family members","volume":"2018","author":"Ionescu","year":"2018","journal-title":"Mediators Inflamm"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00417-020-04929-9","article-title":"Corneal and conjunctival alteration of innate immune expression in first-degree relatives of keratoconus patients","volume":"259","author":"Regueiro","year":"2021","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1093\/hmg\/ddab075","article-title":"Pathogenic alleles in microtubule, secretory granule and extracellular matrix-related genes in familial keratoconus","volume":"30","author":"Shinde","year":"2021","journal-title":"Hum Mol Genet"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s40662-021-00266-y","article-title":"Comparisons of corneal biomechanical and tomographic parameters among thin normal cornea, forme fruste keratoconus, and mild keratoconus","volume":"8","author":"Tian","year":"2021","journal-title":"Eye Vis (Lond)"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"632","DOI":"10.3928\/1081597X-20170621-09","article-title":"Comparison of corneal dynamic and tomographic analysis in normal, forme fruste keratoconic, and keratoconic eyes","volume":"33","author":"Wang","year":"2017","journal-title":"J Refract Surg"},{"key":"bib41","doi-asserted-by":"crossref","first-page":"149","DOI":"10.22336\/rjo.2018.22","article-title":"The importance of corneal biomechanics in assessing first degree family members of keratoconus patients","volume":"62","author":"Ionescu","year":"2018","journal-title":"Rom J Ophthalmol"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1097\/j.jcrs.0000000000001102","article-title":"Comparison of corneal biomechanical properties in healthy thin corneas with matched keratoconus eyes","volume":"49","author":"Sedaghat","year":"2023","journal-title":"J Cataract Refract Surg"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1016\/j.jcrs.2006.06.025","article-title":"Corneal-thickness spatial profile and corneal-volume distribution: tomographic indices to detect keratoconus","volume":"32","author":"Ambr\u00f3sio","year":"2006","journal-title":"J Cataract Refract Surg"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"753","DOI":"10.3928\/1081597X-20110721-01","article-title":"Novel pachymetric parameters based on corneal tomography for diagnosing keratoconus","volume":"27","author":"Ambr\u00f3sio","year":"2011","journal-title":"J Refract Surg"},{"issue":"1","key":"bib45","first-page":"1748579","article-title":"Assessment of corneal pachymetry distribution and morphologic changes in subclinical keratoconus with normal biomechanics","volume":"2019","author":"Song","year":"2019","journal-title":"Biomed Res Int"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1136\/bjo.2008.144253","article-title":"Subclinical keratoconus and inflammatory molecules from tears","volume":"93","author":"Lema","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.exer.2019.03.016","article-title":"Matrix metalloproteinases in keratoconus\u2014too much of a good thing?","volume":"182","author":"di Martino","year":"2019","journal-title":"Exp Eye Res"},{"issue":"9","key":"bib48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0184628","article-title":"Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients","volume":"12","author":"Shetty","year":"2017","journal-title":"PLoS One"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"4361","DOI":"10.1167\/iovs.08-1969","article-title":"Hypersensitive response to oxidative stress in keratoconus corneal fibroblasts","volume":"49","author":"Chwa","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib50","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/jovr.jovr_80_18","article-title":"Corneal oxidative damage in keratoconus cells due to decreased oxidant elimination from modified expression levels of SOD enzymes, PRDX6, SCARA3, CPSF3, and FOXM1","volume":"14","author":"Atilano","year":"2019","journal-title":"J Ophthalmic Vis Res"},{"issue":"6","key":"bib51","doi-asserted-by":"publisher","first-page":"e777","DOI":"10.1111\/aos.14714","article-title":"Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta-analysis","volume":"99","author":"Navel","year":"2021","journal-title":"Acta Ophthalmol"},{"issue":"1","key":"bib52","doi-asserted-by":"publisher","first-page":"9907","DOI":"10.1038\/s41598-020-66735-x","article-title":"RNA sequencing of corneas from two keratoconus patient groups identifies potential biomarkers and decreased NRF2-antioxidant responses","volume":"10","author":"Shinde","year":"2020","journal-title":"Sci Rep"},{"issue":"4","key":"bib53","doi-asserted-by":"publisher","first-page":"e303","DOI":"10.1111\/j.1755-3768.2011.02369.x","article-title":"Proteases, proteolysis, and inflammatory molecules in the tears of people with keratoconus","volume":"90","author":"Balasubramanian","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1080\/09273948.2018.1511813","article-title":"Innate Immunity Biomarkers for Early Detection of Keratoconus","volume":"27","author":"Malfeito","year":"2019","journal-title":"Ocul Immunol Inflamm"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1097\/ICO.0b013e31816a3591","article-title":"Inflammatory