{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:37Z","timestamp":1791928957968,"version":"4.3.4"},"reference-count":54,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,4,28]]},"DOI":"10.1167\/iovs.67.4.66","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:31:15Z","timestamp":1777386675000},"page":"66","source":"Crossref","is-referenced-by-count":0,"title":["PANK4 Regulates YAP to Modulate the Glycolytic Pathway in LEC for Driving LECs-EMT in Early Diabetic Cataract Pathogenesis"],"prefix":"10.1167","volume":"67","author":[{"given":"Xue","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanrui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiumei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zegang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Center, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical Center, Army Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"e70012","DOI":"10.1111\/1753-0407.70012","article-title":"National burden and risk factors of diabetes mellitus in China from 1990 to 2021: results from the Global Burden of Disease Study 2021","volume":"16","author":"Deng","year":"2024","journal-title":"J Diabetes"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12916-025-03890-w","article-title":"Global, regional, and national burdens of type 1 and type 2 diabetes mellitus in adolescents from 1990 to 2021, with forecasts to 2030: a systematic analysis of the global burden of disease study 2021","volume":"23","author":"Chen","year":"2025","journal-title":"BMC Med"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1111\/jcmm.14762","article-title":"SP1-mediated lncRNA PVT1 modulates the proliferation and apoptosis of lens epithelial cells in diabetic cataract via miR-214-3p\/MMP2 axis","volume":"24","author":"Yang","year":"2020","journal-title":"J Cell Mol Med"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1373533","DOI":"10.1155\/2022\/1373533","article-title":"Ghrelin mitigates high-glucose-induced oxidative damage and apoptosis in lens epithelial cells","volume":"2022","author":"Bai","year":"2022","journal-title":"J Diabetes Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1186\/s12967-024-05691-w","article-title":"METTL3-mediated m6A modification of SIRT1 mRNA affects the progression of diabetic cataracts through cellular autophagy and senescence","volume":"22","author":"Dong","year":"2024","journal-title":"J Transl Med"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.aopr.2023.10.001","article-title":"Oxidative stress, epigenetic regulation and pathological processes of lens epithelial cells underlying diabetic cataract","volume":"3","author":"Guo","year":"2023","journal-title":"Adv Ophthalmol Pract Res"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41374-021-00713-3","article-title":"LncRNA GAS5 regulates migration and epithelial-to-mesenchymal transition in lens epithelial cells via the miR-204-3p\/TGFBR1 axis","volume":"102","author":"Li","year":"2022","journal-title":"Lab Invest"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"100226","DOI":"10.1016\/j.labinv.2023.100226","article-title":"KLF5\/MDM2 axis modulates oxidative stress and epithelial-mesenchymal transition in human lens epithelial cells: the role in diabetic cataract","volume":"103","author":"Li","year":"2023","journal-title":"Lab Invest"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.14336\/AD.2023.0216-1","article-title":"Pantothenate kinase 4 governs lens epithelial fibrosis by negatively regulating pyruvate kinase M2-related glycolysis","volume":"14","author":"Li","year":"2023","journal-title":"Aging Dis"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/pro.3611","article-title":"Human pantothenate kinase 4 is a pseudo-pantothenate kinase","volume":"28","author":"Yao","year":"2019","journal-title":"Protein Sci"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s11010-005-5535-1","article-title":"High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2)","volume":"277","author":"Li","year":"2005","journal-title":"Mol Cell Biochem"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/humu.23696","article-title":"A novel mutation of PANK4 causes autosomal dominant congenital posterior cataract","volume":"40","author":"Sun","year":"2019","journal-title":"Hum Mutat"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1146\/annurev-biochem-013118-111829","article-title":"The Hippo pathway: biology and pathophysiology","volume":"88","author":"Ma","year":"2019","journal-title":"Annu Rev Biochem"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s12264-024-01308-w","article-title":"YAP signaling in glia: pivotal roles in neurological development, regeneration and diseases","volume":"41","author":"Lin","year":"2025","journal-title":"Neurosci Bull"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.3390\/ijms19113674","article-title":"YAP\/TAZ signaling as a molecular link between fibrosis and cancer","volume":"19","author":"Noguchi","year":"2018","journal-title":"Int J Mol Sci"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.3390\/cells11152363","article-title":"ENO2 promotes colorectal cancer metastasis by interacting with the lncRNA CYTOR and activating YAP1-induced