{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:02:33Z","timestamp":1791928953405,"version":"4.3.4"},"reference-count":67,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2026,5,6]]},"DOI":"10.1167\/iovs.67.5.11","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T16:30:32Z","timestamp":1778085032000},"page":"11","source":"Crossref","is-referenced-by-count":1,"title":["High-Dose Sucralose Is Associated With Lacrimal Circadian Remodeling, Reduced Immunometabolic Signatures, and Reduced Tear Secretion"],"prefix":"10.1167","volume":"67","author":[{"given":"Di","family":"Qi","sequence":"first","affiliation":[{"name":"Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Pei","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingli","family":"Lu","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenzhen","family":"Huang","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Yang","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Ba","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"6","key":"bib1","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.3390\/nu14061261","article-title":"The effect of artificial sweeteners use on sweet taste perception and weight loss efficacy: a review","volume":"14","author":"Wilk","year":"2022","journal-title":"Nutrients"},{"issue":"11","key":"bib3","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/s41430-023-01314-7","article-title":"WHO guideline on the use of non-sugar sweeteners: a need for reconsideration","volume":"77","author":"Khan","year":"2023","journal-title":"Eur J Clin Nutr"},{"issue":"4","key":"bib4","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1139\/y94-063","article-title":"The development and applications of sucralose, a new high-intensity sweetener","volume":"72","author":"Knight","year":"1994","journal-title":"Can J Physiol Pharmacol"},{"key":"bib5","article-title":"Beyond sugar: a holistic review of sweeteners and their role in modern nutrition.","volume":"14","author":"Dragomir","year":"2025","journal-title":"Foods (Basel, Switzerland)."},{"key":"bib6","doi-asserted-by":"publisher","first-page":"e70208","DOI":"10.1111\/1541-4337.70208","article-title":"Application of FDA-Approved Artificial Sweeteners in Food Science: Technological and Nutritional Challenges","volume":"24","author":"Tahmouzi","year":"2025","journal-title":"Compr Rev Food Sci Food Saf"},{"issue":"5580","key":"bib7","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1038\/263800a0","article-title":"Enhancement in the sweetness of sucrose","volume":"263","author":"Hough","year":"1976","journal-title":"Nature"},{"issue":"9598","key":"bib8","doi-asserted-by":"crossref","first-page":"9598","DOI":"10.1038\/srep09598","article-title":"Thermal degradation of sucralose: a combination of analytical methods to determine stability and chlorinated byproducts","volume":"5","author":"de Oliveira","year":"2015","journal-title":"Sci Rep"},{"issue":"13","key":"bib10","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.3390\/nu14132635","article-title":"Artificial sweeteners in breast milk: a clinical investigation with a kinetic perspective","volume":"14","author":"Stampe","year":"2022","journal-title":"Nutrients"},{"issue":"2","key":"bib11","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.cmet.2020.10.024","article-title":"Low-calorie sweeteners with carbohydrate do not impair insulin sensitivity in humans: re-analysis highlighting the importance of the comparator","volume":"33","author":"Khan","year":"2021","journal-title":"Cell Metab"},{"issue":"3","key":"bib12","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.cmet.2020.01.014","article-title":"Short-term consumption of sucralose with, but not without, carbohydrate impairs neural and metabolic sensitivity to sugar in humans","volume":"31","author":"Dalenberg","year":"2020","journal-title":"Cell Metab"},{"issue":"7953","key":"bib13","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/s41586-023-05801-6","article-title":"The dietary sweetener sucralose is a negative modulator of T cell-mediated responses","volume":"615","author":"Zani","year":"2023","journal-title":"Nature"},{"issue":"18","key":"bib14","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1016\/j.cell.2022.07.016","article-title":"Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance","volume":"185","author":"Suez","year":"2022","journal-title":"Cell"},{"issue":"5","key":"bib15","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41577-023-00873-x","article-title":"Sucralose: not sweet enough for T cells","volume":"23","author":"Bird","year":"2023","journal-title":"Nat Rev Immunol"},{"issue":"7959","key":"bib16","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41586-023-06009-4","article-title":"Cryptochrome-Timeless