{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:42Z","timestamp":1791928902061,"version":"4.3.4"},"reference-count":35,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,10,7]]},"DOI":"10.1167\/iovs.67.12.14","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:30:54Z","timestamp":1791376254000},"page":"14","source":"Crossref","is-referenced-by-count":0,"title":["Surface-Specific Internal Limiting Membrane Biomechanics in Epiretinal Membrane Severity and Visual Outcomes"],"prefix":"10.1167","volume":"67","author":[{"given":"Changsik","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Korea University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangkyung","family":"Choi","sequence":"additional","affiliation":[{"name":"Veterans Health Service Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeseul","family":"Yoon","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Imaging, Seoul Shinsegae Eye Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Young","family":"Kong","sequence":"additional","affiliation":[{"name":"Veterans Health Service Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Gil","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul Shinsegae Eye Center, Uijeongbu, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Yang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Korea University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Seung","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Imaging, Seoul Shinsegae Eye Center, Seoul, Republic of Korea"},{"name":"Department of Ophthalmology, Seoul Shinsegae Eye Center, Uijeongbu, Gyeonggi-do, Republic of Korea"},{"name":"Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.ophtha.2014.10.014","article-title":"The epidemiology of vitreoretinal interface abnormalities as detected by spectral-domain optical coherence tomography: the Beaver Dam Eye Study","volume":"122","author":"Meuer","year":"2015","journal-title":"Ophthalmology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1097\/IAE.0000000000000199","article-title":"Characteristics of spontaneous idiopathic epiretinal membrane separation in spectral domain optical coherence tomography","volume":"34","author":"Yang","year":"2014","journal-title":"Retina"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/IAE.0000000000000276","article-title":"Postoperative restoration of foveal inner retinal configuration in patients with epiretinal membrane and abnormally thick inner retina","volume":"35","author":"Yang","year":"2015","journal-title":"Retina"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ajo.2016.12.006","article-title":"Insights into epiretinal membranes: presence of ectopic inner foveal layers and a new optical coherence tomography staging scheme","volume":"175","author":"Govetto","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1016\/j.ophtha.2022.06.040","article-title":"Correlations between clinical and histopathologic characteristics in idiopathic epiretinal membrane","volume":"129","author":"Wang","year":"2022","journal-title":"Ophthalmology"},{"issue":"14","key":"bib6","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1167\/iovs.65.14.25","article-title":"Epiretinal membrane: correlations among clinical, immunohistochemical, and biochemical features and their prognostic implications","volume":"65","author":"Yang","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ajo.2021.04.028","article-title":"Effects of internal limiting membrane peel for idiopathic epiretinal membrane surgery: a systematic review of randomized controlled trials","volume":"231","author":"Far","year":"2021","journal-title":"Am J Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1097\/IAE.0b013e31828d2fd6","article-title":"Epiretinal membrane recurrence: incidence, characteristics, evolution, and preventive and risk factors","volume":"33","author":"Sandali","year":"2013","journal-title":"Retina"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1097\/IAE.0000000000001263","article-title":"The effect of internal limiting membrane peeling on idiopathic epiretinal membrane surgery, with a review of the literature","volume":"37","author":"Schechet","year":"2017","journal-title":"Retina"},{"issue":"11","key":"bib10","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1167\/iovs.66.11.39","article-title":"Yes-associated protein (YAP) is associated with disease severity and visual prognosis in epiretinal membrane","volume":"66","author":"Yang","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"792","DOI":"10.3341\/jkos.2021.62.6.792","article-title":"Prediction of the expected extent of surgical difficulty when removing an idiopathic epiretinal membrane","volume":"62","author":"Kim","year":"2021","journal-title":"J Korean Ophthalmol Soc"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.ajo.2011.08.042","article-title":"Retinal adherence and fibrillary surface changes correlate with surgical difficulty of epiretinal membrane removal","volume":"153","author":"Kim","year":"2012","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"bib14","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12886-025-03889-0","article-title":"Assessment of clinical outcomes and prognostic factors following membrane peeling in idiopathic epiretinal membrane using EIFL staging system: an optical coherence tomography angiography analysis","volume":"25","author":"Li","year":"2025","journal-title":"BMC Ophthalmol"},{"issue":"2","key":"bib15","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1167\/tvst.10.2.36","article-title":"Intraoperative