{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:08Z","timestamp":1791928928719,"version":"4.3.4"},"reference-count":43,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,3,26]]},"DOI":"10.1167\/iovs.67.3.53","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:30:48Z","timestamp":1774531848000},"page":"53","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Clinical Course and Progression Patterns of Normal-Tension Glaucoma Following Disc Hemorrhage"],"prefix":"10.1167","volume":"67","author":[{"given":"Eun Ji","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjoong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Applied Statistics, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungsuk","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Joon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"4","key":"bib1","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1001\/archopht.1981.03930010635009","article-title":"Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage","volume":"99","author":"Quigley","year":"1981","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"bib2","first-page":"OP290","article-title":"The lamina cribrosa in normal and glaucomatous human eyes","volume":"78","author":"Emery","year":"1974","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"issue":"3","key":"bib3","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/IJG.0b013e3181e0799c","article-title":"Does the enlargement of retinal nerve fiber layer defects relate to disc hemorrhage or progressive visual field loss in normal-tension glaucoma?","volume":"20","author":"Nitta","year":"2011","journal-title":"J Glaucoma"},{"issue":"10","key":"bib4","doi-asserted-by":"publisher","first-page":"7109","DOI":"10.1167\/iovs.11-7448","article-title":"Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma","volume":"52","author":"Yang","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib5","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1167\/iovs.13-12742","article-title":"Recent structural alteration of the peripheral lamina cribrosa near the location of disc hemorrhage in glaucoma","volume":"55","author":"Lee","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib6","first-page":"137","article-title":"Sector haemorrhage\u2013a probable acute ischaemic disc change in chronic simple glaucoma","volume":"5","author":"Drance","year":"1970","journal-title":"Can J Ophthalmol"},{"issue":"1","key":"bib7","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/j.1600-0420.2005.00590.x","article-title":"The pathogenesis of optic disc splinter haemorrhages: a new hypothesis","volume":"84","author":"Grieshaber","year":"2006","journal-title":"Acta Ophthalmol Scand"},{"issue":"1","key":"bib8","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1097\/00061198-200402000-00013","article-title":"Increased expression of matrix metalloproteinases in mononuclear blood cells of normal-tension glaucoma patients","volume":"13","author":"Golubnitschaja","year":"2004","journal-title":"J Glaucoma"},{"issue":"9","key":"bib9","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1016\/j.ophtha.2017.03.059","article-title":"Rates of local retinal nerve fiber layer thinning before and after disc hemorrhage in glaucoma","volume":"124","author":"Akagi","year":"2017","journal-title":"Ophthalmology"},{"issue":"4","key":"bib10","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.ophtha.2005.12.018","article-title":"The relationship between recurrent optic disc hemorrhage and glaucoma progression","volume":"113","author":"Kim","year":"2006","journal-title":"Ophthalmology"},{"issue":"6","key":"bib11","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S0002-9394(01)00964-3","article-title":"Collaborative Normal-Tension Glaucoma Study Group. Risk factors for progression of visual field abnormalities in normal-tension glaucoma","volume":"131","author":"Drance","year":"2001","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1001\/archopht.121.1.48","article-title":"Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial","volume":"121","author":"Leske","year":"2003","journal-title":"Arch Ophthalmol"},{"issue":"6","key":"bib13","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/S0002-9394(00)00441-4","article-title":"Disk hemorrhage is a significantly negative prognostic factor in normal-tension glaucoma","volume":"129","author":"Ishida","year":"2000","journal-title":"Am J Ophthalmol"},{"issue":"11","key":"bib14","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1016\/j.ophtha.2008.05.031","article-title":"Disc hemorrhages and treatment in the early manifest glaucoma trial","volume":"115","author":"Bengtsson","year":"2008","journal-title":"Ophthalmology"},{"issue":"5","key":"bib15","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.ogla.2025.04.009","article-title":"Associations between clustered visual field progression and locations of disc hemorrhages in glaucoma: a 3-year prospective study","volume":"8","author":"Akagi","year":"2025","journal-title":"Ophthalmol Glaucoma"},{"issue":"12","key":"bib16","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1016\/j.ophtha.2006.06.022","article-title":"Detection and prognostic significance of optic disc hemorrhages during the Ocular Hypertension Treatment Study","volume":"113","author":"Budenz","year":"2006","journal-title":"Ophthalmology"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ophtha.2009.06.028","article-title":"Factors affecting rates of visual field progression in glaucoma patients with optic disc hemorrhage","volume":"117","author":"Prata","year":"2010","journal-title":"Ophthalmology"},{"issue":"11","key":"bib18","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/j.ophtha.2007.03.016","article-title":"Predictors of long-term progression in the early manifest glaucoma trial","volume":"114","author":"Leske","year":"2007","journal-title":"Ophthalmology"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","article-title":"The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage","volume":"24","author":"Burgoyne","year":"2005","journal-title":"Prog Retin Eye Res"},{"issue":"8","key":"bib20","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1167\/iovs.65.8.47","article-title":"Underlying microstructure of the lamina cribrosa at the site of microvasculature dropout","volume":"65","author":"Lee","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"13","key":"bib21","doi-asserted-by":"publisher","first-page":"8401","DOI":"10.1167\/iovs.13-13014","article-title":"Factors associated with focal lamina cribrosa defects in