{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:43:22Z","timestamp":1792712602621,"version":"4.5.0"},"reference-count":48,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,8,14]]},"DOI":"10.1167\/iovs.67.10.37","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:30:56Z","timestamp":1786710656000},"page":"37","source":"Crossref","is-referenced-by-count":1,"title":["Pathological P-Selectin Upregulation Promotes Retinal Ganglion Cell Degeneration Accompanied by T-Cell Recruitment in Glaucoma"],"prefix":"10.1167","volume":"67","author":[{"given":"Wenbo","family":"Xiu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"},{"name":"Translational Clinical Immunology Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cheng","sequence":"additional","affiliation":[{"name":"Translational Clinical Immunology Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"},{"name":"Department of Obstetrics & Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Translational Clinical Immunology Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Translational Clinical Immunology Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaonan","family":"Sun","sequence":"additional","affiliation":[{"name":"Translational Clinical Immunology Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Gao","sequence":"additional","affiliation":[{"name":"Translational Clinical Immunology Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Li","sequence":"additional","affiliation":[{"name":"Translational Clinical Immunology Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Translational Clinical Immunology Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"},{"name":"Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Translational Clinical Immunology Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"2","key":"bib1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1001\/jama.2020.21899","article-title":"Glaucoma in adults\u2014screening. Diagnosis, and management.","volume":"325","author":"Stein","year":"2021","journal-title":"JAMA"},{"issue":"3","key":"bib2","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"bib3","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1001\/archopht.120.6.829","article-title":"Answers from the ocular hypertension treatment study","volume":"120","author":"Palmberg","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"100916","DOI":"10.1016\/j.preteyeres.2020.100916","article-title":"Inflammation in glaucoma: from the back to the front of the eye, and beyond","volume":"83","author":"Baudouin","year":"2021","journal-title":"Prog Retinal Eye Res"},{"issue":"1","key":"bib5","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s12974-022-02605-9","article-title":"The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases","volume":"19","author":"DeMaio","year":"2022","journal-title":"J Neuroinflamm"},{"issue":"1","key":"bib6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13619-025-00228-y","article-title":"Preserving blood-retinal barrier integrity: a path to retinal ganglion cell protection in glaucoma and traumatic optic neuropathy","volume":"14","author":"Zhou","year":"2025","journal-title":"Cell Regen"},{"issue":"8","key":"bib7","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1007\/s00417-004-1094-5","article-title":"Autoantibodies in patients with glaucoma: a comparison of IgG serum antibodies against retinal, optic nerve, and optic nerve head antigens","volume":"243","author":"Joachim","year":"2005","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"803485","DOI":"10.3389\/fimmu.2021.803485","article-title":"T Cell-mediated autoimmunity in glaucoma neurodegeneration","volume":"12","author":"Wang","year":"2021","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s12026-016-8837-3","article-title":"Glaucoma: recent advances in the involvement of autoimmunity","volume":"65","author":"Rizzo","year":"2016","journal-title":"Immunol Res."},{"key":"bib10","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.2147\/JIR.S329084","article-title":"Alterations in peripheral B cell subsets correlate with the disease severity of human glaucoma","volume":"14","author":"Yu","year":"2021","journal-title":"J Inflamm Res"},{"issue":"1","key":"bib11","doi-asserted-by":"publisher","first-page":"8063651","DOI":"10.1155\/2022\/8063651","article-title":"Clinical significance of albumin-and bilirubin-based biomarkers in glaucoma: a retrospective case-control study","volume":"2022","author":"He","year":"2022","journal-title":"Oxidative Med Cell Longev."