{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:37Z","timestamp":1791928957933,"version":"4.3.4"},"reference-count":47,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,8,31]]},"DOI":"10.1167\/iovs.67.10.70","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:30:52Z","timestamp":1788179452000},"page":"70","source":"Crossref","is-referenced-by-count":0,"title":["Stress Inference in Retinal Pigment Epithelium in C57BL\/6J Mouse"],"prefix":"10.1167","volume":"67","author":[{"given":"Isaac","family":"Goodspeed","sequence":"first","affiliation":[{"name":"Department of Mathematics and Statistics, Georgia State University, Atlanta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, Georgia State University, Atlanta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Shane","family":"Hutson","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micah A.","family":"Chrenek","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University, Atlanta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Boatright","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University, Atlanta, Georgia, United States"},{"name":"Atlanta Veterans Administration Center for Visual and Neurocognitive Rehabilitation, Decatur, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Nickerson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Emory University, Atlanta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, Georgia State University, Atlanta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"10","key":"bib1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/iovs.61.10.1","article-title":"Gradual increase in environmental light intensity induces oxidative stress and inflammation and accelerates retinal neurodegeneration","volume":"61","author":"Kutsyr","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib2","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.survophthal.2024.07.004","article-title":"Retinal light damage: from mechanisms to protective strategies","volume":"69","author":"Zhang","year":"2024","journal-title":"Surv Ophthalmol"},{"issue":"4","key":"bib3","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1755-3768.2011.02179.x","article-title":"Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration","volume":"90","author":"Kinnunen","year":"2012","journal-title":"Acta Ophthalmol"},{"issue":"4","key":"bib4","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.mam.2012.04.005","article-title":"Understanding age-related macular degeneration (AMD): relationships between the photoreceptor\/retinal pigment epithelium\/Bruch's membrane\/choriocapillaris complex","volume":"33","author":"Bhutto","year":"2012","journal-title":"Mol Aspects Med"},{"issue":"6","key":"bib5","doi-asserted-by":"publisher","first-page":"e2339","DOI":"10.1371\/journal.pone.0002339","article-title":"The aged retinal pigment epithelium\/choroid: a potential substratum for the pathogenesis of age-related macular degeneration","volume":"3","author":"Chen","year":"2008","journal-title":"PLoS One"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1009599","DOI":"10.3389\/fnins.2022.1009599","article-title":"Exploring the pathogenesis of age-related macular degeneration: a review of the interplay between retinal pigment epithelium dysfunction and the innate immune system","volume":"16","author":"Wong","year":"2022","journal-title":"Front Neurosci"},{"issue":"5","key":"bib7","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.survophthal.2025.03.004","article-title":"The role of retinal pigment epithelial senescence and the potential of senotherapeutics in age-related macular degeneration","volume":"70","author":"Chen","year":"2025","journal-title":"Surv Ophthalmol"},{"issue":"12","key":"bib8","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1001\/jamaophthalmol.2022.4401","article-title":"Prevalence of age-related macular degeneration in the US in 2019","volume":"140","author":"Rein","year":"2022","journal-title":"JAMA Ophthalmol"},{"issue":"3","key":"bib9","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol Rev"},{"issue":"pt 3","key":"bib10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/eye.2001.141","article-title":"The role of the retinal pigment epithelium: topographical variation and ageing changes","volume":"15","author":"Boulton","year":"2001","journal-title":"Eye (Lond)"},{"issue":"19","key":"bib11","doi-asserted-by":"publisher","first-page":"e2117553119","DOI":"10.1073\/pnas.2117553119","article-title":"Single-cell\u2013resolution map of human retinal pigment epithelium helps discover subpopulations with differential disease