{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T17:45:21Z","timestamp":1792950321009,"version":"4.5.0"},"reference-count":82,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"DOI":"10.1167\/iovs.67.2.56","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:30:38Z","timestamp":1772116238000},"page":"56","source":"Crossref","is-referenced-by-count":2,"title":["Photodisruption of the Inner Limiting Membrane Promotes Retinal Engraftment of Stem-Cell Derived Retinal Ganglion Cells"],"prefix":"10.1167","volume":"67","author":[{"given":"Emma","family":"De Coster","sequence":"first","affiliation":[{"name":"Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium"},{"name":"https:\/\/orcid.org\/0000-0001-5189-4188"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaat","family":"De Clerck","sequence":"additional","affiliation":[{"name":"Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00eb","family":"De Clercq","sequence":"additional","affiliation":[{"name":"Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiran","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deep","family":"Punj","sequence":"additional","affiliation":[{"name":"Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Vanmeerhaeghe","sequence":"additional","affiliation":[{"name":"Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonie","family":"Verdonck","sequence":"additional","affiliation":[{"name":"Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefaan","family":"De Smedt","sequence":"additional","affiliation":[{"name":"Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Braeckmans","sequence":"additional","affiliation":[{"name":"Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanieh","family":"Hadady","sequence":"additional","affiliation":[{"name":"Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Remaut","sequence":"additional","affiliation":[{"name":"Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas V.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Peynshaert","sequence":"additional","affiliation":[{"name":"Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium"},{"name":"https:\/\/orcid.org\/0000-0002-2987-4938"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"issue":"12","key":"bib1","doi-asserted-by":"publisher","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global causes of blindness and distance vision impairment 1990\u20132020: a systematic review and meta-analysis","volume":"5","author":"Flaxman","year":"2017","journal-title":"Lancet Glob Health"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"04252","DOI":"10.7189\/jogh.14.04252","article-title":"Global incidence and risk factors for glaucoma: a systematic review and meta-analysis of prospective studies","volume":"14","author":"Shan","year":"2024","journal-title":"J Glob Health"},{"issue":"11","key":"bib3","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"108506","DOI":"10.1016\/j.exer.2021.108506","article-title":"Protection of retinal ganglion cells in glaucoma: current status and future","volume":"205","author":"Shen","year":"2021","journal-title":"Exp Eye Res"},{"issue":"6","key":"bib5","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.3390\/cells10061426","article-title":"Retinal ganglion cell transplantation: approaches for overcoming challenges to functional integration","volume":"10","author":"Zhang","year":"2021","journal-title":"Cells. MDPI"},{"issue":"1","key":"bib6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/dvdy.24672","article-title":"Retinal ganglion cell replacement: current status and challenges ahead","volume":"248","author":"Miltner","year":"2019","journal-title":"Developmental Dynamics"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms10472","article-title":"Transplanted neurons integrate into adult retinas and respond to light","volume":"7","author":"Venugopalan","year":"2016","journal-title":"Nat Commun"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2017.00295","article-title":"Intraocular injection of ES cell-derived neural progenitors improve visual function in retinal ganglion cell-depleted mouse models","volume":"11","author":"Divya","year":"2017","journal-title":"Front Cell Neurosci"},{"issue":"11","key":"bib9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.isci.2022.105308","article-title":"Transplanted human induced pluripotent stem cells- derived retinal ganglion cells embed within mouse retinas and are electrophysiologically functional","volume":"25","author":"Vrathasha","year":"2022","journal-title":"iScience"},{"issue":"6","key":"bib10","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.4103\/1673-5374.300443","article-title":"Cell transplantation to replace retinal ganglion cells faces challenges-the Switchboard Dilemma","volume":"16","author":"Liu","year":"2021","journal-title":"Neural Regen Res"},{"issue":"1","key":"bib11","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13024-023-00655-y","article-title":"Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe