{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:46Z","timestamp":1791928966935,"version":"4.3.4"},"reference-count":34,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,2,2]]},"DOI":"10.1167\/iovs.67.2.5","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:30:40Z","timestamp":1770039040000},"page":"5","source":"Crossref","is-referenced-by-count":0,"title":["Ophthalmic Artery Morphology and Hemodynamics in Ocular Ischemic Syndrome: A Computational Fluid Dynamics and Particle Image Velocimetry Study"],"prefix":"10.1167","volume":"67","author":[{"given":"Xue-ru","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-yang","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-tao","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, Beihang University, Beijing,  People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-lan","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, Beihang University, Beijing,  People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, Beihang University, Beijing,  People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China"},{"name":"https:\/\/orcid.org\/0000-0001-7877-1620"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"5249","DOI":"10.3390\/ijms23095249","article-title":"Ocular ischemic syndrome and its related experimental models","volume":"23","author":"Lee","year":"2022","journal-title":"Int J Mol Sci"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1167\/iovs.64.12.20","article-title":"Comparison of ophthalmic artery morphological characteristics and retinal vessel diameter for identifying ocular ischemic syndrome","volume":"64","author":"Cheng","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jamcollsurg.2013.03.016","article-title":"Effects of carotid artery stenting on arterial geometry","volume":"217","author":"Kamenskiy","year":"2013","journal-title":"J Am Coll Surg"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/ncpcardio1397","article-title":"Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology","volume":"6","author":"Davies","year":"2009","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1161\/CIRCRESAHA.124.325685","article-title":"Biophysical and biochemical roles of shear stress on endothelium: a revisit and new insights","volume":"136","author":"Cheng","year":"2025","journal-title":"Circ Res"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41569-019-0239-5","article-title":"Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes","volume":"17","author":"Souilhol","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0161-6420(98)94025-8","article-title":"Collateral blood supply through the ophthalmic artery: a steal phenomenon analyzed by color Doppler imaging","volume":"105","author":"Costa","year":"1998","journal-title":"Ophthalmology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/j.1600-0420.1995.tb00016.x","article-title":"Ocular hemodynamic changes in patients with high-grade carotid occlusive disease and development of chronic ocular ischaemia. I. Doppler and dynamic tonometry findings","volume":"73","author":"Kerty","year":"1995","journal-title":"Acta Ophthalmol Scand"},{"key":"bib10","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1055\/s-0044-1787868","article-title":"How flow diverter selection can affect the flow changes within a jailed ophthalmic artery: a computational fluid dynamics study","volume":"19","author":"\u00dcnsal","year":"2024","journal-title":"Asian J Neurosurg"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12967-023-03908-y","article-title":"Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics","volume":"21","author":"Wang","year":"2023","journal-title":"J Transl Med"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1167\/iovs.62.14.7","article-title":"Ophthalmic artery morphological and hemodynamic features in acute coronary syndrome","volume":"62","author":"Wu","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1186\/s12967-022-03712-0","article-title":"Ophthalmic artery changes in type 2 diabetes with and without acute coronary syndrome","volume":"20","author":"Wu","year":"2022","journal-title":"J Transl Med"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s12967-019-1913-4","article-title":"Hemodynamic impacts of flow diverter devices on the ophthalmic artery","volume":"17","author":"Wu","year":"2019","journal-title":"J Transl Med"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1167\/iovs.09-4555","article-title":"Prolonged multifocal electroretinographic implicit times in the ocular ischemic syndrome","volume":"51","author":"Kofoed","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib16","first-page":"425","article-title":"Segments of the internal carotid artery: a new classification","volume":"38","author":"Bouthillier","year":"1996","journal-title":"Neurosurgery"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.xjon.2025.06.012","article-title":"Impact of mitral valve interventions on left