},{"issue":"707","key":"bib12","doi-asserted-by":"publisher","first-page":"eadg1656","DOI":"10.1126\/scitranslmed.adg1656","article-title":"Gut-licensed \u00df7+ CD4+ T cells contribute to progressive retinal ganglion cell damage in glaucoma","volume":"15","author":"He","year":"2023","journal-title":"Sci Transl Med"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12974-024-03035-5","article-title":"Th1 cells contribute to retinal ganglion cell loss in glaucoma in a VCAM-1-dependent manner","volume":"21","author":"He","year":"2024","journal-title":"J Neuroinflamm"},{"issue":"2","key":"bib14","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/j.1750-3639.2007.00067.x","article-title":"Inflammatory cell migration into the central nervous system: a few new twists on an old tale","volume":"17","author":"Man","year":"2007","journal-title":"Brain Pathol"},{"issue":"2","key":"bib15","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00281-008-0106-7","article-title":"Mechanisms of leukocyte migration across the blood\u2013retina barrier","volume":"30","author":"Crane","year":"2008","journal-title":"Semin Immunopathol."},{"issue":"6398","key":"bib16","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/359848a0","article-title":"Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets","volume":"359","author":"Palabrica","year":"1992","journal-title":"Nature"},{"issue":"1\u20132","key":"bib17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jns.2008.05.019","article-title":"Immune cell entry into the central nervous system: involvement of adhesion molecules and chemokines","volume":"274","author":"Engelhardt","year":"2008","journal-title":"J Neurol Sci"},{"issue":"2","key":"bib18","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.4049\/jimmunol.169.2.1000","article-title":"Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis","volume":"169","author":"Kerfoot","year":"2002","journal-title":"J Immunol"},{"issue":"6","key":"bib19","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.ajo.2015.03.008","article-title":"P-selectin plasma levels and genetic variant associated with diabetic retinopathy in African Americans","volume":"159","author":"Penman","year":"2015","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"bib20","doi-asserted-by":"publisher","first-page":"10167","DOI":"10.3390\/ijms241210167","article-title":"The role of diabetic choroidopathy in the pathogenesis and progression of diabetic retinopathy","volume":"24","author":"Scuderi","year":"2023","journal-title":"Int J Mol Sci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/1471-2350-12-58","article-title":"Evaluation of variants in the selectin genes in age-related macular degeneration","volume":"12","author":"Mullins","year":"2011","journal-title":"BMC Med Genet"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/s41385-020-0282-x","article-title":"MAdCAM-1 mediates retinal neuron degeneration in experimental colitis through recruiting gut-homing CD4+ T cells","volume":"14","author":"Peng","year":"2021","journal-title":"Mucos Immunol"},{"issue":"1\u20132","key":"bib23","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jneuroim.2005.06.019","article-title":"Plasma levels of soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin are associated with relapsing-remitting disease course of multiple sclerosis","volume":"167","author":"Kuenz","year":"2005","journal-title":"J Neuroimmunol"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.2217\/bmm-2023-0651","article-title":"Platelet-to-lymphocyte ratio and lymphocyte-to-monocyte ratio in glaucoma: a meta-analysis","volume":"18","author":"Chuang","year":"2024","journal-title":"Biomark Med"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"701","DOI":"10.2147\/OPTH.S162999","article-title":"Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma","volume":"12","author":"Kondkar","year":"2018","journal-title":"Clin Ophthalmol"},{"issue":"4","key":"bib26","first-page":"512","article-title":"Progressive inflammatory coupling drives glaucoma progression - a longitudinal analysis of cytokine-RNFL dynamics","volume":"69","author":"Nica","year":"2025","journal-title":"Rom J Ophthalmol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1385358","DOI":"10.3389\/fmed.2024.1385358","article-title":"Association of plasma lactoferrin levels with disease severity in glaucoma patients","volume":"11","author":"Wang","year":"2024","journal-title":"Front Med (Lausanne)"},{"issue":"10-12","key":"bib28","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1080\/17520363.2024.2347190","article-title":"a-1 antitrypsin is promising for the identification of glaucoma severity and is associated with glaucomatous neural damage","volume":"18","author":"Yuan","year":"2024","journal-title":"Biomark Med"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1667097","DOI":"10.3389\/fimmu.2025.1667097","article-title":"Pro-inflammatory S100A9 contributes to retinal ganglion cell degeneration in glaucoma","volume":"16","author":"Wang","year":"2025","journal-title":"Front Immunol"},{"issue":"8","key":"bib30","doi-asserted-by":"publisher","first-page":"a017269","DOI":"10.1101\/cshperspect.a017269","article-title":"The complex role of neuroinflammation in glaucoma","volume":"4","author":"Soto","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"101169","DOI":"10.1016\/j.preteyeres.2023.101169","article-title":"Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma","volume":"93","author":"Miao","year":"2023","journal-title":"Prog