{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:28Z","timestamp":1791928888518,"version":"4.3.4"},"reference-count":42,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"9","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"DOI":"10.1167\/iovs.66.9.65","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T13:00:49Z","timestamp":1753794049000},"page":"65","source":"Crossref","is-referenced-by-count":3,"title":["Calcitonin Gene-Related Peptide Regulates Specific Interferon-Stimulating Genes to Inhibit Apoptosis of Corneal Epithelial Cells in Dry Eye Disease"],"prefix":"10.1167","volume":"66","author":[{"given":"Xiaoping","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University; Fujian Medical University, Quanzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadian","family":"Ding","sequence":"additional","affiliation":[{"name":"Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China"},{"name":"Fujian Abdominal Surgery Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University; Fujian Medical University, Quanzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runhua","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University; Fujian Medical University, Quanzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University; Fujian Medical University, Quanzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YingYing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University; Fujian Medical University, Quanzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"issue":"5","key":"bib1","first-page":"71","article-title":"The pathophysiology, diagnosis, and treatment of dry eye disease","volume":"112","author":"Messmer","year":"2015","journal-title":"Dtsch Arztebl Int"},{"issue":"17","key":"bib2","doi-asserted-by":"publisher","first-page":"e2200435","DOI":"10.1002\/advs.202200435","article-title":"Anti-oxidative and anti-inflammatory micelles: break the dry eye vicious cycle","volume":"9","author":"Li","year":"2022","journal-title":"Adv Sci (Weinh)"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"155081","DOI":"10.1016\/j.phymed.2023.155081","article-title":"Berberine ameliorate inflammation and apoptosis via modulating PI3K\/AKT\/NF?B and MAPK pathway on dry eye","volume":"121","author":"Han","year":"2023","journal-title":"Phytomedicine"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jtos.2023.08.004","article-title":"TNF is a critical cytokine in age-related dry eye disease","volume":"30","author":"Kelagere","year":"2023","journal-title":"Ocul Surf"},{"issue":"9","key":"bib5","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.3390\/ijms21093111","article-title":"Dry eye disease and tear cytokine levels - a meta-analysis","volume":"21","author":"Roda","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"3","key":"bib6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1167\/iovs.64.3.34","article-title":"IFN-? facilitates corneal epithelial cell pyroptosis through the JAK2\/STAT1 pathway in dry eye","volume":"64","author":"Yang","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib7","doi-asserted-by":"publisher","first-page":"6279","DOI":"10.1167\/iovs.10-7081","article-title":"Interferon-? exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways","volume":"52","author":"Zhang","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib8","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1152\/physrev.00059.2021","article-title":"CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond","volume":"103","author":"Russo","year":"2022","journal-title":"Physiol Rev"},{"issue":"4","key":"bib9","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/j.pain.0000000000000831","article-title":"The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine","volume":"158","author":"Iyengar","year":"2017","journal-title":"Pain"},{"issue":"4","key":"bib10","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1167\/iovs.65.4.30","article-title":"CGRP released by corneal sensory nerve maintains tear secretion of the lacrimal gland","volume":"65","author":"Ma","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib11","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s42003-024-05934-y","article-title":"Topical application of calcitonin gene-related peptide as a regenerative, antifibrotic, and immunomodulatory therapy for corneal injury","volume":"7","author":"Zidan","year":"2024","journal-title":"Commun Biol"},{"issue":"10","key":"bib12","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1089\/jir.2018.0020","article-title":"Calcitonin gene-related peptide regulates the potential antigen uptake ability of human bronchial epithelial cells","volume":"38","author":"Peng","year":"2018","journal-title":"J Interferon Cytokine Res"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1184766","DOI":"10.3389\/fnins.2023.1184766","article-title":"Calcitonin gene-related peptide: a potential protective agent in cerebral ischemia-reperfusion injury","volume":"17","author":"Xiong","year":"2023","journal-title":"Front Neurosci"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"109814","DOI":"10.1016\/j.exer.2024.109814","article-title":"Establishment of mouse model of neurotrophic keratopathy through TRPV1 neuronal ablation","volume":"240","author":"Zhao","year":"2024","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib15","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/s41401-023-01146-y","article-title":"DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-?B pathway","volume":"45","author":"Wu","year":"2023","journal-title":"Acta Pharmacol Sin"},{"issue":"3","key":"bib16","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1167\/iovs.64.3.26","article-title":"Aim2 deficiency ameliorates lacrimal gland destruction and corneal epithelium defects in an experimental dry eye model","volume":"64","author":"Chen","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1080\/10717544.2021.1902021","article-title":"The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats","volume":"28","author":"Wang","year":"2021","journal-title":"Drug Deliv"},{"issue":"2","key":"bib18","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jtos.2019.02.006","article-title":"Manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin, a superoxide dismutase mimetic, reduces disease severity in in vitro and in vivo models for dry-eye