{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:39Z","timestamp":1791928959923,"version":"4.3.4"},"reference-count":28,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,8,17]]},"DOI":"10.1167\/iovs.67.10.38","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:01:17Z","timestamp":1786971677000},"page":"38","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic and Structural Retinal Microvascular Alterations After Radiation Exposure: Insights From a Large-Animal Model"],"prefix":"10.1167","volume":"67","author":[{"given":"Aashka","family":"Damani","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrahman M.","family":"Elhusseiny","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little\u00a0Rock, Arkansas, United States"},{"name":"Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avigyan","family":"Sinha","sequence":"additional","affiliation":[{"name":"Vasoptic Medical, Inc., Columbia, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah R.","family":"Blair","sequence":"additional","affiliation":[{"name":"University of Florida School of Medicine, Gainesville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-En","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saige","family":"Oechsli","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Faria","sequence":"additional","affiliation":[{"name":"University of Veterinary Resources, University of Maryland, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Triesler","sequence":"additional","affiliation":[{"name":"Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindzy","family":"Calfee","sequence":"additional","affiliation":[{"name":"Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Nuon","sequence":"additional","affiliation":[{"name":"Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenaan","family":"Elbash","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shitiz","family":"Vij","sequence":"additional","affiliation":[{"name":"Vasoptic Medical, Inc., Columbia, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Magder","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Byrne","sequence":"additional","affiliation":[{"name":"University of Florida School of Medicine, Gainesville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Division of Translational Radiation Sciences, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel L.","family":"Jackson","sequence":"additional","affiliation":[{"name":"True North BioPharm, LLC, Rockville, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Rege","sequence":"additional","affiliation":[{"name":"Vasoptic Medical, Inc., Columbia, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamah J.","family":"Saeedi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"2","key":"bib1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1667\/RR14436.1","article-title":"Understanding the pathophysiology and challenges of development of medical countermeasures for radiation-induced vascular\/endothelial cell injuries: report of a NIAID Workshop, August 20, 2015","volume":"186","author":"Satyamitra","year":"2016","journal-title":"Radiat Res"},{"issue":"1","key":"bib2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/02841860510007440","article-title":"The pathology of ionizing radiation as defined by morphologic patterns","volume":"44","author":"Fajardo","year":"2005","journal-title":"Acta Oncol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.radonc.2021.02.007","article-title":"Mechanisms of radiation-induced endothelium damage: emerging models and technologies","volume":"158","author":"Wijerathne","year":"2021","journal-title":"Radiother Oncol"},{"issue":"2","key":"bib4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1667\/RR14445.1","article-title":"Ionizing radiation-induced endothelial cell senescence and cardiovascular diseases","volume":"186","author":"Wang","year":"2016","journal-title":"Radiat Res"},{"issue":"3","key":"bib5","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0039-6257(97)00088-X","article-title":"Radiation therapy for choroidal melanoma","volume":"42","author":"Finger","year":"1997","journal-title":"Surv Ophthalmol"},{"issue":"6","key":"bib6","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1136\/bjo.2004.052159","article-title":"Laser photocoagulation for radiation retinopathy after ophthalmic plaque radiation therapy","volume":"89","author":"Finger","year":"2005","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"bib7","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/0360-3016(94)90347-6","article-title":"Radiation retinopathy after external-beam irradiation: analysis of time-dose factors","volume":"30","author":"Parsons","year":"1994","journal-title":"Int J Radiat Oncol Biol Physics"},{"issue":"2","key":"bib8","doi-asserted-by":"publisher","first-page":"H201","DOI":"10.1152\/ajpheart.00201.2016","article-title":"Retinal microvascular network alterations: potential biomarkers of cerebrovascular and neural diseases","volume":"312","author":"Cabrera DeBuc","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"101095","DOI":"10.1016\/j.preteyeres.2022.101095","article-title":"Retinal vessel diameters and function in cardiovascular risk and disease","volume":"91","author":"Hanssen","year":"2022","journal-title":"Prog Retinal Eye Res"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.exer.2019.01.019","article-title":"Animal models of radiation retinopathy \u2013 From teletherapy to