{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:42Z","timestamp":1791928902157,"version":"4.3.4"},"reference-count":42,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,1,12]]},"DOI":"10.1167\/iovs.67.1.23","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T13:30:42Z","timestamp":1768224642000},"page":"23","source":"Crossref","is-referenced-by-count":2,"title":["Crocin Protects Against Retinal Ischemia\u2013Reperfusion Injury via Regulating Sirt6-Mediated Nrf2\/HO-1 Pathway in Rats"],"prefix":"10.1167","volume":"67","author":[{"given":"Jing-Ni","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Rong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xue","sequence":"additional","affiliation":[{"name":"School of Health Services Management Xi'an Medical University, Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Guang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Yi","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China"},{"name":"Integrated Traditional Chinese and Western Clinical Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"26","key":"bib1","doi-asserted-by":"publisher","first-page":"e2304285","DOI":"10.1002\/adhm.202304285","article-title":"Lycium barbarum polysaccharide-derived nanoparticles protect visual function by inhibiting RGC ferroptosis and microglial activation in retinal ischemia?reperfusion mice","volume":"13","author":"Ni","year":"2024","journal-title":"Adv Healthc Mater"},{"issue":"1","key":"bib2","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1186\/s12974-022-02621-9","article-title":"Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia\/reperfusion injury","volume":"19","author":"Li","year":"2022","journal-title":"J Neuroinflammation"},{"issue":"30","key":"bib3","doi-asserted-by":"publisher","first-page":"e2302909","DOI":"10.1002\/advs.202302909","article-title":"Retinal microenvironment-protected rhein-GFFYE nanofibers attenuate retinal ischemia-reperfusion injury via inhibiting oxidative stress and regulating microglial\/macrophage M1\/M2 polarization","volume":"10","author":"Zhang","year":"2023","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"bib4","first-page":"115","article-title":"Immunological landscape of retinal ischemia-reperfusion injury: insights into resident and peripheral immune cell responses","volume":"16","author":"He","year":"2024","journal-title":"Aging Dis"},{"issue":"1","key":"bib5","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12974-023-02754-5","article-title":"N,N-Dimethyl-3\u00df-hydroxycholenamide attenuates neuronal death and retinal inflammation in retinal ischemia\/reperfusion injury by inhibiting Ninjurin 1","volume":"20","author":"Shi","year":"2023","journal-title":"J Neuroinflammation"},{"issue":"3","key":"bib6","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1021\/acs.nanolett.4c05012","article-title":"A supramolecular deferoxamine\u2013crisaborole nanoparticle targets ferroptosis, inflammation, and oxidative stress in the treatment of retinal ischemia\/reperfusion injury","volume":"25","author":"Lu","year":"2025","journal-title":"Nano Lett"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"116042","DOI":"10.1016\/j.biopha.2023.116042","article-title":"Setanaxib mitigates oxidative damage following retinal ischemia-reperfusion via NOX1 and NOX4 inhibition in retinal ganglion cells","volume":"170","author":"Liao","year":"2024","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"bib8","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/s41435-024-00283-6","article-title":"The ability of microRNAs to regulate the immune response in ischemia\/reperfusion inflammatory pathways","volume":"25","author":"Artimovic","year":"2024","journal-title":"Genes Immun"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"111303","DOI":"10.1016\/j.biopha.2021.111303","article-title":"Anti-cerebral ischemia reperfusion injury of polysaccharides: a review of the mechanisms","volume":"137","author":"Yuan","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"5-6","key":"bib10","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1007\/s10495-023-01824-6","article-title":"Anti-apoptosis effect of traditional Chinese medicine in the treatment of cerebral ischemia\u2013reperfusion injury","volume":"28","author":"Zhao","year":"2023","journal-title":"Apoptosis"},{"issue":"3","key":"bib11","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3390\/nu14030597","article-title":"Saffron (Crocus sativus L.): a source of nutrients for health and for the treatment of neuropsychiatric and age-related diseases","volume":"14","author":"El Midaoui","year":"2022","journal-title":"Nutrients"},{"issue":"14","key":"bib12","doi-asserted-by":"publisher","first-page":"4226","DOI":"10.3390\/molecules26144226","article-title":"Crocus