{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:34Z","timestamp":1791928954571,"version":"4.3.4"},"reference-count":85,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,8,5]]},"DOI":"10.1167\/iovs.67.10.12","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:30:40Z","timestamp":1785933040000},"page":"12","source":"Crossref","is-referenced-by-count":0,"title":["Annexin A1 as a Key Modulator of Inflammatory, Glial, and Angiogenic Signaling Pathways in Diabetic Retinopathy"],"prefix":"10.1167","volume":"67","author":[{"given":"Rafael Andr\u00e9","family":"da Silva","sequence":"first","affiliation":[{"name":"Biosciences Graduate Program, Institute of Biosciences, Letters and Exact Sciences, UNESP, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Philipe de Souza","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Morphology and Genetics, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius Moraes de Paiva","family":"Roda","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Heart Institute (InCor), Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Dias","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Morphology and Genetics, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Silv\u00e9rio","family":"Faria","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigacao Medica (LIM03), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Dalmaso","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Serra","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Beltrame","family":"Del Debbio","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Rodrigues de","family":"Bastos","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias M\u00e9dicas, Universidad Privada del Este filial Ciudad del Este, Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Sandri","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses, USP, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Helena Poliselli","family":"Farsky","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses, USP, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Vinicius Saito","family":"Regatieri","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Damas","family":"Gil","sequence":"additional","affiliation":[{"name":"Biosciences Graduate Program, Institute of Biosciences, Letters and Exact Sciences, UNESP, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"},{"name":"Department of Morphology and Genetics, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"4","key":"bib1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1159\/000499541","article-title":"Diabetic retinopathy in the context of patients with diabetes","volume":"62","author":"Simo-Servat","year":"2019","journal-title":"Ophthalmic Res"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2147\/CIA.S190713","article-title":"Influence of diabetes mellitus on anterior segment of the eye","volume":"14","author":"Han","year":"2019","journal-title":"Clin Interv Aging"},{"issue":"4","key":"bib3","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S2213-8587(19)30411-5","article-title":"Screening for diabetic retinopathy: new perspectives and challenges","volume":"8","author":"Vujosevic","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"bib4","doi-asserted-by":"publisher","first-page":"100947","DOI":"10.1016\/j.xops.2025.100947","article-title":"Classification of diabetic retinopathy severity with aqueous VEGF levels: a prospective, observational study","volume":"6","author":"Steinkerchner","year":"2026","journal-title":"Ophthalmol Sci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"100756","DOI":"10.1016\/j.preteyeres.2019.03.002","article-title":"Human vitreous in proliferative diabetic retinopathy: characterization and translational implications","volume":"72","author":"Nawaz","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"583687","DOI":"10.3389\/fimmu.2020.583687","article-title":"The role of inflammation in diabetic retinopathy","volume":"11","author":"Forrester","year":"2020","journal-title":"Front Immunol"},{"issue":"4","key":"bib7","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.sjopt.2018.05.002","article-title":"Role of oxidative stress, inflammation, hypoxia and angiogenesis in the development of diabetic retinopathy","volume":"32","author":"Al-Kharashi","year":"2018","journal-title":"Saudi J Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"101357","DOI":"10.1016\/j.preteyeres.2025.101357","article-title":"Muller cells trophism and pathology as the next therapeutic targets for retinal diseases","volume":"106","author":"Arrigo","year":"2025","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s12035-025-05546-5","article-title":"Crosstalk between neuronal and glial cells in diabetic retinopathy: mechanisms and implications for neurodegeneration","volume":"63","author":"Kumari","year":"2025","journal-title":"Mol Neurobiol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1047487","DOI":"10.3389\/fcell.2022.1047487","article-title":"The role of retinal Muller cells in diabetic retinopathy and related therapeutic advances","volume":"10","author":"Yang","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"bib11","doi-asserted-by":"crossref","first-page":"976","DOI":"10.4103\/1673-5374.355743","article-title":"Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy","volume":"18","author":"Tang","year":"2023","journal-title":"Neural