{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:16Z","timestamp":1791928876424,"version":"4.3.4"},"reference-count":78,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"9","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2025,7,17]]},"DOI":"10.1167\/iovs.66.9.50","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T13:00:39Z","timestamp":1752757239000},"page":"50","source":"Crossref","is-referenced-by-count":10,"title":["Genetic Associations of Rod- and Cone-Mediated Vision in Aging and Age-Related Macular Degeneration"],"prefix":"10.1167","volume":"66","author":[{"given":"Christine A.","family":"Curcio","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Mullins","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin M.","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Goerdt","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States"},{"name":"Department of Ophthalmology, University of Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepayan","family":"Kar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Gerald","family":"McGwin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States"},{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Owsley","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Global Health"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev-genom-090413-025610","article-title":"Age-related macular degeneration: genetics and biology coming together","volume":"15","author":"Fritsche","year":"2014","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.oret.2024.01.004","article-title":"European unmet needs in the management of neovascular age-related macular degeneration in daily practice: data from the Fight Retinal Blindness! Registry","volume":"8","author":"Boudousq","year":"2024","journal-title":"Ophthalmol Retina"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1097\/IAE.0000000000003796","article-title":"Complement inhibition for geographic atrophy: review of salient functional outcomes and perspective","volume":"43","author":"Spaide","year":"2023","journal-title":"Retina"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1001\/jamaophthalmol.2025.0077","article-title":"Photobiomodulation for age-related macular degeneration","volume":"143","author":"Sadda","year":"2025","journal-title":"JAMA Ophthalmol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/ng.3448","article-title":"A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants","volume":"48","author":"Fritsche","year":"2016","journal-title":"Nat Genet"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1126\/science.1110189","article-title":"Complement factor H polymorphism and age-related macular degeneration","volume":"308","author":"Edwards","year":"2005","journal-title":"Science"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"7227","DOI":"10.1073\/pnas.0501536102","article-title":"A common haplotype in the complement regulatory gene factor H (HF1\/CFH) predisposes individuals to age-related macular degeneration","volume":"102","author":"Hageman","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1126\/science.1110359","article-title":"Complement factor H variant increases the risk of age-related macular degeneration","volume":"308","author":"Haines","year":"2005","journal-title":"Science"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1126\/science.1109557","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"308","author":"Klein","year":"2005","journal-title":"Science"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1086\/422476","article-title":"Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions","volume":"75","author":"Weeks","year":"2004","journal-title":"Am J Hum Genet"},{"key":"bib12","first-page":"57","article-title":"Linkage analysis for age-related macular degeneration supports a gene on chromosome 10q26","volume":"10","author":"Kenealy","year":"2004","journal-title":"Mol Vis"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1126\/science.1133811","article-title":"A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration","volume":"314","author":"Yang","year":"2006","journal-title":"Science"},{"key":"bib14","doi-asserted-by":"crossref","DOI":"10.3390\/genes13071233","article-title":"Molecular genetic mechanisms in age-related macular degeneration","volume":"13","author":"Shughoury","year":"2022","journal-title":"Genes (Basel)"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"R45","DOI":"10.1093\/hmg\/ddx228","article-title":"Genetics of age-related macular degeneration (AMD)","volume":"26","author":"DeAngelis","year":"2017","journal-title":"Hum Mol Genet"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.imbio.2011.07.019","article-title":"Age-related macular degeneration and the complement system","volume":"217","author":"Khandhadia","year":"2012","journal-title":"Immunobiology"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.preteyeres.2004.03.001","article-title":"Dark adaptation and the retinoid cycle of vision","volume":"23","author":"Lamb","year":"2004","journal-title":"Prog Retin Eye Res"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"5137","DOI":"10.1167\/iovs.06-0849","article-title":"Phototransduction, dark adaptation, and rhodopsin regeneration: the Proctor Lecture","volume":"47","author":"Lamb","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"3975","DOI":"10.1016\/S0042-6989(99)00092-9","article-title":"Aging and dark adaptation","volume":"39","author":"Jackson","year":"1999","journal-title":"Vis Res"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.ophtha.2015.09.041","article-title":"Delayed rod-mediated dark adaptation is a functional biomarker for incident early age-related macular degeneration","volume":"123","author":"Owsley","year":"2016","journal-title":"Ophthalmology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1016\/j.ophtha.2006.12.023","article-title":"Cone- and rod-mediated dark adaptation impairment in age-related maculopathy","volume":"114","author":"Owsley","year":"2007","journal-title":"Ophthalmology"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/j.ophtha.2015.06.023","article-title":"Impairments in dark adaptation are associated with age-related macular degeneration severity and reticular pseudodrusen","volume":"122","author":"Flamendorf","year":"2015","journal-title":"Ophthalmology"},{"key":"bib23","first-page":"2857","article-title":"Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging","volume":"35","author":"Ramrattan","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.1016\/j.ajpath.2014.07.017","article-title":"The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning","volume":"184","author":"Mullins","year":"2014","journal-title":"Am J Pathol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1001\/jamaophthalmol.2016.3519","article-title":"Histopathological insights into choroidal vascular loss in clinically documented cases of age-related macular degeneration","volume":"134","author":"Seddon","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"e0207638","DOI":"10.1371\/journal.pone.0207638","article-title":"Topographic distribution of choriocapillaris flow deficits in healthy eyes","volume":"13","author":"Nassisi","year":"2018","journal-title":"PLoS ONE"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ajo.2018.12.025","article-title":"Age-dependent changes in the macular choriocapillaris of normal eyes imaged with swept-source OCT angiography","volume":"200","author":"Zheng","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1097\/IAE.0000000000002556","article-title":"Spatial distribution of choriocapillaris impairment in eyes with choroidal neovascularization secondary to age-related macular degeneration: a quantitative OCT angiography study","volume":"40","author":"Moult","year":"2019","journal-title":"Retina"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"e0212563","DOI":"10.1371\/journal.pone.0212563","article-title":"Choriocapillaris flow impairment surrounding geographic atrophy correlates with disease progression","volume":"14","author":"Nassisi","year":"2019","journal-title":"PLoS ONE"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1167\/iovs.65.3.4","article-title":"Age-related macular degeneration, a mathematically tractable disease","volume":"65","author":"Curcio","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"778404","DOI":"10.3389\/fnagi.2022.778404","article-title":"Variability in retinal neuron populations and associated variations in mass transport systems of the retina in health and aging","volume":"14","author":"Zouache","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/cne.902920402","article-title":"Human photoreceptor topography","volume":"292","author":"Curcio","year":"1990","journal-title":"J Comp Neurol"},{"key":"bib33","first-page":"3278","article-title":"Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina","volume":"34","author":"Curcio","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib34","first-page":"1236","article-title":"Photoreceptor loss in age-related macular degeneration","volume":"37","author":"Curcio","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.ophtha.2018.10.037","article-title":"ARMS2 A69S polymorphism associates with delayed rod-mediated dark adaptation in eyes at risk for incident age-related macular degeneration","volume":"126","author":"Mullins","year":"2019","journal-title":"Ophthalmology"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1038\/s41433-025-03642-3","article-title":"Polygenic risk score impact visual function in healthy: the Northern Ireland Sensory Ageing study","volume":"39","author":"Tang","year":"2025","journal-title":"Eye (Lond)"},{"key":"bib37","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1001\/archopht.123.11.1484","article-title":"The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17","volume":"123","author":"Davis","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.oret.2020.05.001","article-title":"Hyperreflective foci and specks are associated with delayed rod-mediated dark adaptation in non-neovascular age-related macular degeneration","volume":"4","author":"Echols","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/S0002-9394(02)01825-1","article-title":"A