EMT","volume":"11","author":"Lv","year":"2022","journal-title":"Cells"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.exer.2018.01.014","article-title":"A role for Hippo\/YAP-signaling in FGF-induced lens epithelial cell proliferation and fibre differentiation","volume":"169","author":"Dawes","year":"2018","journal-title":"Exp Eye Res"},{"key":"bib18","first-page":"19","article-title":"Untargeted metabolomics reveals the role of lipocalin-2 in the pathological changes of lens and retina in diabetic mice","volume":"65","author":"Yang","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"23417","DOI":"10.1021\/acs.jafc.5c07282","article-title":"csi-miR166e, A microribonucleic acid of considerable abundance in plant food, ameliorates high-fat diet\/streptozotocin-induced type 2 diabetes in mice via oral administration","volume":"73","author":"Li","year":"2025","journal-title":"J Agric Food Chem"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"112362","DOI":"10.1016\/j.yexcr.2020.112362","article-title":"Extracellular vesicles promote epithelial-to-mesenchymal transition of lens epithelial cells under oxidative stress","volume":"398","author":"Wang","year":"2021","journal-title":"Exp Cell Res"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"21635","DOI":"10.1038\/s41598-025-05929-7","article-title":"Hypoxia-induced HIF-1a\/VASN promotes bladder cancer progression","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci Rep"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"3814809","DOI":"10.1155\/2022\/3814809","article-title":"HIF-1a regulates the progression of cervical cancer by targeting YAP\/TAZ","volume":"2022","author":"Abudoukerimu","year":"2022","journal-title":"J Oncol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"5921","DOI":"10.1167\/iovs.17-22264","article-title":"Incidence, progression, and risk factors for cataract in type 2 diabetes","volume":"58","author":"Srinivasan","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"140","DOI":"10.4239\/wjd.v10.i3.140","article-title":"Cataract in diabetes mellitus","volume":"10","author":"Kiziltoprak","year":"2019","journal-title":"World J Diabetes"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"9042","DOI":"10.3390\/ijms25169042","article-title":"The synergistic effects of polyol pathway-induced oxidative and osmotic stress in the aetiology of diabetic cataracts","volume":"25","author":"Thorne","year":"2024","journal-title":"Int J Mol Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1097\/01.iae.0000254895.78766.af","article-title":"Photic retinopathy after cataract surgery in diabetic patients","volume":"26","author":"Cetinkaya","year":"2006","journal-title":"Retina"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"112334","DOI":"10.1016\/j.intimp.2024.112334","article-title":"Evaluation of nintedanib efficacy: attenuating the lens fibrosis in vitro and vivo","volume":"136","author":"Ding","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12929-023-00895-6","article-title":"Pre-hyperglycemia immune cell trafficking underlies subclinical diabetic cataractogenesis","volume":"30","author":"Ranaei Pirmardan","year":"2023","journal-title":"J Biomed Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"665994","DOI":"10.3389\/fphys.2021.665994","article-title":"High glucose activates YAP signaling to promote vascular inflammation","volume":"12","author":"Ortillon","year":"2021","journal-title":"Front Physiol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/s41467-024-55036-w","article-title":"Pantothenate kinase 4 controls skeletal muscle substrate metabolism","volume":"16","author":"Miranda-Cervantes","year":"2025","journal-title":"Nat Commun"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"72","DOI":"10.14712\/fb2022068020072","article-title":"TRPM7 elicits proliferation and differentiation of human lens epithelial cells through the TGF-\u00df\/Smad pathways","volume":"68","author":"Yang","year":"2022","journal-title":"Folia Biol (Praha)"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s10020-020-00250-7","article-title":"microRNA-199a-5p regulates epithelial-to-mesenchymal transition in diabetic cataract by targeting SP1 gene","volume":"26","author":"Liu","year":"2020","journal-title":"Mol Med"},{"key":"bib33","first-page":"1609","article-title":"Effect of high sugar levels on miRNA expression. Studies with galactosemic mice lenses","volume":"18","author":"Varma","year":"2012","journal-title":"Mol Vis"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1080\/02713683.2024.2388698","article-title":"Slit2 promotes H(2)O(2)-induced lens epithelial cells oxidative damage and age-related cataract","volume":"50","author":"Fu","year":"2025","journal-title":"Curr Eye Res"},{"key":"bib35","first-page":"35","article-title":"PERK regulates epithelial-mesenchymal transition through autophagy and lipid metabolism in lens epithelial cells","volume":"66","author":"Wang","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s10020-022-00540-2","article-title":"The interaction between autophagy and the epithelial-mesenchymal transition mediated by NICD\/ULK1 is involved in the formation of diabetic