{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:44Z","timestamp":1791928904481,"version":"4.3.4"},"reference-count":86,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,8,17]]},"DOI":"10.1167\/iovs.67.10.43","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:01:20Z","timestamp":1786971680000},"page":"43","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic Factor Dysregulation and Distinct Expression Signatures in Retinoblastoma: A Transcriptomic Analysis"],"prefix":"10.1167","volume":"67","author":[{"given":"Gaurab Kumar","family":"Jha","sequence":"first","affiliation":[{"name":"The Operation Eyesight Universal Institute for Eye Cancer, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"},{"name":"Professor Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"},{"name":"https:\/\/orcid.org\/0000-0001-7271-1248"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azima","family":"Fatima","sequence":"additional","affiliation":[{"name":"The Operation Eyesight Universal Institute for Eye Cancer, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"},{"name":"Professor Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"},{"name":"https:\/\/orcid.org\/0009-0007-3470-7011"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Professor Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swathi","family":"Kaliki","sequence":"additional","affiliation":[{"name":"The Operation Eyesight Universal Institute for Eye Cancer, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"},{"name":"Professor Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"},{"name":"https:\/\/orcid.org\/0000-0002-0800-9961"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rani","family":"Pallavi","sequence":"additional","affiliation":[{"name":"The Operation Eyesight Universal Institute for Eye Cancer, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"},{"name":"Professor Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"},{"name":"https:\/\/orcid.org\/0000-0002-5720-9150"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"10","key":"bib1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/hmg\/ddn024","article-title":"Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma","volume":"17","author":"Dimaras","year":"2008","journal-title":"Hum Mol Genet"},{"issue":"8","key":"bib2","doi-asserted-by":"crossref","first-page":"e1128","DOI":"10.1016\/S2214-109X(22)00250-9","article-title":"The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries","volume":"10","author":"Fabian","year":"2022","journal-title":"Lancet Glob Health"},{"key":"bib3","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1097\/IAE.0000000000004250","article-title":"High-risk histopathological features of retinoblastoma following primary enucleation: a global study of 1426 patients from 5 continents","volume":"44","author":"Kaliki","year":"2024","journal-title":"Retina"},{"issue":"6","key":"bib4","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1001\/archophthalmol.2011.5","article-title":"Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience","volume":"129","author":"Gobin","year":"2011","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"bib5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.ophtha.2023.10.015","article-title":"Retinoblastoma in Asia: clinical presentation and treatment outcomes in 2112 patients from 33 countries","volume":"131","author":"Kaliki","year":"2024","journal-title":"Ophthalmology"},{"issue":"8","key":"bib6","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.4103\/IJO.IJO_3033_24","article-title":"Survival outcomes and globe salvage rates of retinoblastoma in India - a systematic review","volume":"73","author":"Das","year":"2025","journal-title":"Indian J Ophthalmol"},{"issue":"1","key":"bib7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/ceo.12132","article-title":"The genomic landscape of retinoblastoma: a review","volume":"42","author":"Th\u00e9riault","year":"2014","journal-title":"Clin Exp Ophthalmol"},{"issue":"4","key":"bib8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1470-2045(13)70045-7","article-title":"Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies","volume":"14","author":"Rushlow","year":"2013","journal-title":"Lancet Oncol"},{"issue":"3","key":"bib9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1349-7006.2008.01070.x","article-title":"Array comparative genomic hybridization in retinoma and retinoblastoma tissues","volume":"100","author":"Sampieri","year":"2009","journal-title":"Cancer Sci"},{"issue":"8","key":"bib10","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1200\/JCO.2008.18.1370","article-title":"Supervised risk predictor of breast cancer based on intrinsic subtypes","volume":"27","author":"Parker","year":"2009","journal-title":"J Clin Oncol"},{"issue":"1","key":"bib11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13058-017-0911-9","article-title":"Prognostic value of PAM50 and risk of recurrence score in patients with early-stage breast cancer with long-term follow-up","volume":"19","author":"Ohnstad","year":"2017","journal-title":"Breast Cancer