response to contact lenses in patients with keratoconus compared with myopic subjects","volume":"27","author":"Lema","year":"2008","journal-title":"Cornea"},{"issue":"1","key":"bib56","doi-asserted-by":"publisher","first-page":"e16437","DOI":"10.1371\/journal.pone.0016437","article-title":"Subnormal cytokine profile in the tear fluid of keratoconus patients","volume":"6","author":"Jun","year":"2011","journal-title":"PLoS One"},{"issue":"Pt 1","key":"bib57","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1042\/bj3560129","article-title":"Human tear lipocalin acts as an oxidative-stress-induced scavenger of potentially harmful lipid peroxidation products in a cell culture system","volume":"356","author":"Lechner","year":"2001","journal-title":"Biochem J"},{"key":"bib58","first-page":"1949","article-title":"Tear proteomics in keratoconus","volume":"16","author":"Pannebaker","year":"2010","journal-title":"Mol Vis"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1038\/eye.2011.105","article-title":"Changes in tear protein profile in keratoconus disease","volume":"25","author":"Acera","year":"2011","journal-title":"Eye"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.exer.2011.12.010","article-title":"Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus","volume":"96","author":"Balasubramanian","year":"2012","journal-title":"Exp Eye Res"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"12350","DOI":"10.3390\/ijms232012350","article-title":"Immunomodulatory effect of human lactoferrin on toll-like receptors 2 expression as therapeutic approach for keratoconus","volume":"23","author":"Regueiro","year":"2022","journal-title":"Int J Mol Sci"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.3390\/ijms18091985","article-title":"Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis","volume":"18","author":"Rosa","year":"2017","journal-title":"Int J Mol Sci"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"865","DOI":"10.3390\/pharmaceutics15030865","article-title":"Biomedical applications of lactoferrin on the ocular surface","volume":"15","author":"Regueiro","year":"2023","journal-title":"Pharmaceutics"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.1016\/j.biocel.2005.06.012","article-title":"Extracellular superoxide dismutase","volume":"37","author":"Nozik-Grayck","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"107897","DOI":"10.1016\/j.exer.2019.107897","article-title":"Oxidative stress markers dynamics in keratoconus patients' tears before and after corneal collagen crosslinking procedure","volume":"190","author":"Balmus","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.1167\/iovs.05-1500","article-title":"SOD1: a candidate gene for keratoconus","volume":"47","author":"Udar","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.tibs.2015.05.001","article-title":"Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling","volume":"40","author":"Perkins","year":"2015","journal-title":"Trends Biochem Sci"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"19294","DOI":"10.3390\/ijms140919294","article-title":"Oxidative stress in the pathogenesis of Keratoconus and Fuchs endothelial corneal dystrophy","volume":"14","author":"Wojcik","year":"2013","journal-title":"Int J Mol Sci"},{"issue":"2","key":"bib70","doi-asserted-by":"publisher","first-page":"e0172365","DOI":"10.1371\/journal.pone.0172365","article-title":"Replication of SNP associations with keratoconus in a Czech cohort","volume":"12","author":"Liskova","year":"2017","journal-title":"PLoS One"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/ng.2506","article-title":"Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus","volume":"45","author":"Lu","year":"2013","journal-title":"Nat Genet"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1001\/jamaophthalmol.2019.2058","article-title":"Genetic variants associated with corneal biomechanical properties and potentially conferring susceptibility to keratoconus in a genome-wide association study","volume":"137","author":"Khawaja","year":"2019","journal-title":"JAMA Ophthalmol"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.redox.2015.06.019","article-title":"Redox regulation of FoxO transcription factors","volume":"6","author":"Klotz","year":"2015","journal-title":"Redox Biol"},{"issue":"1-2","key":"bib74","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/BF00142711","article-title":"The keratoconus epithelium studied by SEM","volume":"67","author":"Jongebloed","year":"1987","journal-title":"Doc Ophthalmol"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/j.1444-0938.2007.00195.x","article-title":"New perspectives on keratoconus as revealed by corneal confocal microscopy","volume":"91","author":"Efron","year":"2008","journal-title":"Clin Exp Optom"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1097\/PAT.0b013e3283511b42","article-title":"An in-depth analysis of histopathological characteristics found in keratoconus","volume":"44","author":"Sykakis","year":"2012","journal-title":"Pathology"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1006\/exer.1996.0038","article-title":"Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing","volume":"62","author":"Wilson","year":"1996","journal-title":"Exp