{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:42Z","timestamp":1791928902151,"version":"4.3.4"},"reference-count":34,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,8,10]]},"DOI":"10.1167\/iovs.67.10.23","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:30:49Z","timestamp":1786365049000},"page":"23","source":"Crossref","is-referenced-by-count":0,"title":["SPARC Promotes Corneal Epithelial Wound Healing Through \u03b2-catenin Nuclear Translocation and c-Met Activation"],"prefix":"10.1167","volume":"67","author":[{"given":"Meihua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Qilu Hospital of Shandong University, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Qilu Hospital of Shandong University, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Qilu Hospital of Shandong University, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Qilu Hospital of Shandong University, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Chinese Ministry of Education, The Shandong Provincial Key Laboratory of Infection and Immunology, Department of Pathogenic Biology, School of Basic Medical Sciences, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Chinese Ministry of Education, The Shandong Provincial Key Laboratory of Infection and Immunology, Department of Pathogenic Biology, School of Basic Medical Sciences, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Qilu Hospital of Shandong University, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Qilu Hospital of Shandong University, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Qilu Hospital of Shandong University, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"107709","DOI":"10.1016\/j.exer.2019.107709","article-title":"Corneal injury: clinical and molecular aspects","volume":"186","author":"Barrientez","year":"2019","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1167\/iovs.63.1.22","article-title":"Corneal opacity: cell biological determinants of the transition from transparency to transient haze to scarring fibrosis, and resolution, after injury","volume":"63","author":"Wilson","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib3","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul Surf"},{"issue":"6","key":"bib4","doi-asserted-by":"publisher","first-page":"3471","DOI":"10.3390\/ijms25063471","article-title":"Corneal epithelial changes in diabetic patients: a review","volume":"25","author":"Ladea","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"5","key":"bib5","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/mi.2010.26","article-title":"Autoimmunity at the ocular surface: pathogenesis and regulation","volume":"3","author":"Stern","year":"2010","journal-title":"Mucosal Immunol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.preteyeres.2015.07.002","article-title":"Progress in corneal wound healing","volume":"49","author":"Ljubimov","year":"2015","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/njo.njo_24_19","article-title":"The use of bandage contact lens for epithelial healing in corneal epithelial defect","volume":"28","author":"Zulkarnaen","year":"2020","journal-title":"Niger J Ophthalmol"},{"issue":"7","key":"bib8","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1007\/s40123-025-01143-w","article-title":"A narrative review of amniotic membrane transplantation in ocular surface repair: unveiling the immunoregulatory pathways for timely intervention","volume":"14","author":"Hopkinson","year":"2025","journal-title":"Ophthalmol Ther"},{"issue":"6","key":"bib9","first-page":"e86231","article-title":"Effectiveness of amniotic membrane transplantation in corneal ulcer healing: a systematic review","volume":"17","author":"Ahmed","year":"2025","journal-title":"Cureus"},{"issue":"6","key":"bib10","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1001\/jamaophthalmol.2020.1120","article-title":"Outcomes of limbal stem cell transplant: a meta-analysis","volume":"138","author":"Le","year":"2020","journal-title":"JAMA Ophthalmol"},{"issue":"4","key":"bib11","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nrendo.2010.18","article-title":"SPARC: a key player in the pathologies associated with obesity and diabetes","volume":"6","author":"Kos","year":"2010","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.semcdb.2009.11.018","article-title":"Modulation of matrix remodeling by SPARC in neoplastic progression","volume":"21","author":"Chlenski","year":"2010","journal-title":"Semin Cell Dev Biol"},{"issue":"6","key":"bib13","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.drup.2008.08.005","article-title":"SPARC in cancer biology: its role in cancer progression and potential for therapy","volume":"11","author":"Tai","year":"2008","journal-title":"Drug Resist Updat"},{"issue":"6","key":"bib14","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1089\/scd.2020.0196","article-title":"The effect of SPARC on the proliferation and migration of limbal epithelial stem cells