Res"},{"issue":"4","key":"bib12","doi-asserted-by":"crossref","first-page":"e423","DOI":"10.1016\/j.clbc.2020.01.013","article-title":"Population-based study of Prosigna-PAM50 and outcome among postmenopausal women with estrogen receptor-positive and HER2-negative operable invasive lobular or ductal breast cancer","volume":"20","author":"L\u00e6nkholm","year":"2020","journal-title":"Clin Breast Cancer"},{"issue":"10","key":"bib13","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1056\/NEJMoa043331","article-title":"MGMT gene silencing and benefit from temozolomide in glioblastoma","volume":"352","author":"Hegi","year":"2005","journal-title":"N Engl J Med"},{"issue":"7","key":"bib14","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ebiom.2015.06.022","article-title":"Loss of photoreceptorness and gain of genomic alterations in retinoblastoma reveal tumor progression","volume":"2","author":"Kooi","year":"2015","journal-title":"EBioMedicine"},{"issue":"1","key":"bib15","doi-asserted-by":"crossref","first-page":"16475","DOI":"10.1038\/s41598-023-42253-4","article-title":"Transcriptome analysis reveals molecularly distinct subtypes in retinoblastoma","volume":"13","author":"Zeng","year":"2023","journal-title":"Sci Rep"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"5578","DOI":"10.1038\/s41467-021-25792-0","article-title":"A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal\/ganglion cell gene expression","volume":"12","author":"Liu","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/s42003-024-06596-6","article-title":"A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma","volume":"7","author":"Ryl","year":"2024","journal-title":"Commun Biol"},{"issue":"5","key":"bib18","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1038\/s41388-019-1036-7","article-title":"EZH2 targeting in medulloblastoma reduces tumor growth through epigenetic reactivation of the BAI1\/p53 tumor suppressor pathway","volume":"39","author":"Zhang","year":"2019","journal-title":"Oncogene"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.omto.2022.09.006","article-title":"Dual targeting of EZH1 and EZH2 for the treatment of malignant rhabdoid tumors","volume":"27","author":"Shinohara","year":"2022","journal-title":"Mol Ther Oncolytics"},{"issue":"1","key":"bib20","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41375-019-0497-6","article-title":"Loss of KDM6A confers drug resistance in acute myeloid leukemia","volume":"34","author":"Stief","year":"2019","journal-title":"Leukemia"},{"issue":"13","key":"bib21","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.3390\/cancers17132236","article-title":"KDM6A variants increased relapse risk in adult acute myeloid leukemia","volume":"17","author":"Zhao","year":"2025","journal-title":"Cancers"},{"issue":"11","key":"bib22","doi-asserted-by":"publisher","first-page":"14427","DOI":"10.1007\/s13277-016-5308-3","article-title":"Epigenetic regulation of human retinoblastoma","volume":"37","author":"Singh","year":"2016","journal-title":"Tumor Biology"},{"issue":"3","key":"bib23","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1593\/neo.04565","article-title":"Clinical implications of promoter hypermethylation in RASSF1A and MGMT in retinoblastoma","volume":"7","author":"Choy","year":"2005","journal-title":"Neoplasia"},{"issue":"5","key":"bib24","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1023\/A:1020607010296","article-title":"RB1 and CDKN2A functional defects resulting in retinoblastoma","volume":"36","author":"Babenko","year":"2002","journal-title":"Mol Biol"},{"issue":"3","key":"bib25","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/s41591-019-0383-9","article-title":"Developmental origins and emerging therapeutic opportunities for childhood cancer","volume":"25","author":"Filbin","year":"2019","journal-title":"Nat Med"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1073713","DOI":"10.3389\/fphar.2022.1073713","article-title":"Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Pharmacol"},{"issue":"7","key":"bib27","doi-asserted-by":"publisher","first-page":"e28165","DOI":"10.1016\/j.heliyon.2024.e28165","article-title":"Enhancing m6A modification of lncRNA through METTL3 and RBM15 to promote malignant progression in bladder cancer","volume":"10","author":"Huang","year":"2024","journal-title":"Heliyon"},{"issue":"11","key":"bib28","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1002\/1878-0261.13417","article-title":"Histone-lysine N-methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc-driven liver cancer","volume":"17","author":"Thng","year":"2023","journal-title":"Mol Oncol"},{"issue":"5","key":"bib29","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1309\/AJCPHGQ69FXDFWII","article-title":"Overexpression of DNA methyltransferases 1, 3a, and 3b significantly correlates with retinoblastoma tumorigenesis","volume":"134","author":"Qu","year":"2010","journal-title":"Am J Clin Pathol"},{"issue":"1","key":"bib30","doi-asserted-by":"publisher","first-page":"5523","DOI":"10.1038\/s41467-022-33248-2","article-title":"Characterizing DNA methylation signatures of retinoblastoma