{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:35:01Z","timestamp":1792722901033,"version":"4.5.0"},"reference-count":70,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,3,5]]},"DOI":"10.1167\/iovs.67.3.8","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T13:30:40Z","timestamp":1772717440000},"page":"8","source":"Crossref","is-referenced-by-count":3,"title":["Sfrp2 in Microglia Inhibited S100a8-Mediated Neuroinflammation and Protected Neural Damage Following Retinal Ischemia-Reperfusion"],"prefix":"10.1167","volume":"67","author":[{"given":"Shuya","family":"Tao","sequence":"first","affiliation":[{"name":"Zhongshan Ophthalmic Center, Sun Yat-Sen University, WHO Collaborating Centre for Eye Care and Vision, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Guangxi Key Laboratory of Eye Health, Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Institute of Ophthalmic Diseases, Guangxi Academy of Medical Sciences, Nanning, Guangxi, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaguang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaochu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Lin","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center, Sun Yat-Sen University, WHO Collaborating Centre for Eye Care and Vision, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center, Sun Yat-Sen University, WHO Collaborating Centre for Eye Care and Vision, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxun","family":"Shi","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center, Sun Yat-Sen University, WHO Collaborating Centre for Eye Care and Vision, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ye","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center, Sun Yat-Sen University, WHO Collaborating Centre for Eye Care and Vision, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, People's Republic of China"},{"name":"Department of Ophthalmology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Guangxi Key Laboratory of Eye Health, Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, Institute of Ophthalmic Diseases, Guangxi Academy of Medical Sciences, Nanning, Guangxi, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center, Sun Yat-Sen University, WHO Collaborating Centre for Eye Care and Vision, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantao","family":"Wei","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center, Sun Yat-Sen University, WHO Collaborating Centre for Eye Care and Vision, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhongshan Ophthalmic Center, Sun Yat-Sen University, WHO Collaborating Centre for Eye Care and Vision, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"1","key":"bib1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.preteyeres.2003.12.001","article-title":"Retinal ischemia: mechanisms of damage and potential therapeutic strategies","volume":"23","author":"Osborne","year":"2004","journal-title":"Prog Retin Eye Res"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"121484","DOI":"10.1016\/j.biomaterials.2022.121484","article-title":"TNF-alpha stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3\/miR-21a-5p axis","volume":"284","author":"Yu","year":"2022","journal-title":"Biomaterials"},{"issue":"3","key":"bib3","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.preteyeres.2011.02.001","article-title":"Vascular stem cells and ischaemic retinopathies","volume":"30","author":"Stitt","year":"2011","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib4","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s12974-023-02982-9","article-title":"Empagliflozin targets Mfn1 and Opa1 to attenuate microglia-mediated neuroinflammation in retinal ischemia and reperfusion injury","volume":"20","author":"Yang","year":"2023","journal-title":"J Neuroinflammation"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"100916","DOI":"10.1016\/j.preteyeres.2020.100916","article-title":"Inflammation in glaucoma: from the back to the front of the eye, and beyond","volume":"83","author":"Baudouin","year":"2021","journal-title":"Prog Retin Eye Res"},{"issue":"11","key":"bib6","doi-asserted-by":"publisher","first-page":"8442","DOI":"10.1167\/iovs.11-8152","article-title":"Neurodegenerative and inflammatory pathway components linked to TNF-alpha\/TNFR1 signaling in the glaucomatous human retina","volume":"52","author":"Yang","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib7","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s12974-020-01930-1","article-title":"Transgenic inhibition of astroglial NF-kappaB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma","volume":"17","author":"Yang","year":"2020","journal-title":"J Neuroinflammation"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"105258","DOI":"10.1016\/j.nbd.2021.105258","article-title":"Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma","volume":"150","author":"Yang","year":"2021","journal-title":"Neurobiol Dis"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"100998","DOI":"10.1016\/j.preteyeres.2021.100998","article-title":"Molecular regulation of neuroinflammation in glaucoma: current knowledge and the ongoing search for new treatment targets","volume":"87","author":"Tezel","year":"2022","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib10","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12974-025-03345-2","article-title":"Human breast milk-derived exosomes attenuate lipopolysaccharide-induced activation in microglia","volume":"22","author":"Akinduro","year":"2025","journal-title":"J