{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:36:25Z","timestamp":1792503385585,"version":"4.5.0"},"reference-count":39,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,1,29]]},"DOI":"10.1167\/iovs.67.1.61","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:30:40Z","timestamp":1769689840000},"page":"61","source":"Crossref","is-referenced-by-count":2,"title":["Vitamin E Alleviates Oxidative Damage and Attenuates Ferroptosis Caused by Prolonged Contraction of the Ciliary Muscle by Activating ACOT7"],"prefix":"10.1167","volume":"67","author":[{"given":"Huijie","family":"Cao","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Prevention and Treatment on major blinding diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxue","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Prevention and Treatment on major blinding diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongguo","family":"Xiang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Prevention and Treatment on major blinding diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Prevention and Treatment on major blinding diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Kou","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Prevention and Treatment on major blinding diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, People's Republic of China"},{"name":"The Affiliated Chengdu 363 Hospital of Southwest Medical University, Chengdu, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cheng","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Prevention and Treatment on major blinding diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Tan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Prevention and Treatment on major blinding diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Wan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Prevention and Treatment on major blinding diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liang","sequence":"additional","affiliation":[{"name":"Changdu People's Hospital of Xizang, Xizang, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Kang","sequence":"additional","affiliation":[{"name":"Changdu People's Hospital of Xizang, Xizang, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Zheng","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Prevention and Treatment on major blinding diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Hu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Prevention and Treatment on major blinding diseases, Chongqing Eye Institute, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, People's Republic of China"},{"name":"Changdu People's Hospital of Xizang, Xizang, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"12","key":"bib1","doi-asserted-by":"publisher","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global causes of blindness and distance vision impairment 1990\u20132020: a systematic review and meta-analysis","volume":"5","author":"Flaxman","year":"2017","journal-title":"Lancet Glob Health"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"100902","DOI":"10.1016\/j.preteyeres.2020.100902","article-title":"Zinn's zonule","volume":"82","author":"Bassnett","year":"2021","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"bib3","first-page":"384","article-title":"Uber strukturelle Unterschiede im Aufbau des Ziliarmuskels des Primatenauges. Eine histochemische und morphologische Untersuchung [Structural differences in the structure of the ciliary muscles in eyes of primates. A histochemical and morphological study]","volume":"87","author":"Fl\u00fcgel","year":"1990","journal-title":"Fortschr Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.exer.2012.08.014","article-title":"Diminished ciliary muscle movement on accommodation in myopia","volume":"105","author":"Jeon","year":"2012","journal-title":"Exp Eye Res"},{"issue":"6","key":"bib5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1167\/iovs.63.6.24","article-title":"Ciliary muscle dimension changes with accommodation vary in myopia and emmetropia","volume":"63","author":"Kaphle","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib6","first-page":"168","article-title":"Akkommodaatiospasmi [Spasm of accommodation]","volume":"130","author":"Lindberg","year":"2014","journal-title":"Duodecim"},{"issue":"5","key":"bib7","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"3","key":"bib8","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ"},{"issue":"2","key":"bib9","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis"},{"issue":"15","key":"bib10","doi-asserted-by":"publisher","first-page":"e23878","DOI":"10.1096\/fj.202401286R","article-title":"Pilocarpine mediated excessive calcium accumulation leads to ciliary muscle cell senescence and apoptosis","volume":"38","author":"Gao","year":"2024","journal-title":"FASEB J"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"9961","DOI":"10.2147\/IJN.S276355","article-title":"Pharmacology and pharmacokinetics of vitamin E: nanoformulations to enhance bioavailability","volume":"15","author":"Mohd Zaffarin","year":"2020","journal-title":"Int J Nanomedicine"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"103303","DOI":"10.1016\/j.redox.2024.103303","article-title":"Vitamin E and GPX4 cooperatively protect treg cells from ferroptosis and alleviate intestinal inflammatory damage in necrotizing enterocolitis","volume":"75","author":"Luo","year":"2024","journal-title":"Redox Biol"},{"issue":"7","key":"bib13","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41419-022-05037-8","article-title":"Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity","volume":"13","author":"Ni","year":"2022","journal-title":"Cell Death Dis"},{"issue":"4","key":"bib14","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.plipres.2010.04.001","article-title":"Functional and structural properties of mammalian acyl-coenzyme A thioesterases","volume":"49","author":"Kirkby","year":"2010","journal-title":"Prog Lipid Res"},{"issue":"9","key":"bib15","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/s41556-024-01429-4","article-title":"Mitochondria and cell death","volume":"26","author":"Glover","year":"2024","journal-title":"Nat Cell Biol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"104961","DOI":"10.1016\/j.neubiorev.2022.104961","article-title":"Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: an update on current advances and impediments","volume":"144","author":"Rehman","year":"2023","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"bib17","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"bib18","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1254\/jphs.93.222","article-title":"A