computerized method of visual acuity testing: adaptation of the early treatment of diabetic retinopathy study testing protocol","volume":"135","author":"Beck","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"bib40","first-page":"197","article-title":"The design of a new letter chart for measuring contrast sensitivity","volume":"2","author":"Pelli","year":"1988","journal-title":"Clin Vis Sci"},{"key":"bib41","first-page":"471","article-title":"Improving the reliability of the Pelli-Robson contrast sensitivity test","volume":"6","author":"Elliott","year":"1991","journal-title":"Clin Vis Sci"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/S0161-6420(97)30079-7","article-title":"Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity","volume":"104","author":"Sunness","year":"1997","journal-title":"Ophthalmology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.ophtha.2015.12.034","article-title":"Prevalence of subretinal drusenoid deposits in older persons with and without age-related macular degeneration, by multimodal imaging","volume":"123","author":"Zarubina","year":"2016","journal-title":"Ophthalmology"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.survophthal.2018.05.005","article-title":"Subretinal drusenoid deposits a.k.a. pseudodrusen","volume":"63","author":"Spaide","year":"2018","journal-title":"Surv Ophthalmol"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1167\/iovs.65.10.25","article-title":"Extent and topography of subretinal drusenoid deposits associate with rod-mediated vision in aging and AMD: ALSTAR2 baseline","volume":"65","author":"Goerdt","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1097\/IAE.0b013e31827e25e0","article-title":"Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model","volume":"33","author":"Curcio","year":"2013","journal-title":"Retina"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ajo.2016.02.002","article-title":"Intraretinal hyperreflective foci in acquired vitelliform lesions of the macula: clinical and histologic study","volume":"164","author":"Chen","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1097\/IAE.0000000000002657","article-title":"Subretinal drusenoid deposit in age-related macular degeneration: histologic insights into initiation, progression to atrophy, and imaging","volume":"40","author":"Chen","year":"2020","journal-title":"Retina"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1520\/JFS13724J","article-title":"Anomalous migration of PCR products using nondenaturing polyacrylamide gel electrophoresis: the amelogenin sex-typing system","volume":"39","author":"Eng","year":"1994","journal-title":"J Forensic Sci"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.exger.2007.08.001","article-title":"Complement factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large","volume":"42","author":"Mooijaart","year":"2007","journal-title":"Exp Gerontol"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/opo.12775","article-title":"Low luminance visual acuity as a clinical measure and clinical trial outcome measure: a scoping review","volume":"41","author":"Wood","year":"2021","journal-title":"Ophthalmic Physiol Opt"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"e0280484","DOI":"10.1371\/journal.pone.0280484","article-title":"Rare CIDEC coding variants enriched in age-related macular degeneration patients with small low-luminance deficit cause lipid droplet and fat storage defects","volume":"18","author":"Kim","year":"2023","journal-title":"PLoS ONE"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1097\/00006982-199515030-00001","article-title":"Reticular pseudodrusen. A risk factor in age-related maculopathy","volume":"15","author":"Arnold","year":"1995","journal-title":"Retina"},{"key":"bib54","first-page":"511","article-title":"Macular drusen [in French]","volume":"13","author":"Mimoun","year":"1990","journal-title":"J Fr Ophtalmol"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.oret.2024.01.016","article-title":"Local and global associations of reticular pseudodrusen in age-related macular degeneration","volume":"8","author":"Duic","year":"2024","journal-title":"Ophthalmol Retina"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ajo.2016.02.021","article-title":"Relating retinal morphology and function in aging and early to intermediate age-related macular degeneration subjects","volume":"165","author":"Sevilla","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1097\/IAE.0000000000001454","article-title":"Association between visual function and subretinal drusenoid deposits in normal and early age-related macular degeneration eyes","volume":"37","author":"Neely","year":"2017","journal-title":"Retina"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1167\/iovs.15-18316","article-title":"The association between subretinal drusenoid deposits in older adults in normal macular health and incident age-related macular degeneration","volume":"57","author":"Huisingh","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1167\/iovs.62.1.33","article-title":"Biometrics, impact, and