ventricular hemodynamics: insights into energy loss and flow dynamics","volume":"26","author":"Feng","year":"2025","journal-title":"JTCVS Open"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1161\/ATVBAHA.125.322557","article-title":"Fluid shear stress-regulated vascular remodeling: past, present, and future","volume":"45","author":"Deng","year":"2025","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1161\/CIRCULATIONAHA.120.051078","article-title":"In vivo function of flow-responsive cis-DNA elements of eNOS gene: a role for chromatin-based mechanisms","volume":"144","author":"Ku","year":"2021","journal-title":"Circulation"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1089\/ars.2024.0706","article-title":"Endothelial reactive oxygen species: key players in cardiovascular health and disease","volume":"42","author":"Craige","year":"2025","journal-title":"Antioxid Redox Signal"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1432719","DOI":"10.3389\/fphys.2024.1432719","article-title":"Low or oscillatory shear stress and endothelial permeability in atherosclerosis","volume":"15","author":"Chen","year":"2024","journal-title":"Front Physiol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"707529","DOI":"10.3389\/fcvm.2021.707529","article-title":"Role of lipid accumulation and inflammation in atherosclerosis: focus on molecular and cellular mechanisms","volume":"8","author":"Malekmohammad","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"e031121","DOI":"10.1161\/JAHA.123.031121","article-title":"Phenotypic switching of vascular smooth muscle cells in atherosclerosis","volume":"12","author":"Chen","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"114410","DOI":"10.1016\/j.yexcr.2025.114410","article-title":"Low shear stress induces vascular endothelial cells apoptosis via miR-330 \/SOD2 \/HSP70 signaling pathway","volume":"445","author":"Li","year":"2025","journal-title":"Exp Cell Res"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"e04645","DOI":"10.7554\/eLife.04645","article-title":"Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point","volume":"4","author":"Baeyens","year":"2015","journal-title":"Elife"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1064375","DOI":"10.3389\/fcvm.2022.1064375","article-title":"Slow flow induces endothelial dysfunction by regulating thioredoxin-interacting protein-mediated oxidative metabolism and vascular inflammation","volume":"9","author":"Wang","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.3174\/ajnr.A1500","article-title":"Dangerous extracranial-intracranial anastomoses and supply to the cranial nerves: vessels the neurointerventionalist needs to know","volume":"30","author":"Geibprasert","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1136\/bjo.2003.025809","article-title":"Ophthalmic artery blood flow in patients with internal carotid artery occlusion","volume":"88","author":"Yamamoto","year":"2004","journal-title":"Br J Ophthalmol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.1161\/STROKEAHA.108.514265","article-title":"Assessment of the contribution of the external carotid artery to brain perfusion in patients with internal carotid artery occlusion","volume":"39","author":"van Laar","year":"2008","journal-title":"Stroke"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1136\/bjo.46.2.65","article-title":"The ophthalmic artery: I. Origin and intra-cranial and intra-canalicular course","volume":"46","author":"Hayreh","year":"1962","journal-title":"Br J Ophthalmol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1136\/neurintsurg-2021-018222","article-title":"Ophthalmic artery angioplasty for age-related macular degeneration","volume":"14","author":"Lylyk","year":"2022","journal-title":"J Neurointerv Surg"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"e40286","DOI":"10.1016\/j.heliyon.2024.e40286","article-title":"CFD analysis of non-Newtonian blood flow through human carotid artery bifurcation: carotid sinus susceptible to atherosclerosis","volume":"10","author":"Bashar","year":"2024","journal-title":"Heliyon"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s11596-024-2846-6","article-title":"Differences and correlations of morphological and hemodynamic parameters between anterior circulation bifurcation and side-wall aneurysms","volume":"44","author":"Guo","year":"2024","journal-title":"Curr Med Sci"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1161\/STROKEAHA.107.510644","article-title":"Geometry of the carotid bifurcation predicts its exposure to disturbed flow","volume":"39","author":"Lee","year":"2008","journal-title":"Stroke"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.2.5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:21Z","timestamp":1791927141000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.2.5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.2.5","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,2]]}}}