{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:52:40Z","timestamp":1791985960225,"version":"4.4.0"},"reference-count":40,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,10,14]]},"DOI":"10.1167\/iovs.67.12.21","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:30:49Z","timestamp":1791984649000},"page":"21","source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotective and Anti-Inflammatory Effects of SOCS1 Mimetic Peptides in Mouse Diabetic Retinopathy"],"prefix":"10.1167","volume":"67","author":[{"given":"Elena","family":"Salobrar-Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Immunology, Ophthalmology, and ENT, Ram\u00f3n Castroviejo Institute for Ophthalmic Research, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Opazo-R\u00edos","sequence":"additional","affiliation":[{"name":"Renal, Vascular and Diabetes Research Laboratory IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Universidad Autonoma de Madrid, Madrid, Spain"},{"name":"Health Science Faculty, University of Las Am\u00e9ricas, Concepcion-Talcahuano, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Matamoros","sequence":"additional","affiliation":[{"name":"Department of Immunology, Ophthalmology, and ENT, Ram\u00f3n Castroviejo Institute for Ophthalmic Research, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"S\u00e1nchez-Puebla","sequence":"additional","affiliation":[{"name":"Department of Immunology, Ophthalmology, and ENT, Ram\u00f3n Castroviejo Institute for Ophthalmic Research, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Fern\u00e1ndez-Albarral","sequence":"additional","affiliation":[{"name":"Department of Immunology, Ophthalmology, and ENT, Ram\u00f3n Castroviejo Institute for Ophthalmic Research, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Salazar","sequence":"additional","affiliation":[{"name":"Department of Immunology, Ophthalmology, and ENT, Ram\u00f3n Castroviejo Institute for Ophthalmic Research, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Soto-Catal\u00e1n","sequence":"additional","affiliation":[{"name":"Renal, Vascular and Diabetes Research Laboratory IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Universidad Autonoma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology, Maim\u00f3nides Biomedical Research Institute of Cordoba, UGC Nephrology, Hospital Universitario Reina Sof\u00eda, University of C\u00f3rdoba, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"G\u00f3mez-Guerrero","sequence":"additional","affiliation":[{"name":"Renal, Vascular and Diabetes Research Laboratory IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Universidad Autonoma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Mas","sequence":"additional","affiliation":[{"name":"Renal, Vascular and Diabetes Research Laboratory IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Universidad Autonoma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Egido","sequence":"additional","affiliation":[{"name":"Renal, Vascular and Diabetes Research Laboratory IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Universidad Autonoma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Immunology, Ophthalmology, and ENT, Ram\u00f3n Castroviejo Institute for Ophthalmic Research, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain"},{"name":"Health Research Institute of the Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"6","key":"bib1","doi-asserted-by":"publisher","first-page":"e339","DOI":"10.1016\/S2214-109X(13)70113-X","article-title":"Causes of vision loss worldwide, 1990\u20132010: a systematic analysis","volume":"1","author":"Bourne","year":"2013","journal-title":"Lancet Glob Health"},{"issue":"suppl. 1","key":"bib2","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.2337\/diacare.26.2007.S99","article-title":"Diabetic retinopathy","volume":"26","author":"Fong","year":"2003","journal-title":"Diabetes Care"},{"issue":"1","key":"bib3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/glia.440070117","article-title":"Cytotoxicity of microglia","volume":"7","author":"Banati","year":"1993","journal-title":"Glia"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"705783","DOI":"10.1155\/2014\/705783","article-title":"The role of microglia in diabetic retinopathy","volume":"2014","author":"Grigsby","year":"2014","journal-title":"J Ophthalmol"},{"issue":"3","key":"bib5","doi-asserted-by":"publisher","first-page":"489","DOI":"10.4239\/wjd.v6.i3.489","article-title":"Diabetic retinopathy - ocular complications of diabetes mellitus","volume":"6","author":"Nentwich","year":"2015","journal-title":"World J Diabetes"},{"issue":"1","key":"bib6","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3390\/ijms19010110","article-title":"The role of microglia in diabetic retinopathy: inflammation, microvasculature defects and neurodegeneration","volume":"19","author":"Altmann","year":"2018","journal-title":"Int