{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:45:52Z","timestamp":1792449952839,"version":"4.5.0"},"reference-count":34,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,4,17]]},"DOI":"10.1167\/iovs.67.4.42","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:30:55Z","timestamp":1776432655000},"page":"42","source":"Crossref","is-referenced-by-count":1,"title":["LncRNA DANCR Regulates PARP1-Mediated Oxidative Stress Response in Corneas by Encoding a Novel Micropeptide miPEPDR"],"prefix":"10.1167","volume":"67","author":[{"given":"Xiaolu","family":"Ma","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering, College of Artificial Intelligence, Taiyuan University of Technology, Taiyuan, People's Republic of China"},{"name":"Department of Oral Medicine, Shanxi Provincial People\u2019s Hospital, Taiyuan, Shanxi, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Hao","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Artificial Intelligence, Taiyuan University of Technology, Taiyuan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halima","family":"Ben Hilal","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Artificial Intelligence, Taiyuan University of Technology, Taiyuan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zina","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Artificial Intelligence, Taiyuan University of Technology, Taiyuan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Artificial Intelligence, Taiyuan University of Technology, Taiyuan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Artificial Intelligence, Taiyuan University of Technology, Taiyuan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cornea, Shanxi Aier Eye Hospital, Taiyuan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cornea, Shanxi Aier Eye Hospital, Taiyuan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Artificial Intelligence, Taiyuan University of Technology, Taiyuan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, College of Artificial Intelligence, Taiyuan University of Technology, Taiyuan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"1","key":"bib1","first-page":"37","article-title":"Mutagenicity, toxicity and repair of DNA base damage induced by oxidation","volume":"531","author":"Bjelland","year":"2003","journal-title":"Mutat Res"},{"issue":"8","key":"bib2","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1093\/nar\/gkp100","article-title":"Oxidative stress induces degradation of mitochondrial DNA","volume":"37","author":"Shokolenko","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"bib3","doi-asserted-by":"publisher","first-page":"3834","DOI":"10.1038\/s41467-019-11874-7","article-title":"Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat Commun"},{"issue":"7147","key":"bib4","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/nature05978","article-title":"Base-excision repair of oxidative DNA damage","volume":"447","author":"David","year":"2007","journal-title":"Nature"},{"issue":"8","key":"bib5","doi-asserted-by":"publisher","first-page":"3811","DOI":"10.1093\/nar\/gkz120","article-title":"Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins","volume":"47","author":"Alemasova","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"40","key":"bib6","doi-asserted-by":"publisher","first-page":"14258","DOI":"10.1021\/ja906135d","article-title":"Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications","volume":"131","author":"Tao","year":"2009","journal-title":"J Am Chem Soc"},{"issue":"6","key":"bib7","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.dnarep.2008.03.017","article-title":"Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks","volume":"7","author":"Woodhouse","year":"2008","journal-title":"DNA Repair"},{"issue":"14","key":"bib8","doi-asserted-by":"publisher","first-page":"6934","DOI":"10.1093\/nar\/gkv623","article-title":"The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function","volume":"43","author":"Breslin","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"19","key":"bib9","doi-asserted-by":"publisher","first-page":"8520","DOI":"10.1128\/JVI.01180-16","article-title":"Epstein-Barr virus oncoprotein LMP1 mediates epigenetic changes in host gene expression through PARP1","volume":"90","author":"Martin","year":"2016","journal-title":"J Virol"},{"issue":"21","key":"bib10","first-page":"10386","article-title":"Analyzing structure\u2013function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells","volume":"44","author":"Rank","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"bib11","doi-asserted-by":"publisher","first-page":"10075","DOI":"10.1038\/s41598-019-46358-7","article-title":"PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling of WRN and XRCC1 in a toxicant and protein-specific manner","volume":"9","author":"Veith","year":"2019","journal-title":"Sci Rep"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/jnc.15464","article-title":"Emerging role of PARP-1 and PARthanatos in ischemic stroke","volume":"160","author":"Liu","year":"2022","journal-title":"J Neurochem"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/s41420-024-02114-z","article-title":"Parthanatos initiated by ROS-induced DNA damage is involved in intestinal epithelial injury during necrotizing enterocolitis","volume":"10","author":"Xu","year":"2024","journal-title":"Cell Death Discov"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.freeradbiomed.2024.05.020","article-title":"PARP1 inhibition prevents oxidative stress in age-related hearing loss via PAR-Ca2+-AIF axis in cochlear strial marginal cells","volume":"220","author":"Wan","year":"2024","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"bib15","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.cell.2015.01.009","article-title":"A