Neuroinflammation"},{"issue":"1","key":"bib11","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4103\/1673-5374.290098","article-title":"Argon reduces microglial activation and inflammatory cytokine expression in retinal ischemia\/reperfusion injury","volume":"16","author":"Goebel","year":"2021","journal-title":"Neural Regen Res"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/cdd.2017.141","article-title":"Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation","volume":"25","author":"Huang","year":"2018","journal-title":"Cell Death Differ"},{"issue":"11","key":"bib13","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1002\/glia.24063","article-title":"IL-17 signaling induces iNOS+ microglia activation in retinal vascular diseases","volume":"69","author":"Zhou","year":"2021","journal-title":"Glia"},{"issue":"11","key":"bib14","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1002\/glia.24600","article-title":"MicroRNA-146a-5p protects retinal ganglion cells through reducing neuroinflammation in experimental glaucoma","volume":"72","author":"Zhou","year":"2024","journal-title":"Glia"},{"issue":"1","key":"bib15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12974-023-02721-0","article-title":"Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4\/MyD88\/NF-kappaB pathway in LPC-induced demyelination","volume":"20","author":"Wang","year":"2023","journal-title":"J Neuroinflammation"},{"issue":"1","key":"bib16","first-page":"115","article-title":"Immunological landscape of retinal ischemia-reperfusion injury: insights into resident and peripheral immune cell responses","volume":"16","author":"He","year":"2024","journal-title":"Aging Dis"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.nbd.2017.11.009","article-title":"Axl activation attenuates neuroinflammation by inhibiting the TLR\/TRAF\/NF-kappaB pathway after MCAO in rats","volume":"110","author":"Wu","year":"2018","journal-title":"Neurobiol Dis"},{"issue":"1","key":"bib18","doi-asserted-by":"publisher","first-page":"8251","DOI":"10.1038\/s41467-025-63731-5","article-title":"Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome","volume":"16","author":"Fan","year":"2025","journal-title":"Nat Commun"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10555-020-09941-3","article-title":"Secreted frizzled-related protein 2: a key player in noncanonical Wnt signaling and tumor angiogenesis","volume":"40","author":"van Loon","year":"2021","journal-title":"Cancer Metastasis Rev"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"103282","DOI":"10.1016\/j.resp.2019.103282","article-title":"sFRP2 promotes airway inflammation and Th17\/Treg imbalance in COPD via Wnt\/beta-catenin pathway","volume":"270","author":"Zhou","year":"2019","journal-title":"Respir Physiol Neurobiol"},{"issue":"13","key":"bib21","doi-asserted-by":"publisher","first-page":"3707","DOI":"10.7150\/thno.33908","article-title":"Nerve modulation therapy in gouty arthritis: targeting increased sFRP2 expression in dorsal root ganglion regulates macrophage polarization and alleviates endothelial damage","volume":"9","author":"Mei","year":"2019","journal-title":"Theranostics"},{"issue":"14","key":"bib22","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.1016\/j.jprot.2012.04.052","article-title":"Label-free LC-MSMS analysis of vitreous from autoimmune uveitis reveals a significant decrease in secreted Wnt signalling inhibitors DKK3 and SFRP2","volume":"75","author":"Hauck","year":"2012","journal-title":"J Proteomics"},{"issue":"18","key":"bib23","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1097\/00001756-200012180-00012","article-title":"Modulated expression of secreted frizzled-related proteins in human retinal degeneration","volume":"11","author":"Jones","year":"2000","journal-title":"Neuroreport"},{"issue":"6","key":"bib24","first-page":"1297","article-title":"Altered expression of secreted frizzled-related protein-2 in retinitis pigmentosa retinas","volume":"41","author":"Jones","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib25","first-page":"36","article-title":"Lithium chloride regulates the proliferation of stem-like cells in retinoblastoma cell lines: a potential role for the canonical Wnt signaling pathway","volume":"16","author":"Silva","year":"2010","journal-title":"Mol Vis"},{"issue":"2","key":"bib26","doi-asserted-by":"publisher","first-page":"112103","DOI":"10.1016\/j.celrep.2023.112103","article-title":"Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma","volume":"42","author":"Jayabal","year":"2023","journal-title":"Cell Rep"},{"issue":"19","key":"bib27","doi-asserted-by":"publisher","first-page":"4179","DOI":"10.1242\/dev.065839","article-title":"Secreted frizzled-related proteins are required for Wnt\/beta-catenin signalling activation in the vertebrate optic cup","volume":"138","author":"Esteve","year":"2011","journal-title":"Development"},{"issue":"5","key":"bib28","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/nn.2794","article-title":"SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis","volume":"14","author":"Esteve","year":"2011","journal-title":"Nat Neurosci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.semcdb.2017.11.027","article-title":"Guidance of retinal axons in mammals","volume":"85","author":"Herrera","year":"2019","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"bib30","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12974-017-0905-7","article-title":"The carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase \u00df1 in rats' retinal ganglion cells after ischemia and reperfusion injury","volume":"14","author":"Ulbrich","year":"2017","journal-title":"J