{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:52Z","timestamp":1791928912012,"version":"4.3.4"},"reference-count":56,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,2,27]]},"DOI":"10.1167\/iovs.67.2.61","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T13:30:37Z","timestamp":1772199037000},"page":"61","source":"Crossref","is-referenced-by-count":0,"title":["A Murine Model of HSV-1-Induced Corneal Endotheliitis: Primary Infection, Latency, and Recurrence"],"prefix":"10.1167","volume":"67","author":[{"given":"Yu","family":"Sun","sequence":"first","affiliation":[{"name":"Qingdao University, Qingdao, People's Republic of China"},{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Shandong First Medical University, Qingdao, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingwen","family":"Cao","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Meng","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuli","family":"Wang","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wei","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Xie","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, Eye Institute of Shandong First Medical University, Shandong First Medical University, Qingdao, People's Republic of China"},{"name":"School of Ophthalmology, Shandong First Medical University, Qingdao, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1016\/j.ophtha.2009.04.022","article-title":"Endothelial involvement in herpes simplex virus keratitis: an in vivo confocal microscopy study","volume":"116","author":"Hillenaar","year":"2009","journal-title":"Ophthalmology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1080\/09286586.2021.1962919","article-title":"Incidence of herpes simplex virus keratitis and other ocular disease: global review and estimates","volume":"29","author":"McCormick","year":"2022","journal-title":"Ophthalmic Epidemiol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"e0000624","DOI":"10.1128\/cmr.00006-24","article-title":"The immunobiology of corneal HSV-1 infection and herpetic stromal keratitis","volume":"37","author":"Antony","year":"2024","journal-title":"Clin Microbiol Rev"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00018-018-2938-1","article-title":"Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea","volume":"76","author":"Koujah","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.preteyeres.2012.08.002","article-title":"Herpes keratitis","volume":"32","author":"Rowe","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.jtos.2021.07.002","article-title":"Herpes simplex virus, varicella-zoster virus and cytomegalovirus keratitis: facts for the clinician","volume":"28","author":"Labetoulle","year":"2023","journal-title":"Ocul Surf"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jtos.2021.08.007","article-title":"The epidemiology of infectious keratitis","volume":"28","author":"Stapleton","year":"2023","journal-title":"Ocul Surf"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3390\/vaccines11020325","article-title":"Insights into the novel therapeutics and vaccines against herpes simplex virus","volume":"11","author":"Malik","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.survophthal.2017.07.004","article-title":"A review of the evidence for in vivo corneal endothelial regeneration","volume":"63","author":"Van den Bogerd","year":"2018","journal-title":"Surv Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S1350-9462(02)00059-9","article-title":"Identity and regulation of ion transport mechanisms in the corneal endothelium","volume":"22","author":"Bonanno","year":"2003","journal-title":"Prog Retin Eye Res"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"100904","DOI":"10.1016\/j.preteyeres.2020.100904","article-title":"Corneal endothelial dysfunction: evolving understanding and treatment options","volume":"82","author":"Price","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1167\/iovs.12-11320","article-title":"The ROCK inhibitor eye drop accelerates corneal endothelium wound healing","volume":"54","author":"Okumura","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","first-page":"2152","article-title":"Mechanisms of mitotic inhibition in corneal endothelium: contact inhibition and TGF-beta2","volume":"43","author":"Joyce","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/ICO.0000000000002135","article-title":"Descemet membrane endothelial keratoplasty in irreversible corneal edema due to herpes simplex virus endotheliitis","volume":"39","author":"Basak","year":"2020","journal-title":"Cornea"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1016\/j.ophtha.2006.12.012","article-title":"Corneal transplant survival after onset of severe endothelial rejection","volume":"114","author":"Wagoner","year":"2007","journal-title":"Ophthalmology"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"e0088523","DOI":"10.1128\/jcm.00885-23","article-title":"Diagnostic performance of real-time quantitative PCR in tear samples in various subtypes of herpes simplex keratitis","volume":"61","author":"Hoarau","year":"2023","journal-title":"J