{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:27Z","timestamp":1791928947454,"version":"4.3.4"},"reference-count":50,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,2,2]]},"DOI":"10.1167\/iovs.67.2.2","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:30:38Z","timestamp":1770039038000},"page":"2","source":"Crossref","is-referenced-by-count":3,"title":["Lipoxin B\n                    <sub>4<\/sub>\n                    Mitigates TRPV4-Activated M\u00fcller Cell Gliosis During Ocular Hypertension"],"prefix":"10.1167","volume":"67","author":[{"given":"Matangi","family":"Kumar","sequence":"first","affiliation":[{"name":"Vision Science Graduate Group, University of California Berkeley, Berkeley, California, United States"},{"name":"Herbert Wertheim School of Optometry and Vision Science, University of California Berkeley, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruthi","family":"Karnam","sequence":"additional","affiliation":[{"name":"Herbert Wertheim School of Optometry and Vision Science, University of California Berkeley, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Maurya","sequence":"additional","affiliation":[{"name":"Herbert Wertheim School of Optometry and Vision Science, University of California Berkeley, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama","family":"Nagireddy","sequence":"additional","affiliation":[{"name":"Herbert Wertheim School of Optometry and Vision Science, University of California Berkeley, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Vision Science Graduate Group, University of California Berkeley, Berkeley, California, United States"},{"name":"Herbert Wertheim School of Optometry and Vision Science, University of California Berkeley, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Gronert","sequence":"additional","affiliation":[{"name":"Vision Science Graduate Group, University of California Berkeley, Berkeley, California, United States"},{"name":"Herbert Wertheim School of Optometry and Vision Science, University of California Berkeley, Berkeley, California, United States"},{"name":"Infectious Disease and Immunity Graduate Group, University of California, Berkeley, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib2","doi-asserted-by":"publisher","first-page":"16067","DOI":"10.1038\/nrdp.2016.67","article-title":"Primary open-angle glaucoma","volume":"2","author":"Weinreb","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000328979","article-title":"M\u00fcller glial cells in retinal disease","volume":"227","author":"Bringmann","year":"2012","journal-title":"Ophthalmologica"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1002\/cne.24153","article-title":"Anatomy and spatial organization of M\u00fcller glia in mouse retina","volume":"525","author":"Wang","year":"2017","journal-title":"J Compar Neurol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"M\u00fcller cells in the healthy and diseased retina","volume":"25","author":"Bringmann","year":"2006","journal-title":"Prog Retina Eye Res"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/cne.21730","article-title":"The transcriptome of retinal M\u00fcller glial cells","volume":"509","author":"Roesch","year":"2008","journal-title":"J Comp Neurol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s00441-013-1666-y","article-title":"The role of M\u00fcller glia and microglia in glaucoma","volume":"353","author":"Seitz","year":"2013","journal-title":"Cell Tissue Res"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"13525","DOI":"10.1523\/JNEUROSCI.1987-15.2015","article-title":"TRPV4 and AQP4 channels synergistically regulate cell volume and calcium homeostasis in retinal M\u00fcller glia","volume":"35","author":"Jo","year":"2015","journal-title":"J Neurosci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s12974-021-02315-8","article-title":"TRPV4-induced M\u00fcller cell gliosis and TNF-a elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2\/STAT3\/NF-?B pathway","volume":"18","author":"Li","year":"2021","journal-title":"J Neuroinflammation"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"108257","DOI":"10.1016\/j.exer.2020.108257","article-title":"The role of TRPV4 channels in ocular function and pathologies","volume":"201","author":"Guarino","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1242\/jcs.02372","article-title":"TRPV4 exhibits a functional role in cell-volume regulation","volume":"118","author":"Becker","year":"2005","journal-title":"J Cell Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"5190","DOI":"10.3390\/ijms23095190","article-title":"Statins inhibit the gliosis of MIO-M1, a M\u00fcller glial cell line induced by TRPV4 activation","volume":"23","author":"Jo","year":"2022","journal-title":"Int J Mol Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.tem.2017.11.001","article-title":"JAK\/STAT \u2013 emerging players