structure reveals circadian clock timing mechanisms","volume":"617","author":"Lin","year":"2023","journal-title":"Nature"},{"issue":"2","key":"bib17","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.tcb.2013.07.002","article-title":"Molecular architecture of the mammalian circadian clock","volume":"24","author":"Partch","year":"2014","journal-title":"Trends Cell Biol"},{"issue":"9","key":"bib18","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.chembiol.2023.08.014","article-title":"Metabolic and chemical architecture of the mammalian circadian clock","volume":"30","author":"Laothamatas","year":"2023","journal-title":"Cell Chem Biol"},{"issue":"3","key":"bib19","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1167\/iovs.65.3.2","article-title":"Unraveling the intraday variations in the tear fluid proteome","volume":"65","author":"Jones","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib20","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1167\/iovs.66.1.12","article-title":"Chronic jet lag disrupts circadian rhythms and induces hyperproliferation in murine lacrimal glands via ROS accumulation","volume":"66","author":"Huang","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib21","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1167\/iovs.66.4.40","article-title":"Corneal sensory nerve injury disrupts lacrimal gland function by altering circadian rhythms in mice","volume":"66","author":"Li","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib22","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1167\/iovs.63.6.19","article-title":"Sleep loss causes dysfunction in murine extraorbital lacrimal glands","volume":"63","author":"Huang","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1167\/iovs.63.5.23","article-title":"High-fat nutritional challenge reshapes circadian signatures in murine extraorbital lacrimal glands","volume":"63","author":"Zou","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"110008","key":"bib24","doi-asserted-by":"crossref","first-page":"110008","DOI":"10.1016\/j.exer.2024.110008","article-title":"Long-term high fructose intake reprograms the circadian transcriptome and disrupts homeostasis in mouse extra-orbital lacrimal glands","volume":"246","author":"Qi","year":"2024","journal-title":"Exp Eye Res"},{"issue":"7","key":"bib25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/10937404.2013.842523","article-title":"Sucralose, a synthetic organochlorine sweetener: overview of biological issues","volume":"16","author":"Schiffman","year":"2013","journal-title":"J Toxicol Environ Health B Crit Rev"},{"issue":"2","key":"bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J Basic Clin Pharm"},{"key":"bib27","doi-asserted-by":"crossref","DOI":"10.1002\/0471142727.mb29b03s77","article-title":"Evaluation of glucose homeostasis","author":"Heikkinen","year":"2007","journal-title":"Curr Protoc Mol Biol"},{"issue":"1","key":"bib28","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.1152\/ajpendo.00645.2007","article-title":"Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage","volume":"294","author":"Muniyappa","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"9\u201310","key":"bib29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1242\/dmm.006239","article-title":"Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice","volume":"3","author":"Ayala","year":"2010","journal-title":"Disease Models & Mechanisms"},{"issue":"6","key":"bib30","doi-asserted-by":"crossref","first-page":"pdb.prot5439","DOI":"10.1101\/pdb.prot5439","article-title":"Purification of RNA using TRIzol (TRI reagent)","volume":"2010","author":"Rio","year":"2010","journal-title":"Cold Spring Harb Protoc"},{"key":"bib31","doi-asserted-by":"crossref","first-page":"109573","DOI":"10.1016\/j.exer.2023.109573","article-title":"Long-term high fructose intake promotes lacrimal gland dysfunction by inducing gut dysbiosis in mice","volume":"234","author":"Qi","year":"2023","journal-title":"Exp Eye Res"},{"issue":"5","key":"bib32","first-page":"713","article-title":"SOAP: short oligonucleotide alignment program","volume":"24","author":"Li","year":"2008","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"4","key":"bib33","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"issue":"1","key":"bib34","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41398-022-01959-1","article-title":"Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum","volume":"12","author":"Zillich","year":"2022","journal-title":"Transl Psychiatry"},{"issue":"D1","key":"bib35","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"bib36","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.2353\/ajpath.2007.070388","article-title":"Autoimmune