disease","volume":"17","author":"\u017diniauskaite","year":"2019","journal-title":"Ocul Surf"},{"issue":"4","key":"bib19","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s10565-017-9399-4","article-title":"Exogenous CGRP upregulates profibrogenic growth factors through PKC\/JNK signaling pathway in kidney proximal tubular cells","volume":"34","author":"Yoon","year":"2018","journal-title":"Cell Biol Toxicol"},{"issue":"17","key":"bib20","doi-asserted-by":"publisher","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"4","key":"bib21","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat Methods"},{"issue":"3","key":"bib22","doi-asserted-by":"publisher","first-page":"R22","DOI":"10.1186\/gb-2011-12-3-r22","article-title":"Improving RNA-Seq expression estimates by correcting for fragment bias","volume":"12","author":"Roberts","year":"2011","journal-title":"Genome Biol"},{"issue":"2","key":"bib23","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2013a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2014","journal-title":"Bioinformatics"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1167\/iovs.12-10325","article-title":"Evaluation of lipid oxidative stress status in Sj\u00f6gren syndrome patients","volume":"54","author":"Wakamatsu","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib25","first-page":"e412","article-title":"Dry eye disease and oxidative stress","volume":"96","author":"Seen","year":"2017","journal-title":"Acta Ophthalmol"},{"issue":"1","key":"bib26","first-page":"120","article-title":"Dual-atom nanozyme eye drops attenuate inflammation and break the vicious cycle in dry eye disease","volume":"16","author":"Chu","year":"2024","journal-title":"Nanomicro Lett"},{"issue":"4","key":"bib27","doi-asserted-by":"publisher","first-page":"e48","DOI":"10.1002\/brx2.48","article-title":"Calcitonin gene-related peptide and persistent corneal pain: a trigeminal nerve sensitization perspective","volume":"1","author":"Hong","year":"2023","journal-title":"Brain-X"},{"issue":"0","key":"bib28","first-page":"2958584","article-title":"CGRP regulates nucleus pulposus cell apoptosis and inflammation via the MAPK\/NF-?B signaling pathways during intervertebral disc degeneration","volume":"2021","author":"Sun","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"bib29","doi-asserted-by":"crossref","first-page":"2053149","DOI":"10.1155\/2019\/2053149","article-title":"CGRP reduces apoptosis of DRG cells induced by high-glucose oxidative stress injury through PI3K\/AKT induction of heme oxygenase-1 and Nrf-2 expression","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxid Med Cell Longev"},{"issue":"12","key":"bib30","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1007\/s11064-020-03141-9","article-title":"Exogenous CGRP regulates apoptosis and autophagy to alleviate traumatic brain injury through Akt\/mTOR signalling pathway","volume":"45","author":"Tian","year":"2020","journal-title":"Neurochem Res"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1184766","DOI":"10.3389\/fnins.2023.1184766","article-title":"Calcitonin gene-related peptide: a potential protective agent in cerebral ischemia-reperfusion injury","volume":"17","author":"Xiong","year":"2023","journal-title":"Front Neurosci"},{"issue":"10","key":"bib32","doi-asserted-by":"publisher","first-page":"4743","DOI":"10.21873\/anticanres.15979","article-title":"The CGRP receptor antagonist MK0974 induces EVI1(high) AML cell apoptosis by disrupting ERK signaling","volume":"42","author":"Suekane","year":"2022","journal-title":"Anticancer Res"},{"key":"bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01530","article-title":"IFN-? regulates the expression of MICA in human corneal epithelium through miRNA4448 and NF?B","volume":"9","author":"Wu","year":"2018","journal-title":"Front Immunol"},{"issue":"8","key":"bib34","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1167\/iovs.18-24013","article-title":"0.005% Preservative-free latanoprost induces dry eye-like ocular surface damage via promotion of inflammation in mice","volume":"59","author":"Yang","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.exer.2013.11.011","article-title":"Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye","volume":"118","author":"Zhang","year":"2014","journal-title":"Exp Eye Res"},{"issue":"3","key":"bib36","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1023\/A:1023668705040","article-title":"Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis","volume":"8","author":"Chawla-Sarkar","year":"2003","journal-title":"Apoptosis"},{"issue":"6","key":"bib37","first-page":"e63216","article-title":"Protumorigenic interferon-stimulated genes in cancer: a comprehensive review","volume":"16","author":"Butt","year":"2024","journal-title":"Cureus"},{"issue":"4","key":"bib38","first-page":"419","article-title":"C-MAF expression in adult human ocular surface and its implication in pterygium pathogenesis","volume":"8","author":"Reza","year":"2020","journal-title":"Rep Biochem Mol Biol"},{"key":"bib39","first-page":"2019","article-title":"Novel MAF mutation in a family with congenital cataract-microcornea syndrome","volume":"13","author":"Hansen","year":"2007","journal-title":"Mol Vis"},{"issue":"2","key":"bib40","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.bbrc.2006.07.111","article-title":"Correlation between the expression level of c-maf and glutathione peroxidase-3 in c-maf-\/- mice kidney and c-maf overexpressed renal tubular cells","volume":"348","author":"Shirota","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"bib41","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12964-020-00676-w","article-title":"Inhibition of the Otub1\/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis","volume":"19","author":"Sun","year":"2021","journal-title":"Cell Commun Signal"},{"issue":"1","key":"bib42","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s13045-017-0499-7","article-title":"The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis","volume":"10","author":"Xu","year":"2017","journal-title":"J Hematol Oncol"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:10Z","timestamp":1791927130000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2810599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,29]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.66.9.65","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,29]]}}}