{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:44Z","timestamp":1791928904548,"version":"4.3.4"},"reference-count":58,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,2,13]]},"DOI":"10.1167\/iovs.67.2.33","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:31:08Z","timestamp":1770993068000},"page":"33","source":"Crossref","is-referenced-by-count":1,"title":["Acute Ocular Hypertension Diminishes Flicker-Induced Enhancement in Retinal Blood Flow and Full-Field Electroretinogram in a Mouse Model"],"prefix":"10.1167","volume":"67","author":[{"given":"Milan","family":"Rai","sequence":"first","affiliation":[{"name":"School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, People's Republic of China"},{"name":"Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyip","family":"Choi","sequence":"additional","affiliation":[{"name":"School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, People's Republic of China"},{"name":"Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry Ho-lung","family":"Chan","sequence":"additional","affiliation":[{"name":"School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, People's Republic of China"},{"name":"Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, People's Republic of China"},{"name":"Centre for Eye and Vision Research (CEVR), Hong Kong SAR, People's Republic of China"},{"name":"Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, People's Republic of China"},{"name":"Colour Imaging and Metaverse Research Centre, The Hong Kong Polytechnic University, Hong Kong SAR, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"2","key":"bib1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.preteyeres.2004.07.002","article-title":"Visually evoked hemodynamical response and assessment of neurovascular coupling in the optic nerve and retina","volume":"24","author":"Riva","year":"2005","journal-title":"Prog Retin Eye Res"},{"issue":"11","key":"bib2","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1038\/jcbfm.2013.145","article-title":"Functional hyperemia and mechanisms of neurovascular coupling in the retinal vasculature","volume":"33","author":"Newman","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"issue":"7823","key":"bib3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41586-020-2589-x","article-title":"Interpericyte tunnelling nanotubes regulate neurovascular coupling","volume":"585","author":"Alarcon-Martinez","year":"2020","journal-title":"Nature"},{"issue":"3","key":"bib4","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1097\/00006982-200206000-00013","article-title":"Flickering light increases retinal blood flow","volume":"22","author":"Michelson","year":"2002","journal-title":"Retina"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3389\/fnene.2010.00128","article-title":"Imaging retinal blood flow with laser speckle flowmetry","volume":"2","author":"Srienc","year":"2010","journal-title":"Front Neuroenergetics"},{"issue":"3","key":"bib6","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1161\/HYPERTENSIONAHA.112.192666","article-title":"Impaired increase of retinal capillary blood flow to flicker light exposure in arterial hypertension","volume":"60","author":"Ritt","year":"2012","journal-title":"Hypertension"},{"issue":"2","key":"bib7","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3109\/02713683.2012.756526","article-title":"Quantitative retinal and choroidal blood flow during light, dark adaptation and flicker light stimulation in rats using fluorescent microspheres","volume":"38","author":"Shih","year":"2013","journal-title":"Curr Eye Res"},{"issue":"34","key":"bib8","doi-asserted-by":"publisher","first-page":"11504","DOI":"10.1523\/JNEUROSCI.1971-14.2014","article-title":"Regulation of blood flow in the retinal trilaminar vascular network","volume":"34","author":"Kornfield","year":"2014","journal-title":"J Neurosci"},{"issue":"2","key":"bib9","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1167\/iovs.16-20598","article-title":"Effect of diffuse luminance flicker light stimulation on total retinal blood flow assessed with dual-beam bidirectional Doppler OCT","volume":"58","author":"Aschinger","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib10","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1167\/iovs.17-21543","article-title":"Correlation of visually evoked functional and blood flow changes in the rat retina measured with a combined OCT+ERG system","volume":"58","author":"Tan","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib11","doi-asserted-by":"publisher","first-page":"e0207525","DOI":"10.1371\/journal.pone.0207525","article-title":"Evaluation of flicker-induced hyperemia in the retina and optic nerve head measured by laser speckle flowgraphy","volume":"13","author":"Fondi","year":"2018","journal-title":"PLoS One"},{"issue":"11","key":"bib12","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1080\/02713683.2020.1752390","article-title":"Comparison of neurovascular coupling between normal tension glaucoma patients and healthy individuals with laser speckle flowgraphy","volume":"45","author":"Mursch-Edlmayr","year":"2020","journal-title":"Curr Eye Res"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"16051","DOI":"10.1038\/s41598-020-73032-0","article-title":"Full-field flicker evoked changes in parafoveal retinal blood flow","volume":"10","author":"Warner","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"bib14","doi-asserted-by":"publisher","first-page":"19796","DOI":"10.1038\/s41598-020-75296-y","article-title":"Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy","volume":"10","author":"Hanaguri","year":"2020","journal-title":"Sci Rep"},{"issue":"13","key":"bib15","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1167\/iovs.66.13.26","article-title":"Impact of aging and light stimulation parameters on retinal hyperemia responses in functional optical coherence tomography