{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:00:53Z","timestamp":1791928853467,"version":"4.3.4"},"reference-count":94,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,6,4]]},"DOI":"10.1167\/iovs.66.6.12","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T11:30:36Z","timestamp":1749036636000},"page":"12","source":"Crossref","is-referenced-by-count":6,"title":["Adrenomedullin-RAMP2 System Modulates Inflammation and Tissue Repair in Experimental Autoimmune Uveitis Via T-Cell and M2 Macrophage Regulation"],"prefix":"10.1167","volume":"66","author":[{"given":"Yorishige","family":"Matsuda","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"},{"name":"Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kakihara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"},{"name":"Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Hoshiyama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"},{"name":"Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Kamiyoshi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Ichikawa-Shindo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisaka","family":"Kawate","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiake","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Sanjo","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Immunology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Shindo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Research, Shinshu University School of Medicine, Matsumoto, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"280","DOI":"10.12688\/f1000research.10587.1","article-title":"Recent advances in managing and understanding uveitis","volume":"6","author":"Chen","year":"2017","journal-title":"F1000Res"},{"issue":"3","key":"bib2","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.ophtha.2003.06.014","article-title":"Incidence and prevalence of uveitis in Northern California; the Northern California Epidemiology of Uveitis Study","volume":"111","author":"Gritz","year":"2004","journal-title":"Ophthalmology"},{"issue":"4","key":"bib3","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1136\/bjo.80.4.332","article-title":"Causes and frequency of blindness in patients with intraocular inflammatory disease","volume":"80","author":"Rothova","year":"1996","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/09273948.2016.1196713","article-title":"A focus on the epidemiology of uveitis","volume":"26","author":"Tsirouki","year":"2018","journal-title":"Ocul Immunol Inflamm"},{"issue":"6","key":"bib5","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.preteyeres.2011.06.005","article-title":"Understanding uveitis: the impact of research on visual outcomes","volume":"30","author":"de Smet","year":"2011","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"bib6","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/00005792-200107000-00005","article-title":"Chronic severe uveitis: etiology and visual outcome in 927 patients from a single center","volume":"80","author":"Bodaghi","year":"2001","journal-title":"Med (Baltim)"},{"issue":"9","key":"bib7","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1136\/bjo.2003.037226","article-title":"Degree, duration, and causes of visual loss in uveitis","volume":"88","author":"Durrani","year":"2004","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"bib8","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/s10384-020-00809-1","article-title":"Epidemiology of uveitis in Japan: a 2016 retrospective nationwide survey","volume":"65","author":"Sonoda","year":"2021","journal-title":"Jpn J Ophthalmol"},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s40265-015-0502-y","article-title":"Non-infectious uveitis: optimising the therapeutic response","volume":"76","author":"Airody","year":"2016","journal-title":"Drugs"},{"issue":"4","key":"bib10","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/s10238-022-00954-6","article-title":"Pathogenesis and current therapies for non-infectious uveitis","volume":"23","author":"Wu","year":"2023","journal-title":"Clin Exp Med"},{"issue":"3\u20134","key":"bib11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000119871","article-title":"Mouse models of experimental autoimmune uveitis","volume":"40","author":"Caspi","year":"2008","journal-title":"Ophthalmic Res"},{"issue":"4","key":"bib12","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.4049\/jimmunol.156.4.1654","article-title":"Establishment and characterization of a murine CD4+ T cell line and clone that induce experimental autoimmune uveoretinitis in B10.A mice","volume":"156","author":"Rizzo","year":"1996","journal-title":"J Immunol"},{"issue":"3","key":"bib13","doi-asserted-by":"publisher","first-page":"928","DOI":"10.4049\/jimmunol.136.3.928","article-title":"T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat","volume":"136","author":"Caspi","year":"1986","journal-title":"J Immunol"},{"issue":"2","key":"bib14","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1590\/S0004-27492012000200016","article-title":"Experimental models of autoimmune inflammatory ocular diseases","volume":"75","author":"Gasparin","year":"2012","journal-title":"Arq Bras Oftalmol"},{"issue":"suppl)","key":"bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/02713689008999424","article-title":"Comparison of clinical and experimental