Clin Microbiol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2147\/OPTH.S80475","article-title":"Herpes simplex keratitis: challenges in diagnosis and clinical management","volume":"11","author":"Azher","year":"2017","journal-title":"Clin Ophthalmol (Auckland, NZ)"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"e00115","DOI":"10.1128\/JVI.00115-17","article-title":"Herpesvirus entry mediator and ocular herpesvirus infection: more than meets the eye","volume":"91","author":"Edwards","year":"2017","journal-title":"J Virol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"617578","DOI":"10.3389\/fcimb.2020.617578","article-title":"Herpes simplex virus cell entry mechanisms: an update","volume":"10","author":"Madavaraju","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ijos.2016.3","article-title":"New strategies against drug resistance to herpes simplex virus","volume":"8","author":"Jiang","year":"2016","journal-title":"Int J Oral Sci"},{"issue":"Suppl 1","key":"bib21","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/ICO.0000000000002425","article-title":"Adoption of innovation in herpes simplex virus keratitis","volume":"39","author":"Chodosh","year":"2020","journal-title":"Cornea"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"778","DOI":"10.3390\/microorganisms13040778","article-title":"Herpesvirus infections of the corneal endothelium","volume":"13","author":"Wang","year":"2025","journal-title":"Microorganisms"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1167\/iovs.17-21781","article-title":"Conditionally immortal Slc4a11-\/- mouse corneal endothelial cell line recapitulates disrupted glutaminolysis seen in Slc4a11-\/- mouse model","volume":"58","author":"Zhang","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"110408","DOI":"10.1016\/j.exer.2025.110408","article-title":"Optimizing intracameral injection for targeted gene therapy and glaucoma model development","volume":"256","author":"Chen","year":"2025","journal-title":"Exp Eye Res"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1167\/iovs.64.15.24","article-title":"Loss of TRPM8 exacerbate herpes simplex keratitis infection in mice by promoting the infiltration of CD11b+ Ly6G+ cells and increasing the viral load in the cornea","volume":"64","author":"Feng","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.1167\/iovs.18-23942","article-title":"PEDF reduces the severity of herpetic simplex keratitis in mice","volume":"59","author":"Tian","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1167\/iovs.63.2.4","article-title":"Sensory nerve retraction and sympathetic nerve innervation contribute to immunopathology of murine recurrent herpes stromal keratitis","volume":"63","author":"Yun","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"6859","DOI":"10.1038\/s41598-024-52597-0","article-title":"UVB induced reactivation leads to HSV1 in the corneas of virtually all latently infected mice and requires STING to develop corneal disease","volume":"14","author":"Yin","year":"2024","journal-title":"Sci Rep"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.tim.2012.08.005","article-title":"A cultured affair: HSV latency and reactivation in neurons","volume":"20","author":"Wilson","year":"2012","journal-title":"Trends in microbiology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1016\/S0002-9440(10)63575-4","article-title":"Latent herpesvirus infection in human trigeminal ganglia causes chronic immune response","volume":"163","author":"Theil","year":"2003","journal-title":"Am J Pathol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1136\/bjo-2024-326866","article-title":"CMV corneal endotheliitis","volume":"109","author":"Jhanji","year":"2024","journal-title":"Br J Ophthalmol"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.ophtha.2008.09.030","article-title":"Corneal endotheliitis","volume":"116","author":"Hwang","year":"2009","journal-title":"Ophthalmology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s40123-019-0169-7","article-title":"A review of corneal endotheliitis and endotheliopathy: differential diagnosis, evaluation, and treatment","volume":"8","author":"Moshirfar","year":"2019","journal-title":"Ophthalmol Ther"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1167\/iovs.62.13.22","article-title":"Establishing an animal model of cytomegalovirus keratouveitis in rats: broad infection of anterior segment tissue by cytomegalovirus","volume":"62","author":"Zhang","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.ophtha.2006.07.057","article-title":"Corneal endotheliitis associated with evidence of cytomegalovirus infection","volume":"114","author":"Chee","year":"2007","journal-title":"Ophthalmology"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1167\/iovs.18-25801","article-title":"Varicella zoster virus induces differential cell-type specific responses in human corneal epithelial cells and keratocytes","volume":"60","author":"Como","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00003226-200101000-00001","article-title":"Herpes simplex virus