Regen Res"},{"issue":"9","key":"bib12","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.2337\/db09-1420","article-title":"Muller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage","volume":"59","author":"Wang","year":"2010","journal-title":"Diabetes"},{"issue":"10","key":"bib13","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1096\/fba.2020-00034","article-title":"The G-protein-coupled chemoattractant receptor Fpr2 exacerbates neuroglial dysfunction and angiogenesis in diabetic retinopathy","volume":"2","author":"Yu","year":"2020","journal-title":"FASEB Bioadv"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"109336","DOI":"10.1016\/j.exer.2022.109336","article-title":"Blockade of the TGF-beta pathway by galunisertib inhibits the glial-mesenchymal transition in Muller glial cells","volume":"226","author":"da Silva","year":"2023","journal-title":"Exp Eye Res"},{"issue":"9","key":"bib15","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1002\/prot.26512","article-title":"Annexin A1, A2, A5, and A6 involvement in human pathologies","volume":"91","author":"Ferreira","year":"2023","journal-title":"Proteins"},{"issue":"Pt 13","key":"bib16","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1242\/jcs.01245","article-title":"Annexins\u2013unique membrane binding proteins with diverse functions","volume":"117","author":"Rescher","year":"2004","journal-title":"J Cell Sci"},{"issue":"5","key":"bib17","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.4049\/jimmunol.0903526","article-title":"Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation","volume":"184","author":"Dufton","year":"2010","journal-title":"J Immunol"},{"issue":"20","key":"bib18","doi-asserted-by":"publisher","first-page":"4595","DOI":"10.1111\/bph.15212","article-title":"Formyl peptide receptor type 2 agonists to kick-start resolution pharmacology","volume":"177","author":"Perretti","year":"2020","journal-title":"Br J Pharmacol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"108809","DOI":"10.1016\/j.pharmthera.2025.108809","article-title":"Annexin A1 in neurological disorders: neuroprotection and glial modulation","volume":"267","author":"Ferreira","year":"2025","journal-title":"Pharmacol Ther"},{"issue":"11","key":"bib20","doi-asserted-by":"publisher","first-page":"103367","DOI":"10.1016\/j.drudis.2022.103367","article-title":"Annexins as potential targets in ocular diseases","volume":"27","author":"da Silva","year":"2022","journal-title":"Drug Discov Today"},{"issue":"2","key":"bib21","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1074\/mcp.M115.052183","article-title":"The proteome of native adult muller glial cells from murine retina","volume":"15","author":"Grosche","year":"2016","journal-title":"Mol Cell Proteomics"},{"issue":"11","key":"bib22","doi-asserted-by":"publisher","first-page":"5689","DOI":"10.4049\/jimmunol.1202030","article-title":"Anti-inflammatory mechanisms of the Annexin A1 protein and its mimetic peptide Ac2-26 in models of ocular inflammation in vivo and in vitro","volume":"190","author":"Girol","year":"2013","journal-title":"J Immunol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.gene.2017.02.032","article-title":"ANXA1(Ac2-26) peptide, a possible therapeutic approach in inflammatory ocular diseases","volume":"614","author":"Cardin","year":"2017","journal-title":"Gene"},{"issue":"5","key":"bib24","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1167\/tvst.6.5.10","article-title":"Augmenting endogenous levels of retinal Annexin A1 suppresses uveitis in mice","volume":"6","author":"Gardner","year":"2017","journal-title":"Transl Vis Sci Technol"},{"issue":"5","key":"bib25","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.1007\/s11033-011-1358-1","article-title":"Annexin 1 protects against apoptosis induced by serum deprivation in transformed rat retinal ganglion cells","volume":"39","author":"Sun","year":"2012","journal-title":"Mol Biol Rep"},{"issue":"12","key":"bib26","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1097\/IAE.0000000000000726","article-title":"Intravitreal corticosteroids in diabetic macular edema: pharmacokinetic considerations","volume":"35","author":"Yang","year":"2015","journal-title":"Retina"},{"issue":"10","key":"bib27","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1016\/j.ophtha.2013.02.034","article-title":"Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE","volume":"120","author":"Brown","year":"2013","journal-title":"Ophthalmology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"100161","DOI":"10.1016\/j.clinsp.2022.100161","article-title":"Do anti-VEGFs used in the ophthalmic clinic cause Muller glial cell stress?","volume":"78","author":"da Silva","year":"2023","journal-title":"Clinics (Sao Paulo)"},{"issue":"3","key":"bib29","doi-asserted-by":"publisher","first-page":"e0300370","DOI":"10.1371\/journal.pone.0300370","article-title":"Effects of aflibercept and bevacizumab on cell viability, cell metabolism and inflammation in hypoxic human Muller cells","volume":"19","author":"Matsuda","year":"2024","journal-title":"PLoS One"},{"issue":"2","key":"bib30","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s11739-019-02253-7","article-title":"Intravitreal