in metabolism","volume":"29","author":"Dodington","year":"2018","journal-title":"Trends Endocrinol Metab"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1167\/iovs.14-15695","article-title":"Differential expression of IL-6\/gp130 cytokines, Jak-STAT signaling and neuroprotection after M\u00fcller cell ablation in a transgenic mouse model","volume":"56","author":"Coorey","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"175909142098120","DOI":"10.1177\/1759091420981206","article-title":"Regulation of GFAP expression","volume":"13","author":"Brenner","year":"2021","journal-title":"ASN Neuro"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mam.2017.03.006","article-title":"The role of pro-resolving lipid mediators in ocular diseases","volume":"58","author":"Wei","year":"2017","journal-title":"Mol Aspects Med"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"106815","DOI":"10.1016\/j.prostaglandins.2024.106815","article-title":"Lipid mediators in glaucoma: unraveling their diverse roles and untapped therapeutic potential","volume":"171","author":"Mathew","year":"2024","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"719","DOI":"10.3389\/fphar.2019.00719","article-title":"Regulation and functions of 15-lipoxygenases in human macrophages","volume":"10","author":"Snodgrass","year":"2019","journal-title":"Front Pharmacol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"6558840","DOI":"10.3389\/fimmu.2021.658840","article-title":"Resolution-based therapies: the potential of lipoxins to treat human diseases","volume":"12","author":"Ja\u00e9n","year":"2021","journal-title":"Front Immunol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"781889","DOI":"10.3389\/fphar.2022.781889","article-title":"Lipoxins in the nervous system: brighter prospects for neuroprotection","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Pharmacol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1801076","DOI":"10.1002\/mnfr.201801076","article-title":"Fair-weather friends: evidence of lipoxin dysregulation in neurodegeneration","volume":"64","author":"Kim","year":"2020","journal-title":"Mol Nutr Food Res"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"4403","DOI":"10.1172\/JCI77398","article-title":"Astrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injury","volume":"127","author":"Livne-Bar","year":"2017","journal-title":"J Clin Invest"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s40478-024-01767-2","article-title":"Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension","volume":"12","author":"Karnam","year":"2024","journal-title":"Acta Neuropathol Commun"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13024-024-00775-z","article-title":"Regulation of disease-associated microglia in the optic nerve by lipoxin B4 and ocular hypertension","volume":"19","author":"Maurya","year":"2024","journal-title":"Mol Neurodegener"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"20053","DOI":"10.1038\/s41598-020-77087-x","article-title":"Comparative lipidomic analysis of mammalian retinal ganglion cells and M\u00fcller glia in situ and in vitro using high-resolution imaging mass spectrometry","volume":"10","author":"Pereiro","year":"2020","journal-title":"Sci Rep"},{"key":"bib27","first-page":"153","article-title":"A reversible silicon oil-induced ocular hypertension model in mice","volume":"15","author":"Zhang","year":"2019","journal-title":"J Vis Exp"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"e45881","DOI":"10.7554\/eLife.45881","article-title":"Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse","volume":"8","author":"Zhang","year":"2019","journal-title":"Elife"},{"key":"bib29","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.4103\/1673-5374.276330","article-title":"Comparing silicone oil-induced ocular hypertension with other inducible glaucoma models in mice","volume":"15","author":"Zhang","year":"2020","journal-title":"Neural Regen Res"},{"key":"bib30","doi-asserted-by":"crossref","first-page":"e2429","DOI":"10.21769\/BioProtoc.2429","article-title":"Mouse Muller cell isolation and culture","volume":"7","author":"Liu","year":"2017","journal-title":"Bio Protoc."