consortium","volume":"18","author":"Soucy","year":"2023","journal-title":"Mol Neurodegener"},{"issue":"5","key":"bib12","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.molmed.2022.03.001","article-title":"Strategies of pluripotent stem cell-based therapy for retinal degeneration: update and challenges","volume":"28","author":"Maeda","year":"2022","journal-title":"Trends Mol Med"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"108545","DOI":"10.1016\/j.exer.2021.108545","article-title":"The internal limiting membrane: roles in retinal development and implications for emerging ocular therapies","volume":"206","author":"Zhang","year":"2021","journal-title":"Exp Eye Res"},{"issue":"8","key":"bib14","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1167\/iovs.07-1601","article-title":"Development and characterization of an adult retinal explant organotypic tissue culture system as an in vitro intraocular stem cell transplantation model","volume":"49","author":"Johnson","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib16","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1080\/02713683.2019.1565890","article-title":"Morphology and composition of the inner limiting membrane: species-specific variations and relevance toward drug delivery research","volume":"44","author":"Peynshaert","year":"2019","journal-title":"Curr Eye Res"},{"issue":"15","key":"bib17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/iovs.64.15.25","article-title":"Mechanical disruption of the inner limiting membrane in vivo enhances targeting to the inner retina","volume":"64","author":"Do","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"46","key":"bib18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1073\/pnas.2302089120","article-title":"Controlling donor and newborn neuron migration and maturation in the eye through microenvironment engineering","volume":"120","author":"Soucy","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5957","key":"bib19","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1126\/science.1176009","article-title":"The extracellular matrix: not just pretty fibrils","volume":"326","author":"Hynes","year":"2009","journal-title":"Science"},{"issue":"12","key":"bib20","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"bib21","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.stem.2009.06.016","article-title":"Control of stem cell fate by physical interactions with the extracellular matrix","volume":"5","author":"Guilak","year":"2009","journal-title":"Cell Stem Cell"},{"issue":"3","key":"bib22","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1167\/iovs.04-1185","article-title":"Basement membrane-dependent survival of retinal ganglion cells","volume":"46","author":"Halfter","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib23","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1006\/dbio.2001.0396","article-title":"Temporary disruption of the retinal basal lamina and its effect on retinal histogenesis","volume":"238","author":"Halfter","year":"2001","journal-title":"Dev Biol"},{"issue":"4","key":"bib24","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.neuron.2014.01.036","article-title":"Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling","volume":"81","author":"Riccomagno","year":"2014","journal-title":"Neuron"},{"issue":"5","key":"bib25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0125250","article-title":"Influence of extracellular matrix components on the expression of integrins and regeneration of adult retinal ganglion cells","volume":"10","author":"Vecino","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"bib26","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.neuron.2011.03.013","article-title":"The oriented emergence of axons from retinal ganglion cells is directed by laminin contact in vivo","volume":"70","author":"Randlett","year":"2011","journal-title":"Neuron"},{"issue":"3","key":"bib27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4103\/2008-322X.170354","article-title":"Extracellular matrix components regulate cellular polarity and tissue structure in the developing and mature retina","volume":"10","author":"Varshney","year":"2015","journal-title":"J Ophthalmic Vis Res"},{"issue":"11","key":"bib28","doi-asserted-by":"publisher","first-page":"2406","DOI":"10.1634\/stemcells.2005-0587","article-title":"The simultaneous treatment of MMP-2 stimulants in retinal transplantation enhances grafted cell migration into the host retina","volume":"24","author":"Suzuki","year":"2006","journal-title":"Stem Cells"},{"issue":"1","key":"bib29","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.stemcr.2020.12.001","article-title":"Role of the internal limiting membrane in structural engraftment and topographic spacing of transplanted human stem cell-derived retinal ganglion cells","volume":"16","author":"Zhang","year":"2021","journal-title":"Stem