{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:04:59Z","timestamp":1793376299601,"version":"4.5.0"},"reference-count":45,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"9","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,7,11]]},"DOI":"10.1167\/iovs.66.9.28","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T13:30:31Z","timestamp":1752240631000},"page":"28","source":"Crossref","is-referenced-by-count":8,"title":["Transcriptomic Analysis of Human Lens Epithelium Tissue With and Without Cataract Surgery: Uncovering Novel Pathways of Post-Surgical Lens Epithelium Remodeling"],"prefix":"10.1167","volume":"66","author":[{"given":"Caili","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongbo","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazi Rafsan","family":"Radeen","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Environmental & Public Health, University of Cincinnati, Cincinnati, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharad","family":"Purohit","sequence":"additional","affiliation":[{"name":"Center for Biotechnology & Genomic Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"100008","DOI":"10.1016\/j.aopr.2021.100008","article-title":"Cataract: advances in surgery and whether surgery remains the only treatment in future","volume":"1","author":"Chen","year":"2021","journal-title":"Adv Ophthalmol Pract Res"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.ophtha.2015.12.020","article-title":"Office-based cataract surgery: population health outcomes study of more than 21 000 cases in the United States","volume":"123","author":"Ianchulev","year":"2016","journal-title":"Ophthalmology"},{"key":"bib3","first-page":"e30110","article-title":"Endophthalmitis after cataract surgery: a postoperative complication","volume":"14","author":"Wadbudhe","year":"2022","journal-title":"Cureus"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12348-019-0170-2","article-title":"Evaluation of the etiology of persistent iritis after cataract surgery","volume":"9","author":"Neatrour","year":"2019","journal-title":"J Ophthalmic Inflamm Infect"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1034\/j.1600-0420.1998.760512.x","article-title":"Inflammatory response after cataract surgery","volume":"76","author":"Laurell","year":"1998","journal-title":"Acta Ophthalmol Scand"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1007\/s40123-022-00513-y","article-title":"Prevalence and characteristics of dry eye disease after cataract surgery: a systematic review and meta-analysis","volume":"11","author":"Miura","year":"2022","journal-title":"Ophthalmol Ther"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"e0152460","DOI":"10.1371\/journal.pone.0152460","article-title":"Observation of influence of cataract surgery on the ocular surface","volume":"11","author":"Park","year":"2016","journal-title":"PLoS One"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/aos.16636","article-title":"Long-term risk of glaucoma after cataract surgery in childhood","volume":"102","author":"Schmidt","year":"2024","journal-title":"Acta Ophthalmol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1042\/BCJ20210069","article-title":"Transforming growth factor-beta2-mediated mesenchymal transition in lens epithelial cells is repressed in the absence of RAGE","volume":"478","author":"Nam","year":"2021","journal-title":"Biochem J"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3928\/0191-3913-19990101-06","article-title":"Refractive status in children after long-term follow up of cataract surgery with intraocular lens implantation","volume":"36","author":"Spierer","year":"1999","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"100905","DOI":"10.1016\/j.preteyeres.2020.100905","article-title":"Posterior capsule opacification: what's in the bag?","volume":"82","author":"Wormstone","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.3390\/biom13121767","article-title":"Understanding the role of yes-associated protein (YAP) signaling in the transformation of lens epithelial cells (EMT) and fibrosis","volume":"13","author":"Taiyab","year":"2023","journal-title":"Biomolecules"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"108829","DOI":"10.1016\/j.exer.2021.108829","article-title":"The local wound environment is a key determinant of the outcome of TGFbeta signaling on the fibrotic response of CD44(+) leader cells in an ex vivo post-cataract-surgery model","volume":"213","author":"Basta","year":"2021","journal-title":"Exp Eye Res"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1038\/s41433-022-02204-1","article-title":"The Royal College of Ophthalmologists\u2019 National Ophthalmology Database study of cataract surgery: Report 9, Risk factors for posterior capsule opacification","volume":"37","author":"Donachie","year":"2023","journal-title":"Eye (Lond)"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1471-2415-15-5","article-title":"Square-edge intraocular lenses and epithelial lens cell proliferation: implications on posterior capsule opacification in an in vitro model","volume":"15","author":"Mencucci","year":"2015","journal-title":"BMC Ophthalmol"},{"key":"bib16","first-page":"CD003738","article-title":"Interventions for preventing posterior capsule opacification","volume":"2010","author":"Findl","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"5736","DOI":"10.1167\/iovs.16-20162","article-title":"Beta-catenin\/CBP-dependent signaling regulates TGF-beta-induced epithelial to mesenchymal transition of lens epithelial cells","volume":"57","author":"Taiyab","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.exer.2018.06.020","article-title":"Spatiotemporal dynamics of canonical Wnt signaling during embryonic eye development and posterior capsular opacification (PCO)","volume":"175","author":"Wang","year":"2018","journal-title":"Exp Eye Res"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1016\/j.ajpath.2017.07.018","article-title":"Reduced glutathione level promotes epithelial-mesenchymal transition in lens epithelial cells via a Wnt\/beta-catenin-mediated pathway: relevance for cataract therapy","volume":"187","author":"Wei","year":"2017","journal-title":"Am J Pathol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1167\/iovs.16-21398","article-title":"Transcriptome of the GSH-depleted lens reveals changes in detoxification and EMT signaling