uveitis","volume":"9","author":"Forrester","year":"1990","journal-title":"Curr Eye Res"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1136\/bjo.79.1.81","article-title":"Experimental approaches to specific immunotherapies in autoimmune disease: future treatment of endogenous posterior uveitis?","volume":"79","author":"Dick","year":"1995","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"bib17","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1097\/00004836-200110000-00006","article-title":"Side effects of corticosteroid therapy","volume":"33","author":"Buchman","year":"2001","journal-title":"J Clin Gastroenterol"},{"issue":"5","key":"bib18","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1097\/NOR.0000000000000595","article-title":"Corticosteroids","volume":"38","author":"Kapugi","year":"2019","journal-title":"Orthop Nurs"},{"issue":"5","key":"bib19","doi-asserted-by":"publisher","first-page":"705","DOI":"10.5301\/ejo.5000278","article-title":"Review on the worldwide epidemiology of uveitis","volume":"23","author":"Miserocchi","year":"2013","journal-title":"Eur J Ophthalmol"},{"issue":"2","key":"bib20","doi-asserted-by":"publisher","first-page":"111","DOI":"10.2165\/00002018-200022020-00004","article-title":"Corticosteroid-induced adverse psychiatric effects: incidence, diagnosis and management","volume":"22","author":"Patten","year":"2000","journal-title":"Drug Saf"},{"issue":"11","key":"bib21","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1016\/j.clinthera.2017.09.011","article-title":"Long-term systemic corticosteroid exposure: a systematic literature review","volume":"39","author":"Rice","year":"2017","journal-title":"Clin Ther"},{"issue":"6","key":"bib22","first-page":"337","article-title":"Topical corticosteroids: choice and application","volume":"103","author":"Stacey","year":"2021","journal-title":"Am Fam Physician"},{"issue":"1","key":"bib23","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1471-2415-13-39","article-title":"Local therapies for inflammatory eye disease in translation: past, present and future","volume":"13","author":"Tempest-Roe","year":"2013","journal-title":"BMC Ophthalmol"},{"issue":"6","key":"bib24","doi-asserted-by":"publisher","first-page":"472","DOI":"10.2165\/00003088-199324060-00004","article-title":"Cyclosporin clinical pharmacokinetics","volume":"24","author":"Fahr","year":"1993","journal-title":"Clin Pharmacokinet"},{"issue":"4","key":"bib25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3949\/ccjm.61.4.308","article-title":"Cyclosporine: mechanisms of action and toxicity","volume":"61","author":"Graham","year":"1994","journal-title":"Cleve Clin J Med"},{"issue":"6","key":"bib26","first-page":"356","article-title":"The side-effects of ciclosporine-A and tacrolimus","volume":"49","author":"Mihatsch","year":"1998","journal-title":"Clin Nephrol"},{"issue":"1","key":"bib27","first-page":"CD007893","article-title":"Effect of cyclosporine on blood pressure","author":"Robert","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"bib28","doi-asserted-by":"publisher","first-page":"377","DOI":"10.5414\/CP202171","article-title":"Effectiveness of infliximab, adalimumab and golimumab for non-infectious refractory uveitis in adults","volume":"53","author":"Borr\u00e1s-Blasco","year":"2015","journal-title":"Int J Clin Pharmacol Ther"},{"issue":"5","key":"bib29","first-page":"686","article-title":"Biologics in the treatment of uveitis","volume":"239","author":"Dingerkus","year":"2022","journal-title":"Klin Monbl Augenheilkd"},{"issue":"11","key":"bib30","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.3390\/jcm9113599","article-title":"Biotherapies in uveitis","volume":"9","author":"Leclercq","year":"2020","journal-title":"J Clin Med"},{"issue":"4","key":"bib31","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.3390\/jcm12041630","article-title":"Past, present and (foreseeable) future of biological anti-TNF alpha therapy","volume":"12","author":"Leone","year":"2023","journal-title":"J Clin Med"},{"issue":"1","key":"bib32","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/s12886-023-02987-1","article-title":"Comparison of infliximab with adalimumab for the treatment of non-infectious uveitis: a systematic review and meta-analysis","volume":"23","author":"Liu","year":"2023","journal-title":"BMC Ophthalmol"},{"issue":"1","key":"bib33","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3109\/09273948.2011.633205","article-title":"Infliximab and adalimumab for uveitis","volume":"20","author":"Martel","year":"2012","journal-title":"Ocul Immunol Inflamm"},{"issue":"1","key":"bib34","doi-asserted-by":"publisher","first-page":"e001303","DOI":"10.1136\/bmjophth-2023-001303","article-title":"Systematic review of studies comparing infliximab and adalimumab in autoimmune uveitis","volume":"8","author":"Mase","year":"2023","journal-title":"BMJ Open Ophthalmol"},{"issue":"9","key":"bib35","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.4103\/ijo.IJO_2492_20","article-title":"Systemic immunosuppressive therapies for uveitis in developing countries","volume":"68","author":"Agrawal","year":"2020","journal-title":"Indian J Ophthalmol"},{"issue":"3","key":"bib36","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1006\/bbrc.1993.1451","article-title":"Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma","volume":"192","author":"Kitamura","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.peptides.2018.04.004","article-title":"Regulation