angiography","volume":"66","author":"Zhang","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib16","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s10633-025-10049-8","article-title":"Effects of flickering light stimulation on retinal blood flow and full-field electroretinogram in mice","volume":"151","author":"Rai","year":"2025","journal-title":"Doc Ophthalmol"},{"issue":"5","key":"bib17","doi-asserted-by":"publisher","first-page":"eNeuro.0509","DOI":"10.1523\/ENEURO.0509-23.2024","article-title":"Increased retinal metabolism induced by flicker in the isolated mouse retina","volume":"11","author":"Linsenmeier","year":"2024","journal-title":"eNeuro"},{"issue":"11","key":"bib18","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.2337\/dc09-0075","article-title":"Flicker light-induced retinal vasodilation in diabetes and diabetic retinopathy","volume":"32","author":"Nguyen","year":"2009","journal-title":"Diabetes Care"},{"issue":"7","key":"bib19","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1136\/bjo.2003.033548","article-title":"Reduced response of retinal vessel diameters to flicker stimulation in patients with diabetes","volume":"88","author":"Garh\u00f6fer","year":"2004","journal-title":"Br J Ophthalmol"},{"issue":"12","key":"bib20","doi-asserted-by":"publisher","first-page":"3761","DOI":"10.1007\/s00417-024-06552-4","article-title":"Associations of retinal neurovascular dysfunction with inner retinal layer thickness in non-proliferative diabetic retinopathy","volume":"262","author":"Pemp","year":"2024","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"11","key":"bib21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1167\/tvst.13.11.4","article-title":"Impairment of neurovascular function in intermediate age-related macular degeneration","volume":"13","author":"Bui","year":"2024","journal-title":"Transl Vis Sci Technol"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1167\/iovs.11-8753","article-title":"Acute retinal ischemia inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide production","volume":"53","author":"Hein","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib23","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.survophthal.2022.11.009","article-title":"Retinal ischemic cascade: new insights into the pathophysiology and imaging findings","volume":"68","author":"Abtahi","year":"2023","journal-title":"Surv Ophthalmol"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.preteyeres.2003.12.001","article-title":"Retinal ischemia: mechanisms of damage and potential therapeutic strategies","volume":"23","author":"Osborne","year":"2004","journal-title":"Prog Retin Eye Res"},{"issue":"6","key":"bib25","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1167\/iovs.19-26752","article-title":"Lycium barbarum polysaccharides rescue neurodegeneration in an acute ocular hypertension rat model under pre- and posttreatment conditions","volume":"60","author":"Lakshmanan","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib26","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s40662-023-00353-2","article-title":"Functional and structural changes in the neuroretina are accompanied by mitochondrial dysfunction in a type 2 diabetic mouse model","volume":"10","author":"Lam","year":"2023","journal-title":"Eye Vis (Lond)"},{"issue":"11","key":"bib27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1167\/iovs.64.11.15","article-title":"Long-term effects on retinal structure and function in a mouse endothelin-1 model of retinal ganglion cell degeneration","volume":"64","author":"Lakshmanan","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fnins.2017.00041","article-title":"Characterization of the circumlimbal suture model of chronic IOP elevation in mice and assessment of changes in gene expression of stretch sensitive channels","volume":"11","author":"Zhao","year":"2017","journal-title":"Front Neurosci"},{"issue":"1","key":"bib29","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1186\/s12967-024-05526-8","article-title":"Lycium barbarum glycopeptide promotes neuroprotection in ET-1 mediated retinal ganglion cell degeneration","volume":"22","author":"Lakshmanan","year":"2024","journal-title":"J Transl Med"},{"issue":"12","key":"bib30","doi-asserted-by":"publisher","first-page":"5732","DOI":"10.1167\/iovs.09-3814","article-title":"Functional changes in the retina during and after acute intraocular pressure elevation in mice","volume":"50","author":"Kong","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib31","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1167\/iovs.04-1347","article-title":"Short-term increase of intraocular pressure does not alter the response of retinal and optic nerve head blood flow to flicker stimulation","volume":"46","author":"Garh\u00f6fer","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib32","first-page":"1","article-title":"Retinal hemodynamics during increased intraocular pressure","volume":"5","author":"Schulte","year":"1996","journal-title":"Ger J Ophthalmol"},{"key":"bib33","doi-asserted-by":"crossref","first-page":"864871","DOI":"10.1155\/2015\/864871","article-title":"Ocular blood flow autoregulation mechanisms and methods","volume":"2015","author":"Luo","year":"2015","journal-title":"J Ophthalmol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1006\/mvre.2002.2432","article-title":"Adenosine enhances functional activation of blood flow in cat optic nerve head during photic stimulation independently from nitric oxide","volume":"64","author":"Buerk","year":"2002","journal-title":"Microvasc Res"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.exer.2004.08.008","article-title":"Effects of adenosine on optic nerve head circulation in rabbits","volume":"79","author":"Hirao","year":"2004","journal-title":"Exp Eye Res"},{"key":"bib36","first-page":"2228","article-title":"Nitric oxide controls arteriolar tone in the retina of the miniature pig","volume":"36","author":"Donati","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.1523\/JNEUROSCI.4048-05.2006","article-title":"Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling","volume":"26","author":"Metea","year":"2006","journal-title":"J