{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:39Z","timestamp":1791928959962,"version":"4.3.4"},"reference-count":42,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,3,13]]},"DOI":"10.1167\/iovs.67.3.31","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:30:36Z","timestamp":1773408636000},"page":"31","source":"Crossref","is-referenced-by-count":0,"title":["Identification of COL4A2 as a Biomarker of Extracellular Matrix Remodeling and Vascular Scaffold in Choroid for Myopia"],"prefix":"10.1167","volume":"67","author":[{"given":"Baizhou","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University, Guangdong, China"},{"name":"Department of Pediatric Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangming","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University, Guangdong, China"},{"name":"Department of Pediatric Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Xie","sequence":"additional","affiliation":[{"name":"Medical Department, Guangzhou Medical University, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University, Guangdong, China"},{"name":"Department of Optometry, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University, Guangdong, China"},{"name":"Department of Optometry, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chendong","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University, Guangdong, China"},{"name":"Department of Pediatric Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Ni","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaotian","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University, Guangdong, China"},{"name":"Department of Pediatric Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","first-page":"101484","article-title":"Prevalence and temporal trends in myopia and high myopia children in China: a systematic review and meta-analysis with projections from 2020 to 2050","volume":"55","author":"Pan","year":"2025","journal-title":"Lancet Reg Health West Pac"},{"issue":"11","key":"bib2","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/j.ophtha.2021.04.032","article-title":"The risks and benefits of myopia control","volume":"128","author":"Bullimore","year":"2021","journal-title":"Ophthalmology"},{"issue":"12","key":"bib3","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1001\/jamaophthalmol.2016.4009","article-title":"Association of axial length with risk of uncorrectable visual impairment for Europeans with myopia","volume":"134","author":"Tideman","year":"2016","journal-title":"JAMA Ophthalmol"},{"issue":"6","key":"bib4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1167\/iovs.64.6.4","article-title":"IMI\u2013the dynamic choroid: new insights, challenges, and potential significance for human myopia","volume":"64","author":"Ostrin","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.exer.2013.03.008","article-title":"The choroid as a sclera growth regulator","volume":"114","author":"Summers","year":"2013","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib6","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1186\/s12967-023-04274-5","article-title":"Targeting choroidal vasculopathy via up-regulation of tRNA-derived fragment tRF-22 expression for controlling progression of myopia","volume":"21","author":"Liu","year":"2023","journal-title":"J Transl Med"},{"issue":"1","key":"bib7","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1167\/iovs.62.1.8","article-title":"Assessment of choroidal vascularity and choriocapillaris blood perfusion in anisomyopic adults by SS-OCT\/OCTA","volume":"62","author":"Wu","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1167\/iovs.63.12.20","article-title":"Vascular changes of the choroid and their correlations with visual acuity in pathological myopia","volume":"63","author":"Wang","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib9","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.ophtha.2022.10.002","article-title":"Longitudinal changes and predictive value of choroidal thickness for myopia control after repeated low-level red-light therapy","volume":"130","author":"Xiong","year":"2023","journal-title":"Ophthalmology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.ajo.2021.12.014","article-title":"The association of choroidal thickening by atropine with treatment effects for myopia: two-year clinical trial of the Low-Concentration Atropine for Myopia Progression (LAMP) study","volume":"237","author":"Yam","year":"2022","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"bib11","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s40662-023-00356-z","article-title":"Defocus incorporated multiple segments (DIMS) spectacle lenses increase the choroidal thickness: a two-year randomized clinical trial","volume":"10","author":"Chun","year":"2023","journal-title":"Eye Vis (Lond)"},{"issue":"5","key":"bib12","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1167\/iovs.66.5.5","article-title":"Three-year change in subfoveal choroidal thickness and area with multifocal contact lens wear in the Bifocal Lenses in Nearsighted Kids (BLINK) study","volume":"66","author":"Walker","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib13","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1161\/CIRCRESAHA.123.324055","article-title":"Extracellular matrix interactome in modulating vascular homeostasis and remodeling","volume":"134","author":"Fu","year":"2024","journal-title":"Circ Res"},{"issue":"1","key":"bib14","doi-asserted-by":"publisher","first-page":"7078","DOI":"10.1038\/s41467-022-34643-5","article-title":"Cancer cell survival depends on collagen uptake into tumor-associated stroma","volume":"13","author":"Hsu","year":"2022","journal-title":"Nat Commun"},{"issue":"1","key":"bib15","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/path.4433","article-title":"Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways","volume":"235","author":"Choudhary","year":"2015","journal-title":"J Pathol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"105315","DOI":"10.1016\/j.ebiom.2024.105315","article-title":"Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage","volume":"107","author":"McNeilly","year":"2024","journal-title":"EBioMedicine"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"12903","DOI":"10.1038\/s41598-021-92303-y","article-title":"Basement membrane collagen IV deficiency promotes abdominal aortic aneurysm formation","volume":"11","author":"Steffensen","year":"2021","journal-title":"Sci Rep"},{"issue":"9","key":"bib18","doi-asserted-by":"publisher","first-page":"e147253","DOI":"10.1172\/JCI147253","article-title":"Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy","volume":"132","author":"Aypek","year":"2022","journal-title":"J Clin