of cardiovascular development and homeostasis by the adrenomedullin-RAMP system","volume":"111","author":"Shindo","year":"2019","journal-title":"Peptides"},{"issue":"3","key":"bib38","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1152\/physrev.00037.2003","article-title":"Vascular actions of calcitonin gene-related peptide and adrenomedullin","volume":"84","author":"Brain","year":"2004","journal-title":"Physiol Rev"},{"issue":"12","key":"bib39","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1161\/01.ATV.0000184759.91369.f8","article-title":"Adrenomedullin: a protective factor for blood vessels","volume":"25","author":"Kato","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"bib40","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1161\/01.HYP.0000066846.46422.2C","article-title":"Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress","volume":"41","author":"Shimosawa","year":"2003","journal-title":"Hypertension"},{"issue":"19","key":"bib41","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1161\/01.CIR.101.19.2309","article-title":"Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature","volume":"101","author":"Shindo","year":"2000","journal-title":"Circulation"},{"issue":"1","key":"bib42","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1161\/hc0102.101399","article-title":"Adrenomedullin, an endogenous peptide, counteracts cardiovascular damage","volume":"105","author":"Shimosawa","year":"2002","journal-title":"Circulation"},{"issue":"1\u20133","key":"bib43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0167-0115(03)00027-2","article-title":"Adrenomedullin in the eye","volume":"112","author":"Udono-Fujimori","year":"2003","journal-title":"Regul Pept"},{"issue":"5","key":"bib44","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.ajpath.2017.01.014","article-title":"Adrenomedullin suppresses vascular endothelial growth factor-induced vascular hyperpermeability and inflammation in retinopathy","volume":"187","author":"Imai","year":"2017","journal-title":"Am J Pathol"},{"issue":"2","key":"bib45","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.ajpath.2018.10.021","article-title":"Development of a novel model of central retinal vascular occlusion and the therapeutic potential of the adrenomedullin-receptor activity-modifying protein 2 system","volume":"189","author":"Hirabayashi","year":"2019","journal-title":"Am J Pathol"},{"issue":"4","key":"bib46","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.ajpath.2020.12.012","article-title":"Adrenomedullin-receptor activity-modifying protein 2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in Age-related macular degeneration","volume":"191","author":"Tanaka","year":"2021","journal-title":"Am J Pathol"},{"issue":"16","key":"bib47","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1161\/hc4101.097111","article-title":"Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene","volume":"104","author":"Shindo","year":"2001","journal-title":"Circulation"},{"issue":"1","key":"bib48","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1172\/JCI33022","article-title":"The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity","volume":"118","author":"Ichikawa-Shindo","year":"2008","journal-title":"J Clin Invest"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.yjmcc.2014.09.017","article-title":"Functional differentiation of RAMP2 and RAMP3 in their regulation of vascular system","volume":"77","author":"Yamauchi","year":"2014","journal-title":"J Mol Cell Cardiol"},{"issue":"6","key":"bib50","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1167\/iovs.06-1099","article-title":"Panretinal, high-resolution color photography of the mouse fundus","volume":"48","author":"Paques","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.exer.2016.10.003","article-title":"Invariant natural killer T cells play dual roles in the development of experimental autoimmune uveoretinitis","volume":"153","author":"Satoh","year":"2016","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib52","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1093\/intimm\/dxl125","article-title":"WSX-1 plays a significant role for the initiation of experimental autoimmune uveitis","volume":"19","author":"Sonoda","year":"2007","journal-title":"Int Immunol"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.exer.2014.06.004","article-title":"EBI3 is pivotal for the initiation of experimental autoimmune uveitis","volume":"125","author":"Takeda","year":"2014","journal-title":"Exp Eye Res"},{"issue":"3","key":"bib54","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s10384-018-0587-4","article-title":"Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis","volume":"62","author":"Takeda","year":"2018","journal-title":"Jpn J Ophthalmol"},{"issue":"12","key":"bib55","doi-asserted-by":"publisher","first-page":"5458","DOI":"10.1167\/iovs.08-2348","article-title":"The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation","volume":"49","author":"Copland","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib56","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/S0021-5155(02)00538-5","article-title":"Suppression of experimental autoimmune uveoretinitis by anti-alphabeta TCR monoclonal