Neurosci"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1523\/JNEUROSCI.12-03-00840.1992","article-title":"Energy metabolism of rabbit retina as related to function: high cost of Na+ transport","volume":"12","author":"Ames","year":"1992","journal-title":"J Neurosci"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1600-0420.1997.tb00761.x","article-title":"Effects of constant and flickering light on retinal metabolism in rabbits","volume":"75","author":"Wang","year":"1997","journal-title":"Acta Ophthalmol Scand"},{"issue":"2","key":"bib40","doi-asserted-by":"publisher","first-page":"e31104","DOI":"10.1371\/journal.pone.0031104","article-title":"Blood pressure modifies retinal susceptibility to intraocular pressure elevation","volume":"7","author":"He","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"bib41","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1159\/000055622","article-title":"Regulatory mechanisms in the retinal and choroidal circulation","volume":"32","author":"Delaey","year":"2000","journal-title":"Ophthalmic Res"},{"issue":"Pt 2","key":"bib42","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/eye.1990.43","article-title":"Control of retinal and choroidal blood flow","volume":"4","author":"Bill","year":"1990","journal-title":"Eye (Lond)"},{"issue":"2","key":"bib43","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.exer.2010.09.002","article-title":"The complex interaction between ocular perfusion pressure and ocular blood flow - relevance for glaucoma","volume":"93","author":"Schmidl","year":"2011","journal-title":"Exp Eye Res"},{"issue":"2","key":"bib44","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1167\/iovs.61.2.33","article-title":"Changes in retinal blood flow in response to an experimental increase in IOP in healthy participants as assessed with doppler optical coherence tomography","volume":"61","author":"Puchner","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.mvr.2015.07.001","article-title":"Evaluation of the effect of elevated intraocular pressure and reduced ocular perfusion pressure on retinal capillary bed filling and total retinal blood flow in rats by OMAG\/OCT","volume":"101","author":"Zhi","year":"2015","journal-title":"Microvasc Res"},{"issue":"1 Pt 1","key":"bib46","first-page":"34","article-title":"Autoregulation of retinal circulation in response to decrease of perfusion pressure","volume":"21","author":"Riva","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5 Pt 1","key":"bib47","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0895-7061(00)01285-1","article-title":"Comparison of arterial blood pressure in different strains of mice","volume":"14","author":"Mattson","year":"2001","journal-title":"Am J Hypertens"},{"issue":"15","key":"bib48","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1016\/S0042-6989(99)00038-3","article-title":"The purine nucleoside adenosine in retinal ischemia-reperfusion injury","volume":"39","author":"Ghiardi","year":"1999","journal-title":"Vision Res"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.mcn.2004.04.005","article-title":"A potassium channel-linked mechanism of glial cell swelling in the post ischemic retina","volume":"26","author":"Pannicke","year":"2004","journal-title":"Mol Cell Neurosci"},{"issue":"9","key":"bib50","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.3390\/cells10092440","article-title":"Betulinic acid protects from ischemia-reperfusion injury in the mouse retina","volume":"10","author":"Musayeva","year":"2021","journal-title":"Cells"},{"issue":"7","key":"bib51","doi-asserted-by":"publisher","first-page":"e2110329119","DOI":"10.1073\/pnas.2110329119","article-title":"Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma","volume":"119","author":"Alarcon-Martinez","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"9736047","DOI":"10.1155\/2019\/9736047","article-title":"Elevated intraocular pressure causes abnormal reactivity of mouse retinal arterioles","volume":"2019","author":"Gericke","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"108296","DOI":"10.1016\/j.exer.2020.108296","article-title":"Single transient intraocular pressure elevations cause prolonged retinal ganglion cell dysfunction and retinal capillary abnormalities in mice","volume":"201","author":"Tao","year":"2020","journal-title":"Exp Eye Res"},{"issue":"6","key":"bib54","doi-asserted-by":"publisher","first-page":"603","DOI":"10.2337\/diab.44.6.603","article-title":"Role of blood flow and impaired autoregulation in the pathogenesis of diabetic retinopathy","volume":"44","author":"Kohner","year":"1995","journal-title":"Diabetes"},{"issue":"21","key":"bib55","doi-asserted-by":"publisher","first-page":"8936","DOI":"10.1523\/JNEUROSCI.18-21-08936.1998","article-title":"The major cell populations of the mouse retina","volume":"18","author":"Jeon","year":"1998","journal-title":"J Neurosci"},{"issue":"4","key":"bib56","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/cne.902920402","article-title":"Human photoreceptor topography","volume":"292","author":"Curcio","year":"1990","journal-title":"J Comp Neurol"},{"issue":"4","key":"bib57","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/13816810500374359","article-title":"The mouse's eye and Mfrp: not quite human","volume":"26","author":"Sundin","year":"2005","journal-title":"Ophthalmic Genet"},{"key":"bib58","article-title":"Cell types and cell circuits in human and non-human primate retina [published online ahead of print February 5, 2020]","author":"Gr\u00fcnert","journal-title":"Prog Retin Eye Res"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.2.33","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:18Z","timestamp":1791927138000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.2.33"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.2.33","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,13]]}}}