using aqueous humor liquid biopsy","volume":"13","author":"Li","year":"2022","journal-title":"Nat Commun"},{"issue":"1","key":"bib31","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1038\/s42003-023-05459-w","article-title":"Pan-cancer landscape of epigenetic factor expression predicts tumor outcome","volume":"6","author":"Cheng","year":"2023","journal-title":"Commun Biol"},{"issue":"2","key":"bib32","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.ccr.2011.07.005","article-title":"Coexpression of normally incompatible developmental pathways in retinoblastoma genesis","volume":"20","author":"McEvoy","year":"2011","journal-title":"Cancer Cell"},{"issue":"3","key":"bib33","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"affy\u2014analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"bib34","article-title":"sva: Surrogate Variable Analysis","author":"Leek","journal-title":"Bioconductor - R package"},{"issue":"D1","key":"bib35","doi-asserted-by":"publisher","first-page":"D564","DOI":"10.1093\/nar\/gkac989","article-title":"EpiFactors 2022: expansion and enhancement of a curated database of human epigenetic factors and complexes","volume":"51","author":"Marakulina","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"bib36","doi-asserted-by":"publisher","first-page":"gkaf018","DOI":"10.1093\/nar\/gkaf018","article-title":"edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets","volume":"53","author":"Chen","year":"2025","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"bib37","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/1471-2105-11-367","article-title":"A flexible R package for nonnegative matrix factorization","volume":"11","author":"Gaujoux","year":"2010","journal-title":"BMC Bioinformatics"},{"issue":"43","key":"bib38","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"bib39","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat Genet"},{"issue":"6","key":"bib40","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"issue":"7269","key":"bib41","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature08460","article-title":"Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1","volume":"462","author":"Barbie","year":"2009","journal-title":"Nature"},{"issue":"D1","key":"bib42","doi-asserted-by":"publisher","first-page":"D651","DOI":"10.1093\/nar\/gkae1033","article-title":"CORUM in 2024: protein complexes as drug targets","volume":"53","author":"Steinkamp","year":"2025","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"bib43","doi-asserted-by":"publisher","first-page":"W556","DOI":"10.1093\/nar\/gkz430","article-title":"GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis","volume":"47","author":"Tang","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"1571702","DOI":"10.3389\/fonc.2025.1571702","article-title":"A proteotranscriptomic approach to dissect the molecular landscape of human retinoblastoma","volume":"15","author":"Wolf","year":"2025","journal-title":"Front Oncol"},{"issue":"6755","key":"bib45","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/44565","article-title":"Learning the parts of objects by non-negative matrix factorization","volume":"401","author":"Lee","year":"1999","journal-title":"Nature"},{"issue":"12","key":"bib46","doi-asserted-by":"publisher","first-page":"4164","DOI":"10.1073\/pnas.0308531101","article-title":"Metagenes and molecular pattern discovery using matrix factorization","volume":"101","author":"Brunet","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"bib47","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1093\/bioinformatics\/btm134","article-title":"Sparse non-negative matrix factorizations via alternating non-negativity-constrained least squares for microarray data analysis","volume":"23","author":"Kim","year":"2007","journal-title":"Bioinformatics"},{"issue":"21","key":"bib48","doi-asserted-by":"publisher","first-page":"3970","DOI":"10.1093\/bioinformatics\/bti653","article-title":"Improving molecular cancer class discovery through sparse non-negative matrix factorization","volume":"21","author":"Gao","year":"2005","journal-title":"Bioinformatics"},{"issue":"10","key":"bib49","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1038\/ng.2764","article-title":"The Cancer Genome Atlas Pan-Cancer analysis project","volume":"45","author":"Weinstein","year":"2013","journal-title":"Nat Genet"},{"issue":"1","key":"bib50","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s13148-020-00941-2","article-title":"Rebelled epigenome: histone H3S10 phosphorylation and H3S10 kinases in cancer biology and therapy","volume":"12","author":"Komar","year":"2020","journal-title":"Clin Epigenetics"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"1495221","DOI":"10.3389\/fimmu.2024.1495221","article-title":"The role of histone post-translational modifications in cancer and cancer immunity: functions, mechanisms and therapeutic implications","volume":"15","author":"Duan","year":"2024","journal-title":"Front Immunol"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"1018161","DOI":"10.3389\/fcell.2022.1018161","article-title":"Increased