Cell Reports"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ejpb.2019.05.023","article-title":"The obstacle course to the inner retina: hyaluronic acid-coated lipoplexes cross the vitreous but fail to overcome the inner limiting membrane","volume":"141","author":"Devoldere","year":"2019","journal-title":"Eur J Pharm Biopharm"},{"issue":"1","key":"bib31","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1080\/10717544.2017.1375578","article-title":"Toward smart design of retinal drug carriers: a novel bovine retinal explant model to study the barrier role of the vitreoretinal interface","volume":"24","author":"Peynshaert","year":"2017","journal-title":"Drug Deliv"},{"issue":"Special Issue Nanoparticles in O","key":"bib32","first-page":"1","article-title":"Photodisruption of the inner limiting membrane: exploring ICG loaded nanoparticles as photosensitizers","volume":"14","author":"De Clerck","year":"2022","journal-title":"Pharmaceutics"},{"issue":"12","key":"bib33","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1038\/mt.2009.181","article-title":"Inner limiting membrane barriers to aav-mediated retinal transduction from the vitreous","volume":"17","author":"Dalkara","year":"2009","journal-title":"Molecular Therapy"},{"issue":"2","key":"bib34","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1167\/iovs.09-3884","article-title":"Identification of barriers to retinal engraftment of transplanted stem cells","volume":"51","author":"Johnson","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib35","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.ymthe.2016.10.008","article-title":"Improved intravitreal AAV-mediated inner retinal gene transduction after surgical internal limiting membrane peeling in cynomolgus monkeys","volume":"25","author":"Takahashi","year":"2017","journal-title":"Molecular Therapy"},{"issue":"8","key":"bib38","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.1167\/iovs.18-24333","article-title":"Surgical removal of internal limiting membrane and layering of AAV vector on the retina under air enhances gene transfection in a nonhuman primate","volume":"59","author":"Teo","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib39","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1076\/ceyr.27.6.395.18189","article-title":"Ultrastructure of the vitreoretinal interface following the removal of the internal limiting membrane using indocyanine green","volume":"27","author":"Nakamura","year":"2003","journal-title":"Curr Eye Res"},{"key":"bib40","first-page":"939748","article-title":"Retinal damage induced by internal limiting membrane removal","volume":"2015","author":"Gelman","year":"2015","journal-title":"J Ophthalmol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"101453","DOI":"10.1016\/j.cocis.2021.101453","article-title":"Vapor nanobubble-mediated photoporation constitutes a versatile intracellular delivery technology","volume":"54","author":"Ramon","year":"2021","journal-title":"Curr Opin Colloid Interface Sci"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mex.2024.102548","article-title":"Photoporation-mediated spatial intracellular delivery of stem cell-derived cardiomyocytes","volume":"12","author":"L\u00e9ger","year":"2024","journal-title":"MethodsX"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2018.00080","article-title":"Selective labeling of individual neurons in dense cultured networks with nanoparticle-enhanced photoporation","volume":"12","author":"Xiong","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.jconrel.2022.07.002","article-title":"ICG-mediated photodisruption of the inner limiting membrane enhances retinal drug delivery","volume":"349","author":"Peynshaert","year":"2022","journal-title":"Journal of Controlled Release"},{"issue":"7","key":"bib45","doi-asserted-by":"publisher","first-page":"8401","DOI":"10.1021\/acsnano.9b04050","article-title":"Photoablation of human vitreous opacities by light-induced vapor nanobubbles","volume":"13","author":"Sauvage","year":"2019","journal-title":"ACS Nano"},{"issue":"5","key":"bib46","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/s41565-022-01086-4","article-title":"Laser-induced nanobubbles safely ablate vitreous opacities in vivo","volume":"17","author":"Sauvage","year":"2022","journal-title":"Nat Nanotechnol"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep16595","article-title":"Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line","volume":"5","author":"Sluch","year":"2015","journal-title":"Sci Rep"},{"issue":"11","key":"bib49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0201683","article-title":"Highly efficient scarless knock-in of reporter genes into human and mouse pluripotent stem cells via transient antibiotic selection","volume":"13","author":"Sluch","year":"2018","journal-title":"PLoS One"},{"key":"bib50","first-page":"4641","article-title":"Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells","volume":"8","author":"Bhise","year":"2013","journal-title":"Int