Eye Res"},{"key":"bib78","first-page":"2480","article-title":"Evaluation of differentially expressed genes identified in keratoconus","volume":"15","author":"Lee","year":"2009","journal-title":"Mol Vis"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/s42003-020-1037-7","article-title":"A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness","volume":"3","author":"Choquet","year":"2020","journal-title":"Commun Biol"},{"issue":"4","key":"bib80","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.tcb.2010.01.001","article-title":"ADF\/Cofilin: a functional node in cell biology","volume":"20","author":"Bernstein","year":"2010","journal-title":"Trends Cell Biol"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0074-7696(05)45001-9","article-title":"Calpain proteases in cell adhesion and motility","volume":"245","author":"Wells","year":"2005","journal-title":"Int Rev Cytol"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"3464","DOI":"10.1091\/mbc.E14-12-1584","article-title":"Ezrin regulates focal adhesion and invadopodia dynamics by altering calpain activity to promote breast cancer cell invasion","volume":"26","author":"Hoskin","year":"2015","journal-title":"Mol Biol Cell"},{"issue":"11","key":"bib83","doi-asserted-by":"publisher","first-page":"e13921","DOI":"10.1371\/journal.pone.0013921","article-title":"a-actinin-4 is essential for maintaining the spreading, motility and contractility of fibroblasts","volume":"5","author":"Shao","year":"2010","journal-title":"PLoS One"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"21265","DOI":"10.1074\/jbc.274.30.21265","article-title":"Calpain mediates integrin-induced signaling at a point upstream of Rho family members","volume":"274","author":"Kulkarni","year":"1999","journal-title":"J Biol Chem"},{"issue":"Pt 18","key":"bib85","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1242\/jcs.112.18.3081","article-title":"Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin\/beta-catenin","volume":"112","author":"Hiscox","year":"1999","journal-title":"J Cell Sci"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"101234","DOI":"10.1016\/j.preteyeres.2023.101234","article-title":"Squishy matters\u2014corneal mechanobiology in health and disease","volume":"99","author":"Thomasy","year":"2024","journal-title":"Prog Retin Eye Res"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.exer.2011.01.008","article-title":"Differential epithelial and stromal protein profiles in keratoconus and normal human corneas","volume":"92","author":"Joseph","year":"2011","journal-title":"Exp Eye Res"},{"key":"bib88","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1002\/cm.20007","article-title":"Alpha-actinin revisited: a fresh look at an old player","volume":"58","author":"Otey","year":"2004","journal-title":"Cell Motil Cytoskeleton"},{"key":"bib89","doi-asserted-by":"publisher","first-page":"6181","DOI":"10.1167\/iovs.10-70981","article-title":"Comparative transcriptome and network biology analyses demonstrate antiproliferative and hyperapoptotic phenotypes in human keratoconus corneas","volume":"52","author":"Mac\u00e9","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib90","doi-asserted-by":"publisher","first-page":"7803029","DOI":"10.1155\/2017\/7803029","article-title":"Molecular and histopathological changes associated with keratoconus","volume":"2017","author":"Khaled","year":"2017","journal-title":"Biomed Res Int"},{"key":"bib91","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.3390\/cells10082076","article-title":"Arginine supplementation promotes extracellular matrix and metabolic changes in keratoconus","volume":"10","author":"McKay","year":"2021","journal-title":"Cells"},{"key":"bib92","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00417-016-3520-x","article-title":"Arginase activity, urea, and hydroxyproline concentration are reduced in keratoconus keratocytes","volume":"255","author":"Stachon","year":"2017","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib93","first-page":"451","article-title":"Label-free LC-MS\/MS quantitative analysis of aqueous humor from keratoconic and normal eyes","volume":"21","author":"Soria","year":"2015","journal-title":"Mol Vis"},{"key":"bib94","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1007\/s10792-017-0672-6","article-title":"Comparative proteome analysis of the tear samples in patients with low-grade keratoconus","volume":"38","author":"Yenihayat","year":"2018","journal-title":"Int Ophthalmol"},{"key":"bib65","first-page":"2062","article-title":"Assessment of serum catalase, reduced glutathione, and superoxide dismutase activities and malondialdehyde levels in keratoconus patients","volume-title":"Eye (Lond)","author":"Tekin","year":"2022"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2803029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:05Z","timestamp":1791927125000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2803029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":94,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.5.41","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,28]]}}}