glaucoma","volume":"54","author":"Park","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib22","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/j.ophtha.2016.05.006","article-title":"Topographic correlation between juxtapapillary choroidal thickness and microstructure of parapapillary atrophy","volume":"123","author":"Lee","year":"2016","journal-title":"Ophthalmology"},{"issue":"8","key":"bib23","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1136\/bjophthalmol-2017-311136","article-title":"Topographic correlation between juxtapapillary choroidal thickness and parapapillary deep-layer microvasculature dropout in primary open-angle glaucoma","volume":"102","author":"Lee","year":"2018","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ajo.2011.01.024","article-title":"Visualization of the lamina cribrosa using enhanced depth imaging spectral-domain optical coherence tomography","volume":"152","author":"Lee","year":"2011","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"bib25","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1167\/iovs.16-20802","article-title":"Diagnostic power of lamina cribrosa depth and curvature in glaucoma","volume":"58","author":"Lee","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib26","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.ophtha.2014.10.007","article-title":"Influence of lamina cribrosa thickness and depth on the rate of progressive retinal nerve fiber layer thinning","volume":"122","author":"Lee","year":"2015","journal-title":"Ophthalmology"},{"issue":"5","key":"bib27","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1001\/archopthalmol.2011.1309","article-title":"In vivo evaluation of focal lamina cribrosa defects in glaucoma","volume":"130","author":"Kiumehr","year":"2012","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"bib28","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ophtha.2013.08.018","article-title":"Defects of the lamina cribrosa in eyes with localized retinal nerve fiber layer loss","volume":"121","author":"Tatham","year":"2014","journal-title":"Ophthalmology"},{"issue":"10","key":"bib29","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial","volume":"120","author":"Heijl","year":"2002","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"bib30","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0002-9394(00)00538-9","article-title":"The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration","volume":"130","author":"The AGIS Investigators","year":"2000","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"bib31","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1167\/iovs.16-20509","article-title":"Impact of rates of change of lamina cribrosa and optic nerve head surface depths on visual field progression in glaucoma","volume":"58","author":"Wu","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib32","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1167\/iovs.11-8186","article-title":"Effect of treatment on the rate of visual field change in the ocular hypertension treatment study observation group","volume":"53","author":"De Moraes","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib33","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/S0002-9394(98)00223-2","article-title":"Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures","volume":"126","author":"Collaborative Normal-Tension Glaucoma Study Group","year":"1998","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"bib34","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/S0002-9394(03)00478-1","article-title":"Collaborative Normal-Tension Glaucoma Study Group. Factors that predict the benefit of lowering intraocular pressure in normal tension glaucoma","volume":"136","author":"Anderson","year":"2003","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"bib35","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1097\/00061198-200604000-00014","article-title":"Incidence of disc hemorrhages in open-angle glaucoma before and after trabeculectomy","volume":"15","author":"Miyake","year":"2006","journal-title":"J Glaucoma"},{"issue":"12","key":"bib36","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1001\/archophthalmol.2012.2324","article-title":"Rate of visual field progression in eyes with optic disc hemorrhages in the ocular hypertension treatment study","volume":"130","author":"De Moraes","year":"2012","journal-title":"Arch Ophthalmol"},{"issue":"8","key":"bib37","first-page":"1419","article-title":"The correlation between cerebrospinal fluid pressure and retrolaminar tissue pressure","volume":"39","author":"Morgan","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib38","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1748-1716.1980.tb06575.x","article-title":"Inhibition of fast anterograde axoplasmic transport by a pressure barrier. The effect of pressure gradient and maximal pressure","volume":"109","author":"Hahnenberger","year":"1980","journal-title":"Acta Physiol Scand"},{"issue":"11","key":"bib39","doi-asserted-by":"publisher","first-page":"6344","DOI":"10.1167\/iovs.15-17248","article-title":"Residual and dynamic range of retinal nerve fiber layer thickness in glaucoma: comparison of three OCT platforms","volume":"56","author":"Mwanza","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ajo.2016.11.010","article-title":"Estimating optical coherence tomography structural measurement floors to improve detection of progression in advanced glaucoma","volume":"175","author":"Bowd","year":"2017","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"bib41","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1167\/iovs.11-8383","article-title":"Circadian changes in subfoveal choroidal thickness and the relationship with circulatory factors in healthy subjects","volume":"53","author":"Usui","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib42","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1167\/iovs.11-8782","article-title":"Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography","volume":"53","author":"Tan","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib43","doi-asserted-by":"publisher","first-page":"5121","DOI":"10.1167\/iovs.11-7364","article-title":"Diurnal variations in axial length, choroidal thickness, intraocular pressure, and ocular biometrics","volume":"52","author":"Chakraborty","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.3.53","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:22Z","timestamp":1791927142000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.3.53"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.3.53","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,26]]}}}