cataracts","volume":"28","author":"Ma","year":"2022","journal-title":"Mol Med"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"e85092","DOI":"10.7554\/eLife.85092","article-title":"Hippo signaling impairs alveolar epithelial regeneration in pulmonary fibrosis","volume":"12","author":"Warren","year":"2023","journal-title":"Elife"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.3390\/biom13121767","article-title":"Understanding the role of yes-associated protein (YAP) signaling in the transformation of lens epithelial cells (EMT) and fibrosis","volume":"13","author":"Taiyab","year":"2023","journal-title":"Biomolecules"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1053\/j.gastro.2020.12.077","article-title":"Zinc-dependent regulation of ZEB1 and YAP1 coactivation promotes epithelial-mesenchymal transition plasticity and metastasis in pancreatic cancer","volume":"160","author":"Liu","year":"2021","journal-title":"Gastroenterology"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"e45809","DOI":"10.15252\/embr.201845809","article-title":"YAP and TAZ are essential for basal and squamous cell carcinoma initiation","volume":"19","author":"Debaugnies","year":"2018","journal-title":"EMBO Rep"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"3920","DOI":"10.1167\/iovs.19-26893","article-title":"Lens stretching modulates lens epithelial cell proliferation via YAP regulation","volume":"60","author":"Kumar","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"e22783","DOI":"10.1096\/fj.202201187RR","article-title":"Extracellular HSP90 promotes differentiation of lens epithelial cells to fiber cells by activating LRP1-YAP-PROX1 axis","volume":"37","author":"Li","year":"2023","journal-title":"FASEB J"},{"issue":"1","key":"bib43","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1101\/gad.1843810","article-title":"A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev"},{"issue":"1","key":"bib44","doi-asserted-by":"publisher","first-page":"5205","DOI":"10.1038\/s41598-024-55764-5","article-title":"AMPK stimulation inhibits YAP\/TAZ signaling to ameliorate hepatic fibrosis","volume":"14","author":"Shihan","year":"2024","journal-title":"Sci Rep"},{"issue":"13","key":"bib45","doi-asserted-by":"crossref","first-page":"111412","DOI":"10.1016\/j.celrep.2022.111412","article-title":"A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation","volume":"40","author":"TranDrozdz","year":"2022","journal-title":"Cell Rep"},{"issue":"1","key":"bib46","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s40364-024-00651-4","article-title":"The significant others of aurora kinase a in cancer: combination is the key","volume":"12","author":"Nikhil","year":"2024","journal-title":"Biomark Res"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/s41416-022-02106-9","article-title":"Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP\/TAZ-Hedgehog signalling axis in pancreatic cancer","volume":"128","author":"Liu","year":"2023","journal-title":"Br J Cancer"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1016\/j.celrep.2016.04.027","article-title":"Hippo signaling mediators Yap and Taz are required in the epicardium for coronary vasculature development","volume":"15","author":"Singh","year":"2016","journal-title":"Cell Rep"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/s41598-020-58189-y","article-title":"Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap\/Taz transcriptional activation in lens epithelial cells and explants","volume":"10","author":"Maddala","year":"2020","journal-title":"Sci Rep"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"eaax4067","DOI":"10.1126\/scisignal.aax4067","article-title":"Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-\u00df","volume":"12","author":"Yin","year":"2019","journal-title":"Sci Signal"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1186\/s13046-020-01705-9","article-title":"MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo\/YAP1\/HIF1A axis","volume":"39","author":"Sun","year":"2020","journal-title":"J Exp Clin Cancer Res"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"e150595","DOI":"10.1172\/JCI150595","article-title":"YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload","volume":"132","author":"Kashihara","year":"2022","journal-title":"J Clin Invest"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"225","DOI":"10.7150\/ijbs.75459","article-title":"HIF-1a\/YAP signaling rewrites glucose\/iodine metabolism program to promote papillary thyroid cancer progression","volume":"19","author":"Song","year":"2023","journal-title":"Int J Biol Sci"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1186\/s12967-022-03758-0","article-title":"A novel small molecule glycolysis inhibitor WZ35 exerts anti-cancer effect via metabolic reprogramming","volume":"20","author":"Wang","year":"2022","journal-title":"J Transl Med"}],"container-title":["Investigative Ophthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.4.66","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:23Z","timestamp":1791927143000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.4.66"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.4.66","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,28]]}}}