J Nanomedicine"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-00774-9","article-title":"Photoreceptor outer segment-like structures in long-term 3D retinas from human pluripotent stem cells","volume":"7","author":"Wahlin","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"bib52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/sdata.2018.13","article-title":"Single cell RNA sequencing of stem cell-derived retinal ganglion cells","volume":"5","author":"Daniszewski","year":"2018","journal-title":"Sci Data"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.exer.2017.12.004","article-title":"M\u00fcller glial cells of the primate foveola: an electron microscopical study","volume":"167","author":"Syrbe","year":"2018","journal-title":"Exp Eye Res"},{"issue":"2","key":"bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.xpro.2022.101328","article-title":"Analyses of transplanted human retinal ganglion cell morphology and localization in murine organotypic retinal explant culture","volume":"3","author":"Zhang","year":"2022","journal-title":"STAR Protoc"},{"issue":"11","key":"bib55","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1016\/j.stemcr.2023.09.005","article-title":"Rare intercellular material transfer as a confound to interpreting inner retinal neuronal transplantation following internal limiting membrane disruption","volume":"18","author":"Zhang","year":"2023","journal-title":"Stem Cell Reports"},{"issue":"13","key":"bib57","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1002\/cne.24880","article-title":"From random to regular: variation in the patterning of retinal mosaics","volume":"528","author":"Keeley","year":"2020","journal-title":"J Comp Neurol"},{"issue":"5","key":"bib59","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.matbio.2010.03.004","article-title":"Age-dependent changes in the structure, composition and biophysical properties of a human basement membrane","volume":"29","author":"Candiello","year":"2010","journal-title":"Matrix Biology"},{"key":"bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep08344","article-title":"Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells","volume":"5","author":"Tanaka","year":"2015","journal-title":"Sci Rep"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.preteyeres.2013.07.001","article-title":"Retinal ganglion cells: energetics, compartmentation, axonal transport, cytoskeletons and vulnerability","volume":"36","author":"Yu","year":"2013","journal-title":"Prog Retin Eye Res"},{"issue":"7","key":"bib62","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1089\/ten.tec.2014.0344","article-title":"Suspension-expansion of bone marrow results in small mesenchymal stem cells exhibiting increased transpulmonary passage following intravenous administration","volume":"21","author":"Zanetti","year":"2015","journal-title":"Tissue Eng Part C Methods"},{"issue":"7","key":"bib63","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1002\/bit.260410709","article-title":"Rheological properties of mammalian cell culture suspensions: hybridoma and HeLa cell lines","volume":"41","author":"Shi","year":"1993","journal-title":"Biotechnol Bioeng"},{"issue":"4","key":"bib65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1098\/rsob.220217","article-title":"Retinal self-organization: a model of retinal ganglion cells and starburst amacrine cells mosaic formation","volume":"13","author":"De Montigny","year":"2023","journal-title":"Open Biol"},{"issue":"7","key":"bib66","first-page":"635","article-title":"Enzymatic disruption of retinal extracellular matrix affects surface topology of transplanted human retinal ganglion cells","volume":"61","author":"Zhang","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib68","article-title":"Advancing nanoparticle delivery studies: flow cytometry-based quantification of nanoparticle uptake and transfection in retinal tissue","author":"Paoletti","journal-title":"Drug Deliv Transl Res"},{"key":"bib69","article-title":"Strategic lipid nanoparticle design dictates retinal delivery post inner limiting membrane disruption","author":"De Clerck","journal-title":"Drug Deliv Transl Res"},{"issue":"4","key":"bib70","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/BF02150029","article-title":"Structure and composition of the inner limiting membrane of the retina. SEM on frozen resin-cracked and enzyme-digested retinas of Macaca mulatta.","volume":"224","author":"Heegaard","year":"1986","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jconrel.2025.113849","article-title":"Toward successful retinal drug delivery after intravitreal injection: current strategies to overcome the inner limiting membrane","volume":"384","author":"De Clerck","year":"2025","journal-title":"Journal of Controlled Release"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.omtm.2021.03.004","article-title":"Transplantation