antibody","volume":"46","author":"Inoki","year":"2002","journal-title":"Jpn J Ophthalmol"},{"issue":"20","key":"bib57","doi-asserted-by":"publisher","first-page":"9989","DOI":"10.1073\/pnas.1820387116","article-title":"Retinal microglia initiate neuroinflammation in ocular autoimmunity","volume":"116","author":"Okunuki","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib58","first-page":"1518","article-title":"Treatment of experimental autoimmune uveoretinitis with peroxisome proliferator-activated receptor a agonist fenofibrate","volume":"20","author":"Osada","year":"2014","journal-title":"Mol Vis"},{"issue":"4","key":"bib59","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.exer.2005.09.003","article-title":"Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate","volume":"82","author":"Sakai","year":"2006","journal-title":"Exp Eye Res"},{"issue":"9","key":"bib60","doi-asserted-by":"publisher","first-page":"e0138241","DOI":"10.1371\/journal.pone.0138241","article-title":"Dietary omega-3 fatty acids suppress experimental autoimmune uveitis in association with inhibition of Th1 and Th17 cell function","volume":"10","author":"Shoda","year":"2015","journal-title":"PLoS ONE"},{"issue":"2","key":"bib61","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1046\/j.1365-2249.1997.4571356.x","article-title":"Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): induction of protective tolerance in primed animals","volume":"109","author":"Thurau","year":"1997","journal-title":"Clin Exp Immunol"},{"issue":"23","key":"bib62","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.21037\/atm-22-2293","article-title":"Optimization of determinant factors associated with the efficiency of experimental autoimmune uveitis induction in C57BL\/6 mice","volume":"10","author":"Yang","year":"2022","journal-title":"Ann Transl Med"},{"issue":"6","key":"bib63","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1167\/iovs.09-4754","article-title":"The role of TLR2, TRL3, TRL4, and TRL9 signaling in the pathogenesis of autoimmune disease in a retinal autoimmunity model","volume":"51","author":"Fang","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib64","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/imm.12691","article-title":"Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms","volume":"150","author":"Klaska","year":"2017","journal-title":"Immunology"},{"issue":"11","key":"bib65","doi-asserted-by":"publisher","first-page":"8076","DOI":"10.1167\/iovs.11-7830","article-title":"Aldose reductase deficiency protects from autoimmune- and endotoxin-induced uveitis in mice","volume":"52","author":"Yadav","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2014.12.004","article-title":"Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease","volume":"58","author":"Yazid","year":"2015","journal-title":"J Autoimmun"},{"issue":"1","key":"bib67","doi-asserted-by":"publisher","first-page":"140","DOI":"10.5507\/bp.2015.056","article-title":"The critical points in induction of experimental autoimmune uveitis","volume":"160","author":"Klimova","year":"2016","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"issue":"3","key":"bib68","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.ajpath.2020.09.004","article-title":"Characterization of clinical and immune responses in an experimental chronic autoimmune uveitis model","volume":"191","author":"Fan","year":"2021","journal-title":"Am J Pathol"},{"issue":"12","key":"bib69","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.4049\/jimmunol.2100568","article-title":"The calcium channel inhibitor nimodipine shapes the uveitogenic T cells and protects mice from experimental autoimmune uveitis through the p38-MAPK signaling pathway","volume":"207","author":"Hu","year":"2021","journal-title":"J Immunol"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"859260","DOI":"10.3389\/fimmu.2022.859260","article-title":"Hydroxychloroquine alleviates EAU by inhibiting uveitogenic T cells and ameliorating retinal vascular endothelial cells dysfunction","volume":"13","author":"Hu","year":"2022","journal-title":"Front Immunol"},{"issue":"4","key":"bib71","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1093\/cvr\/cvw166","article-title":"The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis","volume":"111","author":"Tanaka","year":"2016","journal-title":"Cardiovasc Res"},{"issue":"8","key":"bib72","doi-asserted-by":"publisher","first-page":"bqab090","DOI":"10.1210\/endocr\/bqab090","article-title":"Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-\u00df-Smads signaling and myofibroblast differentiation","volume":"162","author":"Wei","year":"2021","journal-title":"Endocrinology"},{"issue":"10","key":"bib73","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/S0196-9781(02)00145-6","article-title":"Elevated immunoreactive-adrenomedullin levels in the aqueous humor of patients with uveitis and vitreoretinal disorders","volume":"23","author":"Udono","year":"2002","journal-title":"Peptides"},{"key":"bib74","first-page":"1339","article-title":"Evidence for a functional adrenomedullin signaling pathway in the mouse retina","volume":"18","author":"Blom","year":"2012","journal-title":"Mol Vis"},{"key":"bib75","first-page":"259","article-title":"Adrenomedullin22-52 suppresses high-glucose-induced migration, proliferation, and tube formation of human retinal endothelial