significance of basal linear deposit and subretinal drusenoid deposit in age-related macular degeneration","volume":"62","author":"Chen","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1097\/IAE.0000000000002210","article-title":"Amish Eye Study: baseline spectral domain optical coherence tomography characteristics of age-related macular degeneration","volume":"39","author":"Nittala","year":"2018","journal-title":"Retina"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/IAE.0000000000000648","article-title":"Prevalence of reticular pseudodrusen in age-related macular degeneration using multimodal imaging","volume":"36","author":"De Bats","year":"2016","journal-title":"Retina"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1167\/iovs.61.13.19","article-title":"Measuring the contributions of basal laminar deposit and Bruch's membrane in age-related macular degeneration","volume":"61","author":"Sura","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1167\/iovs.06-0443","article-title":"Relationship of basal laminar deposit and membranous debris to the clinical presentation of early age-related macular degeneration","volume":"48","author":"Sarks","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.ajo.2025.03.007","article-title":"Genetic distinctions between reticular pseudodrusen and drusen: a genome-wide association study","volume":"274","author":"Schwartz","year":"2025","journal-title":"Am J Ophthalmol"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1167\/tvst.11.12.3","article-title":"A deep learning framework for the detection and quantification of reticular pseudodrusen and drusen on optical coherence tomography","volume":"11","author":"Schwartz","year":"2022","journal-title":"Transl Vis Sci Technol"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1534\/genetics.116.195966","article-title":"Recombinant haplotypes narrow the ARMS2\/HTRA1 association signal for age-related macular degeneration","volume":"205","author":"Grassmann","year":"2017","journal-title":"Genetics"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1093\/hmg\/ddw162","article-title":"The unconventional secretion of ARMS2","volume":"25","author":"Kortvely","year":"2016","journal-title":"Hum Mol Genet"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"100934","DOI":"10.1016\/j.preteyeres.2020.100934","article-title":"Single-cell RNA sequencing in vision research: Insights into human retinal health and disease","volume":"83","author":"Voigt","year":"2020","journal-title":"Prog Retin Eye Res"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"16227","DOI":"10.1073\/pnas.0703933104","article-title":"A variant of mitochondrial protein LOC387715\/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration","volume":"104","author":"Kanda","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1167\/iovs.08-3240","article-title":"Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria","volume":"50","author":"Wang","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib71","first-page":"1317","article-title":"Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina","volume":"16","author":"Kanda","year":"2010","journal-title":"Mol Vis"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12974-016-0776-3","article-title":"Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator","volume":"14","author":"Micklisch","year":"2017","journal-title":"J Neuroinflammation"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1167\/iovs.09-3850","article-title":"ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations","volume":"51","author":"Kortvely","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/s41467-020-14499-3","article-title":"Increased circulating levels of factor H-related protein 4 are strongly associated with age-related macular degeneration","volume":"11","author":"Cipriani","year":"2020","journal-title":"Nat Commun"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/s41467-023-44605-0","article-title":"Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progression","volume":"15","author":"Zouache","year":"2024","journal-title":"Nat Commun"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/j.ajhg.2021.06.002","article-title":"Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration","volume":"108","author":"Lores-Motta","year":"2021","journal-title":"Am J Hum Genet"},{"key":"bib77","first-page":"92","article-title":"Human HtrA1 in the archived eyes with age-related macular degeneration","volume":"105","author":"Chan","year":"2007","journal-title":"Trans Am Ophthalmol Soc"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"e2103617118","DOI":"10.1073\/pnas.2103617118","article-title":"Chromosome 10q26\u2013driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium","volume":"118","author":"Williams","year":"2021","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:07Z","timestamp":1791927127000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":78,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.9.50","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,17]]}}}