{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:22Z","timestamp":1791928942567,"version":"4.3.4"},"reference-count":25,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,3,6]]},"DOI":"10.1167\/iovs.67.3.14","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:30:44Z","timestamp":1772803844000},"page":"14","source":"Crossref","is-referenced-by-count":1,"title":["Plasma Proteomic Dynamics Preceding Glaucoma Reveal a 15-Year Pre-Diagnostic Window: Causal Insights and Predictive Utility in 45,850 Participants"],"prefix":"10.1167","volume":"67","author":[{"given":"Yingke","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, College of Medicine, Fudan University, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Shanghai, China"},{"name":"Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, National Health Commission, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, College of Medicine, Fudan University, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Shanghai, China"},{"name":"Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, National Health Commission, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, College of Medicine, Fudan University, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Shanghai, China"},{"name":"Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, National Health Commission, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, College of Medicine, Fudan University, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Shanghai, China"},{"name":"Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, National Health Commission, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, College of Medicine, Fudan University, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Shanghai, China"},{"name":"Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, National Health Commission, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmou","family":"Sun","sequence":"additional","affiliation":[{"name":"BronxCare Health System Department of Ophthalmology, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, College of Medicine, Fudan University, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Shanghai, China"},{"name":"Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, National Health Commission, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital, College of Medicine, Fudan University, Shanghai, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Shanghai, China"},{"name":"Key Laboratory of Myopia (Fudan University), Chinese Academy of Medical Sciences, National Health Commission, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"12","key":"bib1","doi-asserted-by":"publisher","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global causes of blindness and distance vision impairment 1990\u20132020: a systematic review and meta-analysis","volume":"5","author":"Flaxman","year":"2017","journal-title":"Lancet Glob Health"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1001\/jama.2020.21899","article-title":"Glaucoma in adults\u2014screening, diagnosis, and management: a review","volume":"325","author":"Stein","year":"2021","journal-title":"JAMA"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1038\/s41467-020-20851-4","article-title":"Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries","volume":"12","author":"Gharahkhani","year":"2021","journal-title":"Nat Commun"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1038\/s41588-023-01428-5","article-title":"Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci","volume":"55","author":"Han","year":"2023","journal-title":"Nat Genet"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41467-023-44380-y","article-title":"Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma","volume":"15","author":"Hamel","year":"2024","journal-title":"Nat Commun"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s10571-024-01492-3","article-title":"Proteomic and cytokine profiling in plasma from patients with normal-tension glaucoma and ocular hypertension","volume":"44","author":"Langb\u00f8l","year":"2024","journal-title":"Cell Mol Neurobiol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.molmed.2023.08.002","article-title":"The emerging Janus face of SVEP1 in development and disease","volume":"29","author":"Elenbaas","year":"2023","journal-title":"Trends Mol Med"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1157773","DOI":"10.3389\/fmed.2023.1157773","article-title":"Biochemical\u2013molecular\u2013genetic biomarkers in the tear film, aqueous humor, and blood of primary open-angle glaucoma patients","volume":"10","author":"Pinazo-Dur\u00e1n","year":"2023","journal-title":"Front Med"},{"issue":"7982","key":"bib10","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/s41586-023-06563-x","article-title":"Large-scale plasma proteomics comparisons through genetics and disease associations","volume":"622","author":"Eldjarn","year":"2023","journal-title":"Nature"},{"issue":"7982","key":"bib11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/s43587-025-00818-0","article-title":"Large-scale proteomic analyses of incident Parkinson's disease reveal new pathophysiological insights and potential biomarkers","volume":"5","author":"Gan","year":"2025","journal-title":"Nat Aging"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.ophtha.2015.11.009","article-title":"Spectral-domain optical coherence tomography imaging in 67 321 adults: associations with macular thickness in the UK Biobank Study","volume":"123","author":"Patel","year":"2016","journal-title":"Ophthalmology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.1093\/bioinformatics\/btz166","article-title":"GREP: genome for REPositioning drugs","volume":"35","author":"Sakaue","year":"2019","journal-title":"Bioinforma Oxf Engl"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ophtha.2024.08.005","article-title":"The clinical usefulness of a glaucoma polygenic risk score in 4 population-based European ancestry cohorts","volume":"132","author":"de Vries","year":"2025","journal-title":"Ophthalmology"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"100875","DOI":"10.1016\/j.preteyeres.2020.100875","article-title":"Discovery and clinical translation of novel glaucoma biomarkers","volume":"80","author":"Beykin","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.ophtha.2020.12.020","article-title":"Assessing glaucoma progression using machine learning trained on longitudinal visual field and clinical data","volume":"128","author":"Dixit","year":"2021","journal-title":"Ophthalmology"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.ogla.2024.10.009","article-title":"Validating and updating the OHTS-EGPS model predicting 5-year glaucoma risk among ocular hypertension patients using electronic records","volume":"8","author":"Wright","year":"2025","journal-title":"Ophthalmol Glaucoma"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jprot.2013.12.006","article-title":"Comparative proteomic study in serum of patients with primary open-angle glaucoma and pseudoexfoliation glaucoma","volume":"98","author":"Gonz\u00e1lez-Iglesias","year":"2014","journal-title":"J Proteomics"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1038\/s41591-024-03142-z","article-title":"Proteomic signatures improve risk prediction for common and rare diseases","volume":"30","author":"Carrasco-Zanini","year":"2024","journal-title":"Nat Med"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1001\/jamaophthalmol.2023.1488","article-title":"Compound heterozygous LTBP2 mutations associated with juvenile-onset open-angle glaucoma and marfan-like phenotype","volume":"141","author":"Bergman","year":"2023","journal-title":"JAMA Ophthalmol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1189\/jlb.0208090","article-title":"Neuropilin-1 is a receptor for transforming growth factor beta-1, activates its latent form, and promotes regulatory T cell activity","volume":"84","author":"Glinka","year":"2008","journal-title":"J Leukoc Biol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1083\/jcb.200903137","article-title":"Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3","volume":"188","author":"Xu","year":"2010","journal-title":"J Cell Biol"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"e000395","DOI":"10.1136\/bmjno-2022-000395","article-title":"Neurofilament light oligomers in neurodegenerative diseases: quantification by homogeneous immunoassay in cerebrospinal fluid","volume":"5","author":"Meda","year":"2023","journal-title":"BMJ Neurol Open"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/s44161-022-00113-w","article-title":"Identification of LTBP-2 as a plasma biomarker for right ventricular dysfunction in human pulmonary arterial hypertension","volume":"1","author":"Boucherat","year":"2022","journal-title":"Nat Cardiovasc Res"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.3.14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:14Z","timestamp":1791927134000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.3.14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,6]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.3.14","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,6]]}}}