dacryoadenitis of NOD\/LtJ mice and its subsequent effects on tear protein composition","volume":"171","author":"Doyle","year":"2007","journal-title":"Am J Pathol"},{"issue":"3","key":"bib37","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2020.04.013","article-title":"Type 1 diabetes mellitus impairs diurnal oscillations in murine extraorbital lacrimal glands","volume":"18","author":"Jiao","year":"2020","journal-title":"Ocul Surf"},{"issue":"6","key":"bib38","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3390\/ijms18061209","article-title":"Pathological analysis of ocular lesions in a murine model of Sj\u00f6gren's syndrome","volume":"18","author":"Ushio","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"1","key":"bib39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1167\/iovs.11-8553","article-title":"Therapeutic effects of epidermal growth factor on benzalkonium chloride-induced dry eye in a mouse model","volume":"53","author":"Xiao","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib40","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.3390\/pharmaceutics13091362","article-title":"Poly(lactic-co-glycolic acid) nanoparticles encapsulating the prenylated flavonoid, xanthohumol, protect corneal epithelial cells from dry eye disease-associated oxidative stress","volume":"13","author":"Ghosh","year":"2021","journal-title":"Pharmaceutics"},{"key":"bib41","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1002\/mef2.65","article-title":"High sucralose intake suppresses autoimmunity and promotes tumor growth by limiting T cell-mediated immune responses","volume":"2","author":"Lin","year":"2023","journal-title":"MedComm - Future Medicine"},{"issue":"21","key":"bib42","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.3390\/nu16213628","article-title":"Host or the hosted? Effects of non-nutritive sweeteners on intestinal and microbial mechanisms of glycemic control","volume":"16","author":"Rose","year":"2024","journal-title":"Nutrients"},{"issue":"6","key":"bib43","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1248\/bpb.b25-00047","article-title":"Ameliorative effects of sweeteners on a mouse jet lag model","volume":"48","author":"Li","year":"2025","journal-title":"Biol Pharm Bull"},{"issue":"7","key":"bib44","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1038\/s12276-024-01269-0","article-title":"Circadian disruption reduces MUC4 expression via the clock molecule BMAL1 during dry eye development","volume":"56","author":"Zeng","year":"2024","journal-title":"Exp Mol Med"},{"key":"bib46","doi-asserted-by":"crossref","first-page":"109557","DOI":"10.1016\/j.exer.2023.109557","article-title":"Aquaporin 5 in the eye: expression, function, and roles in ocular diseases","volume":"233","author":"Zhang","year":"2023","journal-title":"Exp Eye Res"},{"key":"bib47","doi-asserted-by":"crossref","first-page":"109676","DOI":"10.1016\/j.exer.2023.109676","article-title":"Aquaporins in lacrimal glands and their role in dry eye disease","volume":"236","author":"Bai","year":"2023","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib48","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12916-023-02848-0","article-title":"Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation","volume":"21","author":"Shon","year":"2023","journal-title":"BMC Med"},{"key":"bib49","doi-asserted-by":"crossref","first-page":"848392","DOI":"10.3389\/fnut.2022.848392","article-title":"Low dose of sucralose alter gut microbiome in mice","volume":"9","author":"Zheng","year":"2022","journal-title":"Front Nutr"},{"issue":"1","key":"bib50","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s13287-020-01753-0","article-title":"Sucralose promotes accumulation of reactive oxygen species (ROS) and adipogenesis in mesenchymal stromal cells","volume":"11","author":"Kundu","year":"2020","journal-title":"Stem Cell Res Ther"},{"issue":"24","key":"bib51","doi-asserted-by":"crossref","first-page":"13635","DOI":"10.3390\/ijms252413635","article-title":"Sucralose-enhanced adipogenesis on preadipocyte human cell line during differentiation process","volume":"25","author":"Maga\u00f1a-G\u00f3mez","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"5","key":"bib52","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3390\/nu15051118","article-title":"Non-nutritive sweeteners acesulfame potassium and sucralose are competitive inhibitors of the human p-glycoprotein\/multidrug resistance protein 1 (PGP\/MDR1)","volume":"15","author":"Danner","year":"2023","journal-title":"Nutrients"},{"key":"bib53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.metabol.2017.11.017","article-title":"Circadian