novel in vitro model for screening and evaluation of anti-asthenopia drugs","volume":"93","author":"Katsuyama","year":"2003","journal-title":"J Pharmacol Sci"},{"issue":"6","key":"bib19","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.ophtha.2023.02.002","article-title":"Global, regional, and national burdens of blindness and vision loss in children and adolescents from 1990 to 2019: a trend analysis","volume":"130","author":"Liu","year":"2023","journal-title":"Ophthalmology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"107741","DOI":"10.1016\/j.exer.2019.107741","article-title":"Prolonged nearwork affects the ciliary muscle morphology","volume":"186","author":"Wagner","year":"2019","journal-title":"Exp Eye Res"},{"issue":"9","key":"bib21","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1111\/bph.12586","article-title":"Efficacy assessment of a combined anticholinergic and oxime treatment against topical sarin-induced miosis and visual impairment in rats","volume":"171","author":"Gore","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"7","key":"bib22","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1097\/OPX.0000000000000304","article-title":"Guinea pig ciliary muscle development","volume":"91","author":"Pucker","year":"2014","journal-title":"Optom Vis Sci"},{"issue":"10","key":"bib23","doi-asserted-by":"publisher","first-page":"4353","DOI":"10.1167\/iovs.08-2008","article-title":"Ciliary body thickness and refractive error in children","volume":"49","author":"Bailey","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib24","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1038\/eye.2008.178","article-title":"Ciliary body thickness in unilateral high axial myopia","volume":"23","author":"Muftuoglu","year":"2009","journal-title":"Eye (Lond)"},{"issue":"2","key":"bib25","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.ajo.2005.01.047","article-title":"Ciliary body thickness increases with increasing axial myopia","volume":"140","author":"Oliveira","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.omtn.2018.04.016","article-title":"MicroRNA-125b promotes hepatic stellate cell activation and liver fibrosis by activating RhoA signaling","volume":"12","author":"You","year":"2018","journal-title":"Mol Ther Nucleic Acids"},{"issue":"6","key":"bib27","doi-asserted-by":"publisher","first-page":"e37388","DOI":"10.1371\/journal.pone.0037388","article-title":"Swimming exercise prevents fibrogenesis in chronic kidney disease by inhibiting the myofibroblast transdifferentiation","volume":"7","author":"Peng","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"bib28","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.7150\/ijbs.83348","article-title":"The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks","volume":"19","author":"Li","year":"2023","journal-title":"Int J Biol Sci"},{"issue":"9","key":"bib29","doi-asserted-by":"publisher","first-page":"e202105043","DOI":"10.1083\/jcb.202105043","article-title":"Mitochondrial regulation of ferroptosis","volume":"220","author":"Gan","year":"2021","journal-title":"J Cell Biol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"115892","DOI":"10.1016\/j.biopha.2023.115892","article-title":"The mitochondrial regulation in ferroptosis signaling pathway and its potential strategies for cancer","volume":"169","author":"Sun","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"bib31","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s10020-024-00910-y","article-title":"Capsaicin mitigates ventilator-induced lung injury by suppressing ferroptosis and maintaining mitochondrial redox homeostasis through SIRT3-dependent mechanisms","volume":"30","author":"Lin","year":"2024","journal-title":"Mol Med"},{"issue":"3","key":"bib32","doi-asserted-by":"publisher","first-page":"e18076","DOI":"10.1111\/jcmm.18076","article-title":"Loss of nephric augmenter of liver regeneration facilitates acute kidney injury via ACSL4-mediated ferroptosis","volume":"28","author":"Huang","year":"2024","journal-title":"J Cell Mol Med"},{"issue":"7","key":"bib33","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s11626-022-00703-9","article-title":"ACOT7 protects epidermal stem cells against lipid peroxidation","volume":"58","author":"Zhang","year":"2022","journal-title":"In Vitro Cell Dev Biol Anim"},{"issue":"1","key":"bib34","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12860-022-00450-5","article-title":"ARNTL2 upregulation of ACOT7 promotes NSCLC cell proliferation through inhibition of apoptosis and ferroptosis","volume":"24","author":"Wang","year":"2023","journal-title":"BMC Mol Cell Biol"},{"issue":"48","key":"bib35","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1038\/s41388-024-03185-z","article-title":"m6A-driven NAT10 translation facilitates fatty acid metabolic rewiring to suppress ferroptosis and promote ovarian tumorigenesis through enhancing ACOT7 mRNA acetylation","volume":"43","author":"Liu","year":"2024","journal-title":"Oncogene"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.freeradbiomed.2021.10.027","article-title":"Reported evidence of vitamin E protection against cataract and glaucoma","volume":"177","author":"Tanito","year":"2021","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"bib37","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1080\/10520295.2020.1818284","article-title":"Effects of vitamin E in a glucocorticoid induced cataract model in chicken embryos","volume":"96","author":"Vurmaz","year":"2021","journal-title":"Biotech Histochem"},{"issue":"9","key":"bib38","doi-asserted-by":"publisher","first-page":"842","DOI":"10.3109\/02713683.2010.489728","article-title":"Dietary deficiency of vitamin E aggravates retinal ganglion cell death in experimental glaucoma of rats","volume":"35","author":"Ko","year":"2010","journal-title":"Curr Eye Res"},{"key":"bib39","first-page":"100224","article-title":"The use of vitamin E in ocular health: bridging omics approaches with Tocopherol and Tocotrienol in the management of glaucoma","volume":"9","author":"Latib","year":"2024","journal-title":"Food Chem (Oxf)"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.1.61","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:23Z","timestamp":1791927143000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.1.61"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,5]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.1.61","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,29]]}}}