Aurora B expression reduces substrate phosphorylation and induces chromosomal instability","volume":"10","author":"Britigan","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"20","key":"bib53","doi-asserted-by":"publisher","first-page":"3566","DOI":"10.1128\/MCB.01286-14","article-title":"Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development","volume":"35","author":"Gonz\u00e1lez-Loyola","year":"2015","journal-title":"Mol Cell Biol"},{"issue":"2","key":"bib54","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1136\/jcp.2006.036806","article-title":"Aurora B expression correlates with aggressive behaviour in glioblastoma multiforme","volume":"60","author":"Zeng","year":"2007","journal-title":"J Clin Pathol"},{"issue":"9","key":"bib55","doi-asserted-by":"publisher","first-page":"e0203397","DOI":"10.1371\/journal.pone.0203397","article-title":"Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells","volume":"13","author":"Mon","year":"2018","journal-title":"PLoS One"},{"issue":"3","key":"bib56","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1167\/iovs.62.3.16","article-title":"Aurora kinase B expression, its regulation and therapeutic targeting in human retinoblastoma","volume":"62","author":"Borah","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib57","doi-asserted-by":"publisher","first-page":"e23829","DOI":"10.1016\/j.heliyon.2023.e23829","article-title":"ANP32B promotes colorectal cancer cell progression and reduces cell sensitivity to PRAP1 inhibitor through up-regulating HPF1","volume":"10","author":"Yang","year":"2024","journal-title":"Heliyon"},{"issue":"6","key":"bib58","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1002\/1878-0261.12202","article-title":"ANP32E induces tumorigenesis of triple-negative breast cancer cells by upregulating E2F1","volume":"12","author":"Xiong","year":"2018","journal-title":"Mol Oncol"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"874235","DOI":"10.3389\/fphar.2022.874235","article-title":"VRK1 predicts poor prognosis and promotes bladder cancer growth and metastasis in vitro and in vivo","volume":"13","author":"Wu","year":"2022","journal-title":"Front Pharmacol"},{"issue":"2","key":"bib60","first-page":"144","article-title":"Expression of heat shock protein 27 and proliferating cell nuclear antigen in human retinoblastoma","volume":"17","author":"Qin","year":"2013","journal-title":"Contemp Oncol (Pozn)"},{"issue":"1","key":"bib61","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1186\/s13046-022-02528-6","article-title":"UBR7 inhibits HCC tumorigenesis by targeting Keap1\/Nrf2\/Bach1\/HK2 and glycolysis","volume":"41","author":"Zhao","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"bib62","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1186\/s12885-022-09552-x","article-title":"Low level of fibrillarin, a ribosome biogenesis factor, is a new independent marker of poor outcome in breast cancer","volume":"22","author":"Nguyen Van Long","year":"2022","journal-title":"BMC Cancer"},{"issue":"7","key":"bib63","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1136\/bjo-2023-323388","article-title":"Subset of retinoblastoma tumours is associated with BRCA1\/2 mutations","volume":"108","author":"Kim","year":"2024","journal-title":"Br J Ophthalmol"},{"issue":"7","key":"bib64","doi-asserted-by":"publisher","first-page":"3527","DOI":"10.21037\/tcr-21-1034","article-title":"Exploration of retinoblastoma pathogenesis with bioinformatics","volume":"10","author":"Zhang","year":"2021","journal-title":"Transl Cancer Res"},{"issue":"2","key":"bib65","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41389-020-0210-7","article-title":"Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression","volume":"9","author":"Zocchi","year":"2020","journal-title":"Oncogenesis"},{"issue":"3\u20134","key":"bib66","doi-asserted-by":"crossref","first-page":"23","DOI":"10.18632\/oncoscience.502","article-title":"Heavenly HELLS? A potential new therapeutic target for retinoblastoma","volume":"7","author":"Zocchi","year":"2020","journal-title":"Oncoscience"},{"issue":"20","key":"bib67","doi-asserted-by":"publisher","first-page":"9594","DOI":"10.18632\/oncotarget.2468","article-title":"Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression","volume":"5","author":"Benavente","year":"2014","journal-title":"Oncotarget"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"113436","DOI":"10.1016\/j.intimp.2024.113436","article-title":"ANP32E promotes esophageal cancer progression and paclitaxel resistance via P53\/SLC7A11 axis-regulated ferroptosis","volume":"144","author":"Sun","year":"2025","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"bib69","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/s41419-024-07145-z","article-title":"The interaction between UBR7 and PRMT5 drives PDAC resistance to gemcitabine by regulating glycolysis and immune microenvironment","volume":"15","author":"Feng","year":"2024","journal-title":"Cell Death