Neuroinflammation"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.pharmthera.2016.07.015","article-title":"S100A8\/A9: from basic science to clinical application","volume":"167","author":"Pruenster","year":"2016","journal-title":"Pharmacol Ther"},{"issue":"2","key":"bib32","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/s41419-023-05617-2","article-title":"A lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia\/reperfusion injury","volume":"14","author":"Zheng","year":"2023","journal-title":"Cell Death Dis"},{"issue":"3","key":"bib33","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1167\/iovs.63.3.18","article-title":"Intravitreal injection of PACAP attenuates acute ocular hypertension-induced retinal injury via anti-apoptosis and anti-inflammation in mice","volume":"63","author":"Lu","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1167\/iovs.64.4.31","article-title":"Neuroprotection of SRT2104 in murine ischemia\/reperfusion injury through the enhancement of Sirt1-mediated deacetylation","volume":"64","author":"Bai","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"103532","DOI":"10.1016\/j.redox.2025.103532","article-title":"Inhibition of S100A8\/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury","volume":"81","author":"Shi","year":"2025","journal-title":"Redox Biol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/issn.0250-3751","article-title":"Retinal anatomy and pathology","volume":"55","author":"Gupta","year":"2016","journal-title":"Dev Ophthalmol"},{"issue":"5","key":"bib37","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s10735-011-9346-2","article-title":"Unusual retinal layer organization in HPC-1\/syntaxin 1A knockout mice","volume":"42","author":"Kaneko","year":"2011","journal-title":"J Mol Histol"},{"issue":"5","key":"bib38","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1167\/iovs.17-23276","article-title":"Topical ripasudil suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma","volume":"59","author":"Akaiwa","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10633-017-9621-y","article-title":"ISCEV guide to visual electrodiagnostic procedures","volume":"136","author":"Robson","year":"2018","journal-title":"Doc Ophthalmol"},{"issue":"7","key":"bib40","doi-asserted-by":"publisher","first-page":"4691","DOI":"10.1167\/iovs.13-12415","article-title":"The photopic negative response of the mouse electroretinogram: reduction by acute elevation of intraocular pressure","volume":"54","author":"Chrysostomou","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib41","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.it.2017.01.006","article-title":"IL-17 signaling: the Yin and the Yang","volume":"38","author":"Amatya","year":"2017","journal-title":"Trends Immunol"},{"issue":"12","key":"bib42","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1038\/s41590-019-0514-y","article-title":"IL-17 receptor-based signaling and implications for disease","volume":"20","author":"Li","year":"2019","journal-title":"Nat Immunol"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/1742-2094-11-59","article-title":"Curcumin attenuates acute inflammatory injury by inhibiting the TLR4\/MyD88\/NF-kappaB signaling pathway in experimental traumatic brain injury","volume":"11","author":"Zhu","year":"2014","journal-title":"J Neuroinflammation"},{"issue":"3","key":"bib44","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/cr.2013.21","article-title":"UBE2O negatively regulates TRAF6-mediated NF-kappaB activation by inhibiting TRAF6 polyubiquitination","volume":"23","author":"Zhang","year":"2013","journal-title":"Cell Res"},{"issue":"6","key":"bib45","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s004010000232","article-title":"Differential regulation of the monocytic calcium-binding peptides macrophage-inhibiting factor related protein-8 (MRP8\/S100A8) and allograft inflammatory factor-1 (AIF-1) following human traumatic brain injury","volume":"100","author":"Beschorner","year":"2000","journal-title":"Acta Neuropathol"},{"issue":"1","key":"bib46","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s12974-017-0939-x","article-title":"Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro","volume":"14","author":"Fourrier","year":"2017","journal-title":"J Neuroinflammation"},{"issue":"1","key":"bib47","doi-asserted-by":"publisher","first-page":"3208","DOI":"10.1038\/s41467-023-38842-6","article-title":"Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging","volume":"14","author":"Feng","year":"2023","journal-title":"Nat Commun"},{"issue":"4","key":"bib48","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol"},{"issue":"3","key":"bib49","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.nbd.2009.11.004","article-title":"Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention","volume":"37","author":"Tansey","year":"2010","journal-title":"Neurobiol Dis"},{"issue":"2","key":"bib50","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.survophthal.2005.12.001","article-title":"The role of inflammation in the pathogenesis of age-related macular degeneration","volume":"51","author":"Donoso","year":"2006","journal-title":"Surv Ophthalmol"},{"issue":"3","key":"bib51","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1136\/bjo.2005.080895","article-title":"Effect of non-steroidal anti-inflammatory ophthalmic solution on intraocular pressure reduction by latanoprost in patients with primary open angle glaucoma or ocular hypertension","volume":"90","author":"Chiba","year":"2006","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"bib52","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1097\/IJG.0b013e3181e07933","article-title":"The