during the corneal epithelial wound healing","volume":"30","author":"Wang","year":"2021","journal-title":"Stem Cells Dev"},{"issue":"1","key":"bib15","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/stem.3100","article-title":"SPARC promotes self-renewal of limbal epithelial stem cells and ocular surface restoration through JNK and p38-MAPK signaling pathways","volume":"38","author":"Zhu","year":"2020","journal-title":"Stem Cells"},{"issue":"6","key":"bib16","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/\u00df-catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12943-022-01503-1","article-title":"Molecular mechanism(s) of regulation(s) of c-MET\/HGF signaling in head and neck cancer","volume":"21","author":"Raj","year":"2022","journal-title":"Mol Cancer"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1172\/JCI70921","article-title":"SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome","volume":"124","author":"Alachkar","year":"2014","journal-title":"J Clin Invest"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.3390\/biom13071103","article-title":"Omics overview of the SPARC gene in mesothelioma","volume":"13","author":"Wu","year":"2023","journal-title":"Biomolecules"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0014-4835(03)00060-5","article-title":"Increased SPARC accumulation during corneal repair","volume":"77","author":"Berryhill","year":"2003","journal-title":"Exp Eye Res"},{"issue":"2","key":"bib21","doi-asserted-by":"publisher","first-page":"e2204134120","DOI":"10.1073\/pnas.2204134120","article-title":"Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis","volume":"120","author":"Lin","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib22","first-page":"2547","article-title":"SPARC from corneal epithelial cells modulates collagen contraction by keratocytes","volume":"39","author":"Mishima","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/j.1600-065X.2008.00706.x","article-title":"Interleukin-10: new perspectives on an old cytokine","volume":"226","author":"Mosser","year":"2008","journal-title":"Immunol Rev"},{"issue":"7","key":"bib24","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/ncb2985","article-title":"Adherens junction treadmilling during collective migration","volume":"16","author":"Peglion","year":"2014","journal-title":"Nat Cell Biol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3892\/etm.2023.12072","article-title":"Lithium chloride promotes diabetic corneal epithelial wound healing by activating the Wnt\/\u00df catenin signaling pathway","volume":"26","author":"Dan","year":"2023","journal-title":"Exp Ther Med"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"110022","DOI":"10.1016\/j.exer.2024.110022","article-title":"Wnt\/\u00df-catenin signaling in corneal epithelium development, homeostasis, and pathobiology","volume":"246","author":"Wang","year":"2024","journal-title":"Exp Eye Res"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12943-018-0796-y","article-title":"Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol Cancer"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.1167\/iovs.07-0709","article-title":"Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing","volume":"49","author":"Kakazu","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"A357","DOI":"10.1016\/S0016-5085(08)81775-1","article-title":"Hepatocyte growth factor induces wnt-1 independent nuclear translocation of beta-catenin through association of \u00df-catenin and c-met in rat hepatocytes","volume":"120","author":"Michalopoulos","year":"2001","journal-title":"Gastroenterology"},{"key":"bib30","first-page":"5126","article-title":"Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer","volume":"62","author":"Boon","year":"2002","journal-title":"Cancer Res"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/sj.onc.1209859","article-title":"A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth","volume":"26","author":"Rasola","year":"2007","journal-title":"Oncogene"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1369\/jhc.3A6153.2004","article-title":"Functional analysis of the matricellular protein SPARC with novel monoclonal antibodies","volume":"52","author":"Sweetwyne","year":"2004","journal-title":"J Histochem Cytochem"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1167\/iovs.09-4569","article-title":"Normalization of wound healing and diabetic markers in organ cultured human diabetic corneas by adenoviral delivery of c-Met gene","volume":"51","author":"Saghizadeh","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.survophthal.2023.06.001","article-title":"New developments in the management of persistent corneal epithelial defects","volume":"68","author":"Thia","year":"2023","journal-title":"Surv Ophthalmol"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:16Z","timestamp":1791927136000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.10.23","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,10]]}}}