Dis"},{"issue":"7","key":"bib70","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.18632\/oncotarget.1678","article-title":"Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response","volume":"5","author":"Salzano","year":"2014","journal-title":"Oncotarget"},{"issue":"7","key":"bib71","doi-asserted-by":"publisher","first-page":"e126140","DOI":"10.1172\/jci.insight.126140","article-title":"Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC","volume":"4","author":"Zhang","year":"2019","journal-title":"JCI Insight"},{"issue":"1","key":"bib72","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/cam4.3627","article-title":"HELLS, a chromatin remodeler is highly expressed in pancreatic cancer and downregulation of it impairs tumor growth and sensitizes to cisplatin by reexpressing the tumor suppressor TGFBR3","volume":"10","author":"Hou","year":"2020","journal-title":"Cancer Med"},{"issue":"1","key":"bib73","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/s41419-025-07641-w","article-title":"VRK1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma mediated by SNAI1 via phosphorylating CHD1L","volume":"16","author":"Li","year":"2025","journal-title":"Cell Death Dis"},{"issue":"1","key":"bib74","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41698-023-00407-7","article-title":"Targeting CDK1 in cancer: mechanisms and implications","volume":"7","author":"Wang","year":"2023","journal-title":"NPJ Precis Oncol"},{"issue":"3","key":"bib75","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1021\/acs.jmedchem.4c00526","article-title":"Targeting the \u201cUndruggable\u201d: small-molecule inhibitors of proliferating cell nuclear antigen (PCNA) in the spotlight in cancer therapy","volume":"68","author":"Wang","year":"2025","journal-title":"J Med Chem"},{"issue":"2","key":"bib76","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/iovs.62.2.6","article-title":"Retinoblastoma is characterized by a cold, CD8+ cell poor, PD-L1- microenvironment, which turns into hot, CD8+ cell rich, PD-L1+ after chemotherapy","volume":"62","author":"Miracco","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"1106638","DOI":"10.3389\/fcell.2023.1106638","article-title":"Advances in holliday junction recognition protein (HJURP): Structure, molecular functions, and roles in cancer","volume":"11","author":"Li","year":"2023","journal-title":"Front Cell Dev Biol"},{"issue":"8","key":"bib78","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.3390\/molecules28083385","article-title":"Aurora B inhibitors as cancer therapeutics","volume":"28","author":"Kovacs","year":"2023","journal-title":"Molecules"},{"issue":"24","key":"bib79","doi-asserted-by":"publisher","first-page":"3207","DOI":"10.1016\/j.scib.2023.11.027","article-title":"Engineering redirected NF-?B\/OIP5 expression programs to enhance tumor responses to chemotherapy in bladder cancer","volume":"68","author":"Zheng","year":"2023","journal-title":"Sci Bull (Beijing)"},{"issue":"1","key":"bib80","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/1476-4598-13-125","article-title":"DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells","volume":"13","author":"Bachmann","year":"2014","journal-title":"Mol Cancer"},{"issue":"1","key":"bib81","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.bbalip.2011.09.014","article-title":"The retinoid X receptors and their ligands","volume":"1821","author":"Dawson","year":"2011","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"bib82","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3892\/ol.2024.14343","article-title":"p160 nuclear receptor coactivator family members and their role in rare fusion-driven neoplasms (Review)","volume":"27","author":"Segovia","year":"2024","journal-title":"Oncol Lett"},{"issue":"1","key":"bib83","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/s41392-021-00674-5","article-title":"Disruption of KDM4C-ALDH1A3 feed-forward loop inhibits stemness, tumorigenesis and chemoresistance of gastric cancer stem cells","volume":"6","author":"Lang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"bib84","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.ymthe.2022.10.012","article-title":"N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis","volume":"31","author":"Lin","year":"2023","journal-title":"Mol Ther"},{"issue":"4","key":"bib85","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.ccell.2019.03.006","article-title":"Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia","volume":"35","author":"Huang","year":"2019","journal-title":"Cancer Cell"},{"issue":"10","key":"bib86","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1097\/CAD.0000000000001514","article-title":"TACH101, a first-in-class pan-inhibitor of KDM4 histone demethylase","volume":"34","author":"Chandhasin","year":"2023","journal-title":"Anticancer Drugs"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.43","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:19Z","timestamp":1791927139000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.43"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":86,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.10.43","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,17]]}}}