sensitivity","volume":"119","author":"Ortolan","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"bib12","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1001\/archophthalmol.2010.92","article-title":"The prevalence of age-related macular degeneration and associated risk factors","volume":"128","author":"Klein","year":"2010","journal-title":"Arch Ophthalmol"},{"issue":"13","key":"bib13","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1167\/iovs.66.13.42","article-title":"Total retinal pigment epithelium thickness and reflectivity, in relation to histology and vision, at the aging-AMD transition: ALSTAR2 baseline","volume":"66","author":"Habibi","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0039-6257(03)00030-4","article-title":"Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies","volume":"48","author":"Ambati","year":"2003","journal-title":"Surv Ophthalmol"},{"issue":"3","key":"bib15","first-page":"353","article-title":"Age-related macular degeneration (AMD): pathogenesis and therapy","volume":"58","author":"Nowak","year":"2006","journal-title":"Pharmacol Rep"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"213343","DOI":"10.1016\/j.bioadv.2023.213343","article-title":"Mechanobiological implications of age-related remodelling in the outer retina","volume":"147","author":"Piskova","year":"2023","journal-title":"Biomater Adv"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0074-7696(07)58004-6","article-title":"Development and role of tight junctions in the retinal pigment epithelium","volume":"258","author":"Rizzolo","year":"2007","journal-title":"Int Rev Cytol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1393057","DOI":"10.3389\/fmed.2024.1393057","article-title":"The mechanics of the retina: M\u00fcller glia role on retinal extracellular matrix and modelling","volume":"11","author":"Prieto-L\u00f3pez","year":"2024","journal-title":"Front Med (Lausanne)"},{"issue":"8","key":"bib19","first-page":"2524","article-title":"Mechanical stress and geographic atrophy: investigating the role of retinal pigment epithelium disruptions in age-related macular degeneration","volume":"66","author":"Raja","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","first-page":"641","article-title":"Explanatory notes and discussion of the nature of the prismatic forms of a group of columnar basalts, Giant's Causeway","volume":"26","author":"O'Reilly","year":"1879","journal-title":"Trans R Irish Acad"},{"issue":"1","key":"bib21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s004540010071","article-title":"The honeycomb conjecture","volume":"25","author":"Hales","year":"2001","journal-title":"Discrete Comput Geom"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1103\/PhysRevA.36.306","article-title":"Dynamics of two-dimensional soap froths","volume":"36","author":"Glazier","year":"1987","journal-title":"Phys Rev A"},{"issue":"8","key":"bib23","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nrm2222","article-title":"Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis","volume":"8","author":"Lecuit","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"5762","DOI":"10.1038\/s41467-023-41449-6","article-title":"Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density","volume":"14","author":"Eckert","year":"2023","journal-title":"Nat Commun"},{"issue":"5","key":"bib25","doi-asserted-by":"publisher","first-page":"e1012993","DOI":"10.1371\/journal.pcbi.1012993","article-title":"Vertex models capturing subcellular scales in epithelial tissues","volume":"21","author":"Lange","year":"2025","journal-title":"PLoS Comput Biol"},{"issue":"5","key":"bib26","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/S1350-9462(03)00039-9","article-title":"Neural remodeling in retinal degeneration","volume":"22","author":"Marc","year":"2003","journal-title":"Prog Retin Eye Res"},{"issue":"12","key":"bib27","doi-asserted-by":"publisher","first-page":"7274","DOI":"10.1167\/iovs.13-12450","article-title":"Functional principal component analysis reveals discriminating categories of retinal pigment epithelial morphology in mice","volume":"54","author":"Jiang","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"13","key":"bib28","doi-asserted-by":"publisher","first-page":"5479","DOI":"10.1167\/iovs.16-19816","article-title":"Associations between retinal pigment epithelium and drusen volume changes during the lifecycle of large drusenoid pigment epithelial detachments","volume":"57","author":"Balaratnasingam","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","first-page":"898","article-title":"Analysis of RPE morphometry in human eyes","volume":"22","author":"Bhatia","year":"2016","journal-title":"Mol Vis"},{"issue":"8","key":"bib30","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1167\/tvst.11.8.19","article-title":"Histologic