epidemiology and ocular importance","volume":"20","author":"Liesegang","year":"2001","journal-title":"Cornea"},{"key":"bib38","first-page":"1065","article-title":"Ocular disease induced in mice by anterior chamber inoculation of herpes simplex virus","volume":"25","author":"Whittum","year":"1984","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib39","first-page":"377","article-title":"Experimental corneal endotheliitis in rabbit","volume":"41","author":"Zheng","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2012.07.002","article-title":"Pathogenesis of herpes stromal keratitis\u2013a focus on corneal neovascularization","volume":"33","author":"Gim\u00e9nez","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1080\/21505594.2021.1982373","article-title":"Pathogenesis and virulence of herpes simplex virus","volume":"12","author":"Zhu","year":"2021","journal-title":"Virulence"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1167\/iovs.64.14.18","article-title":"Endoplasmic reticulum stress disrupts mitochondrial bioenergetics, dynamics and causes corneal endothelial cell apoptosis","volume":"64","author":"Qureshi","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.3390\/cells10081888","article-title":"Mitochondrial dysfunction and mitophagy in Fuchs endothelial corneal dystrophy","volume":"10","author":"Kumar","year":"2021","journal-title":"Cells"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"101303","DOI":"10.1016\/j.preteyeres.2024.101303","article-title":"The relationship between intraocular pressure and glaucoma: an evolving concept","volume":"103","author":"Asrani","year":"2024","journal-title":"Prog Retin Eye Res"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/S0002-9394(99)00018-5","article-title":"Herpes simplex virus in the trabeculum of an eye with corneal endotheliitis","volume":"127","author":"Amano","year":"1999","journal-title":"Am J Ophthalmol"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"3935","DOI":"10.1167\/iovs.09-4027","article-title":"Role of insulin in regulation of Na+-\/K+-dependent ATPase activity and pump function in corneal endothelial cells","volume":"51","author":"Hatou","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"eaaz5195","DOI":"10.1126\/sciadv.aaz5195","article-title":"Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice","volume":"6","author":"Yamaguchi","year":"2020","journal-title":"Sci Adv"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"e00103","DOI":"10.1128\/JVI.00103-19","article-title":"The latency-associated transcript inhibits apoptosis via downregulation of components of the type I interferon pathway during latent herpes simplex virus 1 ocular infection","volume":"93","author":"Tormanen","year":"2019","journal-title":"J Virol"},{"issue":"Suppl 1","key":"bib49","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1086\/505359","article-title":"The cycle of human herpes simplex virus infection: virus transport and immune control","volume":"194","author":"Cunningham","year":"2006","journal-title":"J Infect Dis"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"e2054","DOI":"10.1002\/rmv.2054","article-title":"Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development","volume":"29","author":"Xu","year":"2019","journal-title":"Rev Med Virol"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/ICO.0b013e3181ef241d","article-title":"Ocular herpes simplex virus type 1: is the cornea a reservoir for viral latency or a fast pit stop?","volume":"30","author":"Kennedy","year":"2011","journal-title":"Cornea"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1111\/ceo.13319","article-title":"Clinical translation of recommendations from randomized trials for management of herpes simplex virus keratitis","volume":"46","author":"Cabrera-Aguas","year":"2018","journal-title":"Clin Exp Ophthalmol"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.survophthal.2012.01.005","article-title":"Herpes simplex epithelial and stromal keratitis: an epidemiologic update","volume":"57","author":"Farooq","year":"2012","journal-title":"Surv Ophthalmol"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.apsb.2019.06.005","article-title":"Disturbed Yin-Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1","volume":"10","author":"Yan","year":"2020","journal-title":"Acta Pharm Sin B"},{"key":"bib55","first-page":"364","article-title":"Animal models of varicella zoster virus infection","volume":"2","author":"Haberthur","year":"2013","journal-title":"Pathogens (Basel, Switzerland)"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1097\/ICU.0000000000000996","article-title":"Neuro-ophthalmic complications of varicella-zoster virus","volume":"34","author":"Tofade","year":"2023","journal-title":"Curr Opin Ophthalmol"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.2.61","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:23Z","timestamp":1791927143000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.2.61"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.2.61","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,27]]}}}