{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:38Z","timestamp":1791928958090,"version":"4.3.4"},"reference-count":28,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,8,27]]},"DOI":"10.1167\/iovs.67.10.67","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:30:40Z","timestamp":1787837440000},"page":"67","source":"Crossref","is-referenced-by-count":0,"title":["Machine Learning\u2013Based Cytokine Endotyping of Thyroid Eye Disease"],"prefix":"10.1167","volume":"67","author":[{"given":"Gaojing","family":"Jing","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China"},{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou, China"},{"name":"Gansu Clinical Medical Research Center for Endocrine Disease, Lanzhou, China"},{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyin","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou, China"},{"name":"School of Basic Medical Sciences, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxia","family":"Huang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Tang","sequence":"additional","affiliation":[{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"},{"name":"Shandong Second Medical University, Weifang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhan","family":"Ao","sequence":"additional","affiliation":[{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"},{"name":"School of Medicine, Nankai University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinji","family":"Yang","sequence":"additional","affiliation":[{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ma","sequence":"additional","affiliation":[{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xulei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China"},{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou, China"},{"name":"Gansu Clinical Medical Research Center for Endocrine Disease, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songbo","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China"},{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou, China"},{"name":"Gansu Clinical Medical Research Center for Endocrine Disease, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"7","key":"bib1","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/S2213-8587(25)00066-X","article-title":"Thyroid eye disease (Graves' orbitopathy): clinical presentation, epidemiology, pathogenesis, and management","volume":"13","author":"Wiersinga","year":"2025","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"2","key":"bib2","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1097\/IOP.0000000000001446","article-title":"Quality of life in thyroid eye disease: a systematic review","volume":"36","author":"Lee","year":"2020","journal-title":"Ophthalmic Plast Reconstr Surg"},{"issue":"2","key":"bib3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ecl.2021.12.004","article-title":"Update on clinical management of Graves disease and thyroid eye disease","volume":"51","author":"Hoang","year":"2022","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"3","key":"bib4","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s11154-021-09702-9","article-title":"A systematic review of multimodal clinical biomarkers in the management of thyroid eye disease","volume":"23","author":"Poon","year":"2022","journal-title":"Rev Endocr Metab Disord"},{"issue":"1148","key":"bib5","doi-asserted-by":"publisher","first-page":"20220972","DOI":"10.1259\/bjr.20220972","article-title":"Interobserver variability studies in diagnostic imaging: a methodological systematic review","volume":"96","author":"Quinn","year":"2023","journal-title":"Br J Radiol"},{"issue":"4","key":"bib6","first-page":"044001","article-title":"Imaging biomarkers in thyroid eye disease and their clinical associations","volume":"5","author":"Chaganti","year":"2018","journal-title":"J Med Imaging (Bellingham)"},{"issue":"15","key":"bib7","doi-asserted-by":"publisher","first-page":"6038","DOI":"10.7150\/ijbs.103977","article-title":"Multi-omics approaches to discover biomarkers of thyroid eye disease: a systematic review","volume":"20","author":"Zhang","year":"2024","journal-title":"Int J Biol Sci"},{"issue":"6","key":"bib8","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1007\/BF03346614","article-title":"Pathogenesis of Graves' orbitopathy: a 2010 update","volume":"33","author":"Smith","year":"2010","journal-title":"J Endocrinol Invest"},{"issue":"1","key":"bib9","doi-asserted-by":"publisher","first-page":"e260","DOI":"10.1210\/clinem\/dgaf273","article-title":"Thyrotrophin receptor antibody: objective and quantitative inflammatory indicator in patients with thyroid eye disease","volume":"111","author":"Jing","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"bib10","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1167\/iovs.66.3.33","article-title":"Orbital clinicopathological differences in thyroid eye disease: an analysis of cytokines with histopathological and clinical