{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:57Z","timestamp":1791928917062,"version":"4.3.4"},"reference-count":18,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,10,5]]},"DOI":"10.1167\/iovs.67.12.9","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:30:40Z","timestamp":1791203440000},"page":"9","source":"Crossref","is-referenced-by-count":0,"title":["Intraretinal Hyperreflective Foci as an OCT Feature Associated With Retinal Remodeling After Macular Hole Closure"],"prefix":"10.1167","volume":"67","author":[{"given":"Nicola","family":"Valsecchi","sequence":"first","affiliation":[{"name":"Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum University of Bologna, Bologna, Italy"},{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Gregorio","family":"Fusca","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum University of Bologna, Bologna, Italy"},{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Apa","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum University of Bologna, Bologna, Italy"},{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Del Monte","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum University of Bologna, Bologna, Italy"},{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Scardovelli Fava","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum University of Bologna, Bologna, Italy"},{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Finzi","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum University of Bologna, Bologna, Italy"},{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Moramarco","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum University of Bologna, Bologna, Italy"},{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Mete","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum University of Bologna, Bologna, Italy"},{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Fontana","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater Studiorum University of Bologna, Bologna, Italy"},{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"12","key":"bib1","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1007\/s00417-020-04920-4","article-title":"Macular hole closure patterns: an updated classification","volume":"258","author":"Rossi","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"11","key":"bib2","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1007\/s10792-020-01477-3","article-title":"Two different populations of M\u00fcller cells stabilize the structure of the fovea: an optical coherence tomography study","volume":"40","author":"Bringmann","year":"2020","journal-title":"Int Ophthalmol"},{"issue":"7","key":"bib3","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/S0161-6420(88)33075-7","article-title":"Idiopathic macular holes. Observations, stages of formation, and implications for surgical intervention","volume":"95","author":"Johnson","year":"1988","journal-title":"Ophthalmology"},{"issue":"2","key":"bib4","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00417-012-2058-9","article-title":"Glial proliferation after vitrectomy for a macular hole: a spectral domain optical coherence tomography study","volume":"251","author":"Oh","year":"2013","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"9","key":"bib5","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1007\/s00417-010-1370-5","article-title":"Continuous changes in macular morphology after macular hole closure visualized with spectral optical coherence tomography","volume":"248","author":"Michalewska","year":"2010","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"6","key":"bib6","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1001\/archopht.124.6.827","article-title":"Ultrahigh-resolution optical coherence tomography of surgically closed macular holes","volume":"124","author":"Ko","year":"2006","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"bib7","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1167\/iovs.61.4.50","article-title":"Hyperreflective stress lines and macular holes","volume":"61","author":"Scharf","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib8","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1097\/IAE.0000000000003727","article-title":"Healing mechanisms after macular hole repair suggests process of foveation","volume":"43","author":"Spaide","year":"2023","journal-title":"Retina"},{"issue":"9","key":"bib9","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1167\/iovs.66.9.14","article-title":"Hyperreflective foci in the ectopic inner foveal layer of advanced idiopathic epiretinal membranes","volume":"66","author":"Valsecchi","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"101464","DOI":"10.1016\/j.preteyeres.2026.101464","article-title":"Intraretinal hyperreflective foci: Pathophysiology, imaging features, and clinical implications across retinal diseases","volume":"112","author":"Boscia","year":"2026","journal-title":"Prog Retin Eye Res"},{"issue":"9","key":"bib11","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.3390\/jcm14093021","article-title":"Hyperreflective retinal foci (HRF): definition and role of an invaluable OCT sign","volume":"14","author":"Frizziero","year":"2025","journal-title":"J Clin Med"},{"issue":"12","key":"bib12","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1136\/bjophthalmol-2019-315432","article-title":"Optical coherence tomography-based consensus definition for lamellar macular hole","volume":"104","author":"Hubschman","year":"2020","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"bib13","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1167\/tvst.10.11.17","article-title":"Human foveal cone and m\u00fcller cells examined by adaptive optics optical coherence tomography","volume":"10","author":"Kadomoto","year":"2021","journal-title":"Transl Vis Sci Technol"},{"issue":"6","key":"bib14","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1001\/archopht.117.6.821","article-title":"M\u00fcller cell cone, an overlooked part of the anatomy of the fovea centralis: hypotheses concerning its role in the pathogenesis of macular hole and foveomacualr retinoschisis","volume":"117","author":"Gass","year":"1999","journal-title":"Arch Ophthalmol"},{"issue":"7","key":"bib15","doi-asserted-by":"publisher","first-page":"4439","DOI":"10.1167\/iovs.10-6732","article-title":"The dynamic healing process of idiopathic macular holes after surgical repair: a spectral-domain optical coherence tomography study","volume":"52","author":"Bottoni","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib16","doi-asserted-by":"publisher","first-page":"101078","DOI":"10.1016\/j.xops.2026.101078","article-title":"Postoperative dynamics of full-thickness macular holes: insights from high-resolution OCT under gas tamponade","volume":"6","author":"Francone","year":"2026","journal-title":"Ophthalmol Sci"},{"issue":"2","key":"bib17","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/IAE.0000000000004672","article-title":"Hyperreflective retinal spots in epiretinal membranes: evolving significance across disease stages","volume":"46","author":"Quarta","year":"2026","journal-title":"Retina"},{"issue":"2","key":"bib18","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.survophthal.2025.09.019","article-title":"Fibrogliosis in neovascular age-related macular degeneration: a new mechanistic perspective","volume":"71","author":"Merle","year":"2026","journal-title":"Surv Ophthalmol"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.12.9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:24Z","timestamp":1791927144000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.12.9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.12.9","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,5]]}}}