of miPSC\/mESC-derived retinal ganglion cells into healthy and glaucomatous retinas","volume":"21","author":"Oswald","year":"2021","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"7","key":"bib75","doi-asserted-by":"publisher","first-page":"855","DOI":"10.3727\/096368913X667024","article-title":"Survival and integration of developing and progenitor-derived retinal ganglion cells following transplantation","volume":"23","author":"Hertz","year":"2014","journal-title":"Cell Transplant"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.exer.2016.07.010","article-title":"A mouse retinal explant model for use in studying neuroprotection in glaucoma","volume":"151","author":"Pattamatta","year":"2016","journal-title":"Exp Eye Res"},{"issue":"6","key":"bib77","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.1167\/iovs.10-6873","article-title":"Use of an adult rat retinal explant model for screening of potential retinal ganglion cell neuroprotective therapies","volume":"52","author":"Bull","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1159\/issn.0250-3751","article-title":"The use of vital dyes during vitreoretinal surgery-chromovitrectomy","volume":"55","author":"Farah","year":"2015","journal-title":"Dev Ophthalmol"},{"issue":"6","key":"bib79","doi-asserted-by":"publisher","first-page":"837","DOI":"10.18240\/ijo.2023.06.01","article-title":"How internal limiting membrane peeling revolutionized macular surgery in the last three decades","volume":"16","author":"Wiedemann","year":"2023","journal-title":"Int J Ophthalmol"},{"issue":"7","key":"bib80","first-page":"696","article-title":"Impact of experimental glaucoma severity on structural and functional outcomes after internal limiting membrane peel for retinal ganglion cell replacement in nonhuman primates","volume":"65","author":"Dunn","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib81","first-page":"4571","article-title":"Internal limiting membrane peel is associated with increased ganglion cell loss and poor visual outcome in patients with primary open angle glaucoma","volume":"56","author":"Prager","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib82","first-page":"919","article-title":"Glaucoma-related central visual field deterioration after vitrectomy for epiretinal membrane: topographic characteristics and risk factors","volume":"35","author":"Tsuchiya","year":"2021","journal-title":"Eye (Basingstoke)"},{"key":"bib15","first-page":"1207","article-title":"Origin and turnover of ECM proteins from the inner limiting membrane and vitreous body","volume-title":"Eye","author":"Halfter","year":"2008"},{"key":"bib36","article-title":"Title: internal limiting membrane disruption facilitates engraftment of transplanted human stem cell derived retinal ganglion cells running title: ILM disruption enables RGC engraftment","author":"Aguzzi"},{"key":"bib37","doi-asserted-by":"crossref","article-title":"Internal limiting basement membrane inhibits functional engraftment of transplanted human retinal ganglion cells","author":"Aguzzi","DOI":"10.1101\/2022.12.13.519327"},{"key":"bib47","doi-asserted-by":"crossref","article-title":"Enhanced stem cell differentiation and immunopurification of genome engineered human retinal ganglion cells","author":"Sluch","DOI":"10.1002\/sctm.17-0059"},{"key":"bib56","author":"Nearest Neighbor Distance Plugin - Image Analysis - Image.sc Forum"},{"key":"bib58","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/978-94-007-3858-4_12","article-title":"Cellular spacing: analysis and modelling of retinal mosaics","volume-title":"Computational Systems Neurobiology","author":"Eglen","year":"2012"},{"key":"bib64","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-1-4939-1086-1_11","article-title":"Vitreoretinal interface and inner limiting membrane","volume-title":"Vitreous: In Health and Disease","author":"Halfter","year":"2014"},{"key":"bib67","first-page":"445","article-title":"Distance to nearest neighbor as a measure of spatial relationships in populations.","volume-title":"Ecology.","author":"Clark","year":"1954"},{"key":"bib72","first-page":"801","article-title":"Collagenase-induced intracerebral hemorrhage in rats.","volume-title":"Stroke.","author":"Rosenberg","year":"1990"},{"key":"bib73","first-page":"779","article-title":"Amount of bleeding and hematoma size in the collagenase-induced intracerebral hemorrhage rat model.","volume-title":"Neurochem Res.","author":"Terai","year":"2003"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.2.56","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:22Z","timestamp":1791927142000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.2.56"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":82,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.2.56","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.04.14.648093","asserted-by":"object"}]},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,26]]}}}