{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:01:58Z","timestamp":1791928918956,"version":"4.3.4"},"reference-count":46,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,4,17]]},"DOI":"10.1167\/iovs.67.4.40","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:30:49Z","timestamp":1776432649000},"page":"40","source":"Crossref","is-referenced-by-count":0,"title":["A Porcine Model of Rhegmatogenous Retinal Detachment and Repair With Pars Plana Vitrectomy and Silicone Oil Tamponade"],"prefix":"10.1167","volume":"67","author":[{"given":"Jonathan F.","family":"Russell","sequence":"first","affiliation":[{"name":"Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"},{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Boyce","sequence":"additional","affiliation":[{"name":"Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"},{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"De Melo Haefeli","sequence":"additional","affiliation":[{"name":"Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"},{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Russell","sequence":"additional","affiliation":[{"name":"Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"},{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily E.","family":"Meyering","sequence":"additional","affiliation":[{"name":"Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"},{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallory J.","family":"Lang","sequence":"additional","affiliation":[{"name":"Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"},{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam A.","family":"Goeken","sequence":"additional","affiliation":[{"name":"Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"},{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian C.","family":"Han","sequence":"additional","affiliation":[{"name":"Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"},{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budd A.","family":"Tucker","sequence":"additional","affiliation":[{"name":"Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"},{"name":"Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States"},{"name":"Department of Neuroscience and Pharmacology, Carver College of Medicine University of Iowa, Iowa City, Iowa, United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.survophthal.2023.11.005","article-title":"International incidence and temporal trends for rhegmatogenous retinal detachment: a systematic review and meta-analysis","volume":"69","author":"Ge","year":"2024","journal-title":"Surv Ophthalmol"},{"key":"bib2","first-page":"1","article-title":"Pathogenesis and pathological anatomy of retinal detachments [in French]","volume":"33","author":"Gonin","year":"1920","journal-title":"Rapport Soc franc d'opht Bulletins et memoires (XXXIII annee)"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.oret.2020.02.014","article-title":"Primary retinal detachment outcomes study: methodology and overall outcomes\u2013Primary Retinal Detachment Outcomes Study Report Number 1","volume":"4","author":"Ryan","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.oret.2020.09.013","article-title":"Outcomes of pars plana vitrectomy alone versus combined scleral buckling plus pars plana vitrectomy for primary retinal detachment","volume":"5","author":"Echegaray","year":"2021","journal-title":"Ophthalmol Retina"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1097\/IIO.0000000000000258","article-title":"Proliferative vitreoretinopathy: a review","volume":"59","author":"Idrees","year":"2019","journal-title":"Int Ophthalmol Clin"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s40135-020-00247-9","article-title":"Retinal tamponades: current uses and future technologies","volume":"8","author":"Deobhakta","year":"2020","journal-title":"Curr Ophthalmol Rep"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/0002-9394(68)91522-5","article-title":"Experimental retinal detachment in the owl monkey. I. Methods of production and clinical picture","volume":"66","author":"Machemer","year":"1968","journal-title":"Am J Ophthalmol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/0002-9394(68)90816-7","article-title":"Experimental retinal detachment in the owl monkey. IV. The reattached retina","volume":"66","author":"Machemer","year":"1968","journal-title":"Am J Ophthal"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.survophthal.2023.08.001","article-title":"Histologic changes in retinal detachment: a systematic review for the clinician","volume":"69","author":"Melo","year":"2024","journal-title":"Surv Ophthalmol"},{"key":"bib11","first-page":"278","article-title":"Use of nonhuman primates in research in North America","volume":"53","author":"Lankau","year":"2014","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"100179","DOI":"10.1016\/j.xops.2022.100179","article-title":"Optimizing retinal thermofusion in retinal detachment repair","volume":"2","author":"Heriot","year":"2022","journal-title":"Ophthalmol Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1001\/archopht.1995.01100070113034","article-title":"Debridement of the pig retinal pigment epithelium in vivo","volume":"113","author":"Del Priore","year":"1995","journal-title":"Arch Ophthalmol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1076\/ceyr.16.6.556.5082","article-title":"Porcine model of proliferative vitreoretinopathy with platelets","volume":"16","author":"Garcia-Layana","year":"1997","journal-title":"Curr Eye Res"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/s41598-020-80267-4","article-title":"ROCK inhibition reduces morphological and functional damage to rod synapses after injury","volume":"11","author":"Halasz","year":"2021","journal-title":"Sci Rep"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1167\/iovs.07-0879","article-title":"Early activation of inflammation- and immune response-related genes after experimental detachment of the porcine retina","volume":"49","author":"Hollborn","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1167\/iovs.05-0595","article-title":"Glial cell reactivity in a porcine model of retinal detachment","volume":"47","author":"Iandiev","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"4026","DOI":"10.1167\/iovs.02-1264","article-title":"An experimental model of rhegmatogenous retinal detachment: surgical results and glial cell response","volume":"44","author":"Jackson","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"100296","DOI":"10.1016\/j.xops.2023.100296","article-title":"Aerosolized, gas-phase, intravitreal methotrexate reduces proliferative vitreoretinopathy in a randomized trial in a porcine model","volume":"3","author":"Olsen","year":"2023","journal-title":"Ophthalmol Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1159\/000522110","article-title":"Controlled