J Mol Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"564077","DOI":"10.3389\/fimmu.2020.564077","article-title":"Microglia and inflammatory responses in diabetic retinopathy","volume":"11","author":"Kinuthia","year":"2020","journal-title":"Front Immunol"},{"issue":"2","key":"bib8","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1001\/archophthalmol.2010.362","article-title":"An integrated approach to diabetic retinopathy research","volume":"129","author":"Gardner","year":"2011","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"bib9","doi-asserted-by":"publisher","first-page":"5594","DOI":"10.1167\/iovs.17-21973","article-title":"Assessment of neurotrophins and inflammatory mediators in vitreous of patients with diabetic retinopathy","volume":"58","author":"Boss","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib10","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1038\/sj.eye.6702138","article-title":"Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy","volume":"20","author":"Demircan","year":"2006","journal-title":"Eye (Lond)"},{"issue":"6","key":"bib11","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/j.1464-5491.2005.01538.x","article-title":"Interleukin-8, monocyte chemoattractant protein-1 and IL-10 in the vitreous fluid of patients with proliferative diabetic retinopathy","volume":"22","author":"Hern\u00e1ndez","year":"2005","journal-title":"Diabet Med"},{"issue":"9-10","key":"bib12","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.imbio.2010.05.010","article-title":"Microglia in the healthy and degenerating retina: insights from novel mouse models","volume":"215","author":"Karlstetter","year":"2010","journal-title":"Immunobiology"},{"issue":"2","key":"bib13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.4103\/0975-3583.83035","article-title":"Inflammation and diabetic retinal microvascular complications","volume":"2","author":"Zhang","year":"2011","journal-title":"J Cardiovasc Dis Res"},{"issue":"5","key":"bib14","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.preteyeres.2011.05.002","article-title":"Inflammation in diabetic retinopathy","volume":"30","author":"Tang","year":"2011","journal-title":"Prog Retin Eye Res"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3389\/fneur.2015.00081","article-title":"The ischemic environment drives microglia and macrophage function","volume":"6","author":"Fumagalli","year":"2015","journal-title":"Front Neurol"},{"issue":"3-4","key":"bib16","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1177\/09727531211070532","article-title":"Role of JAK\/STAT in neuroinflammation and its association with neurological disorders","volume":"28","author":"Jain","year":"2021","journal-title":"Ann Neurosci"},{"issue":"6","key":"bib17","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1007\/s40123-022-00581-0","article-title":"A narrative review of STAT proteins in diabetic retinopathy: from mechanisms to therapeutic prospects","volume":"11","author":"Hong","year":"2022","journal-title":"Ophthalmol Ther"},{"issue":"11","key":"bib18","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.1007\/s00417-022-05694-7","article-title":"Role of the JAK\/STAT pathway in a streptozotocin-induced diabetic retinopathy mouse model","volume":"260","author":"Cho","year":"2022","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"21","key":"bib19","doi-asserted-by":"publisher","first-page":"11876","DOI":"10.3390\/ijms222111876","article-title":"Tofacitinib ameliorates retinal vascular leakage in a murine model of diabetic retinopathy with type 2 diabetes","volume":"22","author":"Byrne","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"bib20","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1449397","DOI":"10.3389\/fimmu.2024.1449397","article-title":"Unravelling the druggability and immunological roles of the SOCS-family proteins","volume":"15","author":"Lynch","year":"2024","journal-title":"Front Immunol"},{"issue":"9","key":"bib22","doi-asserted-by":"publisher","first-page":"6978","DOI":"10.1167\/iovs.11-7688","article-title":"Suppressor of cytokine signaling-1 (SOCS1) inhibits lymphocyte recruitment into the retina and protects SOCS1 transgenic rats and mice from ocular inflammation","volume":"52","author":"Yu","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"crossref","first-page":"2939370","DOI":"10.1155\/2016\/2939370","article-title":"SOCS1 mimetic peptide suppresses chronic intraocular inflammatory disease (uveitis)","volume":"2016","author":"He","year":"2016","journal-title":"Mediators Inflamm"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.exer.2018.07.020","article-title":"A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis","volume":"177","author":"Ahmed","year":"2018","journal-title":"Exp Eye Res"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1513157","DOI":"10.3389\/fimmu.2024.1513157","article-title":"A