sativus L. extract and its constituents: chemistry, pharmacology and therapeutic potential","volume":"26","author":"Pitsikas","year":"2021","journal-title":"Molecules"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.biopha.2018.01.113","article-title":"A comprehensive review on regulatory effects of crocin on ischemia\/reperfusion injury in multiple organs","volume":"99","author":"Akbari","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"7","key":"bib14","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.1167\/iovs.05-1621","article-title":"Protective effect of crocin against blue light- and white light-mediated photoreceptor cell death in bovine and primate retinal primary cell culture","volume":"47","author":"Laabich","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"bib15","doi-asserted-by":"publisher","first-page":"8454","DOI":"10.1007\/s12035-024-04105-8","article-title":"Resveratrol ameliorates retinal ischemia-reperfusion injury by modulating the NLRP3 inflammasome and Keap1\/Nrf2\/HO-1 signaling pathway","volume":"61","author":"Feng","year":"2024","journal-title":"Mol Neurobiol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.biopha.2018.11.133","article-title":"Targeting Nrf2\/HO-1 signaling by crocin: role in attenuation of AA-induced ulcerative colitis in rats","volume":"110","author":"Khodir","year":"2019","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"bib17","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1002\/med.21753","article-title":"Emerging roles of SIRT6 in human diseases and its modulators","volume":"41","author":"Liu","year":"2021","journal-title":"Med Res Rev"},{"issue":"1","key":"bib18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s00011-025-01998-6","article-title":"SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2\/HO-1 signaling to alleviate osteoarthritis","volume":"74","author":"Shi","year":"2025","journal-title":"Inflamm Res"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2022.01.012","article-title":"Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway","volume":"180","author":"Chen","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"114653","DOI":"10.1016\/j.jep.2021.114653","article-title":"BaZiBuShen alleviates cognitive deficits and regulates Sirt6\/NRF2\/HO-1 and Sirt6\/P53-PGC-1a-TERT signaling pathways in aging mice","volume":"282","author":"Li","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1595121","DOI":"10.3389\/fcell.2025.1595121","article-title":"Protein misfolding and mitochondrial dysfunction in glaucoma","volume":"13","author":"Venkatesan","year":"2025","journal-title":"Front Cell Dev Biol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"113297","DOI":"10.1016\/j.biopha.2022.113297","article-title":"An evaluation on potential anti-oxidant and anti-inflammatory effects of crocin","volume":"153","author":"Bastani","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"bib23","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3892\/ijmm.2015.2418","article-title":"Crocin protects retinal ganglion cells against H2O2-induced damage through the mitochondrial pathway and activation of NF-?B","volume":"37","author":"Lv","year":"2016","journal-title":"Int J Mol Med"},{"issue":"7-8","key":"bib24","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s10495-023-01858-w","article-title":"Endoplasmic reticulum stress in diabetic kidney disease: adaptation and apoptosis after three UPR pathways","volume":"28","author":"Zhang","year":"2023","journal-title":"Apoptosis"},{"issue":"7","key":"bib25","doi-asserted-by":"publisher","first-page":"3161","DOI":"10.1007\/s10571-023-01373-1","article-title":"Regulated cell death of retinal ganglion cells in glaucoma: molecular insights and therapeutic potentials","volume":"43","author":"Zhao","year":"2023","journal-title":"Cell Mol Neurobiol"},{"issue":"1","key":"bib26","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/biof.1809","article-title":"Crocin attenuates inflammation of lung tissue in ovalbumin-sensitized mice by altering the expression of endoplasmic reticulum stress markers","volume":"48","author":"Aslani","year":"2022","journal-title":"Biofactors"},{"issue":"4","key":"bib27","first-page":"439","article-title":"Crocin protects against endoplasmic reticulum stress-related tubular injury in diabetic nephropathy via the activation of the PI3K\/AKT\/Nrf2 pathway","volume":"27","author":"Wang","year":"2024","journal-title":"Iran J Basic Med Sci"},{"issue":"12","key":"bib28","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1002\/tox.22185","article-title":"Crocin and quercetin prevent PAT-induced apoptosis in mammalian cells: involvement of ROS-mediated ER stress pathway","volume":"31","author":"Boussabbeh","year":"2016","journal-title":"Environ Toxicol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"102475","DOI":"10.1016\/j.redox.2022.102475","article-title":"Mitochondrial ferritin alleviates apoptosis by enhancing mitochondrial bioenergetics and stimulating glucose metabolism in cerebral ischemia reperfusion","volume":"57","author":"Wang","year":"2022","journal-title":"Redox Biol"},{"issue":"1","key":"bib30","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41392-025-02178-y","article-title":"Deep insight into cytokine storm: from pathogenesis to treatment","volume":"10","author":"Nie","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"119542","DOI":"10.1016\/j.lfs.2021.119542","article-title":"Crocin alleviates the inflammation and oxidative stress responses associated with diabetic nephropathy in rats via NLRP3 inflammasomes","volume":"278","author":"Zhang","year":"2021","journal-title":"Life Sci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"639458","DOI":"10.3389\/fphar.2021.639458","article-title":"The protection of crocin against ulcerative colitis and colorectal cancer via suppression of NF-?B-mediated inflammation","volume":"12","author":"Teng","year":"2021","journal-title":"Front Pharmacol"},{"issue":"1","key":"bib33","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1080\/13880209.2022.2042328","article-title":"Protective role of crocin against sepsis-induced injury in the liver, kidney and lungs via inhibition of p38 MAPK\/NF-?B and Bax\/Bcl-2 signalling pathways","volume":"60","author":"Gao","year":"2022","journal-title":"Pharm Biol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"110713","DOI":"10.1016\/j.biopha.2020.110713","article-title":"Crocin ameliorates arsenic trioxide-induced cardiotoxicity via Keap1-Nrf2\/HO-1 pathway: reducing oxidative stress, inflammation, and apoptosis","volume":"131","author":"Liang","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"pt 2","key":"bib35","doi-asserted-by":"crossref","first-page":"118858","DOI":"10.1016\/j.jep.2024.118858","article-title":"Targeting Nrf2\/HO-1 signaling by crocin: role in attenuation of arsenic trioxide-induced neurotoxicity in mice","volume":"337","author":"Chu","year":"2025","journal-title":"J Ethnopharmacol"},{"issue":"5","key":"bib36","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/s41419-022-04866-x","article-title":"Energy restriction induced SIRT6 inhibits microglia activation and promotes angiogenesis in cerebral ischemia via transcriptional inhibition of TXNIP","volume":"13","author":"Song","year":"2022","journal-title":"Cell Death Dis"},{"issue":"1","key":"bib37","doi-asserted-by":"publisher","first-page":"e12698","DOI":"10.1111\/jpi.12698","article-title":"Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia-reperfusion injury by improving mitochondrial quality control: role of SIRT6","volume":"70","author":"Yu","year":"2021","journal-title":"J Pineal Res"},{"issue":"6","key":"bib38","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1016\/j.ymthe.2024.04.030","article-title":"Sirt6 protects retinal ganglion cells and optic nerve from degeneration during aging and glaucoma","volume":"32","author":"Xia","year":"2024","journal-title":"Mol Ther"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.cbi.2019.01.018","article-title":"SIRT6 protects retinal ganglion cells against hydrogen peroxide-induced apoptosis and oxidative stress by promoting Nrf2\/ARE signaling via inhibition of Bach1","volume":"300","author":"Yu","year":"2019","journal-title":"Chem Biol Interact"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"105007","DOI":"10.1016\/j.neuint.2021.105007","article-title":"Retinal Nrf2 expression in normal and early streptozotocin-diabetic rats","volume":"145","author":"Albert-Garay","year":"2021","journal-title":"Neurochem Int"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"156202","DOI":"10.1016\/j.phymed.2024.156202","article-title":"20(R)-ginsenoside Rg3 alleviates diabetic retinal injury in T2DM mice by attenuating ROS-mediated ER stress through the activation of the Nrf2\/HO-1 axis","volume":"135","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"bib42","doi-asserted-by":"publisher","first-page":"113409","DOI":"10.1016\/j.yexcr.2022.113409","article-title":"Sirt6 mediates antioxidative functions by increasing Nrf2 abundance","volume":"422","author":"Liu","year":"2023","journal-title":"Exp Cell Res"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2811353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:16Z","timestamp":1791927136000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2811353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,5]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.1.23","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,12]]}}}