anti-VEGF agents and cardiovascular risk","volume":"15","author":"Porta","year":"2020","journal-title":"Intern Emerg Med"},{"issue":"1","key":"bib31","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s40942-021-00307-7","article-title":"Mechanisms of sterile inflammation after intravitreal injection of antiangiogenic drugs: a narrative review","volume":"7","author":"Anderson","year":"2021","journal-title":"Int J Retina Vitreous"},{"issue":"3","key":"bib32","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3390\/cells12030425","article-title":"Role of Annexin A1 secreted by neutrophils in melanoma metastasis","volume":"12","author":"Sandri","year":"2023","journal-title":"Cells"},{"issue":"3","key":"bib33","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s10753-023-01959-3","article-title":"Lack of Annexin A1 exacerbates inflammatory response in acute endometritis model","volume":"47","author":"Vieira","year":"2024","journal-title":"Inflammation"},{"issue":"2","key":"bib34","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/neuroglia6020019","article-title":"Electroretinographic and morphological characterization of the retina of Annexin A1 knockout mice","volume":"6","author":"da Silva","year":"2025","journal-title":"Neuroglia"},{"issue":"10","key":"bib35","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s11892-017-0913-0","article-title":"Animal models of diabetic retinopathy","volume":"17","author":"Olivares","year":"2017","journal-title":"Curr Diabetes Rep"},{"issue":"2","key":"bib36","first-page":"262","article-title":"Rodent models of diabetic retinopathy as a useful research tool to study neurovascular cross-talk","volume":"12","author":"Polewik","year":"2023","journal-title":"Biology (Basel)"},{"issue":"11","key":"bib37","doi-asserted-by":"publisher","first-page":"4665","DOI":"10.1096\/fj.201700336R","article-title":"Animal models of ocular angiogenesis: from development to pathologies","volume":"31","author":"Liu","year":"2017","journal-title":"FASEB J"},{"issue":"4","key":"bib38","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"15","key":"bib39","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.21037\/atm-20-6737","article-title":"Animal models of diabetic retinopathy","volume":"9","author":"Quiroz","year":"2021","journal-title":"Ann Transl Med"},{"issue":"13","key":"bib40","doi-asserted-by":"publisher","first-page":"7105","DOI":"10.3390\/ijms25137105","article-title":"Pathology of diabetes-induced immune dysfunction","volume":"25","author":"Alexander","year":"2024","journal-title":"Int J Mol Sci"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.biopha.2018.07.157","article-title":"Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: an update on glucose toxicity","volume":"107","author":"Giri","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"14","key":"bib42","doi-asserted-by":"publisher","first-page":"6455","DOI":"10.1167\/iovs.16-20215","article-title":"Retinal neurodegeneration in diabetic patients without diabetic retinopathy","volume":"57","author":"Tavares Ferreira","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib43","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1097\/IAE.0000000000003473","article-title":"Quantitative optical coherence tomography reveals rod photoreceptor degeneration in early diabetic retinopathy","volume":"42","author":"Le","year":"2022","journal-title":"Retina"},{"issue":"6","key":"bib44","doi-asserted-by":"publisher","first-page":"3721","DOI":"10.1167\/iovs.14-16289","article-title":"Characterization of retinal vascular and neural damage in a novel model of diabetic retinopathy","volume":"56","author":"Weerasekera","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib45","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/s41433-018-0268-z","article-title":"Time-dependent changes in hypoxia- and gliosis-related factors in experimental diabetic retinopathy","volume":"33","author":"Gu","year":"2019","journal-title":"Eye (Lond)"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"109461","DOI":"10.1016\/j.exer.2023.109461","article-title":"Mustard gas exposure instigates retinal Muller cell gliosis","volume":"230","author":"Mahaling","year":"2023","journal-title":"Exp Eye Res"},{"issue":"12","key":"bib47","doi-asserted-by":"publisher","first-page":"104553","DOI":"10.1016\/j.drudis.2025.104553","article-title":"FPR2 at the crossroads of inflammation and repair in the eye","volume":"30","author":"da Silva","year":"2025","journal-title":"Drug Discov Today"},{"issue":"20","key":"bib48","doi-asserted-by":"publisher","first-page":"7458","DOI":"10.3390\/ijms21207458","article-title":"Activation of STAT3 regulates reactive astrogliosis and neuronal death induced by A\u00dfO neurotoxicity","volume":"21","author":"Toral-Rios","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"7","key":"bib49","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1111\/bph.14927","article-title":"Annexin-A1 deficiency exacerbates pathological remodelling of the mesenteric vasculature in insulin-resistant, but not insulin-deficient, mice","volume":"177","author":"Jelinic","year":"2020","journal-title":"Br J