micropeptide encoded by a putative long noncoding RNA regulates muscle performance","volume":"160","author":"Anderson","year":"2015","journal-title":"Cell"},{"issue":"1","key":"bib16","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12943-020-1147-3","article-title":"Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA","volume":"19","author":"Wu","year":"2020","journal-title":"Mol Cancer"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12943-024-02131-7","article-title":"CircRNA and lncRNA-encoded peptide in diseases, an update review","volume":"23","author":"Yi","year":"2024","journal-title":"Mol Cancer"},{"issue":"7822","key":"bib18","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/s41586-020-2612-2","article-title":"Effects of extracellular matrix viscoelasticity on cellular behaviour","volume":"584","author":"Chaudhuri","year":"2020","journal-title":"Nature"},{"issue":"5","key":"bib19","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41419-024-06700-y","article-title":"RAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair","volume":"15","author":"Ma","year":"2024","journal-title":"Cell Death Dis"},{"issue":"8","key":"bib20","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s41419-019-1762-3","article-title":"Grb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response","volume":"10","author":"Hou","year":"2019","journal-title":"Cell Death Dis"},{"issue":"1","key":"bib21","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12882-024-03562-6","article-title":"Depression of LncRNA DANCR alleviates tubular injury in diabetic nephropathy by regulating KLF5 through sponge miR-214-5p","volume":"25","author":"Kuang","year":"2024","journal-title":"BMC Nephrol"},{"issue":"1","key":"bib22","doi-asserted-by":"publisher","first-page":"e1163","DOI":"10.1002\/iid3.1163","article-title":"Exploring the effect of LncRNA DANCR to regulate the Keap1-Nrf2\/ARE pathway on oxidative stress in rheumatoid arthritis","volume":"12","author":"Cai","year":"2024","journal-title":"Immun Inflamm Dis"},{"issue":"4","key":"bib23","first-page":"636","article-title":"SmProt: a database of small proteins encoded by annotated coding and non-coding RNA loci","volume":"19","author":"Hao","year":"2018","journal-title":"Brief Bioinform"},{"issue":"6414","key":"bib24","doi-asserted-by":"publisher","first-page":"eaat8407","DOI":"10.1126\/science.aat8407","article-title":"Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson's disease","volume":"362","author":"Kam","year":"2018","journal-title":"Science"},{"issue":"4","key":"bib25","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1101\/gad.182121.111","article-title":"Suppression of progenitor differentiation requires the long noncoding RNA ANCR","volume":"26","author":"Kretz","year":"2012","journal-title":"Genes Dev"},{"issue":"5","key":"bib26","doi-asserted-by":"publisher","first-page":"e2313656121","DOI":"10.1073\/pnas.2313656121","article-title":"Dancr-BRG1 regulates Nfatc1 transcription and Pgc1\u00df-dependent metabolic shifts in osteoclastogenesis","volume":"121","author":"Zhang","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"175732","DOI":"10.1016\/j.ejphar.2023.175732","article-title":"LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1\/DDAH1\/ADMA signaling pathway","volume":"950","author":"Wu","year":"2023","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"bib28","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12935-022-02612-z","article-title":"A review on the role of DANCR in the carcinogenesis","volume":"22","author":"Ghafouri-Fard","year":"2022","journal-title":"Cancer Cell Int"},{"issue":"2","key":"bib29","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0921-8777(89)90012-8","article-title":"Poly(ADP-ribose) catabolism in mammalian cells exposed to DNA-damaging agents","volume":"218","author":"Alvarez-Gonzalez","year":"1989","journal-title":"Mutat Res"},{"issue":"4","key":"bib30","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41594-022-00747-1","article-title":"PARP inhibition impedes the maturation of nascent DNA strands during DNA replication","volume":"29","author":"Vaitsiankova","year":"2022","journal-title":"Nat Struct Mol Biol"},{"issue":"5","key":"bib31","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/nrd.2015.6","article-title":"Regulated necrosis: disease relevance and therapeutic opportunities","volume":"15","author":"Conrad","year":"2016","journal-title":"Nat Rev Drug Discov"},{"issue":"3","key":"bib32","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1039\/C6MB00740F","article-title":"Crosstalk between the nucleolus and the DNA damage response","volume":"13","author":"Ogawa","year":"2017","journal-title":"Mol BioSyst"},{"issue":"3","key":"bib33","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.dnarep.2008.11.018","article-title":"Delocalization of nucleolar poly(ADP-ribose) polymerase-1 to the nucleoplasm and its novel link to cellular sensitivity to DNA damage","volume":"8","author":"Rancourt","year":"2009","journal-title":"DNA Repair"},{"issue":"7","key":"bib34","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.3390\/cancers12071813","article-title":"The nucleolus and PARP1 in cancer biology","volume":"12","author":"Engbrecht","year":"2020","journal-title":"Cancers (Basel)"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.4.42","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:19Z","timestamp":1791927139000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.4.42"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,17]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.4.42","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,17]]}}}