{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:33Z","timestamp":1791928893654,"version":"4.3.4"},"reference-count":29,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"9","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,7,3]]},"DOI":"10.1167\/iovs.66.9.10","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T09:30:41Z","timestamp":1751535041000},"page":"10","source":"Crossref","is-referenced-by-count":3,"title":["Diabetes-Induced Dysregulation of Peripapillary and Macular Neurovascular Units"],"prefix":"10.1167","volume":"66","author":[{"given":"Mizuho","family":"Mitamura","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Kase","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"},{"name":"Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Nara Medical University, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiyuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Katsuta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"1","key":"bib1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00417-016-3548-y","article-title":"The neurovascular unit and the pathophysiologic basis of diabetic retinopathy","volume":"255","author":"Gardner","year":"2017","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"2","key":"bib2","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood\u2013brain barrier\/neurovascular unit in health and disease","volume":"57","author":"Hawkins","year":"2005","journal-title":"Pharmacol Rev"},{"issue":"4","key":"bib3","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1113\/expphysiol.2006.036376","article-title":"Signalling within the neurovascular unit in the mammalian retina","volume":"92","author":"Metea","year":"2007","journal-title":"Exp Physiol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.ajo.2019.04.035","article-title":"Measurable aspects of the retinal neurovascular unit in diabetes, glaucoma, and controls","volume":"207","author":"Spaide","year":"2019","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"bib5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00417-022-05773-9","article-title":"Peripapillary circulatory dysfunction precedes structural loss in treatment-naive diabetic retinopathy","volume":"261","author":"Mitamura","year":"2023","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"42201","DOI":"10.1038\/srep42201","article-title":"Detailed vascular anatomy of the human retina by projection-resolved optical coherence tomography angiography","volume":"7","author":"Campbell","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"bib7","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/IJG.0000000000001216","article-title":"Effect of scan size on glaucoma diagnostic performance using OCT angiography en face images of the radial peripapillary capillaries","volume":"28","author":"Chang","year":"2019","journal-title":"J Glaucoma"},{"issue":"11","key":"bib8","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1136\/bjophthalmol-2020-317181","article-title":"Intrasession repeatability and intersession reproducibility of peripapillary OCTA vessel parameters in non-glaucomatous and glaucomatous eyes","volume":"105","author":"Lee","year":"2021","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3390\/medicina56010044","article-title":"Functional and structural reliability of optic nerve head measurements in healthy eyes by means of optical coherence tomography angiography","volume":"56","author":"Mastropasqua","year":"2020","journal-title":"Medicina (Kaunas)"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"102008","DOI":"10.1016\/j.pdpdt.2020.102008","article-title":"The correlation of radial peripapillary capillary density measurements with optic nerve head morphology and retinal nerve fiber layer thickness in healthy eyes","volume":"32","author":"Ozcan","year":"2020","journal-title":"Photodiagnosis Photodyn Ther"},{"issue":"2","key":"bib11","doi-asserted-by":"publisher","first-page":"125","DOI":"10.21037\/qims.2016.03.05","article-title":"Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography","volume":"6","author":"Chen","year":"2016","journal-title":"Quant Imaging Med Surg"},{"issue":"9","key":"bib12","doi-asserted-by":"publisher","first-page":"OCT475","DOI":"10.1167\/iovs.15-18909","article-title":"Peripapillary retinal nerve fiber layer vascular microcirculation in glaucoma using optical coherence tomography-based microangiography","volume":"57","author":"Chen","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1373363","DOI":"10.3389\/fendo.2024.1373363","article-title":"Correlation between vessel density and thickness in the retina and choroid of severe non-proliferative diabetic retinopathy patients","volume":"15","author":"He","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7","key":"bib14","doi-asserted-by":"publisher","first-page":"e0219164","DOI":"10.1371\/journal.pone.0219164","article-title":"Reduced vessel density in the superficial and deep plexuses in diabetic retinopathy is