Pharmacol"},{"issue":"1","key":"bib50","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.kint.2021.02.025","article-title":"Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy","volume":"100","author":"Wu","year":"2021","journal-title":"Kidney Int"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3389\/fimmu.2019.00571","article-title":"Identification of AnnexinA1 as an endogenous regulator of RhoA, and its role in the pathophysiology and experimental therapy of type-2 diabetes","volume":"10","author":"Purvis","year":"2019","journal-title":"Front Immunol"},{"issue":"12","key":"bib52","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1167\/tvst.10.12.8","article-title":"Circulating biomarkers of inflammation and endothelial activation in diabetic retinopathy","volume":"10","author":"Storti","year":"2021","journal-title":"Transl Vis Sci Technol"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"1055087","DOI":"10.3389\/fimmu.2022.1055087","article-title":"The role of inflammation in immune system of diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications","volume":"13","author":"Yue","year":"2022","journal-title":"Front Immunol"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.exer.2015.03.013","article-title":"Beneficial effect of Annexin A1 in a model of experimental allergic conjunctivitis","volume":"134","author":"Gimenes","year":"2015","journal-title":"Exp Eye Res"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2014.12.004","article-title":"Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease","volume":"58","author":"Yazid","year":"2015","journal-title":"J Autoimmun"},{"issue":"11","key":"bib56","doi-asserted-by":"publisher","first-page":"11776","DOI":"10.1096\/fj.201802614RRR","article-title":"Erianin alleviates diabetic retinopathy by reducing retinal inflammation initiated by microglial cells via inhibiting hyperglycemia-mediated ERK1\/2-NF-kappaB signaling pathway","volume":"33","author":"Zhang","year":"2019","journal-title":"FASEB J"},{"issue":"2","key":"bib57","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.bbrc.2018.03.148","article-title":"NLRP1 deficiency attenuates diabetic retinopathy (DR) in mice through suppressing inflammation response","volume":"501","author":"Li","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"bib58","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1097\/WNR.0000000000002030","article-title":"Annexin A1 conveys neuroprotective function via inhibiting oxidative stress in diffuse axonal injury of rats","volume":"35","author":"Zheng","year":"2024","journal-title":"Neuroreport"},{"issue":"10","key":"bib59","doi-asserted-by":"publisher","first-page":"6317","DOI":"10.4049\/jimmunol.1001095","article-title":"Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia","volume":"185","author":"McArthur","year":"2010","journal-title":"J Immunol"},{"issue":"6","key":"bib60","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.tins.2015.04.003","article-title":"Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker","volume":"38","author":"Yang","year":"2015","journal-title":"Trends Neurosci"},{"issue":"7","key":"bib61","doi-asserted-by":"publisher","first-page":"978","DOI":"10.3390\/cells12070978","article-title":"STAT3 drives GFAP accumulation and astrocyte pathology in a mouse model of Alexander disease","volume":"12","author":"Hagemann","year":"2023","journal-title":"Cells"},{"issue":"6","key":"bib62","doi-asserted-by":"publisher","first-page":"2406","DOI":"10.3390\/jcm12062406","article-title":"Retinal ischaemia in diabetic retinopathy: understanding and overcoming a therapeutic challenge","volume":"12","author":"Mohite","year":"2023","journal-title":"J Clin Med"},{"issue":"4","key":"bib63","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s12079-018-00500-8","article-title":"Monocyte chemoattractant protein-1 (MCP-1\/CCL2) in diabetic retinopathy: latest evidence and clinical considerations","volume":"13","author":"Taghavi","year":"2019","journal-title":"J Cell Commun Signal"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"858972","DOI":"10.3389\/fimmu.2022.858972","article-title":"Gene Biomarkers related to th17 cells in macular edema of diabetic retinopathy: cutting-edge comprehensive bioinformatics analysis and in vivo validation","volume":"13","author":"Huang","year":"2022","journal-title":"Front Immunol"},{"issue":"5","key":"bib65","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s10571-015-0164-z","article-title":"IL-4 induces cholinergic differentiation of retinal cells in vitro","volume":"35","author":"Granja","year":"2015","journal-title":"Cell Mol Neurobiol"},{"issue":"1\u20132","key":"bib66","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jneuroim.2008.03.003","article-title":"Interleukin-4 blocks proliferation of retinal progenitor cells and increases rod photoreceptor differentiation through distinct signaling pathways","volume":"196","author":"da Silva","year":"2008","journal-title":"J Neuroimmunol"},{"issue":"12","key":"bib67","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/s41419-022-05433-0","article-title":"IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Death Dis"},{"issue":"1","key":"bib68","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/s12964-024-01604-y","article-title":"Interleukin-4 protects retinal ganglion cells and promotes axon