influence of topical diclofenac sodium on the ocular hypotensive effect of latanoprost in glaucoma patients","volume":"20","author":"Sorkhabi","year":"2011","journal-title":"J Glaucoma"},{"issue":"7","key":"bib53","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1073\/pnas.94.7.2859","article-title":"A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors","volume":"94","author":"Rattner","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"bib54","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12886-022-02296-z","article-title":"The role of lipopolysaccharides in diabetic retinopathy","volume":"22","author":"Qin","year":"2022","journal-title":"BMC Ophthalmol"},{"issue":"4","key":"bib55","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nrneurol.2014.38","article-title":"Microglial priming in neurodegenerative disease","volume":"10","author":"Perry","year":"2014","journal-title":"Nat Rev Neurol"},{"issue":"11","key":"bib56","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nri3086","article-title":"Microglial cell origin and phenotypes in health and disease","volume":"11","author":"Saijo","year":"2011","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"bib57","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/glia.22350","article-title":"Microglia and neurodegeneration: the role of systemic inflammation","volume":"61","author":"Cunningham","year":"2013","journal-title":"Glia"},{"issue":"36","key":"bib58","doi-asserted-by":"publisher","first-page":"e2309459","DOI":"10.1002\/advs.202309459","article-title":"PROTAC-mediated HDAC7 protein degradation unveils its deacetylase-independent proinflammatory function in macrophages","volume":"11","author":"Kadier","year":"2024","journal-title":"Adv Sci (Weinh)"},{"issue":"9","key":"bib59","doi-asserted-by":"publisher","first-page":"5466","DOI":"10.1167\/iovs.14-14380","article-title":"Retinal ischemia\/reperfusion injury is mediated by Toll-like receptor 4 activation of NLRP3 inflammasomes","volume":"55","author":"Qi","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"117864","DOI":"10.1016\/j.lfs.2020.117864","article-title":"Inhibition of myeloid differentiation protein 2 attenuates renal ischemia\/reperfusion-induced oxidative stress and inflammation via suppressing TLR4\/TRAF6\/NF-kB pathway","volume":"256","author":"Hu","year":"2020","journal-title":"Life Sci"},{"issue":"3","key":"bib61","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/(SICI)1097-0134(19991115)37:3&lt;499::AID-PROT17&gt;3.0.CO;2-Y","article-title":"Diversity of conformational states and changes within the EF-hand protein superfamily","volume":"37","author":"Yap","year":"1999","journal-title":"Proteins"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"728052","DOI":"10.1155\/2010\/728052","article-title":"The calcium-dependent interaction of S100B with its protein targets","volume":"2010","author":"Zimmer","year":"2010","journal-title":"Cardiovasc Psychiatry Neurol"},{"issue":"4","key":"bib63","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.2741\/s223","article-title":"The importance of Ca2+\/Zn2+ signaling S100 proteins and RAGE in translational medicine","volume":"3","author":"Leclerc","year":"2011","journal-title":"Front Biosci (Schol Ed)"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3389\/fphar.2012.00067","article-title":"S100 calcium binding proteins and ion channels","volume":"3","author":"Hermann","year":"2012","journal-title":"Front Pharmacol"},{"issue":"1","key":"bib65","doi-asserted-by":"publisher","first-page":"24","DOI":"10.2174\/156652413804486214","article-title":"Functions of S100 proteins","volume":"13","author":"Donato","year":"2013","journal-title":"Curr Mol Med"},{"issue":"1","key":"bib66","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1183\/13993003.00159-2015","article-title":"Differential release and deposition of S100A8\/A9 proteins in inflamed upper airway tissue","volume":"47","author":"Van Crombruggen","year":"2016","journal-title":"Eur Respir J."},{"issue":"5","key":"bib67","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1161\/CIRCRESAHA.120.315865","article-title":"S100A9 links inflammation and repair in myocardial infarction","volume":"127","author":"Marinkovic","year":"2020","journal-title":"Circ Res"},{"issue":"12","key":"bib68","doi-asserted-by":"publisher","first-page":"e2103675","DOI":"10.1002\/advs.202103675","article-title":"Single cell RNA sequencing identifies a unique inflammatory macrophage subset as a druggable target for alleviating acute kidney injury","volume":"9","author":"Yao","year":"2022","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"bib69","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1167\/iovs.66.1.35","article-title":"S100A8\/A9 promotes dendritic cell-mediated Th17 cell response in Sjogren's dry eye disease by regulating the Acod1\/STAT3 pathway","volume":"66","author":"Wei","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"113938","DOI":"10.1016\/j.intimp.2024.113938","article-title":"Mechanism of S100A9-mediated astrocyte activation via TLR4\/NF-kappaB in Parkinson's disease","volume":"146","author":"Qiao","year":"2025","journal-title":"Int Immunopharmacol"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.3.8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:24Z","timestamp":1791927144000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.3.8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.3.8","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,5]]}}}