Retinal Eye Res"},{"issue":"3","key":"bib32","doi-asserted-by":"publisher","first-page":"391","DOI":"10.4103\/1673-5374.245465","article-title":"Neuroinflammation as a target for glaucoma therapy","volume":"14","author":"Adornetto","year":"2019","journal-title":"Neural Regen Res"},{"issue":"14","key":"bib33","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1167\/iovs.61.14.18","article-title":"T and B lymphocyte deficiency in Rag1-\/- mice reduces retinal ganglion cell loss in experimental glaucoma","volume":"61","author":"Gramlich","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib34","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s40478-015-0234-y","article-title":"Adoptive transfer of immune cells from glaucomatous mice provokes retinal ganglion cell loss in recipients","volume":"3","author":"Gramlich","year":"2015","journal-title":"Acta Neuropathol Commun."},{"key":"bib35","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1471-4906(03)00117-0","article-title":"Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response","volume":"24","author":"Muller","year":"2003","journal-title":"Trends Immunol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1007\/s00018-016-2211-4","article-title":"Mechanisms of T cell organotropism","volume":"73","author":"Fu","year":"2016","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"bib37","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1091\/mbc.3.3.309","article-title":"Cytoplasmic domain of P-selectin (CD62) contains the signal for sorting into the regulated secretory pathway","volume":"3","author":"Disdier","year":"1992","journal-title":"Mol Biol Cell"},{"issue":"3","key":"bib38","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1002\/jlb.65.3.299","article-title":"P-selectin mediates neutrophil adhesion to endothelial cell borders","volume":"65","author":"Burns","year":"1999","journal-title":"J Leukoc Biol"},{"issue":"3","key":"bib39","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1084\/jem.181.3.1179","article-title":"P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor alpha-activated vascular endothelium under flow","volume":"181","author":"Luscinskas","year":"1995","journal-title":"J Exp Med"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1442613","DOI":"10.3389\/fneur.2024.1442613","article-title":"The role of P-selectin\/PSGL-1 in regulating NETs as a novel mechanism in cerebral ischemic injury","volume":"15","author":"Li","year":"2024","journal-title":"Front Neurol."},{"issue":"3","key":"bib41","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0304-3940(97)00385-6","article-title":"Postischemic expression of P-selectin immunoreactivity in rat brain","volume":"228","author":"Suzuki","year":"1997","journal-title":"Neurosci Lett"},{"issue":">12","key":"bib42","doi-asserted-by":"publisher","first-page":"4775","DOI":"10.1182\/blood-2002-10-3309","article-title":"CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1","volume":"101","author":"Battistini","year":"2003","journal-title":"Blood"},{"issue":"3","key":"bib43","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1167\/iovs.03-0526","article-title":"Platelets adhering to the vascular wall mediate postischemic leukocyte-endothelial cell interactions in retinal microcirculation","volume":"45","author":"Nishijima","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib44","first-page":"1610","article-title":"Role of P-selectin in endotoxin-induced uveitis","volume":"38","author":"Suzuma","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib45","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.4049\/jimmunol.168.4.1940","article-title":"Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors","volume":"168","author":"Piccio","year":"2002","journal-title":"J Immunol"},{"issue":"5","key":"bib46","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1056\/NEJMoa1611770","article-title":"Crizanlizumab for the prevention of pain crises in sickle cell disease","volume":"376","author":"Ataga","year":"2017","journal-title":"N Engl J Med"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"6138145","DOI":"10.1155\/2017\/6138145","article-title":"The interaction of selectins and PSGL-1 as a key component in thrombus formation and cancer progression","volume":"2017","author":"Kappelmayer","year":"2017","journal-title":"Biomed Res Int."},{"issue":"12","key":"bib48","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.2967\/jnumed.118.225169","article-title":"Targeting P-selectin adhesion molecule in molecular imaging: P-selectin expression as a valuable imaging biomarker of inflammation in cardiovascular disease","volume":"60","author":"Perkins","year":"2019","journal-title":"J Nucl Med"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.37","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:18Z","timestamp":1791927138000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.37"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.10.37","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,14]]}}}