regeneration","volume":"22","author":"Zuo","year":"2024","journal-title":"Cell Commun Signal"},{"key":"bib69","doi-asserted-by":"crossref","DOI":"10.1038\/s41433-022-02127-x","article-title":"Changes in aqueous and vitreous inflammatory cytokine levels in proliferative diabetic retinopathy: a systematic review and meta-analysis","author":"Mason","year":"2022","journal-title":"Eye (Lond)"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"115334","DOI":"10.1016\/j.bcp.2022.115334","article-title":"MCP-1 facilitates VEGF production by removing miR-374b-5p blocking of VEGF mRNA translation","volume":"206","author":"Zhao","year":"2022","journal-title":"Biochem Pharmacol"},{"issue":"22","key":"bib71","doi-asserted-by":"publisher","first-page":"6428","DOI":"10.1111\/febs.16043","article-title":"Mesoglycan connects syndecan-4 and VEGFR2 through Annexin A1 and formyl peptide receptors to promote angiogenesis in vitro","volume":"288","author":"Pessolano","year":"2021","journal-title":"FEBS J"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.3389\/fphar.2018.01015","article-title":"Annexin A1(2\u201326) treatment improves skin heterologous transplantation by modulating inflammation and angiogenesis processes","volume":"9","author":"Lacerda","year":"2018","journal-title":"Front Pharmacol"},{"issue":"1","key":"bib73","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1159\/000529578","article-title":"The G-protein-coupled formyl peptide receptor 2 promotes endothelial-mesenchymal transition in diabetic retinopathy","volume":"66","author":"Lou","year":"2023","journal-title":"Ophthalmic Res"},{"issue":"6","key":"bib74","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.3390\/ijms19061816","article-title":"Diabetic retinopathy: pathophysiology and treatments","volume":"19","author":"Wang","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"1","key":"bib75","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1007\/s10753-021-01555-3","article-title":"Crosstalk between RPE cells and choroidal endothelial cells via the ANXA1\/FPR2\/SHP2\/NLRP3 inflammasome\/pyroptosis axis promotes choroidal neovascularization","volume":"45","author":"Zhu","year":"2022","journal-title":"Inflammation"},{"issue":"3","key":"bib76","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cyto.2009.11.004","article-title":"Roles of endothelin-1 and selected proinflammatory cytokines in the pathogenesis of proliferative diabetic retinopathy: analysis of vitreous samples","volume":"49","author":"Adamiec-Mroczek","year":"2010","journal-title":"Cytokine"},{"issue":"1","key":"bib77","doi-asserted-by":"publisher","first-page":"e0191285","DOI":"10.1371\/journal.pone.0191285","article-title":"Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes","volume":"13","author":"Chang","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"bib78","doi-asserted-by":"publisher","first-page":"e0175443","DOI":"10.1371\/journal.pone.0175443","article-title":"The ET-1-mediated carbonylation and degradation of ANXA1 induce inflammatory phenotype and proliferation of pulmonary artery smooth muscle cells in HPS","volume":"12","author":"He","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"bib79","doi-asserted-by":"publisher","first-page":"e0268353","DOI":"10.1371\/journal.pone.0268353","article-title":"Elevated aqueous endothelin-1 concentrations in advanced diabetic retinopathy","volume":"17","author":"Kang","year":"2022","journal-title":"PLoS One"},{"issue":"10","key":"bib80","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1038\/eye.2017.74","article-title":"Aqueous humor endothelin-1 and total retinal blood flow in patients with non-proliferative diabetic retinopathy","volume":"31","author":"Khuu","year":"2017","journal-title":"Eye (Lond)"},{"issue":"3","key":"bib81","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1161\/CIRCRESAHA.107.159814","article-title":"Protein carbonylation as a novel mechanism in redox signaling","volume":"102","author":"Wong","year":"2008","journal-title":"Circ Res"},{"issue":"5","key":"bib82","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.3390\/ijms25053052","article-title":"TGF-beta signaling pathways in the development of diabetic retinopathy","volume":"25","author":"Callan","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"bib83","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12938-024-01258-4","article-title":"Nuclear proteins and diabetic retinopathy: a review","volume":"23","author":"Li","year":"2024","journal-title":"Biomed Eng Online"},{"issue":"1","key":"bib84","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/s41420-023-01717-2","article-title":"Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy","volume":"9","author":"Li","year":"2023","journal-title":"Cell Death Discov"},{"issue":"7","key":"bib85","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.18240\/ijo.2022.07.20","article-title":"Molecules related to diabetic retinopathy in the vitreous and involved pathways","volume":"15","author":"Xia","year":"2022","journal-title":"Int J Ophthalmol"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:13Z","timestamp":1791927133000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":85,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.10.12","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,5]]}}}