subretinal injection pressure prevents damage in pigs","volume":"245","author":"Olufsen","year":"2022","journal-title":"Ophthalmologica"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1167\/iovs.65.10.35","article-title":"Wound healing in a porcine model of retinal holes","volume":"65","author":"Olufsen","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00417-011-1782-x","article-title":"The effect of subretinal viscoelastics on the porcine retinal function","volume":"250","author":"Sorensen","year":"2012","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1007\/s00417-013-2331-6","article-title":"Functional recovery after experimental RPE debridement, mfERG studies in a porcine model","volume":"251","author":"Sorensen","year":"2013","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1007\/s00417-017-3704-z","article-title":"Repeated subretinal surgery and removal of subretinal decalin is well tolerated \u2013 evidence from a porcine model","volume":"255","author":"Sorensen","year":"2017","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/aos.14188","article-title":"Loss of retinal tension and permanent decrease in retinal function: a new porcine model of rhegmatogenous retinal detachment","volume":"98","author":"Sorensen","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1167\/tvst.6.3.22","article-title":"Fasudil, a clinically used ROCK inhibitor, stabilizes rod photoreceptor synapses after retinal detachment","volume":"6","author":"Townes-Anderson","year":"2017","journal-title":"Transl Vis Sci Technol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1600-0420.2007.00983.x","article-title":"Functional implications of short-term retinal detachment in porcine eyes: study by multifocal electroretinography","volume":"86","author":"Voss Kyn","year":"2008","journal-title":"Acta Ophthalmol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"3892","DOI":"10.1167\/iovs.16-19447","article-title":"RhoA signaling and synaptic damage occur within hours in a live pig model of CNS injury, retinal detachment","volume":"57","author":"Wang","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1001\/archopht.123.10.1385","article-title":"Retinal progenitor cell xenografts to the pig retina","volume":"123","author":"Warfvinge","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.actbio.2019.04.057","article-title":"Two-photon polymerized poly(caprolactone) retinal cell delivery scaffolds and their systemic and retinal biocompability","volume":"94","author":"Thompson","year":"2019","journal-title":"Acta Biomater"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"11791","DOI":"10.1038\/srep11791","article-title":"Allogenic iPSC-derived RPE cell transplants induce immune response in pigs: a pilot study","volume":"5","author":"Sohn","year":"2015","journal-title":"Sci Rep"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1167\/tvst.7.6.18","article-title":"Correlation of optical coherence tomography and retinal histology in normal and Pro23His retinal degeneration pig","volume":"7","author":"Cheng","year":"2018","journal-title":"Transl Vis Sci Technol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1089\/crispr.2023.0039","article-title":"CRISPRi-mediated treatment of dominant rhodopsin-associated retinitis pigmentosa","volume":"6","author":"Burnight","year":"2023","journal-title":"CRISPR J"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/sctm.18-0210","article-title":"Optimizing donor cellular dissociation and subretinal injection parameters for stem cell-based treatments","volume":"8","author":"Scruggs","year":"2019","journal-title":"Stem Cells Transl Med"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.cvfa.2010.09.002","article-title":"Porcine ophthalmology","volume":"26","author":"Middleton","year":"2010","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1177\/0192623316641784","article-title":"The miniature swine as a model in experimental and translational medicine","volume":"44","author":"Stricker-Krongrad","year":"2016","journal-title":"Toxicol Pathol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.ajo.2024.05.008","article-title":"Pars plana vitrectomy with silicone oil or gas tamponade for uncomplicated retinal detachment: a systematic review and meta-analysis","volume":"266","author":"Huang","year":"2024","journal-title":"Am J Ophthalmol"},{"key":"bib38","first-page":"175","article-title":"Recovery of photoreceptor outer segment length and analysis of membrane assembly rates in regenerating primate photoreceptor outer segments","volume":"34","author":"Guerin","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib39","first-page":"2412","article-title":"The ability of rapid retinal reattachment to stop or reverse the cellular and molecular events initiated by detachment","volume":"43","author":"Lewis","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s004170050014","article-title":"The process of closure of experimental retinal holes in rabbit eyes","volume":"238","author":"Yamana","year":"2000","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0002-9394(75)90458-4","article-title":"Sulfur hexafluoride in owl monkey vitreous cavity","volume":"79","author":"Fineberg","year":"1975","journal-title":"Am J Ophthalmol"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1001\/archopht.1980.01020040462012","article-title":"Intravitreal longevity of three perfluorocarbon gases","volume":"98","author":"Lincoff","year":"1980","journal-title":"Arch Ophthalmol"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1001\/archopht.1962.00960030394013","article-title":"Ocular tolerance to silicones. I. Replacement of aqueous and vitreous by silicone fluids","volume":"68","author":"Armaly","year":"1962","journal-title":"Arch Ophthalmol"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1001\/archopht.1962.00960030594005","article-title":"The use of liquid silicone in retinal detachment surgery","volume":"68","author":"Cibis","year":"1962","journal-title":"Arch Ophthalmol"},{"key":"bib45","first-page":"50660","article-title":"Retinal detachment model in rodents by subretinal injection of sodium hyaluronate","volume":"79","author":"Matsumoto","year":"2013","journal-title":"J Vis Exp"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol Rev"},{"key":"bib3","volume-title":"2018 Global Trends in Retina.","author":"Singh","year":"2018"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.4.40","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:19Z","timestamp":1791927139000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.4.40"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,17]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.4.40","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,17]]}}}