genes, transport systems, and lipid homeostasis","volume":"58","author":"Whitson","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.freeradbiomed.2021.02.010","article-title":"Aging lens epithelium is susceptible to ferroptosis","volume":"167","author":"Wei","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"bib22","first-page":"100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"btafd672","DOI":"10.1093\/bioinformatics\/btad672","article-title":"aPEAR: an R package for autonomous visualization of pathway enrichment networks","volume":"39","author":"Kerseviciute","year":"2023","journal-title":"Bioinformatics"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"e2407842121","DOI":"10.1073\/pnas.2407842121","article-title":"Deficiency in glutathione peroxidase 4 (GPX4) results in abnormal lens development and newborn cataract","volume":"121","author":"Wei","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.3390\/molecules23123205","article-title":"Function and interactions of ERCC1-XPF in DNA damage response","volume":"23","author":"Faridounnia","year":"2018","journal-title":"Molecules"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1097\/ICU.0b013e32834cd60e","article-title":"Postcataract surgical inflammation","volume":"23","author":"Taravati","year":"2012","journal-title":"Curr Opin Ophthalmol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1167\/iovs.66.4.12","article-title":"Elevated inflammatory cytokines persist in the aqueous humor years after cataract surgery","volume":"66","author":"Hao","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"4986","DOI":"10.1167\/iovs.18-25067","article-title":"Lens epithelial cells initiate an inflammatory response following cataract surgery","volume":"59","author":"Jiang","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"3456","DOI":"10.3390\/cells11213456","article-title":"The immediate early response of lens epithelial cells to lens injury","volume":"11","author":"Novo","year":"2022","journal-title":"Cells"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"108663","DOI":"10.1016\/j.exer.2021.108663","article-title":"The aging mouse lens transcriptome","volume":"209","author":"Faranda","year":"2021","journal-title":"Exp Eye Res"},{"key":"bib31","first-page":"348","article-title":"Human lens epithelial cells induce the inflammatory response when placed into the lens capsular bag model of posterior capsular opacification","volume":"30","author":"Novo","year":"2024","journal-title":"Mol Vis"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"9316","DOI":"10.1096\/fj.202000289R","article-title":"An immune response to the avascular lens following wounding of the cornea involves ciliary zonule fibrils","volume":"34","author":"DeDreu","year":"2020","journal-title":"FASEB J"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1089\/jop.2000.16.121","article-title":"Glutathione: a vital lens antioxidant","volume":"16","author":"Giblin","year":"2000","journal-title":"J Ocul Pharmacol Ther"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"3914","DOI":"10.1167\/iovs.16-19592","article-title":"Evidence of dual mechanisms of glutathione uptake in the rodent lens: a novel role for vitreous humor in lens glutathione homeostasis","volume":"57","author":"Whitson","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.tcb.2018.02.001","article-title":"Hallmarks of cellular senescence","volume":"28","author":"Hernandez-Segura","year":"2018","journal-title":"Trends Cell Biol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1091\/mbc.e11-10-0884","article-title":"Lamin B1 loss is a senescence-associated biomarker","volume":"23","author":"Freund","year":"2012","journal-title":"Mol Biol Cell"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"e14249","DOI":"10.1111\/acel.14249","article-title":"Lens capsule advanced glycation end products induce senescence in epithelial cells: implications for secondary cataracts","volume":"23","author":"Cooksley","year":"2024","journal-title":"Aging Cell"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3390\/cells12060827","article-title":"FGF-2 differentially regulates lens epithelial cell behaviour during TGF-beta-induced EMT","volume":"12","author":"Flokis","year":"2023","journal-title":"Cells"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1042\/BCJ20190540","article-title":"Aspirin inhibits TGFbeta2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3","volume":"477","author":"Nam","year":"2020","journal-title":"Biochem J"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1111\/jcmm.13030","article-title":"FGF2 antagonizes aberrant TGFbeta regulation of tropomyosin: role for posterior capsule opacity","volume":"21","author":"Kubo","year":"2017","journal-title":"J Cell Mol Med"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"5318","DOI":"10.1167\/iovs.08-3223","article-title":"TGFbeta\/Smad4-dependent and -independent regulation of human lens epithelial cells","volume":"50","author":"Dawes","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.freeradbiomed.2017.09.019","article-title":"Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins","volume":"113","author":"Whitson","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.exer.2004.04.007","article-title":"Identification and functional clustering of global gene expression differences between age-related cataract and clear human lenses and aged human lenses","volume":"79","author":"Hawse","year":"2004","journal-title":"Exp Eye Res"},{"key":"bib44","first-page":"515","article-title":"Identification and functional clustering of global gene expression differences between human age-related cataract and clear lenses","volume":"9","author":"Hawse","year":"2003","journal-title":"Mol Vis"},{"key":"bib45","first-page":"274","article-title":"Identification of global gene expression differences between human lens epithelial and cortical fiber cells reveals specific genes and their associated pathways important for specialized lens cell functions","volume":"11","author":"Hawse","year":"2005","journal-title":"Mol Vis"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2809217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:01Z","timestamp":1791927121000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2809217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.9.28","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,11]]}}}