peptide mimic of SOCS1 modulates equine peripheral immune cells in vitro and ocular effector functions in vivo: implications for recurrent uveitis","volume":"15","author":"Stafford","year":"2025","journal-title":"Front Immunol"},{"issue":"15","key":"bib26","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.3390\/ijms20153615","article-title":"SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes","volume":"20","author":"Hern\u00e1ndez","year":"2019","journal-title":"Int J Mol Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"625642","DOI":"10.3389\/fnagi.2020.625642","article-title":"Retinal thickness changes over time in a murine AD model APPNL-F\/NL-F","volume":"12","author":"Salobrar-Garc\u00eda","year":"2021","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"bib28","doi-asserted-by":"publisher","first-page":"4890","DOI":"10.1038\/s41598-020-61848-9","article-title":"Time course of bilateral microglial activation in a mouse model of laser-induced glaucoma","volume":"10","author":"Ram\u00edrez","year":"2020","journal-title":"Sci Rep"},{"issue":"17","key":"bib29","doi-asserted-by":"publisher","first-page":"E4110","DOI":"10.3390\/ijms20174110","article-title":"Neuroprotective and anti-inflammatory effects of a hydrophilic saffron extract in a model of glaucoma","volume":"20","author":"Fern\u00e1ndez-Albarral","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"11","key":"bib30","doi-asserted-by":"publisher","first-page":"e0143278","DOI":"10.1371\/journal.pone.0143278","article-title":"Automatic counting of microglial cells in healthy and glaucomatous mouse retinas","volume":"10","author":"de Gracia","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"bib31","doi-asserted-by":"publisher","first-page":"e97302","DOI":"10.1371\/journal.pone.0097302","article-title":"The db\/db mouse: a useful model for the study of diabetic retinal neurodegeneration","volume":"9","author":"Bogdanov","year":"2014","journal-title":"PLoS One"},{"key":"bib32","doi-asserted-by":"crossref","first-page":"757412","DOI":"10.1155\/2015\/757412","article-title":"Retinal neurodegeneration in db\/db mice at the early period of diabetes","volume":"2015","author":"Yang","year":"2015","journal-title":"J Ophthalmol"},{"issue":"9","key":"bib33","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1258\/ebm.2011.010400","article-title":"Dietary wolfberry ameliorates retinal structure abnormalities in db\/db mice at the early stage of diabetes","volume":"236","author":"Tang","year":"2011","journal-title":"Exp Biol Med (Maywood)"},{"issue":"9","key":"bib34","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/j.bbadis.2016.05.024","article-title":"Modulation of microglia polarization dynamics during diabetic retinopathy in db\/db mice","volume":"1862","author":"Arroba","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"1271102","DOI":"10.3389\/fimmu.2023.1271102","article-title":"SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis","volume":"14","author":"Pandey","year":"2023","journal-title":"Front Immunol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1416181","DOI":"10.3389\/fimmu.2024.1416181","article-title":"Corneal application of SOCS1\/3 peptides for the treatment of eye diseases mediated by inflammation and oxidative stress","volume":"15","author":"Ahmed","year":"2024","journal-title":"Front Immunol"},{"issue":"133","key":"bib37","first-page":"1742","article-title":"Microglia in mouse retina contralateral to experimental glaucoma exhibit multiple signs of activation in all retinal layers","volume":"11","author":"Rojas","year":"2014","journal-title":"J Neuroinflammation"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.exer.2018.03.006","article-title":"Bilateral early activation of retinal microglial cells in a mouse model of unilateral laser-induced experimental ocular hypertension","volume":"171","author":"de Hoz","year":"2018","journal-title":"Exp Eye Res"},{"issue":"3","key":"bib39","doi-asserted-by":"publisher","first-page":"816","DOI":"10.3390\/ijms21030816","article-title":"Microglial activation in the retina of a triple-transgenic Alzheimer's disease mouse model (3xTg-AD)","volume":"21","author":"Salobrar-Garc\u00eda","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"bib40","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12974-023-02740-x","article-title":"Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies","volume":"20","author":"Vargas-Soria","year":"2023","journal-title":"J Neuroinflammation"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.12.21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:30:50Z","timestamp":1791984650000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.12.21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.12.21","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,14]]}}}