{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:51:47Z","timestamp":1792072307266,"version":"4.4.0"},"reference-count":25,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,10,15]]},"DOI":"10.1167\/iovs.67.12.29","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:30:46Z","timestamp":1792071046000},"page":"29","source":"Crossref","is-referenced-by-count":0,"title":["Retinal Flattening Associated With Photoreceptor Degeneration Leads to the Formation of Staphyloma-Like Morphology in Retinitis Pigmentosa"],"prefix":"10.1167","volume":"67","author":[{"given":"Yuki","family":"Yamabe","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Fujibayashi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ichinohe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoma","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitaro","family":"Imura","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiga","family":"Inooka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Kominami","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Fujita Health University, Toyoake, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Terasaki","sequence":"additional","affiliation":[{"name":"Institutes of Innovation for Future Society, Nagoya University, Nagoya, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.preteyeres.2018.03.005","article-title":"Non-syndromic retinitis pigmentosa","volume":"66","author":"Verbakel","year":"2018","journal-title":"Prog Retin Eye Res"},{"issue":"9549","key":"bib2","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa","volume":"368","author":"Hartong","year":"2006","journal-title":"Lancet"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.preteyeres.2017.08.004","article-title":"The mechanism of cone cell death in retinitis pigmentosa","volume":"62","author":"Campochiaro","year":"2018","journal-title":"Prog Retin Eye Res"},{"issue":"2","key":"bib4","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s10384-025-01163-w","article-title":"Classification of fundus autofluorescence images based on macular function in retinitis pigmentosa using convolutional neural networks","volume":"69","author":"Kominami","year":"2025","journal-title":"Jpn J Ophthalmol"},{"issue":"6","key":"bib5","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s10384-024-01122-x","article-title":"Visual activities of daily living survey for retinitis pigmentosa","volume":"68","author":"Sugawara","year":"2024","journal-title":"Jpn J Ophthalmol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.exer.2016.03.018","article-title":"Retinal remodeling in human retinitis pigmentosa","volume":"150","author":"Jones","year":"2016","journal-title":"Exp Eye Res"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"100771","DOI":"10.1016\/j.preteyeres.2019.07.004","article-title":"Persistent remodeling and neurodegeneration in late-stage retinal degeneration","volume":"74","author":"Pfeiffer","year":"2020","journal-title":"Prog Retin Eye Res"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.exer.2019.04.026","article-title":"Course of loss of photoreceptor function and progressive M\u00fcller cell gliosis in rhodopsin P347L transgenic rabbits","volume":"184","author":"Ueno","year":"2019","journal-title":"Exp Eye Res"},{"issue":"suppl 1","key":"bib9","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1097\/IAE.0000000000001256","article-title":"Multimodal imaging of disease-associated pigmentary changes in retinitis pigmentosa","volume":"36","author":"Schuerch","year":"2016","journal-title":"Retina"},{"issue":"3","key":"bib10","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/s10384-025-01179-2","article-title":"Study protocol for a prospective natural history registry investigating the relationships between inflammatory markers and disease progression in retinitis pigmentosa: the RP-PRIMARY study","volume":"69","author":"Murakami","year":"2025","journal-title":"Jpn J Ophthalmol"},{"issue":"3","key":"bib11","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1097\/j.jcrs.0000000000001101","article-title":"Cataract surgery in patients with retinitis pigmentosa: systematic review","volume":"49","author":"Khojasteh","year":"2023","journal-title":"J Cataract Refract Surg"},{"issue":"7","key":"bib12","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1097\/IAE.0000000000002180","article-title":"Posterior staphylomas in eyes with retinitis pigmentosa without high myopia","volume":"39","author":"Xu","year":"2019","journal-title":"Retina"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10633-018-9646-x","article-title":"Macular staphyloma in patients affected by Joubert syndrome with retinal dystrophy: a new finding detected by SD-OCT","volume":"137","author":"Toma","year":"2018","journal-title":"Doc Ophthalmol"},{"issue":"8","key":"bib14","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1167\/iovs.19-27334","article-title":"Steeper macular curvature in eyes with non-highly myopic retinitis pigmentosa","volume":"60","author":"Komori","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"bib15","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/iovs.61.10.6","article-title":"Relationship between macular curvature and common causative genes of retinitis pigmentosa in Japanese patients","volume":"61","author":"Koyanagi","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"bib16","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1167\/tvst.9.10.11","article-title":"Longitudinal changes of macular curvature in patients with retinitis pigmentosa","volume":"9","author":"Meinert","year":"2020","journal-title":"Transl Vis Sci Technol"},{"issue":"9","key":"bib17","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1007\/s10792-020-01396-3","article-title":"Posterior staphylomas in non-highly myopic eyes with retinitis pigmentosa","volume":"40","author":"El Matri","year":"2020","journal-title":"Int Ophthalmol"},{"issue":"22","key":"bib18","doi-asserted-by":"publisher","first-page":"6806","DOI":"10.3390\/jcm13226806","article-title":"Curvature of posterior pole in eyes with retinitis pigmentosa","volume":"13","author":"Kakisu","year":"2024","journal-title":"J Clin Med"},{"issue":"9","key":"bib19","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1016\/j.ophtha.2014.03.035","article-title":"Proposed classification of posterior staphylomas based on analyses of eye shape by three-dimensional magnetic resonance imaging and wide-field fundus imaging","volume":"121","author":"Ohno-Matsui","year":"2014","journal-title":"Ophthalmology"},{"issue":"1","key":"bib20","doi-asserted-by":"publisher","first-page":"4594","DOI":"10.1038\/s41598-018-22759-y","article-title":"Prevalence of posterior staphyloma and factors associated with its shape in the Japanese population","volume":"8","author":"Numa","year":"2018","journal-title":"Sci Rep"},{"issue":"9","key":"bib21","doi-asserted-by":"publisher","first-page":"e107923","DOI":"10.1371\/journal.pone.0107923","article-title":"Analysis of fundus shape in highly myopic eyes by using curvature maps constructed from optical coherence tomography","volume":"9","author":"Miyake","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"bib22","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"issue":"403","key":"bib23","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1080\/01621459.1988.10478639","article-title":"Locally weighted regression: an approach to regression analysis by local fitting","volume":"83","author":"Cleveland","year":"1988","journal-title":"J Am Stat Assoc"},{"issue":"12","key":"bib24","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3390\/diagnostics14121295","article-title":"Involvement of sclera in lattice retinal degeneration: an optical coherence tomography study","volume":"14","author":"Maltsev","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"bib25","first-page":"1333108","article-title":"Analyzing structural changes in scleral collagen induced by retinal degeneration using second harmonic generation microscopy","volume":"13331","author":"Tecse","year":"2025","journal-title":"Proc SPIE"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.12.29","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:30:47Z","timestamp":1792071047000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.12.29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.12.29","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,15]]}}}