Invest"},{"issue":"5","key":"bib19","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/jemt.20564","article-title":"Mammalian collagen IV","volume":"71","author":"Khoshnoodi","year":"2008","journal-title":"Microsc Res Tech"},{"issue":"11","key":"bib20","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1002\/pro.3283","article-title":"Building collagen IV smart scaffolds on the outside of cells","volume":"26","author":"Brown","year":"2017","journal-title":"Protein Sci"},{"issue":"2","key":"bib21","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1136\/bjo.87.2.212","article-title":"Distribution of the collagen IV isoforms in human Bruch's membrane","volume":"87","author":"Chen","year":"2003","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2009.08.003","article-title":"The dynamic nature of Bruch's membrane","volume":"29","author":"Booij","year":"2010","journal-title":"Prog Retin Eye Res"},{"issue":"2","key":"bib23","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1167\/tvst.14.2.18","article-title":"Refractive development and choroidal vascularity in the form-deprivation pigmented rabbit model","volume":"14","author":"Jiang","year":"2025","journal-title":"Transl Vis Sci Technol"},{"issue":"11","key":"bib24","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/s41580-024-00767-3","article-title":"Mechanisms of assembly and remodelling of the extracellular matrix","volume":"25","author":"Naba","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"bib25","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.matbio.2009.02.004","article-title":"Developmental distribution of collagen IV isoforms and relevance to ocular diseases","volume":"28","author":"Bai","year":"2009","journal-title":"Matrix Biol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"115517","DOI":"10.1016\/j.bcp.2023.115517","article-title":"Inhibitory effect of miR-138-5p on choroidal fibrosis in lens-induced myopia guinea pigs via suppressing the HIF-1a signaling pathway","volume":"211","author":"Li","year":"2023","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"bib27","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.aopr.2024.06.001","article-title":"Animal modeling for myopia","volume":"4","author":"Zheng","year":"2024","journal-title":"Adv Ophthalmol Pract Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.visres.2012.09.002","article-title":"Recovery of peripheral refractive errors and ocular shape in rhesus monkeys (Macaca mulatta) with experimentally induced myopia","volume":"73","author":"Huang","year":"2012","journal-title":"Vision Res"},{"issue":"1","key":"bib29","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1167\/iovs.11-8652","article-title":"Protective effects of high ambient lighting on the development of form-deprivation myopia in rhesus monkeys","volume":"53","author":"Smith","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib30","first-page":"461","article-title":"Topical dopamine application on form-deprivation myopia in rabbits","volume":"15","author":"Kim","year":"2025","journal-title":"Life (Basel)"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.exer.2014.07.019","article-title":"Scleral cross-linking using riboflavin and ultraviolet-a radiation for prevention of progressive myopia in a rabbit model","volume":"127","author":"Dotan","year":"2014","journal-title":"Exp Eye Res"},{"issue":"5","key":"bib32","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1111\/opo.12717","article-title":"Topical bendazol inhibits experimental myopia progression and decreases the ocular accumulation of HIF-1a protein in young rabbits","volume":"40","author":"Tong","year":"2020","journal-title":"Ophthalmic Physiol Opt"},{"issue":"8","key":"bib33","doi-asserted-by":"publisher","first-page":"3074","DOI":"10.1167\/iovs.18-26397","article-title":"Changes in choroidal thickness and choroidal blood perfusion in guinea pig myopia","volume":"60","author":"Zhang","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"13","key":"bib34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1167\/iovs.61.13.25","article-title":"Increased choroidal blood perfusion can inhibit form deprivation myopia in guinea pigs","volume":"61","author":"Zhou","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"24","key":"bib35","doi-asserted-by":"publisher","first-page":"5091","DOI":"10.1182\/blood-2009-05-222364","article-title":"Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation","volume":"114","author":"Stratman","year":"2009","journal-title":"Blood"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.semcdb.2018.08.007","article-title":"Extracellular matrix scaffolding in angiogenesis and capillary homeostasis","volume":"89","author":"Marchand","year":"2019","journal-title":"Semin Cell Dev Biol"},{"issue":"14","key":"bib38","doi-asserted-by":"publisher","first-page":"3979","DOI":"10.1182\/blood-2010-10-313296","article-title":"Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane","volume":"118","author":"Bignon","year":"2011","journal-title":"Blood"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"108818","DOI":"10.1016\/j.cbi.2019.108818","article-title":"FOXP1 inhibits high glucose-induced ECM accumulation and oxidative stress in mesangial cells","volume":"313","author":"Xiang","year":"2019","journal-title":"Chem Biol Interact"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"920280","DOI":"10.1155\/2015\/920280","article-title":"The PI3K\/Akt signaling pathway mediates the high glucose-induced expression of extracellular matrix molecules in human retinal pigment epithelial cells","volume":"2015","author":"Qin","year":"2015","journal-title":"J Diabetes Res"},{"issue":"4","key":"bib41","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.1074\/jbc.M311901200","article-title":"av\u00df3 and av\u00df5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the a3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesion","volume":"279","author":"Pedchenko","year":"2004","journal-title":"J Biol Chem"},{"issue":"5","key":"bib42","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.matbio.2010.03.002","article-title":"Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease","volume":"29","author":"Gross","year":"2010","journal-title":"Matrix Biol"},{"key":"bib36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/B978-0-443-15617-5.00017-2","article-title":"Type IV collagen","volume-title":"Biochemistry of Collagens, Laminins and Elastin","author":"Sand","year":"2024","edition":"3rd ed"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.3.31","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:17Z","timestamp":1791927137000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.3.31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.3.31","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,13]]}}}