regulation of glucose, lipid, and energy metabolism in humans","volume":"84","author":"Poggiogalle","year":"2018","journal-title":"Metabolism"},{"issue":"4","key":"bib54","doi-asserted-by":"crossref","first-page":"e12956","DOI":"10.1111\/jpi.12956","article-title":"Circadian desynchrony and glucose metabolism","volume":"76","author":"Speksnijder","year":"2024","journal-title":"J Pineal Res"},{"issue":"1","key":"bib55","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12937-020-00549-5","article-title":"Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial","volume":"19","author":"Bueno-Hern\u00e1ndez","year":"2020","journal-title":"Nutr J"},{"issue":"4","key":"bib56","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.3390\/nu15041050","article-title":"The effect of non-nutritive sweetened beverages on postprandial glycemic and endocrine responses: a systematic review and network meta-analysis","volume":"15","author":"Zhang","year":"2023","journal-title":"Nutrients"},{"key":"bib57","doi-asserted-by":"crossref","first-page":"101985","DOI":"10.1016\/j.molmet.2024.101985","article-title":"Long-term metabolic effects of non-nutritive sweeteners","volume":"88","author":"Rathaus","year":"2024","journal-title":"Mol Metab"},{"key":"bib58","doi-asserted-by":"crossref","first-page":"1387646","DOI":"10.3389\/fnut.2024.1387646","article-title":"Unveiling the profound influence of sucralose on metabolism and its role in shaping obesity trends","volume":"11","author":"Singh","year":"2024","journal-title":"Front Nutr"},{"issue":"1","key":"bib59","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41598-023-46634-7","article-title":"Complement activation products in tears of dry eye and meibomian gland dysfunction","volume":"14","author":"Maehara","year":"2024","journal-title":"Sci Rep"},{"issue":"2","key":"bib60","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0092-8674(02)00825-5","article-title":"The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator","volume":"110","author":"Preitner","year":"2002","journal-title":"Cell"},{"issue":"6","key":"bib61","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1210\/me.2005-0057","article-title":"The orphan nuclear receptor Rev-erbalpha recruits the N-CoR\/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene","volume":"19","author":"Yin","year":"2005","journal-title":"Mol Endocrinol"},{"issue":"7396","key":"bib62","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature11048","article-title":"Regulation of circadian behaviour and metabolism by REV-ERB-a and REV-ERB-\u00df","volume":"485","author":"Cho","year":"2012","journal-title":"Nature"},{"issue":"5","key":"bib63","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1177\/0748730405277232","article-title":"Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors","volume":"20","author":"Guillaumond","year":"2005","journal-title":"J Biol Rhythms"},{"issue":"5","key":"bib64","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4155\/fmc.11.9","article-title":"The REV-ERBs and RORs: molecular links between circadian rhythms and lipid homeostasis","volume":"3","author":"Solt","year":"2011","journal-title":"Future Med Chem"},{"key":"bib65","doi-asserted-by":"crossref","first-page":"e58765","DOI":"10.7554\/eLife.58765","article-title":"REV-ERBa mediates complement expression and diurnal regulation of microglial synaptic phagocytosis","volume":"9","author":"Griffin","year":"2020","journal-title":"eLife"},{"issue":"1","key":"bib66","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4049\/jimmunol.1301982","article-title":"A circadian clock gene, Rev-erba, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression","volume":"192","author":"Sato","year":"2014","journal-title":"J Immunol"},{"issue":"9","key":"bib67","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/s41590-025-02240-5","article-title":"Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of ROR?t","volume":"26","author":"Bhattarai","year":"2025","journal-title":"Nat Immunol"},{"key":"bib2","volume-title":"Use of non-sugar sweeteners: WHO guideline","author":"WHO Guidelines Approved by the Guidelines Review Committee","year":"2023"},{"key":"bib9","volume-title":"Drugs and Lactation Database (LactMed)","author":"Sucralose","year":"2006"},{"key":"bib45","author":"Ohno","year":"2024"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.5.11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:32:13Z","timestamp":1791927133000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.67.5.11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":67,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.67.5.11","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,6]]}}}