retinal changes may predict surgical outcomes after epiretinal membrane peeling","volume":"10","author":"Mukkamala","year":"2021","journal-title":"Transl Vis Sci Technol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ajo.2016.05.011","article-title":"Inner-retinal irregularity index predicts postoperative visual prognosis in idiopathic epiretinal membrane","volume":"168","author":"Cho","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1063\/1.1143970","article-title":"Calibration of atomic-force microscope tips","volume":"64","author":"Hutter","year":"1993","journal-title":"Rev Sci Instrum"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"3967","DOI":"10.1063\/1.1150021","article-title":"Calibration of rectangular atomic force microscope cantilevers","volume":"70","author":"Sader","year":"1999","journal-title":"Rev Sci Instrum"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1016\/S0006-3495(02)75620-8","article-title":"Determination of elastic moduli of thin layers of soft material using the atomic force microscope","volume":"82","author":"Dimitriadis","year":"2002","journal-title":"Biophys J"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Stat Methodol"},{"issue":"suppl 2","key":"bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000353866","article-title":"Material properties of the internal limiting membrane and their significance in chromovitrectomy","volume":"230","author":"Henrich","year":"2013","journal-title":"Ophthalmologica"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1167\/iovs.11-8502","article-title":"Nanoscale topographic and biomechanical studies of the human internal limiting membrane","volume":"53","author":"Henrich","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib23","doi-asserted-by":"publisher","first-page":"e0220571","DOI":"10.1371\/journal.pone.0220571","article-title":"Nanomechanical mapping helps explain differences in outcomes of eye microsurgery: a comparative study of macular pathologies","volume":"14","author":"Ciasca","year":"2019","journal-title":"PLoS One"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"5569","DOI":"10.1167\/iovs.18-24676","article-title":"Morphologic, biomechanical, and compositional features of the internal limiting membrane in pathologic myopic foveoschisis","volume":"59","author":"Chen","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"12390","DOI":"10.1111\/jcmm.15739","article-title":"YAP is essential for TGF-\u00df-induced retinal fibrosis in diabetic rats via promoting the fibrogenic activity of M\u00fcller cells","volume":"24","author":"Zhang","year":"2020","journal-title":"J Cell Mol Med"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"3014","DOI":"10.1167\/iovs.11-8450","article-title":"M\u00fcller cell expression of genes implicated in proliferative vitreoretinopathy is influenced by substrate elastic modulus","volume":"53","author":"Davis","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7350","key":"bib27","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1097\/01.iae.0000250001.45661.95","article-title":"Biomechanical significance of the human internal limiting lamina","volume":"26","author":"Wollensak","year":"2006","journal-title":"Retina"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.1111\/j.1742-4658.2007.05823.x","article-title":"Biomechanical properties of native basement membranes","volume":"274","author":"Candiello","year":"2007","journal-title":"FEBS J"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.matbio.2010.03.004","article-title":"Age-dependent changes in the structure, composition and biophysical properties of a human basement membrane","volume":"29","author":"Candiello","year":"2010","journal-title":"Matrix Biol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1038\/eye.2013.178","article-title":"Vital dyes increase the rigidity of the internal limiting membrane","volume":"27","author":"Haritoglou","year":"2013","journal-title":"Eye"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.1167\/iovs.12-9493","article-title":"Time course of changes in metamorphopsia, visual acuity, and OCT parameters after successful epiretinal membrane surgery","volume":"53","author":"Kinoshita","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.ajo.2010.05.037","article-title":"Long-term temporal changes of macular thickness and visual outcome after vitrectomy for idiopathic epiretinal membrane","volume":"150","author":"Kim","year":"2010","journal-title":"Am J Ophthalmol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1038\/s41433-021-01437-w","article-title":"Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance","volume":"35","author":"Ferrara","year":"2021","journal-title":"Eye."},{"key":"bib35","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1167\/iovs.17-22971","article-title":"In vivo elasticity mapping of posterior ocular layers using acoustic radiation force optical coherence elastography","volume":"59","author":"Qu","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-1-4939-1086-1_11","article-title":"Vitreoretinal interface and inner limiting membrane","volume-title":"Vitreous: In Health and Disease","author":"Halfter","year":"2014"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.12.14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:14Z","timestamp":1791927134000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.12.14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.12.14","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,7]]}}}