cell shape descriptors for the retinal pigment epithelium in age-related macular degeneration: a comparison to unaffected eyes","volume":"11","author":"von der Emde","year":"2022","journal-title":"Transl Vis Sci Technol"},{"issue":"12","key":"bib31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/iovs.65.12.7","article-title":"Retinal pigment epithelium curvature can predict late age-related macular degeneration","volume":"65","author":"Cheung","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib32","first-page":"40","article-title":"Methodologies for analysis of patterning in the mouse RPE sheet","volume":"21","author":"Boatright","year":"2015","journal-title":"Mol Vis"},{"issue":"5","key":"bib33","doi-asserted-by":"publisher","first-page":"e1002512","DOI":"10.1371\/journal.pcbi.1002512","article-title":"Mechanical stress inference for two dimensional cell arrays","volume":"8","author":"Chiou","year":"2012","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"bib34","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: a generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nat Methods"},{"issue":"7","key":"bib35","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"issue":"6","key":"bib36","doi-asserted-by":"publisher","first-page":"e99116","DOI":"10.1371\/journal.pone.0099116","article-title":"CellFIT: a cellular force-inference toolkit using curvilinear cell boundaries","volume":"9","author":"Brodland","year":"2014","journal-title":"PLoS One"},{"issue":"18","key":"bib37","doi-asserted-by":"publisher","first-page":"dev192773","DOI":"10.1242\/dev.192773","article-title":"Inferring cell junction tension and pressure from cell geometry","volume":"148","author":"Roffay","year":"2021","journal-title":"Development"},{"issue":"3","key":"bib38","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/ar.1090380305","article-title":"The correlation between cell division and the shapes and sizes of prismatic cells in the epidermis of cucumis","volume":"38","author":"Lewis","year":"1928","journal-title":"Anat Rec"},{"issue":"1","key":"bib39","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0026-0800(80)90021-X","article-title":"The arrangement of cells in a net","volume":"13","author":"Aboav","year":"1980","journal-title":"Metallography"},{"issue":"3","key":"bib40","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0026-0800(83)90012-5","article-title":"The arrangement of cells in a net. II","volume":"16","author":"Aboav","year":"1983","journal-title":"Metallography"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/ncomms1536","article-title":"Epithelial organisation revealed by a network of cellular contacts","volume":"2","author":"Escudero","year":"2011","journal-title":"Nat Commun"},{"issue":"2","key":"bib42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/1044-5803(94)00081-U","article-title":"Aboav-Weaire's and Lewis\u2019 laws\u2014a review","volume":"34","author":"Chiu","year":"1995","journal-title":"Mater Charact"},{"issue":"5","key":"bib43","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1152\/japplphysiol.00844.2009","article-title":"The effect of tissue elastic properties and surfactant on alveolar stability","volume":"109","author":"Andreassen","year":"2010","journal-title":"J Appl Physiol"},{"key":"bib44","doi-asserted-by":"crossref","first-page":"138","DOI":"10.9734\/bpi\/nvbs\/v10\/1886A","article-title":"Laplace pressure controls cell blebbing to regulate the symmetry of cell division","volume":"10","author":"Wang","year":"2022","journal-title":"New Vis Biol Sci"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.jtbi.2012.08.017","article-title":"Bayesian inference of force dynamics during morphogenesis","volume":"313","author":"Ishihara","year":"2012","journal-title":"J Theor Biol"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/978-1-4614-3209-8","article-title":"Analysis of mouse RPE sheet morphology gives discriminatory categories","volume":"801","author":"Jiang","year":"2014","journal-title":"Adv Exp Med Biol"},{"issue":"11-12","key":"bib47","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.mod.2009.09.002","article-title":"Determination of mechanical stress distribution in Drosophila wing discs using photoelasticity","volume":"126","author":"Nienhaus","year":"2009","journal-title":"Mech Dev"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.70","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:24Z","timestamp":1791927144000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.10.70"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.10.70","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,31]]}}}