associated with structural changes in corresponding retinal layers","volume":"14","author":"Lavia","year":"2019","journal-title":"PLoS One"},{"issue":"4","key":"bib15","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1159\/000522527","article-title":"Association between neurodegeneration and macular perfusion in the progression of diabetic retinopathy: a 3-year longitudinal study","volume":"245","author":"Marques","year":"2022","journal-title":"Ophthalmologica"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1167\/iovs.16-20531","article-title":"Quantitative retinal optical coherence tomography angiography in patients with diabetes without diabetic retinopathy","volume":"58","author":"Dimitrova","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/s12886-021-01988-2","article-title":"Quantitative analysis of retinal vessel density and thickness changes in diabetes mellitus evaluated using optical coherence tomography angiography: a cross-sectional study","volume":"21","author":"Li","year":"2021","journal-title":"BMC Ophthalmol"},{"issue":"4","key":"bib18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1167\/tvst.8.4.14","article-title":"Peripapillary region perfusion and retinal nerve fiber layer thickness abnormalities in diabetic retinopathy assessed by OCT angiography","volume":"8","author":"Liu","year":"2019","journal-title":"Transl Vis Sci Technol"},{"issue":"12","key":"bib19","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1097\/IAE.0000000000002328","article-title":"Peripapillary neurovascular coupling in the early stages of diabetic retinopathy","volume":"39","author":"Rodrigues","year":"2019","journal-title":"Retina"},{"issue":"12","key":"bib20","doi-asserted-by":"publisher","first-page":"5074","DOI":"10.1167\/iovs.18-24891","article-title":"Peripapillary microvascular and neural changes in diabetes mellitus: an OCT-angiography study","volume":"59","author":"Vujosevic","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib21","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1167\/iovs.18-26288","article-title":"Changes in peripapillary microvasculature and retinal thickness in the fellow eyes of patients with unilateral retinal vein occlusion: an OCTA study","volume":"60","author":"Shin","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.1038\/s41598-021-82334-w","article-title":"Factors based on optical coherence tomography correlated with vision impairment in diabetic patients","volume":"11","author":"Endo","year":"2021","journal-title":"Sci Rep"},{"issue":"3","key":"bib23","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1167\/iovs.16-21079","article-title":"Alterations of the foveal avascular zone measured by optical coherence tomography angiography in glaucoma patients with central visual field defects","volume":"58","author":"Kwon","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"16299","DOI":"10.1038\/s41598-019-52818-x","article-title":"Signal strength as an important factor in the analysis of peripapillary microvascular density using optical coherence tomography angiography","volume":"9","author":"Lim","year":"2019","journal-title":"Sci Rep"},{"key":"bib25","first-page":"5014035","article-title":"Quantification of microvascular density of the optic nerve head in diabetic retinopathy using optical coherence tomographic angiography","volume":"2020","author":"Huang","year":"2020","journal-title":"J Ophthalmol"},{"issue":"5","key":"bib26","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00592-019-01288-8","article-title":"Do microvascular changes occur preceding neural impairment in early-stage diabetic retinopathy? Evidence based on the optic nerve head using optical coherence tomography angiography","volume":"56","author":"Li","year":"2019","journal-title":"Acta Diabetol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"937999","DOI":"10.3389\/fnagi.2022.937999","article-title":"Neuroinflammation and neurodegeneration in diabetic retinopathy","volume":"14","author":"Bianco","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ajo.2020.09.032","article-title":"Early detection of microvascular impairments with optical coherence tomography angiography in diabetic patients without clinical retinopathy: a meta-analysis","volume":"222","author":"Zhang","year":"2021","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"bib29","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1001\/jamaophthalmol.2019.4821","article-title":"Assessing the use of incorrectly scaled optical coherence tomography angiography images in peer-reviewed studies: a systematic review","volume":"138","author":"Llanas","year":"2020","journal-title":"JAMA Ophthalmol"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2809184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:57Z","timestamp":1791927117000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2809184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.9.10","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,3]]}}}