cells","volume":"20","author":"Chen","year":"2014","journal-title":"Mol Vis"},{"issue":"13","key":"bib76","first-page":"3245","article-title":"Effects of adrenomedullin on cyclic AMP formation and on relaxation in iris sphincter smooth muscle","volume":"40","author":"Yousufzai","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib77","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1006\/exer.1999.0737","article-title":"Ocular effects of adrenomedullin","volume":"69","author":"Taniguchi","year":"1999","journal-title":"Exp Eye Res"},{"issue":"10","key":"bib78","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1038\/s41436-019-0507-0","article-title":"Mutant RAMP2 causes primary open-angle glaucoma via the CRLR-cAMP axis","volume":"21","author":"Gong","year":"2019","journal-title":"Genet Med"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.bbi.2013.11.021","article-title":"Adrenomedullin protects from experimental autoimmune encephalomyelitis at multiple levels","volume":"37","author":"Pedre\u00f1o","year":"2014","journal-title":"Brain Behav Immun"},{"issue":"1","key":"bib80","doi-asserted-by":"publisher","first-page":"263","DOI":"10.2353\/ajpath.2007.060596","article-title":"Adrenomedullin protects from experimental arthritis by down-regulating inflammation and Th1 response and inducing regulatory T cells","volume":"170","author":"Gonzalez-Rey","year":"2007","journal-title":"Am J Pathol"},{"issue":"2","key":"bib81","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3390\/biom12020156","article-title":"Adrenomedullin: not just another gastrointestinal peptide","volume":"12","author":"Mart\u00ednez-Herrero","year":"2022","journal-title":"Biomolecules"},{"issue":"2","key":"bib82","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/j.1365-2567.2012.03577.x","article-title":"Adrenomedullin, a neuropeptide with immunoregulatory properties induces semi-mature tolerogenic dendritic cells","volume":"136","author":"Rull\u00e9","year":"2012","journal-title":"Immunology"},{"key":"bib83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2012.10.553","article-title":"IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes\/macrophages","volume":"54","author":"Bhattacharjee","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep"},{"issue":"3","key":"bib85","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"issue":"pt 2","key":"bib86","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/brain\/awh707","article-title":"Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis","volume":"129","author":"Boven","year":"2006","journal-title":"Brain"},{"issue":"9","key":"bib87","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1084\/jem.20100209","article-title":"IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells","volume":"207","author":"Grinberg-Bleyer","year":"2010","journal-title":"J Exp Med"},{"issue":"4","key":"bib88","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1053\/j.gastro.2009.12.041","article-title":"In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice","volume":"138","author":"Hunter","year":"2010","journal-title":"Gastroenterology"},{"issue":"2","key":"bib89","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/cea.12880","article-title":"Revisiting type 2-high and type 2-low airway inflammation in asthma: current knowledge and therapeutic implications","volume":"47","author":"Robinson","year":"2017","journal-title":"Clin Exp Allergy"},{"issue":"10","key":"bib90","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1016\/j.mayocp.2021.04.025","article-title":"Eosinophils in health and disease: a state-of-the-art review","volume":"96","author":"Wechsler","year":"2021","journal-title":"Mayo Clin Proc"},{"issue":"22","key":"bib91","doi-asserted-by":"publisher","first-page":"9311","DOI":"10.1158\/0008-5472.CAN-08-2810","article-title":"Human adrenomedullin up-regulates interleukin-13 receptor alpha2 chain in prostate cancer in vitro and in vivo: a novel approach to sensitize prostate cancer to anticancer therapy","volume":"68","author":"Joshi","year":"2008","journal-title":"Cancer Res"},{"issue":"11","key":"bib92","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1248\/bpb.b20-00373","article-title":"Activation of calcitonin gene-related peptide and adrenomedullin receptors by PEGylated adrenomedullin","volume":"43","author":"Akashi","year":"2020","journal-title":"Biol Pharm Bull"},{"issue":"3\u20134","key":"bib93","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/ddr.21383","article-title":"Anti-inflammatory effects of PEGylated human adrenomedullin in a mouse DSS-induced colitis model","volume":"78","author":"Nagata","year":"2017","journal-title":"Drug Dev Res"},{"key":"bib94","doi-asserted-by":"publisher","first-page":"170133","DOI":"10.1016\/j.peptides.2019.170133","article-title":"Polyethylene glycol-conjugated human adrenomedullin as a possible treatment for vascular dementia","volume":"121","author":"Nagata","year":"2019","journal-title":"Peptides"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2803075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:58Z","timestamp":1791927118000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2803075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":94,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.6.12","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,4]]}}}