},{"key":"bib31","doi-asserted-by":"crossref","first-page":"e4179","DOI":"10.21769\/BioProtoc.4179","article-title":"Isolation, culture, and identification of primary Mu\u00a8ller cells from human retina","volume":"11","author":"Chen","year":"2021","journal-title":"Bio Protoc"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fncel.2020.00007","article-title":"Optimization of a method to isolate and culture adult porcine, rats and mice M\u00fcller glia in order to study retinal diseases","volume":"14","author":"Pereiro","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nature11351","article-title":"Rapid induction of inflammatory lipid mediators by the inflammasome in vivo","volume":"490","author":"Von Moltke","year":"2012","journal-title":"Nature"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.4049\/jimmunol.0802064","article-title":"Acute changes in dietary omega-3 and omega-6 polyunsaturated fatty acids have a pronounced impact on survival following ischemic renal injury and formation of renoprotective docosahexaenoic acid-derived protectin D1","volume":"182","author":"Hassan","year":"2009","journal-title":"J Immunol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/s12974-021-02366-x","article-title":"Interplay between M\u00fcller cells and microglia aggravates retinal inflammatory response in experimental glaucoma","volume":"18","author":"Hu","year":"2021","journal-title":"J Neuroinflammation"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"4403","DOI":"10.1172\/JCI77398","article-title":"Astrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injury","volume":"127","author":"Livne-Bar","year":"2017","journal-title":"J Clin Invest"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"7231","DOI":"10.1523\/JNEUROSCI.1709-08.2008","article-title":"STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury","volume":"28","author":"Herrmann","year":"2008","journal-title":"J Neurosci"},{"key":"bib40","first-page":"3192","article-title":"Decreasing gliosis by inhibition of the Stat3 pathway in a microbead mouse model of glaucoma","volume":"51","author":"Lupien","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1111\/all.12937","article-title":"STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model","volume":"71","author":"Gavino","year":"2016","journal-title":"Allergy"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.exer.2010.07.004","article-title":"Resolution, the grail for healthy ocular inflammation","volume":"91","author":"Gronert","year":"2010","journal-title":"Exp Eye Res"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"106805","DOI":"10.1016\/j.prostaglandins.2023.106805","article-title":"12-HETE activates M\u00fcller glial cells: the potential role of GPR31 and miR-29","volume":"171","author":"Moustafa","year":"2024","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"e70064","DOI":"10.1096\/fj.202401362R","article-title":"12-HETE\/GPR31 induces endothelial dysfunction in diabetic retinopathy","volume":"38","author":"Chen","year":"2024","journal-title":"FASEB J"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"159395","DOI":"10.1016\/j.bbalip.2023.159395","article-title":"Maresin-1 prevents blood-spinal cord barrier disruption associated with TRPV4 elevation in the experimental model of spinal cord injury","volume":"1868","author":"Pathak","year":"2023","journal-title":"Biochim Biophys Acta"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-016-0540-8","article-title":"Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection","volume":"13","author":"Martini","year":"2016","journal-title":"J Neuroinflammation"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-024-03010-0","article-title":"Lipoxins A4 and B4 inhibit glial cell activation via CXCR3 signaling in acute retinal neuroinflammation","volume":"21","author":"Livne-Bar","year":"2024","journal-title":"J Neuroinflammation"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"M\u00fcller cells in the healthy and diseased retina","volume":"25","author":"Bringmann","year":"2006","journal-title":"Prog Retin Eye Res"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1002\/glia.24181","article-title":"NFkB-signaling promotes glial reactivity and suppresses M\u00fcller glia-mediated neuron regeneration in the mammalian retina","volume":"70","author":"Palazzo","year":"2022","journal-title":"Glia"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1038\/cdd.2009.220","article-title":"Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K\/Akt and the ERK\/Nrf-2 defense pathways","volume":"17","author":"Prieto","year":"2010","journal-title":"Cell Death Differ"},{"key":"bib1","article-title":"What is glaucoma?","volume-title":"Webvision: The Organization of the Retina and Visual System [Internet]","author":"Kri\u017eaj","year":"1995"},{"key":"bib25","doi-asserted-by":"crossref","article-title":"Lipidomic analysis reveals drug-induced lipoxins in glaucoma treatment","author":"Mathew","DOI":"10.1101\/2025.01.24.634771"},{"key":"bib36","article-title":"Protective effects of lipoxin A4 and B4 signaling on the inner retina in a mouse model of experimental glaucoma","author":"Liu","year":"2024"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.2.2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:15Z","timestamp":1791927135000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.2.2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.2.2","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.09.17.673801","asserted-by":"object"}]},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,2]]}}}