correlation","volume":"66","author":"Li","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1\u20132","key":"bib11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jim.2009.06.007","article-title":"Multiplex cytokine profiling with highly pathogenic material: use of formalin solution in Luminex analysis","volume":"348","author":"Dowall","year":"2009","journal-title":"J Immunol Methods"},{"issue":"2","key":"bib12","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.autrev.2014.10.016","article-title":"Autoimmune thyroid disorders","volume":"14","author":"Antonelli","year":"2015","journal-title":"Autoimmun Rev"},{"issue":"12","key":"bib13","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1089\/thy.2022.0251","article-title":"Management of thyroid eye disease: a consensus statement by the American Thyroid Association and the European Thyroid Association","volume":"32","author":"Burch","year":"2022","journal-title":"Thyroid"},{"issue":"1","key":"bib14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1046\/j.1365-2265.1997.2331047.x","article-title":"Clinical activity score as a guide in the management of patients with Graves' ophthalmopathy","volume":"47","author":"Mourits","year":"1997","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"bib15","doi-asserted-by":"publisher","first-page":"G43","DOI":"10.1530\/EJE-21-0479","article-title":"The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy","volume":"185","author":"Bartalena","year":"2021","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"bib16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1089\/thy.1991.1.357","article-title":"Classification of the eye changes of Graves' disease","volume":"1","author":"Wiersinga","year":"1991","journal-title":"Thyroid"},{"issue":"7","key":"bib17","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"bib18","doi-asserted-by":"crossref","first-page":"D1049","DOI":"10.1093\/nar\/gku1179","article-title":"Gene Ontology Consortium: going forward","volume":"43","author":"Gene Ontology Consortium","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto Encyclopedia of Genes and Genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"bib20","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkad1025","article-title":"The Reactome Pathway Knowledgebase 2024","volume":"52","author":"Milacic","year":"2024","journal-title":"Nucleic Acids Res"},{"issue":"21","key":"bib21","doi-asserted-by":"publisher","first-page":"9647","DOI":"10.1073\/pnas.92.21.9647","article-title":"The VLA4\/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen","volume":"92","author":"Papayannopoulou","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"bib22","doi-asserted-by":"publisher","first-page":"e140315","DOI":"10.1172\/JCI140315","article-title":"Macrophage-mediated vascular permeability via VLA4\/VCAM1 pathway dictates ascites development in ovarian cancer","volume":"131","author":"Zhang","year":"2021","journal-title":"J Clin Invest"},{"issue":"2","key":"bib23","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1046\/j.1365-2249.1997.3621258.x","article-title":"Adhesion molecule expression in vivo on extraocular muscles (EOM) in thyroid-associated ophthalmopathy (TAO)","volume":"108","author":"Pappa","year":"1997","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"bib24","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.cell.2024.11.031","article-title":"Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes","volume":"188","author":"Chen","year":"2025","journal-title":"Cell"},{"issue":"5","key":"bib25","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.cmet.2025.01.006","article-title":"Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation","volume":"37","author":"Wu","year":"2025","journal-title":"Cell Metab"},{"issue":"2","key":"bib26","doi-asserted-by":"publisher","first-page":"e14393","DOI":"10.1111\/acel.14393","article-title":"Neuronal cathepsin S increases neuroinflammation and causes cognitive decline via CX3CL1-CX3CR1 axis and JAK2-STAT3 pathway in aging and Alzheimer's disease","volume":"24","author":"Liu","year":"2025","journal-title":"Aging Cell"},{"issue":"2","key":"bib27","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1080\/02713683.2020.1786132","article-title":"Altered expression of CXCL13 and its chemokine receptor CXCR5 on B lymphocytes during active Graves' orbitopathy","volume":"46","author":"Wan","year":"2021","journal-title":"Curr Eye Res"},{"issue":"7","key":"bib28","doi-asserted-by":"publisher","first-page":"776","DOI":"10.3390\/jpm14070776","article-title":"Thyroid eye disease: advancements in orbital and ocular pathology management","volume":"14","author":"Scarabosio","year":"2024","journal-title":"J Pers Med"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.67","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:23Z","timestamp":1791927143000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.67"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.10.67","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,27]]}}}