brachytherapy","volume":"181","author":"Ramos","year":"2019","journal-title":"Exp Eye Res"},{"issue":"sup1","key":"bib11","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1080\/09553002.2021.2002661","article-title":"Interagency approaches to animal models for acute radiation exposure","volume":"97","author":"Hunter","year":"2021","journal-title":"Int J Radiat Biol"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1364\/BOE.575278","article-title":"Development of a laser speckle contrast imaging analysis pipeline reveals a triphasic retinal blood flow waveform","volume":"17","author":"Tate","year":"2026","journal-title":"Biomed Opt Express"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"5713","DOI":"10.1038\/s41598-018-24141-4","article-title":"Ocular blood flow in rabbits under deep anesthesia: a real-time measurement technique and its application in characterizing retinal ischemia","volume":"8","author":"Bhatti","year":"2018","journal-title":"Sci Rep"},{"issue":"suppl 1","key":"bib14","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1080\/09553002.2020.1820606","article-title":"The New Zealand white rabbit animal model of acute radiation syndrome: hematopoietic and coagulation-based parameters by radiation dose following supportive care","volume":"97","author":"Paredes","year":"2021","journal-title":"Int J Radiat Biol"},{"issue":"3","key":"bib15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1160\/TH08-02-0103","article-title":"Interspecies differences in coagulation profile","volume":"100","author":"Siller-Matula","year":"2008","journal-title":"Thromb Haemost"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"20236","DOI":"10.1038\/s41598-020-76407-5","article-title":"Portable, non-invasive video imaging of retinal blood flow dynamics","volume":"10","author":"Cho","year":"2020","journal-title":"Sci Rep"},{"issue":"3","key":"bib17","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/ceo.14203","article-title":"Imaging in retinal vascular disease: a review","volume":"51","author":"H\u00e4ner","year":"2023","journal-title":"Clin Exp Ophthalmol"},{"issue":"suppl 1","key":"bib18","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1080\/09553002.2019.1665215","article-title":"Use of CT simulation and 3-D radiation therapy treatment planning system to develop and validate a total-body irradiation technique for the New Zealand White rabbit","volume":"97","author":"Poirier","year":"2021","journal-title":"Int J Radiat Biol"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"20236","DOI":"10.1038\/s41598-020-76407-5","article-title":"Portable, non-invasive video imaging of retinal blood flow dynamics","volume":"10","author":"Cho","year":"2020","journal-title":"Sci Rep"},{"issue":"6","key":"bib20","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/tvst.7.6.7","article-title":"Noninvasive assessment of retinal blood flow using a novel handheld laser speckle contrast imager","volume":"7","author":"Rege","year":"2018","journal-title":"Transl Vis Sci Technol"},{"issue":"9","key":"bib21","first-page":"1566","article-title":"Monitoring blood flow dynamics in retinal arteries and veins using the XyCAM RI","volume":"60","author":"Rege","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib22","doi-asserted-by":"publisher","first-page":"7699","DOI":"10.1167\/iovs.13-12930","article-title":"Waveform analysis of ocular blood flow and the early detection of normal tension glaucoma","volume":"54","author":"Shiga","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/photonics1030220","article-title":"Basic technology and clinical applications of the updated model of laser speckle flowgraphy to ocular diseases","volume":"1","author":"Sugiyama","year":"2014","journal-title":"Photonics"},{"issue":"12","key":"bib24","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.3109\/02713683.2014.905608","article-title":"Pulse-waveform analysis of normal population using laser speckle flowgraphy","volume":"39","author":"Tsuda","year":"2014","journal-title":"Curr Eye Res"},{"issue":"4","key":"bib26","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.jacbts.2018.01.014","article-title":"Radiation-induced endothelial vascular injury: a review of possible mechanisms","volume":"3","author":"Venkatesulu","year":"2018","journal-title":"JACC Basic Transl Sci"},{"issue":"1","key":"bib27","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1038\/s41598-021-04323-3","article-title":"Asymmetry between right and left fundus images identified using convolutional neural networks","volume":"12","author":"Kang","year":"2022","journal-title":"Sci Rep"},{"issue":"8","key":"bib28","first-page":"929","article-title":"Determinants of human asymmetry: does asymmetrical retinal vasculature predict asymmetry elsewhere in the body?","volume":"14","author":"Pleca\u0161","year":"2024","journal-title":"Life (Basel)"},{"key":"bib25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/B978-0-12-818561-2.00007-2","article-title":"Effects of radiation on endothelial barrier and vascular integrity","volume-title":"Tissue Barriers in Disease, Injury and Regeneration","author":"Bouten","year":"2021"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.38","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:18Z","timestamp":1791927138000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.38"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.10.38","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,17]]}}}